Connectivity Map Batch 02 Random Load - CMAP34

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	91.95 2.09 % 94.93
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 0.0005microM of valproic acid					88.3953 0.37 % 94.01
PC3 perturbed by 1e-06microM of nordihydroguaiaretic acid					91.9548 0.01 % 95.97
PC3 perturbed by 1e-07microM of trichostatin A					91.7066 0 % 95.85
MCF7 perturbed by 1.44e-05microM of azathioprine					93.197 2.09 % 95.55
MCF7 perturbed by 9.6e-06microM of dehydrocholic acid					93.6309 0.07 % 96.78
MCF7 perturbed by 9e-06microM of hydroxyzine					93.894 0 % 96.95
MCF7 perturbed by 9.6e-06microM of miconazole					93.5478 0.31 % 96.62
MCF7 perturbed by 5e-06microM of troleandomycin					93.3255 1.78 % 95.77
MCF7 perturbed by 9.4e-06microM of fludrocortisone					93.3842 0 % 96.69
MCF7 perturbed by 1.68e-05microM of nitrofurantoin					93.6607 0.02 % 96.82
MCF7 perturbed by 7.4e-06microM of pentolonium					92.8897 1.47 % 95.71
MCF7 perturbed by 6e-06microM of dilazep					93.8636 4.21 % 94.83
HL60 perturbed by 1.42e-05microM of hydroxyachillin					90.3645 0.18 % 95.09
HL60 perturbed by 1e-07microM of trichostatin A					91.6092 0.08 % 95.76
HL60 perturbed by 1.2e-05microM of seneciphylline					90.5871 0.28 % 95.15
HL60 perturbed by 1.52e-05microM of sulfamerazine					91.0372 0.12 % 95.46
vehicle					91.1921 0.22 % 95.48
HL60 perturbed by 8.6e-06microM of benfotiamine					91.6223 0.55 % 95.54
HL60 perturbed by 1.82e-05microM of xylazine					92.2487 0.03 % 96.11
vehicle					92.3114 0.13 % 96.09
HL60 perturbed by 1.04e-05microM of lomefloxacin					92.169 0.07 % 96.05
HL60 perturbed by 1.38e-05microM of trimethoprim					92.3207 0.33 % 96
PC3 perturbed by 1.02e-05microM of triamcinolone					89.4066 1.45 % 93.98
PC3 perturbed by 1.02e-05microM of nalbuphine					90.0874 1.74 % 94.17
PC3 perturbed by 1.38e-05microM of hyoscyamine					88.3692 4.51 % 91.93
PC3 perturbed by 7.2e-06microM of antimycin A					86.373 4.89 % 90.74
PC3 perturbed by 1.2e-05microM of piroxicam					88.8525 3.93 % 92.46
MCF7 perturbed by 1.24e-05microM of acetohexamide					92.6377 0 % 96.32
MCF7 perturbed by 1e-05microM of haloperidol					93.3951 0.26 % 96.57
HL60 perturbed by 1.46e-05microM of naringenin					90.4353 2.02 % 94.21
HL60 perturbed by 3.4e-06microM of ciclosporin					90.4057 1.55 % 94.43
HL60 perturbed by 1e-05microM of SR-95639A					90.8009 1.4 % 94.7
HL60 perturbed by 1.1e-05microM of amoxicillin					90.6082 0.48 % 95.06
HL60 perturbed by 1e-07microM of trichostatin A					91.235 0.39 % 95.42
PC3 perturbed by 1.12e-05microM of thiamphenicol					90.4293 1.2 % 94.62
vehicle					87.7426 0.29 % 93.73
PC3 perturbed by 1.08e-05microM of morantel					88.5009 0.13 % 94.18
HL60 perturbed by 6.8e-06microM of pentamidine					90.8967 0.11 % 95.4
HL60 perturbed by 1.22e-05microM of velnacrine					90.8013 1.7 % 94.55
MCF7 perturbed by 1.18e-05microM of meclofenamic acid					92.8968 0.61 % 96.14
MCF7 perturbed by 1.62e-05microM of pindolol					92.3889 1.08 % 95.66
MCF7 perturbed by 8.8e-06microM of ursolic acid					93.586 1.7 % 95.94
MCF7 perturbed by 1.02e-05microM of nalbuphine					92.7948 1.77 % 95.51
MCF7 perturbed by 1.42e-05microM of flufenamic acid					92.9751 1.05 % 95.96
MCF7 perturbed by 1.12e-05microM of nomifensine					93.1585 0.29 % 96.43
HL60 perturbed by 1.6e-05microM of phenazopyridine					91.1548 0.54 % 95.31
HL60 perturbed by 1.58e-05microM of naproxen					92.1794 0.31 % 95.94
HL60 perturbed by 1.04e-05microM of altizide					91.9031 0.89 % 95.51
vehicle					89.7434 4.04 % 92.85
MCF7 perturbed by 7.4e-06microM of domperidone					92.0775 7.02 % 92.53
MCF7 perturbed by 1.42e-05microM of cicloheximide					92.4465 0.01 % 96.22
MCF7 perturbed by 9.8e-06microM of flumetasone					90.3182 0 % 95.16
MCF7 perturbed by 8.2e-06microM of flunixin					90.0563 0 % 95.03
