Connectivity Map Batch 02 Random Load - CMAP8

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	93.17 0.09 % 96.54
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-04microM of acetylsalicylic acid					89.4363 0.12 % 94.66
MCF7 perturbed by 4.6e-06microM of paclitaxel					93.1674 0.81 % 96.18
MCF7 perturbed by 8.8e-06microM of diltiazem					93.1644 0.23 % 96.47
MCF7 perturbed by 8e-06microM of chlorhexidine					92.3897 0.09 % 96.15
MCF7 perturbed by 1.78e-05microM of 6-benzylaminopurine					93.5376 0.06 % 96.74
MCF7 perturbed by 1.46e-05microM of nalidixic acid					93.5524 0.55 % 96.5
HL60 perturbed by 9.2e-06microM of flunisolide					91.1299 0.03 % 95.55
HL60 perturbed by 1.26e-05microM of phentolamine					91.7054 3.19 % 94.26
HL60 perturbed by 1.48e-05microM of tolbutamide					91.0946 4.92 % 93.09
HL60 perturbed by 1.18e-05microM of metoclopramide					91.2993 4.15 % 93.57
vehicle					91.6105 0.63 % 95.49
HL60 perturbed by 9.8e-06microM of pimethixene					90.8473 0.96 % 94.94
PC3 perturbed by 1.18e-05microM of meclofenamic acid					88.3283 1.61 % 93.36
PC3 perturbed by 9.2e-06microM of dexamethasone					87.7295 1.85 % 92.94
MCF7 perturbed by 1.08e-05microM of morantel					92.3528 0 % 96.18
HL60 perturbed by 7.4e-06microM of domperidone					90.7212 0.31 % 95.2
vehicle					89.4088 0.56 % 94.43
HL60 perturbed by 8.2e-06microM of clebopride					89.2076 2.07 % 93.57
vehicle					89.5153 0.81 % 94.35
HL60 perturbed by 1.2e-05microM of isoxicam					88.5114 0.11 % 94.2
HL60 perturbed by 1.46e-05microM of nifuroxazide					90.2751 2.62 % 93.83
HL60 perturbed by 2.34e-05microM of propylthiouracil					90.1164 0.13 % 94.99
HL60 perturbed by 6.6e-06microM of naringin					90.5216 3.23 % 93.64
MCF7 perturbed by 1.44e-05microM of iproniazid					92.9085 0.88 % 96.01
MCF7 perturbed by 8.8e-06microM of cloxacillin					92.9591 0.58 % 96.19
MCF7 perturbed by 1.54e-05microM of flumequine					93.1205 0.48 % 96.32
vehicle					92.3206 0.76 % 95.78
vehicle					92.9722 0.34 % 96.31
HL60 perturbed by 1.48e-05microM of leflunomide					89.7213 0.19 % 94.76
HL60 perturbed by 1.5e-05microM of streptozocin					88.4802 0.02 % 94.23
HL60 perturbed by 1.62e-05microM of tinidazole					89.5758 5.95 % 91.81
HL60 perturbed by 1e-05microM of glycopyrronium bromide					91.0521 0.06 % 95.5
HL60 perturbed by 1.84e-05microM of ethoxyquin					91.1848 0.12 % 95.53
HL60 perturbed by 1.48e-05microM of hexestrol					90.639 0.25 % 95.2
HL60 perturbed by 1.68e-05microM of tetryzoline					89.9095 1.16 % 94.37
MCF7 perturbed by 1.48e-05microM of procainamide					92.365 0.1 % 96.13
MCF7 perturbed by 1.04e-05microM of benfluorex					91.89 0 % 95.95
MCF7 perturbed by 2.34e-05microM of gabapentin					92.226 0.01 % 96.11
MCF7 perturbed by 6e-06microM of deferoxamine					90.3051 0.04 % 95.13
MCF7 perturbed by 1.42e-05microM of sulfamethoxypyridazine					89.97 0.03 % 94.97
MCF7 perturbed by 1.5e-05microM of dienestrol					92.7663 0 % 96.38
MCF7 perturbed by 1.2e-05microM of propoxycaine					89.5272 6.41 % 91.56
MCF7 perturbed by 1.22e-05microM of ondansetron					90.1096 4.14 % 92.98
HL60 perturbed by 1e-07microM of sirolimus					88.5345 4.06 % 92.24
HL60 perturbed by 1e-05microM of LY-294002					89.2538 3.74 % 92.76
MCF7 perturbed by 1.46e-05microM of rolipram					93.0299 7.15 % 92.94
PC3 perturbed by 2.74e-05microM of myosmine					88.4296 4.36 % 92.03
