Connectivity Map Batch 02 Random Load - CMAP7

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.7 0.09 % 93.81
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-08microM of estradiol					88.9151 1.09 % 93.91
HL60 perturbed by 1e-05microM of LY-294002					87.7048 0.42 % 93.64
HL60 perturbed by 1e-06microM of tanespimycin					88.1283 0.81 % 93.66
HL60 perturbed by 1e-06microM of tanespimycin					90.3477 0.09 % 95.13
HL60 perturbed by 1e-06microM of tanespimycin					87.2729 3.8 % 91.74
HL60 perturbed by 1e-06microM of tretinoin					87.328 1.08 % 93.12
MCF7 perturbed by 1.96e-05microM of 4-hydroxyphenazone					92.9734 0.02 % 96.48
MCF7 perturbed by 1.6e-05microM of pyrimethamine					93.1308 1.37 % 95.88
MCF7 perturbed by 1.34e-05microM of ticlopidine					93.1254 0 % 96.56
MCF7 perturbed by 1.28e-05microM of ethisterone					92.3668 50.76 % 70.8
HL60 perturbed by 1.96e-05microM of ethotoin					88.3097 3.03 % 92.64
HL60 perturbed by 8.4e-06microM of Prestwick-664					91.4492 0.01 % 95.72
HL60 perturbed by 2.52e-05microM of citiolone					91.0272 0.03 % 95.5
vehicle					91.1154 0 % 95.56
HL60 perturbed by 1.02e-05microM of chenodeoxycholic acid					90.5759 1.82 % 94.38
HL60 perturbed by 1.78e-05microM of 6-benzylaminopurine					91.4434 0 % 95.72
HL60 perturbed by 1.28e-05microM of triprolidine					91.5891 0 % 95.79
PC3 perturbed by 1.18e-05microM of dizocilpine					88.3818 4.76 % 91.81
PC3 perturbed by 8.4e-06microM of alverine					88.0943 3.43 % 92.33
PC3 perturbed by 4.2e-06microM of neomycin					86.8093 8.84 % 88.98
PC3 perturbed by 1.12e-05microM of nomifensine					87.5488 6.09 % 90.73
MCF7 perturbed by 1e-07microM of sirolimus					92.9186 0.13 % 96.39
MCF7 perturbed by 1e-08microM of fulvestrant					92.7229 4.67 % 94.02
MCF7 perturbed by 1.12e-05microM of sulindac					91.4005 1.35 % 95.02
MCF7 perturbed by 1.58e-05microM of diprophylline					91.2858 0.04 % 95.62
MCF7 perturbed by 0.0002microM of valproic acid					92.5415 1.87 % 95.33
MCF7 perturbed by 1.48e-05microM of todralazine					92.3007 19.07 % 86.62
MCF7 perturbed by 1.28e-05microM of sulfaphenazole					92.4382 1.39 % 95.52
HL60 perturbed by 6.6e-06microM of clomifene					88.2366 14.64 % 86.8
HL60 perturbed by 2.2e-05microM of carcinine					89.0005 0.49 % 94.26
HL60 perturbed by 2.2e-05microM of heptaminol					89.6444 4.49 % 92.58
HL60 perturbed by 1.12e-05microM of sulindac					85.9298 46.99 % 69.47
PC3 perturbed by 2.62e-05microM of 8-azaguanine					89.2237 3.28 % 92.97
HL60 perturbed by 1.04e-05microM of felodipine					89.8079 1.51 % 94.15
HL60 perturbed by 1.4e-05microM of probenecid					90.28 0.12 % 95.08
MCF7 perturbed by 2.92e-05microM of isoniazid					91.3866 10.63 % 90.38
MCF7 perturbed by 1.02e-05microM of triamcinolone					92.2495 1.08 % 95.59
