Connectivity Map Batch 02 Random Load - CMAP6

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	88.14 0 % 94.07
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of fluphenazine					88.1763 0.23 % 93.97
HL60 perturbed by 1e-05microM of clozapine					88.1394 2.89 % 92.62
PC3 perturbed by 1e-07microM of estradiol					88.4743 2.46 % 93.01
PC3 perturbed by 1e-07microM of sirolimus					91.3782 0 % 95.69
MCF7 perturbed by 1.12e-05microM of prednisone					92.5492 0.21 % 96.17
MCF7 perturbed by 1.1e-05microM of naloxone					93.472 0.24 % 96.61
MCF7 perturbed by 1.48e-05microM of tolbutamide					92.5552 0.36 % 96.1
MCF7 perturbed by 1.4e-05microM of tropicamide					93.0641 0.14 % 96.46
vehicle					91.3516 0 % 95.67
HL60 perturbed by 4e-06microM of lanatoside C					90.3343 1.02 % 94.66
HL60 perturbed by 1.12e-05microM of yohimbic acid					90.8517 0.01 % 95.42
PC3 perturbed by 1.04e-05microM of metampicillin					89.1065 1.1 % 94
PC3 perturbed by 6.2e-06microM of thioproperazine					88.7299 4.12 % 92.3
PC3 perturbed by 1.62e-05microM of chlorphenesin					88.1096 3.24 % 92.43
HL60 perturbed by 1.16e-05microM of buflomedil					89.8408 44.17 % 72.83
HL60 perturbed by 1.28e-05microM of cyclobenzaprine					89.8835 1.97 % 93.96
HL60 perturbed by 1.14e-05microM of chlorprothixene					89.595 51.35 % 69.12
HL60 perturbed by 1.26e-05microM of thioguanosine					90.5786 34.12 % 78.23
vehicle					90.967 0.29 % 95.34
HL60 perturbed by 1.24e-05microM of acetohexamide					85.8346 29.99 % 77.92
PC3 perturbed by 2.42e-05microM of metformin					89.1378 39.49 % 74.82
PC3 perturbed by 1.26e-05microM of imipramine					88.6819 13.6 % 87.54
HL60 perturbed by 1.2e-05microM of hydroflumethiazide					86.7718 90.88 % 47.94
HL60 perturbed by 1.7e-05microM of carbamazepine					87.5888 75.2 % 56.19
HL60 perturbed by 1.24e-05microM of chloramphenicol					89.0889 77.39 % 55.85
HL60 perturbed by 8.6e-06microM of cisapride					90.8993 0.26 % 95.32
HL60 perturbed by 5.8e-06microM of amiodarone					90.5611 1.94 % 94.31
MCF7 perturbed by 1.34e-05microM of fenspiride					91.8437 0.6 % 95.62
MCF7 perturbed by 1.18e-05microM of atropine oxide					91.7551 2.19 % 94.78
HL60 perturbed by 7.6e-06microM of guanadrel					90.6998 3.71 % 93.5
HL60 perturbed by 8e-06microM of demeclocycline					88.526 2.39 % 93.07
MCF7 perturbed by 1.08e-05microM of dextromethorphan					92.4321 1.53 % 95.45
MCF7 perturbed by 5e-06microM of atractyloside					92.3002 0.18 % 96.06
MCF7 perturbed by 9e-06microM of cefapirin					90.3648 2.1 % 94.13
MCF7 perturbed by 7.4e-06microM of cefepime					90.0992 3.03 % 93.53
MCF7 perturbed by 1.24e-05microM of naftifine					90.1774 3.01 % 93.58
MCF7 perturbed by 8.8e-06microM of Prestwick-1083					91.2342 3.2 % 94.02
MCF7 perturbed by 1.22e-05microM of azaperone					90.1243 3.61 % 93.26
MCF7 perturbed by 8.6e-06microM of pivampicillin					92.323 2.14 % 95.09
HL60 perturbed by 1.3e-05microM of butacaine					89.4187 10.59 % 89.41
HL60 perturbed by 1e-07microM of estradiol					89.5739 2.72 % 93.42
MCF7 perturbed by 8.8e-06microM of betulinic acid					90.1861 0.72 % 94.73
MCF7 perturbed by 2.28e-05microM of N-acetyl-L-aspartic acid					89.4491 12.95 % 88.25
MCF7 perturbed by 6e-06microM of cephaeline					87.869 0.73 % 93.57
vehicle					90.0665 0.21 % 94.93
MCF7 perturbed by 9e-06microM of loxapine					92.4877 11.57 % 90.46
MCF7 perturbed by 1.1e-05microM of hydrocortisone					91.8936 89.94 % 50.98
