Connectivity Map Batch 02 Random Load - CMAP9

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	92.98 0.05 % 96.47
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-05microM of haloperidol					88.2728 1.95 % 93.16
vehicle					92.9829 0.33 % 96.33
MCF7 perturbed by 1.7e-05microM of phenelzine					94.1345 0 % 97.07
HL60 perturbed by 2.42e-05microM of benzocaine					91.2939 0.05 % 95.62
vehicle					92.0636 0.07 % 96
HL60 perturbed by 8.8e-06microM of halcinonide					92.1268 0.03 % 96.05
HL60 perturbed by 1.06e-05microM of Prestwick-685					89.453 0.06 % 94.7
HL60 perturbed by 1.56e-05microM of prilocaine					92.1985 1.24 % 95.48
HL60 perturbed by 1.66e-05microM of phenformin					92.0384 1.21 % 95.41
PC3 perturbed by 8.4e-06microM of cefotaxime					89.8209 0.05 % 94.88
MCF7 perturbed by 1.38e-05microM of diphenhydramine					92.9621 0.01 % 96.47
MCF7 perturbed by 1e-05microM of clozapine					92.5819 0.24 % 96.17
MCF7 perturbed by 1e-05microM of troglitazone					93.1935 0 % 96.6
MCF7 perturbed by 1e-07microM of alvespimycin					93.3291 0.19 % 96.57
HL60 perturbed by 9e-06microM of bisoprolol					89.692 1.13 % 94.28
vehicle					89.9977 0.68 % 94.66
HL60 perturbed by 1.1e-05microM of cefadroxil					90.1607 0.53 % 94.82
PC3 perturbed by 9.6e-06microM of isoflupredone					89.4724 0 % 94.74
HL60 perturbed by 9.6e-06microM of isoflupredone					88.4164 0.16 % 94.13
HL60 perturbed by 1.58e-05microM of sulfacetamide					87.1695 0.23 % 93.47
HL60 perturbed by 2.42e-05microM of metformin					86.8326 3.63 % 91.6
PC3 perturbed by 1.58e-05microM of diprophylline					86.4199 8.64 % 88.89
HL60 perturbed by 1.28e-05microM of sulfaphenazole					89.1727 2.45 % 93.36
HL60 perturbed by 1.28e-05microM of progesterone					91.067 1.58 % 94.74
MCF7 perturbed by 1.18e-05microM of dizocilpine					93.2421 1.3 % 95.97
HL60 perturbed by 9e-06microM of cefuroxime					91.4252 0.35 % 95.54
HL60 perturbed by 1.86e-05microM of kinetin					91.8789 4.47 % 93.71
MCF7 perturbed by 6.6e-06microM of oxantel					93.784 0.21 % 96.79
MCF7 perturbed by 1.26e-05microM of thioguanosine					93.5195 0 % 96.76
MCF7 perturbed by 1.1e-05microM of amoxicillin					93.0422 0.08 % 96.48
MCF7 perturbed by 7.8e-06microM of bucladesine					91.5373 0 % 95.77
MCF7 perturbed by 1.84e-05microM of ethoxyquin					89.8677 0.24 % 94.82
MCF7 perturbed by 9.2e-06microM of pipenzolate bromide					88.7889 0 % 94.39
vehicle					89.9251 0.1 % 94.91
MCF7 perturbed by 1.46e-05microM of ebselen					91.3771 0.04 % 95.67
MCF7 perturbed by 1.24e-05microM of oxyphenbutazone					91.6329 2.22 % 94.7
MCF7 perturbed by 1.96e-05microM of mecamylamine					90.7183 4.73 % 93
MCF7 perturbed by 1.46e-05microM of Prestwick-1085					89.3137 4.49 % 92.41
MCF7 perturbed by 2e-05microM of ronidazole					89.1479 3.66 % 92.74
MCF7 perturbed by 1.48e-05microM of meprylcaine					90.0074 3.91 % 93.05
vehicle					91.04 0.23 % 95.4
HL60 perturbed by 2.34e-05microM of gabapentin					91.6739 0.08 % 95.79
HL60 perturbed by 3.08e-05microM of mevalolactone					88.6733 4.74 % 91.97
vehicle					90.42 0.04 % 95.19
MCF7 perturbed by 8e-06microM of bacampicillin					92.3193 0.21 % 96.05
MCF7 perturbed by 1.88e-05microM of serotonin					90.9248 0.02 % 95.45
MCF7 perturbed by 5e-06microM of metrizamide					89.565 0.2 % 94.68
MCF7 perturbed by 8.8e-06microM of diltiazem					92.7357 7.32 % 92.71