MCF7 perturbed by 8.4e-06microM of tetracycline					92.029 1.43 % 95.3
HL60 perturbed by 6e-06microM of propidium iodide					88.1938 80.54 % 53.83
HL60 perturbed by 6e-06microM of nadide					88.5869 80.27 % 54.16
HL60 perturbed by 1.22e-05microM of eucatropine					91.0917 0.01 % 95.54
MCF7 perturbed by 1.78e-05microM of 3-hydroxy-DL-kynurenine					91.5837 0.05 % 95.77
MCF7 perturbed by 1.7e-05microM of arecoline					91.0446 1.11 % 94.97
MCF7 perturbed by 1.16e-05microM of testosterone					92.5758 0 % 96.29
MCF7 perturbed by 7.6e-06microM of pentoxyverine					92.8347 0 % 96.42
MCF7 perturbed by 2.4e-05microM of pyrithyldione					91.5284 0 % 95.76
MCF7 perturbed by 1.42e-05microM of sulfamonomethoxine					91.5367 0.01 % 95.76
MCF7 perturbed by 8.2e-06microM of cefamandole					90.5982 0.56 % 95.02
MCF7 perturbed by 7.4e-06microM of piperacillin					90.1301 1.15 % 94.49
MCF7 perturbed by 1.22e-05microM of eucatropine					91.0371 0.75 % 95.15
MCF7 perturbed by 1.14e-05microM of drofenine					90.5218 3.72 % 93.4
MCF7 perturbed by 7.2e-06microM of fenoprofen					89.9153 4.54 % 92.69
MCF7 perturbed by 2.8e-06microM of netilmicin					90.8839 5.94 % 92.47
vehicle					87.2447 6.92 % 90.16
MCF7 perturbed by 1.12e-05microM of chlorogenic acid					89.0386 0.99 % 94.02
MCF7 perturbed by 1.04e-05microM of felodipine					90.6431 0.17 % 95.24
MCF7 perturbed by 6.6e-06microM of amikacin					90.223 23.92 % 83.15
vehicle					91.5965 43.16 % 74.22
PC3 perturbed by 1.26e-05microM of diphenylpyraline					87.2625 18.37 % 84.45
PC3 perturbed by 1e-07microM of trichostatin A					87.815 3.98 % 91.92
PC3 perturbed by 6e-06microM of deferoxamine					90.7623 2.91 % 93.93
MCF7 perturbed by 1.42e-05microM of hydroxyachillin					89.5467 83.12 % 53.21
MCF7 perturbed by 5.8e-06microM of atropine					90.4268 1.86 % 94.29
vehicle					87.8029 1.71 % 93.05
MCF7 perturbed by 9e-06microM of bephenium hydroxynaphthoate					91.3656 0.97 % 95.2
vehicle					92.1409 0.05 % 96.04
vehicle					91.7014 0.93 % 95.39
MCF7 perturbed by 1e-06microM of tretinoin					91.818 0.23 % 95.79
MCF7 perturbed by 1e-07microM of trichostatin A					91.9637 0.27 % 95.84
MCF7 perturbed by 1.48e-05microM of estrone					91.6953 0.86 % 95.42
vehicle					92.1798 0.36 % 95.91
vehicle					91.0112 3.54 % 93.73
MCF7 perturbed by 3.24e-05microM of nicotinic acid					91.929 0.35 % 95.79
MCF7 perturbed by 8.8e-06microM of betulinic acid					91.4406 70.44 % 60.5
vehicle					91.6821 52.22 % 69.73
PC3 perturbed by 2.04e-05microM of hydralazine					89.3916 5.36 % 92.02
PC3 perturbed by 1.68e-05microM of nitrofurantoin					89.0739 8.13 % 90.47
PC3 perturbed by 1.44e-05microM of Prestwick-674					89.7303 2.19 % 93.77
PC3 perturbed by 1.28e-05microM of heliotrine					90.5187 0.42 % 95.05
HL60 perturbed by 9.6e-06microM of nimodipine					90.1627 0.42 % 94.87