PC3 perturbed by 1.06e-05microM of indapamide					90.4553 0.27 % 95.09
PC3 perturbed by 1e-06microM of PHA-00851261E					89.5861 0.04 % 94.77
PC3 perturbed by 8.4e-06microM of flecainide					90.1257 0.03 % 95.05
PC3 perturbed by 1.1e-05microM of cloperastine					89.6125 1.75 % 93.93
MCF7 perturbed by 2.04e-05microM of hydralazine					88.2933 0.21 % 94.04
MCF7 perturbed by 1.44e-05microM of sulfabenzamide					90.5465 1.96 % 94.29
MCF7 perturbed by 1.28e-05microM of dydrogesterone					89.909 4.91 % 92.5
MCF7 perturbed by 1e-08microM of estradiol					91.4751 0.2 % 95.64
MCF7 perturbed by 9.2e-06microM of timolol					91.4949 0.15 % 95.67
MCF7 perturbed by 1e-05microM of LY-294002					92.6051 0.06 % 96.27
MCF7 perturbed by 1.5e-05microM of equilin					91.7795 0.3 % 95.74
MCF7 perturbed by 1e-05microM of phthalylsulfathiazole					91.6305 0.71 % 95.46
MCF7 perturbed by 1.44e-05microM of sulfabenzamide					91.6405 0.58 % 95.53
MCF7 perturbed by 1.5e-05microM of ciclopirox					90.981 0.5 % 95.24
MCF7 perturbed by 3.24e-05microM of pyrazinamide					91.9442 1.38 % 95.28
MCF7 perturbed by 1.86e-05microM of methoxsalen					91.2462 0.43 % 95.41
MCF7 perturbed by 1.1e-05microM of bezafibrate					92.1592 0.31 % 95.93
MCF7 perturbed by 1.98e-05microM of edrophonium chloride					91.38 0.61 % 95.39
vehicle					90.4817 0.01 % 95.23
MCF7 perturbed by 1e-07microM of trichostatin A					92.033 0 % 96.02
MCF7 perturbed by 2.58e-05microM of bemegride					91.7845 0 % 95.89
MCF7 perturbed by 2.12e-05microM of 3-acetylcoumarin					90.7514 0.21 % 95.27
MCF7 perturbed by 1.24e-05microM of procyclidine					92.1118 0.01 % 96.05
MCF7 perturbed by 7.6e-06microM of rolitetracycline					91.8738 0 % 95.94
MCF7 perturbed by 1.24e-05microM of mycophenolic acid					92.5731 0.22 % 96.18
MCF7 perturbed by 1.16e-05microM of oxybuprocaine					92.4507 0 % 96.22
PC3 perturbed by 1.12e-05microM of benzamil					90.7888 0 % 95.39
PC3 perturbed by 1e-05microM of 0173570-0000					88.8796 1.73 % 93.57
HL60 perturbed by 9.4e-06microM of pizotifen					90.6205 0.01 % 95.3
MCF7 perturbed by 1.22e-05microM of scoulerine					91.8756 0.2 % 95.84
MCF7 perturbed by 1.04e-05microM of cefaclor					92.1134 0.15 % 95.98
MCF7 perturbed by 1e-05microM of sulfasalazine					91.9239 0.22 % 95.85
MCF7 perturbed by 2.34e-05microM of propylthiouracil					91.068 3.79 % 93.64
MCF7 perturbed by 1.34e-05microM of imipenem					91.9246 1.48 % 95.22
vehicle					91.5183 0.78 % 95.37
vehicle					91.5805 0.62 % 95.48
PC3 perturbed by 1.34e-05microM of fenbendazole					91.3196 1.23 % 95.05
PC3 perturbed by 1.62e-05microM of santonin					91.6307 0.65 % 95.49
PC3 perturbed by 1.34e-05microM of nialamide					91.767 1.53 % 95.12
PC3 perturbed by 1.44e-05microM of oxamniquine					91.3208 0.27 % 95.52
vehicle					91.0996 0.32 % 95.39
PC3 perturbed by 8.8e-06microM of nafcillin					89.2356 0.56 % 94.34
MCF7 perturbed by 1e-05microM of bambuterol					91.732 2.91 % 94.41
MCF7 perturbed by 6.6e-06microM of amikacin					93.06 2.11 % 95.48
MCF7 perturbed by 7.8e-06microM of probucol					92.147 2.13 % 95.01
MCF7 perturbed by 1.14e-05microM of vinpocetine					92.5761 4.14 % 94.22
MCF7 perturbed by 1.02e-05microM of oxybutynin					92.8944 5.12 % 93.89
PC3 perturbed by 1.92e-05microM of minoxidil					89.9228 5.91 % 92.01
PC3 perturbed by 1.5e-05microM of R-atenolol					91.6296 6.73 % 92.45
PC3 perturbed by 7.2e-06microM of emetine					89.0042 0.92 % 94.04