MCF7 perturbed by 2e-05microM of monobenzone					92.5909 7.51 % 92.54
vehicle					92.5702 5.73 % 93.42
MCF7 perturbed by 1.04e-05microM of felodipine					93.1791 7.3 % 92.94
PC3 perturbed by 1e-05microM of PNU-0230031					92.0112 0.07 % 95.97
PC3 perturbed by 7.4e-06microM of helveticoside					91.7535 0.04 % 95.86
PC3 perturbed by 1.44e-05microM of Prestwick-674					91.259 0 % 95.63
PC3 perturbed by 9.6e-06microM of solasodine					90.4468 2.42 % 94.01
MCF7 perturbed by 1.12e-05microM of succinylsulfathiazole					91.172 0.18 % 95.5
MCF7 perturbed by 1.82e-05microM of harman					92.0211 3.74 % 94.14
MCF7 perturbed by 6e-06microM of syrosingopine					90.8389 0 % 95.42
MCF7 perturbed by 1.26e-05microM of diclofenac					92.9063 0.02 % 96.44
MCF7 perturbed by 8e-06microM of diflorasone					90.826 1.33 % 94.75
MCF7 perturbed by 1.12e-05microM of conessine					91.9872 0 % 95.99
MCF7 perturbed by 1.14e-05microM of retrorsine					90.7192 0.13 % 95.3
MCF7 perturbed by 1.02e-05microM of corynanthine					91.1098 0.05 % 95.53
MCF7 perturbed by 1e-07microM of sirolimus					92.6742 0.74 % 95.96
MCF7 perturbed by 2.26e-05microM of cotinine					92.2093 3.87 % 94.17
MCF7 perturbed by 1.18e-05microM of phenoxybenzamine					93.2397 0.01 % 96.61
MCF7 perturbed by 6.8e-06microM of etoposide					93.4129 1.56 % 95.93
MCF7 perturbed by 9.8e-06microM of lovastatin					92.4129 1.98 % 95.21
vehicle					93.282 1.61 % 95.83
MCF7 perturbed by 6.6e-06microM of prochlorperazine					93.2575 1.45 % 95.9
MCF7 perturbed by 1.4e-05microM of luteolin					93.4721 0.33 % 96.57
MCF7 perturbed by 2.22e-05microM of theobromine					93.2308 1.05 % 96.09
MCF7 perturbed by 6.6e-06microM of clomifene					92.9744 0.32 % 96.32
MCF7 perturbed by 1.34e-05microM of methapyrilene					93.1985 0 % 96.6
MCF7 perturbed by 9e-06microM of glipizide					93.2471 0.11 % 96.57
MCF7 perturbed by 1.18e-05microM of scopolamine					93.2338 3.15 % 95.04
MCF7 perturbed by 1.96e-05microM of crotamiton					93.1268 0.07 % 96.53
MCF7 perturbed by 1e-07microM of trichostatin A					91.9344 3.11 % 94.41
MCF7 perturbed by 1.3e-05microM of nadolol					91.4909 2.34 % 94.58
MCF7 perturbed by 9.6e-06microM of sitosterol					93.3783 0 % 96.69
MCF7 perturbed by 1.36e-05microM of cinchonine					92.4183 0.61 % 95.91
MCF7 perturbed by 5.2e-06microM of levothyroxine sodium					92.9059 0.21 % 96.35
MCF7 perturbed by 4e-06microM of lanatoside C					91.6381 2.62 % 94.51
PC3 perturbed by 5.8e-06microM of monensin					89.4195 1.04 % 94.19
PC3 perturbed by 2.74e-05microM of myosmine					91.3378 0 % 95.67
PC3 perturbed by 1.56e-05microM of prilocaine					92.0101 0 % 96.01
HL60 perturbed by 1.24e-05microM of promethazine					91.408 1.89 % 94.76
MCF7 perturbed by 1.26e-05microM of pregnenolone					91.9628 0.82 % 95.57
MCF7 perturbed by 1.46e-05microM of harmalol					92.7231 0.07 % 96.33
MCF7 perturbed by 1.62e-05microM of methoxamine					93.1429 0.23 % 96.45
MCF7 perturbed by 4.8e-06microM of rifampicin					92.3806 0.75 % 95.81
MCF7 perturbed by 1.32e-05microM of cyclizine					92.0479 0.28 % 95.88
MCF7 perturbed by 1.64e-05microM of salsolidin					93.1845 0.46 % 96.36
vehicle					92.7072 0.22 % 96.24
PC3 perturbed by 1.44e-05microM of flutamide					92.7769 0.29 % 96.24
vehicle					92.1066 0.54 % 95.78
PC3 perturbed by 1.22e-05microM of niclosamide					91.4834 0.2 % 95.64
PC3 perturbed by 1.12e-05microM of yohimbic acid					89.1554 0.03 % 94.56