HL60 perturbed by 1.76e-05microM of oxybenzone					89.5424 5.52 % 92.01
HL60 perturbed by 1.18e-05microM of (-)-MK-801					90.3056 0.14 % 95.08
MCF7 perturbed by 7e-06microM of thiocolchicoside					91.723 0.82 % 95.45
MCF7 perturbed by 1.08e-05microM of iobenguane					92.0609 0.6 % 95.73
MCF7 perturbed by 2.24e-05microM of phenacetin					91.1459 2.83 % 94.16
vehicle					91.7338 42.03 % 74.85
vehicle					89.5726 67.5 % 61.04
PC3 perturbed by 4.8e-06microM of rifampicin					90.3292 11.86 % 89.24
MCF7 perturbed by 1.28e-05microM of maprotiline					91.8264 48.22 % 71.8
MCF7 perturbed by 2.24e-05microM of ascorbic acid					92.3042 15.66 % 88.32
PC3 perturbed by 9.2e-06microM of zuclopenthixol					88.6715 84.28 % 52.19
PC3 perturbed by 1.4e-05microM of piperine					90.928 0.16 % 95.39
PC3 perturbed by 1.02e-05microM of doxylamine					90.4417 0.68 % 94.88
PC3 perturbed by 1.54e-05microM of salsolinol					90.568 12.27 % 89.15
HL60 perturbed by 6.6e-06microM of lasalocid					88.8349 58.36 % 65.24
HL60 perturbed by 1.4e-05microM of luteolin					90.6475 0.03 % 95.31
HL60 perturbed by 1.3e-05microM of capsaicin					91.3183 0.13 % 95.59
HL60 perturbed by 8.6e-06microM of sulconazole					90.5023 12.37 % 89.06
MCF7 perturbed by 1.28e-05microM of ethisterone					88.8742 4.32 % 92.28
MCF7 perturbed by 1.18e-05microM of chlorcyclizine					90.7424 1.58 % 94.58
MCF7 perturbed by 9.6e-06microM of solasodine					91.5872 3.33 % 94.13
HL60 perturbed by 1.12e-05microM of alprostadil					89.4275 0.87 % 94.28
HL60 perturbed by 1.24e-05microM of naftifine					90.3667 5.28 % 92.54
HL60 perturbed by 1.08e-05microM of lansoprazole					91.3263 0 % 95.66
HL60 perturbed by 1.14e-05microM of tridihexethyl					91.0977 1.06 % 95.02
HL60 perturbed by 1.18e-05microM of tracazolate					90.2913 83.54 % 53.37
vehicle					91.2621 0 % 95.63
MCF7 perturbed by 1.46e-05microM of 7-aminocephalosporanic acid					91.3566 2.98 % 94.19
PC3 perturbed by 1.12e-05microM of chlorpromazine					91.3723 0.76 % 95.3
PC3 perturbed by 7e-06microM of thiocolchicoside					89.3861 2.52 % 93.43
PC3 perturbed by 1.08e-05microM of rimexolone					87.2854 2.27 % 92.51
PC3 perturbed by 8e-06microM of bacampicillin					91.1986 1.51 % 94.84
PC3 perturbed by 1.62e-05microM of tinidazole					91.5338 3.47 % 94.03
PC3 perturbed by 1.84e-05microM of etilefrine					91.1771 34.52 % 78.33
vehicle					91.2938 0.64 % 95.33
PC3 perturbed by 7.6e-06microM of beclometasone					90.8131 87.22 % 51.8
MCF7 perturbed by 1.48e-05microM of apigenin					92.1504 0.03 % 96.06
MCF7 perturbed by 9e-06microM of Prestwick-1100					92.8287 0.02 % 96.4
MCF7 perturbed by 1.7e-05microM of phenelzine					91.8573 0.27 % 95.79
MCF7 perturbed by 8.8e-06microM of cefixime					92.993 0 % 96.5
MCF7 perturbed by 5.4e-06microM of pancuronium bromide					92.6531 0.78 % 95.94