PC3 perturbed by 1e-05microM of 0317956-0000					92.0584 9.65 % 91.2
PC3 perturbed by 1.4e-05microM of acacetin					91.1251 2.58 % 94.27
PC3 perturbed by 8.2e-06microM of flunixin					89.6269 61.91 % 63.86
vehicle					88.3457 16.08 % 86.13
vehicle					88.5849 12.13 % 88.23
MCF7 perturbed by 1.14e-05microM of tetrahydroalstonine					89.1102 1.77 % 93.67
vehicle					92.6246 0.6 % 96.01
MCF7 perturbed by 1.4e-05microM of harmaline					91.5159 2.44 % 94.54
MCF7 perturbed by 9.2e-06microM of oxolamine					91.6069 2.3 % 94.66
MCF7 perturbed by 1.18e-05microM of tracazolate					92.4936 0.96 % 95.77
MCF7 perturbed by 7e-06microM of ketanserin					92.6939 0.65 % 96.02
MCF7 perturbed by 9.8e-06microM of thioperamide					90.6094 6.59 % 92.01
MCF7 perturbed by 1.84e-05microM of fosfosal					92.6924 0 % 96.35
MCF7 perturbed by 1.14e-05microM of profenamine					92.2921 0.68 % 95.81
MCF7 perturbed by 6.2e-06microM of liothyronine					91.7688 1.01 % 95.38
MCF7 perturbed by 1.32e-05microM of diclofenamide					90.4363 3.06 % 93.69
MCF7 perturbed by 1.64e-05microM of azacitidine					91.2478 13.16 % 89.04
vehicle					91.3291 0.38 % 95.47
MCF7 perturbed by 1.12e-05microM of vincamine					89.4994 67.19 % 61.16
MCF7 perturbed by 1.1e-05microM of furaltadone					91.3598 2.42 % 94.47
PC3 perturbed by 7.6e-06microM of guanadrel					90.1094 3.25 % 93.43
PC3 perturbed by 1e-06microM of 0175029-0000					91.582 1.16 % 95.21
PC3 perturbed by 1e-05microM of glycopyrronium bromide					91.5598 1.1 % 95.23
HL60 perturbed by 1.7e-05microM of Prestwick-983					89.899 8.57 % 90.67
HL60 perturbed by 8.4e-06microM of lorglumide					91.2546 1.81 % 94.72
HL60 perturbed by 6.8e-06microM of tonzonium bromide					91.006 0 % 95.5
HL60 perturbed by 1.48e-05microM of estrone					90.6199 0.04 % 95.29
HL60 perturbed by 2.06e-05microM of butyl hydroxybenzoate					90.6169 0.05 % 95.28
MCF7 perturbed by 1.24e-05microM of mycophenolic acid					91.2651 4.84 % 93.21
vehicle					92.1217 1.11 % 95.5
MCF7 perturbed by 1.6e-05microM of Trolox C					91.5977 21.05 % 85.27
vehicle					91.7693 2.84 % 94.46
PC3 perturbed by 1.28e-05microM of ethisterone					90.7981 88.52 % 51.14
PC3 perturbed by 2.68e-05microM of 2-6-dimethylpiperidine					90.8881 19.06 % 85.92
PC3 perturbed by 1.26e-05microM of tolmetin					91.3761 5.22 % 93.08
PC3 perturbed by 1.1e-05microM of cefadroxil					89.4035 34.18 % 77.61
PC3 perturbed by 8e-06microM of diflorasone					88.4065 72.56 % 57.92
PC3 perturbed by 5.2e-06microM of levothyroxine sodium					90.9658 3.61 % 93.68
MCF7 perturbed by 1.1e-05microM of adenosine phosphate					91.9408 66.84 % 62.55
MCF7 perturbed by 9.4e-06microM of alfuzosin					92.5317 2.27 % 95.13
HL60 perturbed by 2.58e-05microM of bemegride					90.8895 0.17 % 95.36
MCF7 perturbed by 1e-05microM of 0317956-0000					90.093 10.45 % 89.82
vehicle					90.8176 0.17 % 95.32
HL60 perturbed by 2.04e-05microM of bethanechol					90.7187 49.51 % 70.61
HL60 perturbed by 9.2e-06microM of fursultiamine					90.2116 89.79 % 50.21
HL60 perturbed by 1e-07microM of trichostatin A					91.2427 0.01 % 95.62
MCF7 perturbed by 1.26e-05microM of pregnenolone					91.5626 1.65 % 94.95
MCF7 perturbed by 1.3e-05microM of epitiostanol					91.4146 1.08 % 95.17
MCF7 perturbed by 1.48e-05microM of meptazinol					90.8141 0 % 95.41
vehicle					91.1045 2.13 % 94.49