PC3 perturbed by 1.32e-05microM of amiloride					92.1199 0.29 % 95.92
PC3 perturbed by 2.22e-05microM of L-methionine sulfoximine					91.5575 0.42 % 95.57
MCF7 perturbed by 1.18e-05microM of chlortalidone					92.5196 2.61 % 94.95
MCF7 perturbed by 1.06e-05microM of methylprednisolone					93.4267 3.97 % 94.73
PC3 perturbed by 1.26e-05microM of pregnenolone					91.1876 12.15 % 89.52
PC3 perturbed by 1.24e-05microM of procyclidine					91.8277 0.22 % 95.8
HL60 perturbed by 6.6e-06microM of iocetamic acid					91.6339 3.5 % 94.07
HL60 perturbed by 1.22e-05microM of diloxanide					91.4009 7.4 % 92
HL60 perturbed by 7.6e-06microM of beclometasone					90.5016 8.61 % 90.95
HL60 perturbed by 1.6e-05microM of etidronic acid					92.2837 2.39 % 94.95
HL60 perturbed by 1.66e-05microM of moxonidine					91.7342 0.09 % 95.82
HL60 perturbed by 7e-06microM of iopanoic acid					90.513 6.78 % 91.86
vehicle					91.3998 0.23 % 95.58
vehicle					93.0182 0.62 % 96.2
PC3 perturbed by 8e-06microM of minocycline					91.5953 0.31 % 95.64
PC3 perturbed by 1.22e-05microM of scoulerine					91.5457 0.91 % 95.32
PC3 perturbed by 1.04e-05microM of metampicillin					90.9011 1.39 % 94.76
PC3 perturbed by 1.14e-05microM of torasemide					91.4166 1.01 % 95.2
PC3 perturbed by 1.62e-05microM of santonin					89.5226 2.23 % 93.65
MCF7 perturbed by 2.4e-06microM of thiostrepton					93.5587 0 % 96.78
PC3 perturbed by 1.22e-05microM of clozapine					92.6507 0.32 % 96.17
PC3 perturbed by 9.8e-06microM of thioperamide					92.7784 0.02 % 96.38
PC3 perturbed by 1.86e-05microM of niridazole					91.7117 1.25 % 95.23
PC3 perturbed by 9.8e-06microM of zimeldine					91.9079 1.47 % 95.22
PC3 perturbed by 6e-06microM of cephaeline					90.8898 1.9 % 94.49
MCF7 perturbed by 5e-06microM of merbromin					93.1127 0 % 96.56
MCF7 perturbed by 1e-06microM of PNU-0230031					92.271 0.31 % 95.98
MCF7 perturbed by 1.68e-05microM of nitrofurantoin					91.6362 0.47 % 95.58
vehicle					92.1115 1.44 % 95.34
MCF7 perturbed by 1.48e-05microM of riluzole					91.9944 0.97 % 95.51
PC3 perturbed by 1e-06microM of nordihydroguaiaretic acid					92.5187 0.35 % 96.08
PC3 perturbed by 1e-04microM of acetylsalicylic acid					92.7331 0.34 % 96.19
PC3 perturbed by 1.18e-05microM of tracazolate					92.447 0.09 % 96.18
PC3 perturbed by 8.6e-06microM of sulconazole					92.3655 0.19 % 96.09
PC3 perturbed by 1.34e-05microM of methapyrilene					92.9727 0.16 % 96.41
PC3 perturbed by 2.02e-05microM of nitrofural					91.5503 1.02 % 95.26
PC3 perturbed by 7.4e-06microM of fusidic acid					92.651 0.35 % 96.15
PC3 perturbed by 1.66e-05microM of idazoxan					92.7015 0.08 % 96.31
PC3 perturbed by 1.64e-05microM of biotin					91.553 0.38 % 95.59
MCF7 perturbed by 2.32e-05microM of 2-aminobenzenesulfonamide					93.1759 0.02 % 96.58
MCF7 perturbed by 3.1e-05microM of vigabatrin					93.1499 0 % 96.57
MCF7 perturbed by 8.4e-06microM of butoconazole					93.7838 0 % 96.89
MCF7 perturbed by 1.2e-05microM of proxymetacaine					93.4444 0 % 96.72
MCF7 perturbed by 1.62e-05microM of dapsone					92.7965 0.24 % 96.28
MCF7 perturbed by 1.6e-05microM of sulfadiazine					92.8266 0.49 % 96.17
MCF7 perturbed by 1.78e-05microM of etofylline					92.4529 0.52 % 95.96
vehicle					92.4674 0.57 % 95.95
PC3 perturbed by 9e-06microM of cefuroxime					93.326 0.79 % 96.27
PC3 perturbed by 9.6e-06microM of methanthelinium bromide					93.1772 0.49 % 96.34