HL60 perturbed by 5.6e-06microM of paromomycin					90.778 5.03 % 92.87
vehicle					90.9588 2.48 % 94.24
HL60 perturbed by 1.24e-05microM of procyclidine					91.4574 2.45 % 94.51
HL60 perturbed by 3.1e-05microM of dimethadione					91.5039 2.16 % 94.67
MCF7 perturbed by 1.86e-05microM of mexiletine					90.0179 1.99 % 94.02
MCF7 perturbed by 1.32e-05microM of chlorambucil					92.3959 0.5 % 95.95
HL60 perturbed by 2.58e-05microM of Prestwick-967					90.1059 4.03 % 93.04
HL60 perturbed by 8.6e-06microM of naftopidil					90.2338 4.67 % 92.78
HL60 perturbed by 1.52e-05microM of etamsylate					90.251 4.94 % 92.65
HL60 perturbed by 6.6e-06microM of lymecycline					89.9221 4.2 % 92.86
HL60 perturbed by 9.8e-06microM of risperidone					91.1919 0.91 % 95.14
MCF7 perturbed by 1.02e-05microM of doxylamine					91.7798 2.62 % 94.58
MCF7 perturbed by 8e-06microM of calcium pantothenate					90.8569 0.54 % 95.16
PC3 perturbed by 1.34e-05microM of enilconazole					88.9655 2.42 % 93.27
PC3 perturbed by 9e-06microM of telenzepine					90.9701 1.74 % 94.61
vehicle					89.2473 2.2 % 93.52
vehicle					89.1058 1.7 % 93.7
PC3 perturbed by 2.02e-05microM of guaifenesin					91.3682 0.07 % 95.65
PC3 perturbed by 1.12e-05microM of prednisone					91.9374 0.3 % 95.82
PC3 perturbed by 8.8e-06microM of cefixime					91.5657 0.6 % 95.48
vehicle					91.9553 0 % 95.98
MCF7 perturbed by 1e-05microM of CP-320650-01					92.3229 0 % 96.16
PC3 perturbed by 7.4e-06microM of domperidone					91.2036 0.98 % 95.11
vehicle					92.08 0.21 % 95.94
PC3 perturbed by 8.4e-06microM of clofazimine					91.6751 0.35 % 95.66
PC3 perturbed by 1.96e-05microM of crotamiton					91.6473 0.3 % 95.67
PC3 perturbed by 1.18e-05microM of phenoxybenzamine					92.0113 0.09 % 95.96
MCF7 perturbed by 1.1e-05microM of tiapride					92.1475 1.3 % 95.42
PC3 perturbed by 1.32e-05microM of hydrocotarnine					92.0278 1.18 % 95.42
PC3 perturbed by 1.1e-05microM of piretanide					92.5029 0.46 % 96.02
PC3 perturbed by 1e-06microM of chlorpromazine					91.8596 0.53 % 95.66
PC3 perturbed by 8e-06microM of sertaconazole					92.2514 1.1 % 95.57
PC3 perturbed by 1.18e-05microM of suloctidil					92.1078 1.38 % 95.36
PC3 perturbed by 9e-06microM of hydroxyzine					92.3814 0.86 % 95.76
vehicle					91.7786 0.18 % 95.8
PC3 perturbed by 6.2e-06microM of liothyronine					91.3883 0.86 % 95.26
PC3 perturbed by 9.2e-06microM of Prestwick-984					91.4106 0 % 95.7
PC3 perturbed by 1.26e-05microM of thioguanosine					91.9589 0.3 % 95.83
vehicle					91.4527 0.74 % 95.35
MCF7 perturbed by 1.64e-05microM of pinacidil					93.0012 0.44 % 96.28
MCF7 perturbed by 1.2e-05microM of alfaxalone					92.6644 0.14 % 96.26
MCF7 perturbed by 1.1e-05microM of nitrendipine					92.4669 0.04 % 96.21
MCF7 perturbed by 2.06e-05microM of aminohippuric acid					93.3404 0.01 % 96.66
MCF7 perturbed by 1.46e-05microM of procaine					93.306 0.25 % 96.53
PC3 perturbed by 1.16e-05microM of calycanthine					90.7499 0 % 95.37
MCF7 perturbed by 1e-07microM of sirolimus					92.186 0.1 % 96.04
MCF7 perturbed by 1e-05microM of LY-294002					92.6058 0.04 % 96.28
PC3 perturbed by 1e-07microM of monorden					91.1756 0.42 % 95.38
MCF7 perturbed by 1e-04microM of H-7					91.872 1.01 % 95.43
vehicle					91.8053 0.02 % 95.89
MCF7 perturbed by 6.2e-06microM of aconitine					90.2385 2.68 % 93.78
MCF7 perturbed by 1.04e-05microM of altizide					90.3421 0.11 % 95.12
