Expression data from T-cell prolymphocytic leukemia (TPLL) and normal T cells

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PubMed ID: 17713554
Contact: Ludger Klein-Hitpass

Image:email_GSE5788.png
Institut fuer Zellbiologie

Species: Homo sapiens
Platform: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A
Number of Samples: 14
Date Range: 03/19/2003 - 08/19/2005
Experiment Quality: 92.66
2.77 %
Link to Repository: GSE5788
Original Intensity Data: Download
Clean Intensity Data: Download
Original PLIER Data: Download
Clean PLIER Data: Download
Clean CEL Files:
Data Rank:

T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations.

We used microarrays to compare the transcriptomes of eight immunomagnetically purified CD3+ normal donor derived peripheral blood cells with five highly purified inv(14)-positive T-PLL blood samples.

Design: Purified T-PLL cells and normal T-cells were analyzed on microarrays to identify differentially expressed genes. High-resolution copy number determination using SNP-chip technology and FISH in twelve inv(14)-positive T-PLL showed that differentially expressed genes clustered significantly in regions affectd by recurrent chromosomal imbalances.

Type: desease state analysis


Contents

[edit] Contributors

  • Jan Dürig
  • Stefanie Bug
  • Ludger Klein-Hitpass
  • Tanja Boes
  • Thomas Jöns
  • Jose I Martin-Dubero
  • Lana Harder
  • Michael Baudis
  • Ulrich Dührsen
  • Reiner Siebert

[edit] Protocols

[edit] References

[edit] Links

GEO Accession for this experiment: GSE5788. (Public on Aug 27 2007)

PubMed abstract: 17713554

RAW data: tar file.

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample Date Scanned Source Link Probe Variance Data Artifact Mask Quality Score
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 1 10/01/03 10:18:42 GSM135264 Probe variance for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 1 Artifact mask for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 1 95.5912
0.13 %
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 2 04/21/04 10:27:50 GSM135265 Probe variance for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 2 Artifact mask for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 2 90.7078
1.1 %
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 3 10/12/04 09:26:39 GSM135266 Probe variance for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 3 Artifact mask for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 3 88.9057
7.33 %
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 4 08/17/04 10:40:45 GSM135267 Probe variance for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 4 Artifact mask for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 4 90.9681
5.24 %
T-cell prolymphocytic leukemia, inv(14)(q11q32), case 5 08/19/05 09:56:25 GSM135268 Probe variance for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 5 Artifact mask for T-cell prolymphocytic leukemia, inv(14)(q11q32), case 5 92.0337
9.94 %
T-cell prolymphocytic leukemia, no inv(14)(q11q32), case 8 10/27/04 09:45:47 GSM135269 Probe variance for T-cell prolymphocytic leukemia, no inv(14)(q11q32), case 8 Artifact mask for T-cell prolymphocytic leukemia, no inv(14)(q11q32), case 8 88.0287
3.21 %
Normal T-cells, CD3+, donor 1 03/21/03 09:53:15 GSM135270 Probe variance for Normal T-cells, CD3+, donor 1 Artifact mask for Normal T-cells, CD3+, donor 1 93.2406
0.79 %
Normal T-cells, CD3+, donor 2 03/21/03 09:32:26 GSM135271 Probe variance for Normal T-cells, CD3+, donor 2 Artifact mask for Normal T-cells, CD3+, donor 2 93.2313
0.77 %
Normal T-cells, CD3+, donor 3 03/19/03 13:20:34 GSM135272 Probe variance for Normal T-cells, CD3+, donor 3 Artifact mask for Normal T-cells, CD3+, donor 3 95.6793
0.11 %
Normal T-cells, CD3+, donor 4 04/07/03 11:31:30 GSM135273 Probe variance for Normal T-cells, CD3+, donor 4 Artifact mask for Normal T-cells, CD3+, donor 4 94.2988
5.15 %
Normal T-cells, CD3+, donor 5 03/21/03 10:53:10 GSM135274 Probe variance for Normal T-cells, CD3+, donor 5 Artifact mask for Normal T-cells, CD3+, donor 5 94.1988
1.19 %
Normal T-cells, CD3+, donor 6 03/21/03 09:42:52 GSM135275 Probe variance for Normal T-cells, CD3+, donor 6 Artifact mask for Normal T-cells, CD3+, donor 6 93.6038
0.74 %
Normal T-cells, CD3+, donor 7 03/19/03 11:44:56 GSM135276 Probe variance for Normal T-cells, CD3+, donor 7 Artifact mask for Normal T-cells, CD3+, donor 7 92.5746
0.15 %
Normal T-cells, CD3+, donor 8 03/21/03 09:22:00 GSM135277 Probe variance for Normal T-cells, CD3+, donor 8 Artifact mask for Normal T-cells, CD3+, donor 8 94.1995
2.95 %
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