MCF7 perturbed by 1.64e-05microM of dioxybenzone					88.6153 4.47 % 92.07
MCF7 perturbed by 6.8e-06microM of doxorubicin					92.8145 0.12 % 96.35
vehicle					92.2552 0.22 % 96.02
MCF7 perturbed by 1e-05microM of 15-delta prostaglandin J2					92.6176 0.38 % 96.12
MCF7 perturbed by 1.64e-05microM of flurbiprofen					93.2611 0.04 % 96.61
vehicle					92.3666 0.02 % 96.18
MCF7 perturbed by 5.8e-06microM of amiodarone					93.0424 1.18 % 95.93
MCF7 perturbed by 7.6e-06microM of pentoxyverine					92.0835 1.07 % 95.51
MCF7 perturbed by 9.4e-06microM of alfuzosin					92.6922 0 % 96.34
MCF7 perturbed by 7.8e-06microM of clofilium tosylate					91.8619 1.94 % 94.96
MCF7 perturbed by 2.22e-05microM of stachydrine					91.0372 2.26 % 94.39
MCF7 perturbed by 9.4e-06microM of hydroquinine					94.2525 0.03 % 97.11
MCF7 perturbed by 1.06e-05microM of fluorometholone					90.5684 4.02 % 93.28
vehicle					93.7914 1.59 % 96.1
HL60 perturbed by 2.62e-05microM of mesalazine					87.6827 7.43 % 90.13
HL60 perturbed by 2.84e-05microM of tropine					90.6455 0.02 % 95.31
HL60 perturbed by 1.1e-05microM of dorzolamide					90.0463 1.17 % 94.44
HL60 perturbed by 9.6e-06microM of methanthelinium bromide					90.7721 0.01 % 95.38
HL60 perturbed by 1e-07microM of sirolimus					90.4072 0.54 % 94.93
PC3 perturbed by 1.18e-05microM of hexetidine					91.0017 1.42 % 94.79
vehicle					91.3593 2.9 % 94.23
PC3 perturbed by 1e-07microM of trichostatin A					89.9803 4.25 % 92.86
PC3 perturbed by 1e-05microM of scopolamine N-oxide					91.0229 3.71 % 93.66
PC3 perturbed by 3.4e-06microM of pyrvinium					91.7234 3.55 % 94.09
PC3 perturbed by 1.18e-05microM of dobutamine					91.6571 1.74 % 94.96
vehicle					76.4889 2.34 % 87.07
MCF7 perturbed by 2e-05microM of erastin					93.5758 2.09 % 95.74
PC3 perturbed by 1e-05microM of PF-00539758-00					92.3261 2.13 % 95.1
PC3 perturbed by 1e-05microM of C-75					93.256 0 % 96.63
PC3 perturbed by 1e-05microM of STOCK1N-35215					92.6041 0.59 % 96
vehicle					93.0764 0.11 % 96.48
vehicle					93.9452 0 % 96.97
MCF7 perturbed by 2.46e-05microM of anabasine					91.6282 0.01 % 95.81
vehicle					80.8265 0.93 % 89.95
MCF7 perturbed by 1e-06microM of nordihydroguaiaretic acid					80.3739 0.91 % 89.73
MCF7 perturbed by 1.24e-05microM of promethazine					92.5728 0.01 % 96.28
MCF7 perturbed by 1.24e-05microM of articaine					92.9073 0 % 96.45
MCF7 perturbed by 1.04e-05microM of megestrol					92.2507 0.14 % 96.05
MCF7 perturbed by 1.12e-05microM of florfenicol					92.2062 0 % 96.1
MCF7 perturbed by 1e-05microM of 5155877					92.4784 3.56 % 94.46
vehicle					92.565 0.15 % 96.21
MCF7 perturbed by 1e-05microM of LY-294002					83.7362 5.73 % 89
MCF7 perturbed by 1.5e-05microM of streptozocin					85.776 1.04 % 92.37
vehicle					83.693 1.09 % 91.3
MCF7 perturbed by 8.6e-06microM of clindamycin					83.479 0.46 % 91.51
vehicle					81.871 2.93 % 89.47
vehicle					82.7801 1.67 % 90.56
PC3 perturbed by 1.18e-05microM of chlortalidone					77.9213 0.98 % 88.47
PC3 perturbed by 1e-05microM of canrenoic acid					75.2153 1.04 % 87.09
MCF7 perturbed by 9.6e-06microM of decamethonium bromide					75.3854 0.23 % 87.58
vehicle					78.8329 0.02 % 89.41
PC3 perturbed by 1e-05microM of PHA-00816795					77.4609 0.55 % 88.46
MCF7 perturbed by 8.2e-06microM of enalapril					84.2491 0.17 % 92.04
PC3 perturbed by 1e-05microM of BCB000039					77.3414 8.92 % 84.21