MCF7 perturbed by 1e-07microM of trichostatin A					90.4784 0.95 % 94.76
MCF7 perturbed by 9.8e-06microM of spectinomycin					91.4171 0 % 95.71
MCF7 perturbed by 2.02e-05microM of theophylline					91.4648 1.24 % 95.11
PC3 perturbed by 8.4e-06microM of flucloxacillin					91.4604 1.68 % 94.89
PC3 perturbed by 1.12e-05microM of indometacin					90.4731 2.69 % 93.89
PC3 perturbed by 2.1e-05microM of octopamine					91.1129 3.01 % 94.05
PC3 perturbed by 2.4e-05microM of ethionamide					91.0286 5.34 % 92.84
PC3 perturbed by 1.06e-05microM of lithocholic acid					90.4583 4.93 % 92.77
PC3 perturbed by 1.96e-05microM of ethotoin					91.4694 0.01 % 95.73
PC3 perturbed by 1.98e-05microM of tiabendazole					91.6551 0.43 % 95.61
PC3 perturbed by 1.52e-05microM of homosalate					91.6934 1.69 % 95
MCF7 perturbed by 1e-06microM of PHA-00745360					91.1649 28.11 % 81.53
PC3 perturbed by 1.46e-05microM of chlormezanone					92.3742 10.07 % 91.15
vehicle					92.0555 0.16 % 95.95
PC3 perturbed by 1.1e-05microM of bisacodyl					91.5082 2.62 % 94.45
PC3 perturbed by 1.48e-05microM of procainamide					91.7002 17.35 % 87.18
MCF7 perturbed by 1.28e-05microM of sulfadimethoxine					92.6979 0.43 % 96.14
MCF7 perturbed by 7.8e-06microM of gossypol					92.9036 0.02 % 96.44
PC3 perturbed by 1e-05microM of rosiglitazone					92.3903 0.72 % 95.84
PC3 perturbed by 1e-06microM of tanespimycin					92.6571 2.34 % 95.16
vehicle					92.3993 1.22 % 95.59
PC3 perturbed by 6e-06microM of Prestwick-682					91.1153 5.97 % 92.57
vehicle					92.5902 0.02 % 96.28
PC3 perturbed by 7.4e-06microM of apramycin					92.3004 0 % 96.15
PC3 perturbed by 2.22e-05microM of caffeic acid					92.5707 3.49 % 94.54
PC3 perturbed by 2.02e-05microM of mimosine					91.5526 1.17 % 95.19
PC3 perturbed by 1.72e-05microM of metanephrine					92.0558 0.61 % 95.72
PC3 perturbed by 1.5e-05microM of (-)-atenolol					91.2128 9.65 % 90.78
MCF7 perturbed by 1.18e-05microM of hexetidine					92.6409 9.47 % 91.59
MCF7 perturbed by 1.08e-05microM of nomegestrol					91.6769 31.01 % 80.33
MCF7 perturbed by 1.52e-05microM of tolfenamic acid					93.0308 3.19 % 94.92
MCF7 perturbed by 1e-05microM of ampicillin					93.3666 4.01 % 94.68
vehicle					93.3524 0.7 % 96.33
MCF7 perturbed by 1.1e-05microM of amoxicillin					92.54 3.82 % 94.36
MCF7 perturbed by 8.2e-06microM of verapamil					92.2067 3.96 % 94.12
PC3 perturbed by 1.02e-05microM of triamcinolone					90.4067 1 % 94.7
PC3 perturbed by 7.8e-06microM of fluphenazine					91.7818 0 % 95.89
vehicle					91.7967 0.3 % 95.75
PC3 perturbed by 1.36e-05microM of trifluridine					91.9654 0.12 % 95.92
PC3 perturbed by 1.14e-05microM of vinpocetine					91.6541 0.08 % 95.79
PC3 perturbed by 9.6e-06microM of noscapine					91.3655 0.1 % 95.63
MCF7 perturbed by 1.32e-05microM of cyclizine					92.2975 2.37 % 94.96
MCF7 perturbed by 1.04e-05microM of imidurea					92.1931 1.23 % 95.48
MCF7 perturbed by 1.38e-05microM of hyoscyamine					90.5144 7.42 % 91.54
MCF7 perturbed by 1.34e-05microM of adrenosterone					91.3327 2.35 % 94.49
vehicle					92.7015 6.68 % 93.01
PC3 perturbed by 1.06e-05microM of lobeline					91.1391 71.18 % 59.98
vehicle					91.9387 47.27 % 72.33
MCF7 perturbed by 2.3e-05microM of N-acetyl-L-leucine					90.0466 1.44 % 94.3
MCF7 perturbed by 7.8e-06microM of loperamide					92.0909 4.42 % 93.84
MCF7 perturbed by 1e-07microM of trichostatin A					90.5865 2.86 % 93.86
MCF7 perturbed by 7.8e-06microM of probucol					91.2077 1.6 % 94.8