PC3 perturbed by 1.38e-05microM of androsterone					91.9874 45.86 % 73.07
PC3 perturbed by 2.28e-05microM of hymecromone					91.7397 26.43 % 82.65
vehicle					91.3384 0.39 % 95.47
vehicle					92.5634 4.14 % 94.21
MCF7 perturbed by 1e-06microM of 0173570-0000					91.8782 0.19 % 95.84
MCF7 perturbed by 9.4e-06microM of mephentermine					92.1197 0.1 % 96.01
MCF7 perturbed by 1.44e-05microM of Prestwick-674					90.2441 1.89 % 94.18
MCF7 perturbed by 1.1e-05microM of cloperastine					91.5455 2.71 % 94.42
PC3 perturbed by 1.96e-05microM of ampyrone					91.8609 0.05 % 95.9
PC3 perturbed by 3e-06microM of dihydroergotamine					91.681 3.09 % 94.3
PC3 perturbed by 1e-06microM of tanespimycin					91.2537 0.64 % 95.3
PC3 perturbed by 1.18e-05microM of lisuride					91.4166 64.26 % 63.58
PC3 perturbed by 1e-05microM of SR-95639A					92.0021 2.58 % 94.71
PC3 perturbed by 1.84e-05microM of primidone					90.9296 42.17 % 74.38
MCF7 perturbed by 8.6e-06microM of dimenhydrinate					92.2204 17.32 % 87.45
MCF7 perturbed by 8e-06microM of chlorhexidine					92.5127 3.58 % 94.46
MCF7 perturbed by 7.6e-06microM of dequalinium chloride					91.9681 9.09 % 91.44
PC3 perturbed by 5.2e-06microM of iopamidol					91.012 0.14 % 95.44
PC3 perturbed by 5.8e-06microM of atropine					90.7137 0.01 % 95.35
PC3 perturbed by 1.94e-05microM of pyridoxine					91.1639 0 % 95.58
MCF7 perturbed by 1.8e-05microM of mafenide					90.03 65.56 % 62.24
MCF7 perturbed by 1.34e-05microM of enilconazole					91.5287 8.16 % 91.69
MCF7 perturbed by 8.4e-06microM of rilmenidine					91.1433 11.15 % 90
vehicle					91.1003 0.13 % 95.49
MCF7 perturbed by 8.4e-06microM of ifenprodil					90.3578 1.91 % 94.22
PC3 perturbed by 1e-05microM of pheneticillin					90.279 92.15 % 49.06
PC3 perturbed by 1e-05microM of PF-00539745-00					91.3334 0.05 % 95.64
MCF7 perturbed by 1e-08microM of alpha-estradiol					91.181 1.9 % 94.64
MCF7 perturbed by 8.6e-06microM of meclozine					91.1873 15.8 % 87.69
vehicle					91.4725 0.41 % 95.53
MCF7 perturbed by 1.34e-05microM of acetylsalicylsalicylic acid					90.4137 1.16 % 94.63
vehicle					91.7305 3.13 % 94.3
MCF7 perturbed by 1.7e-05microM of epirizole					92.1309 0 % 96.07
MCF7 perturbed by 1.02e-05microM of alpha-yohimbine					92.1599 3.31 % 94.43
MCF7 perturbed by 2.06e-05microM of butamben					92.7096 0 % 96.35
MCF7 perturbed by 1.06e-05microM of papaverine					91.022 0.13 % 95.45
HL60 perturbed by 1.12e-05microM of benzylpenicillin					87.8989 2.82 % 92.54
HL60 perturbed by 1e-05microM of clozapine					88.9878 12.53 % 88.23
HL60 perturbed by 1.36e-05microM of trifluridine					89.5501 5.31 % 92.12
PC3 perturbed by 5.8e-06microM of cefoperazone					90.0943 4.67 % 92.71
PC3 perturbed by 1.08e-05microM of dextromethorphan					90.3575 0.01 % 95.18