MCF7 perturbed by 9.2e-06microM of pipenzolate bromide					92.6505 0 % 96.33
MCF7 perturbed by 9.6e-06microM of cefalotin					90.8228 0.04 % 95.39
MCF7 perturbed by 8.2e-06microM of lidoflazine					93.1788 2.46 % 95.36
MCF7 perturbed by 8.2e-06microM of azlocillin					93.2058 4.11 % 94.55
MCF7 perturbed by 1.42e-05microM of cicloheximide					92.112 3.78 % 94.17
HL60 perturbed by 1e-05microM of LY-294002					87.412 3.47 % 91.97
HL60 perturbed by 1e-06microM of trichostatin A					86.9003 1.65 % 92.63
HL60 perturbed by 1.12e-05microM of piperidolate					89.3261 3.9 % 92.71
vehicle					90.4514 3.42 % 93.52
MCF7 perturbed by 1e-05microM of SC-560					79.9685 2.13 % 88.92
MCF7 perturbed by 1e-06microM of AH-23848					80.5643 3.38 % 88.59
MCF7 perturbed by 2e-05microM of STOCK1N-28457					80.8505 2.86 % 89
PC3 perturbed by 2e-05microM of erastin					91.4264 1.74 % 94.84
vehicle					92.6652 1.04 % 95.81
PC3 perturbed by 1e-05microM of 0225151-0000					92.1473 0.81 % 95.67
MCF7 perturbed by 2.74e-05microM of myosmine					90.4342 0 % 95.22
MCF7 perturbed by 9.4e-06microM of terazosin					92.6569 0 % 96.33
MCF7 perturbed by 1.44e-05microM of Prestwick-674					92.168 0 % 96.08
MCF7 perturbed by 1e-06microM of tanespimycin					81.8877 0.15 % 90.87
vehicle					92.2092 0.01 % 96.1
MCF7 perturbed by 1.64e-05microM of flurbiprofen					91.5568 0.09 % 95.73
MCF7 perturbed by 1e-06microM of Gly-His-Lys					91.9133 0.09 % 95.91
PC3 perturbed by 1e-05microM of dinoprostone					90.9084 2.16 % 94.37
vehicle					92.4252 0.56 % 95.93
MCF7 perturbed by 1e-05microM of vorinostat					82.0858 2.17 % 89.96
MCF7 perturbed by 7.8e-06microM of fluphenazine					83.4182 0.57 % 91.42
MCF7 perturbed by 1.14e-05microM of acenocoumarol					86.3435 0.09 % 93.13
vehicle					83.8712 1.13 % 91.37
MCF7 perturbed by 1e-05microM of mepyramine					82.8183 1.19 % 90.81
MCF7 perturbed by 1.16e-05microM of bergenin					82.9191 1.38 % 90.77
MCF7 perturbed by 1.38e-05microM of estriol					82.6158 0.14 % 91.24
MCF7 perturbed by 4.6e-06microM of ivermectin					88.4546 0.14 % 94.16
PC3 perturbed by 1.3e-05microM of nifenazone					83.2598 2.96 % 90.15
PC3 perturbed by 1.6e-05microM of Trolox C					82.1857 0.99 % 90.6
PC3 perturbed by 9.8e-06microM of carbinoxamine					76.4186 0.02 % 88.2
vehicle					75.4365 0.61 % 87.41
MCF7 perturbed by 1.9e-05microM of zalcitabine					74.9752 0.46 % 87.26
PC3 perturbed by 7.6e-06microM of guanadrel					76.035 0.71 % 87.66
PC3 perturbed by 1e-05microM of 0173570-0000					74.5576 1.53 % 86.51
MCF7 perturbed by 2.58e-05microM of Prestwick-967					75.4088 0.81 % 87.3
MCF7 perturbed by 7.4e-06microM of apramycin					77.6829 1.13 % 88.28
vehicle					77.3019 0.25 % 88.53
vehicle					81.175 0.04 % 90.57
MCF7 perturbed by 1e-05microM of CAY-10397					76.2102 1.72 % 87.25
MCF7 perturbed by 1.02e-05microM of perhexiline					83.8927 0.11 % 91.89
MCF7 perturbed by 9.8e-06microM of pergolide					82.9831 0.03 % 91.48
MCF7 perturbed by 1.12e-05microM of indometacin					79.3303 0.16 % 89.58
MCF7 perturbed by 1.62e-05microM of triflusal					78.6657 0.03 % 89.32
MCF7 perturbed by 8.4e-06microM of ifenprodil					82.5981 0.12 % 91.24
PC3 perturbed by 1e-05microM of CP-944629					79.7916 4.97 % 87.41
PC3 perturbed by 1e-05microM of meteneprost					83.7361 2.28 % 90.73
PC3 perturbed by 1e-06microM of IC-86621					80.2124 2.47 % 88.87