MCF7 perturbed by 3.92e-05microM of cycloserine					91.2285 12.26 % 89.48
MCF7 perturbed by 1.5e-05microM of clonidine					90.0859 1.54 % 94.27
MCF7 perturbed by 7.4e-06microM of cefepime					92.5319 8.25 % 92.14
MCF7 perturbed by 1.54e-05microM of ifosfamide					92.2951 0.29 % 96
MCF7 perturbed by 2.84e-05microM of tropine					93.2678 3.3 % 94.98
vehicle					93.3631 0 % 96.68
MCF7 perturbed by 1.22e-05microM of cyclopentolate					93.5604 0 % 96.78
MCF7 perturbed by 1.14e-05microM of tetrahydroalstonine					93.0932 0 % 96.55
MCF7 perturbed by 1.48e-05microM of meprylcaine					92.9704 0 % 96.49
HL60 perturbed by 9.6e-06microM of cyproterone					88.1912 19.9 % 84.15
PC3 perturbed by 1.44e-05microM of iproniazid					91.3219 6.2 % 92.56
PC3 perturbed by 7e-06microM of iopanoic acid					91.2916 0.03 % 95.63
PC3 perturbed by 1.36e-05microM of S-propranolol					91.0904 0.79 % 95.15
PC3 perturbed by 1e-05microM of 0297417-0002B					77.3469 96.71 % 40.32
MCF7 perturbed by 1e-06microM of trichostatin A					76.538 96.39 % 40.07
MCF7 perturbed by 1e-05microM of NS-398					76.2405 96.23 % 40.01
vehicle					76.0726 98.15 % 38.96
vehicle					90.7404 97.38 % 46.68
MCF7 perturbed by 1e-05microM of C-75					93.3645 54.89 % 69.24
vehicle					92.6968 85.76 % 53.47
vehicle					92.6645 0.03 % 96.32
MCF7 perturbed by 1.08e-05microM of finasteride					91.3193 88.49 % 51.41
MCF7 perturbed by 1.5e-05microM of streptozocin					92.3276 3.22 % 94.55
MCF7 perturbed by 1.2e-05microM of metamizole sodium					92.0195 1.23 % 95.4
MCF7 perturbed by 1.06e-05microM of fluorometholone					92.3045 9 % 91.65
vehicle					92.2536 4.53 % 93.86
MCF7 perturbed by 2.3e-05microM of N-acetyl-L-leucine					92.5922 0.01 % 96.29
MCF7 perturbed by 1e-07microM of trichostatin A					91.7055 0.04 % 95.83
PC3 perturbed by 1e-05microM of dinoprostone					91.9715 0.76 % 95.6
PC3 perturbed by 1e-05microM of alprostadil					91.8601 0.08 % 95.89
PC3 perturbed by 1e-06microM of Gly-His-Lys					91.682 0.03 % 95.83
MCF7 perturbed by 1e-05microM of genistein					84.4756 94.97 % 44.76
MCF7 perturbed by 1.14e-05microM of fendiline					86.1863 95.62 % 45.28
MCF7 perturbed by 2.1e-05microM of pseudopelletierine					82.9105 98.41 % 42.25
MCF7 perturbed by 1.9e-05microM of milrinone					82.6588 98.25 % 42.2
PC3 perturbed by 1.2e-05microM of Prestwick-1082					81.5968 97.84 % 41.88
vehicle					84.1861 97.98 % 43.1
MCF7 perturbed by 1.06e-05microM of cyclopenthiazide					78.8411 96.21 % 41.32
PC3 perturbed by 1e-06microM of AH-6809					79.4185 97.14 % 41.14
MCF7 perturbed by 1e-05microM of SC-19220					79.5665 98.26 % 40.65
PC3 perturbed by 1e-05microM of MS-275					75.7741 97.92 % 38.93
PC3 perturbed by 1e-05microM of GW-8510					75.8739 98.79 % 38.54
PC3 perturbed by 1e-05microM of CAY-10397					76.1184 98.6 % 38.76
vehicle					79.9631 98.34 % 40.81
vehicle					80.6043 96.96 % 41.82
MCF7 perturbed by 1.34e-05microM of noretynodrel					79.7114 98.17 % 40.77
MCF7 perturbed by 1.22e-05microM of dyclonine					82.7139 97.02 % 42.85
MCF7 perturbed by 8.2e-06microM of Prestwick-559					77.9699 98.57 % 39.7
MCF7 perturbed by 1e-04microM of semustine					83.5213 92.63 % 45.45
PC3 perturbed by 1e-04microM of semustine					80.0579 92.58 % 43.74
PC3 perturbed by 1e-05microM of BCB000038					81.9263 85.41 % 48.26
MCF7 perturbed by 1e-05microM of BCB000038					79.9764 95.91 % 42.03