PC3 perturbed by 1.06e-05microM of propafenone					90.192 0.03 % 95.08
MCF7 perturbed by 2e-05microM of STOCK1N-28457					82.0753 89.02 % 46.53
MCF7 perturbed by 1e-06microM of SB-202190					76.9474 97.45 % 39.75
PC3 perturbed by 1e-05microM of F0447-0125					91.5551 0.18 % 95.69
PC3 perturbed by 1e-06microM of trichostatin A					91.47 10.85 % 90.31
MCF7 perturbed by 1.3e-05microM of foliosidine					90.8732 89.61 % 50.63
MCF7 perturbed by 1.68e-05microM of tetryzoline					88.8757 58.95 % 64.97
MCF7 perturbed by 1e-05microM of haloperidol					83.6017 93.9 % 44.85
MCF7 perturbed by 1e-05microM of LY-294002					83.1518 95.07 % 44.04
MCF7 perturbed by 1.12e-05microM of thiamphenicol					84.3373 87.59 % 48.38
MCF7 perturbed by 9.8e-06microM of glafenine					80.5228 97.86 % 41.33
MCF7 perturbed by 1e-06microM of tretinoin					80.5503 98.31 % 41.12
MCF7 perturbed by 1.5e-05microM of (-)-atenolol					91.5147 43.87 % 73.82
MCF7 perturbed by 2.06e-05microM of butyl hydroxybenzoate					90.828 67.86 % 61.48
PC3 perturbed by 1e-06microM of trichostatin A					90.9878 2.94 % 94.02
vehicle					90.8634 0.08 % 95.39
MCF7 perturbed by 1e-06microM of trichostatin A					84.2095 79.81 % 52.2
PC3 perturbed by 1.08e-05microM of lansoprazole					82.3818 97.23 % 42.58
PC3 perturbed by 1.22e-05microM of dyclonine					86.4648 96.41 % 45.03
vehicle					81.2092 97.31 % 41.95
PC3 perturbed by 1.58e-05microM of naproxen					77.3786 97.6 % 39.89
PC3 perturbed by 1.06e-05microM of methylprednisolone					75.9078 98 % 38.95
PC3 perturbed by 1.04e-05microM of dipivefrine					78.2485 97.88 % 40.18
MCF7 perturbed by 1.74e-05microM of tocainide					75.9002 96.19 % 39.86
PC3 perturbed by 1.38e-05microM of trimethoprim					77.5064 93.97 % 41.77
MCF7 perturbed by 1e-06microM of trichostatin A					81.8872 94.13 % 43.88
PC3 perturbed by 1e-05microM of 0198306-0000					77.5021 97.9 % 39.8
MCF7 perturbed by 1.34e-05microM of isotretinoin					83.3413 96.8 % 43.27
MCF7 perturbed by 1.7e-05microM of Prestwick-983					82.0682 95.49 % 43.29
MCF7 perturbed by 1.02e-05microM of chenodeoxycholic acid					82.0782 96.98 % 42.55
MCF7 perturbed by 1.02e-05microM of triflupromazine					82.823 94.77 % 44.02
MCF7 perturbed by 1.8e-05microM of bufexamac					79.1482 97.93 % 40.61
MCF7 perturbed by 1e-05microM of CP-319743					83.4835 88.91 % 47.29
MCF7 perturbed by 1e-05microM of 11-deoxy-16-16-dimethylprostaglandin E2					79.3726 91.56 % 43.91
MCF7 perturbed by 1e-05microM of BCB000038					78.5478 90.97 % 43.79
PC3 perturbed by 1e-05microM of 11-deoxy-16-16-dimethylprostaglandin E2					79.1342 92.07 % 43.53
MCF7 perturbed by 1e-04microM of irinotecan					79.9523 17.64 % 81.16
PC3 perturbed by 1e-04microM of irinotecan					76.9466 86.83 % 45.06
MCF7 perturbed by 1e-05microM of CP-944629					79.5428 94.71 % 42.42