MCF7 perturbed by 2.04e-05microM of methacholine chloride					91.938 0.38 % 95.78
MCF7 perturbed by 8.4e-06microM of pivmecillinam					91.766 4 % 93.88
MCF7 perturbed by 1.08e-05microM of lansoprazole					91.1073 4.61 % 93.25
MCF7 perturbed by 8e-06microM of sertaconazole					89.315 4.25 % 92.53
vehicle					91.3291 5.26 % 93.03
MCF7 perturbed by 8.4e-06microM of tribenoside					90.8381 4.46 % 93.19
HL60 perturbed by 1e-08microM of estradiol					90.1918 1.67 % 94.26
vehicle					89.9024 0.07 % 94.92
MCF7 perturbed by 7.4e-06microM of puromycin					92.3969 0.01 % 96.19
MCF7 perturbed by 1.1e-05microM of cefadroxil					89.4011 0.24 % 94.58
MCF7 perturbed by 1.54e-05microM of carisoprodol					89.7268 0.16 % 94.78
vehicle					91.6137 0.06 % 95.78
vehicle					92.5651 10.25 % 91.16
MCF7 perturbed by 1.14e-05microM of profenamine					93.1508 2.38 % 95.39
MCF7 perturbed by 1.72e-05microM of metanephrine					93.128 4.29 % 94.42
MCF7 perturbed by 1.36e-05microM of vinburnine					89.7753 2.71 % 93.53
MCF7 perturbed by 1e-05microM of 15-delta prostaglandin J2					92.7543 1.87 % 95.44
MCF7 perturbed by 1e-05microM of rosiglitazone					92.4425 1.63 % 95.41
MCF7 perturbed by 1.88e-05microM of serotonin					92.4568 1.04 % 95.71
MCF7 perturbed by 1.18e-05microM of suloctidil					92.635 0.32 % 96.16
MCF7 perturbed by 1.04e-05microM of megestrol					92.9793 1.32 % 95.83
MCF7 perturbed by 1.4e-05microM of nifurtimox					93.1331 1.31 % 95.91
MCF7 perturbed by 1.42e-05microM of indoprofen					93.1053 0.38 % 96.36
MCF7 perturbed by 8e-06microM of diflorasone					91.8116 0.01 % 95.9
MCF7 perturbed by 1.16e-05microM of corticosterone					91.3926 0.91 % 95.24
MCF7 perturbed by 8.6e-06microM of methylbenzethonium chloride					91.9511 1.3 % 95.33
MCF7 perturbed by 1.4e-05microM of sulfachlorpyridazine					91.8692 1.63 % 95.12
PC3 perturbed by 1.38e-05microM of etiocholanolone					90.5849 0 % 95.29
PC3 perturbed by 1.78e-05microM of 6-benzylaminopurine					92.4181 0 % 96.21
PC3 perturbed by 1.16e-05microM of Prestwick-665					90.6336 0 % 95.32
PC3 perturbed by 1.68e-05microM of salbutamol					91.3081 0.06 % 95.63
PC3 perturbed by 1.36e-05microM of mebendazole					92.098 0.91 % 95.59
HL60 perturbed by 1.24e-05microM of pirlindole					91.4507 0.04 % 95.71
vehicle					92.1033 0.81 % 95.65
MCF7 perturbed by 1.66e-05microM of tetramisole					92.0471 1.26 % 95.39
MCF7 perturbed by 7.6e-06microM of terconazole					91.2978 3.6 % 93.85
MCF7 perturbed by 1.28e-05microM of tolazamide					92.5938 0.82 % 95.89
PC3 perturbed by 7e-06microM of alpha-ergocryptine					92.1624 1.64 % 95.26
MCF7 perturbed by 1e-05microM of metergoline					92.4294 2.11 % 95.16
MCF7 perturbed by 8.8e-06microM of methotrexate					93.3227 2.14 % 95.59
PC3 perturbed by 9.6e-06microM of gabexate					90.5087 8.31 % 91.1
PC3 perturbed by 2.04e-05microM of tolazoline					91.8996 8.06 % 91.92
PC3 perturbed by 1.46e-05microM of 7-aminocephalosporanic acid					92.3959 0.64 % 95.88
PC3 perturbed by 8.6e-06microM of cetirizine					91.1156 1.63 % 94.74
vehicle					91.175 0.76 % 95.21
HL60 perturbed by 1.28e-05microM of mestranol					91.3613 2.43 % 94.47
HL60 perturbed by 1.2e-05microM of nizatidine					91.6982 3.52 % 94.09
HL60 perturbed by 1.02e-05microM of pentetic acid					91.9695 4.49 % 93.74
HL60 perturbed by 2.18e-05microM of carbachol					92.0965 0.65 % 95.72
HL60 perturbed by 1e-07microM of trichostatin A					91.6153 1.29 % 95.16
HL60 perturbed by 1.5e-05microM of equilin					90.826 1.1 % 94.86
HL60 perturbed by 6.2e-06microM of liothyronine					92.1006 2.36 % 94.87
MCF7 perturbed by 1.12e-05microM of vincamine					89.9862 0.55 % 94.72
MCF7 perturbed by 1e-05microM of PHA-00745360					91.8138 0.57 % 95.62
MCF7 perturbed by 1e-06microM of CP-320650-01					90.3967 6.6 % 91.9
MCF7 perturbed by 1e-06microM of PHA-00851261E					91.2574 1.06 % 95.1
MCF7 perturbed by 2.02e-05microM of guaifenesin					92.6122 0.33 % 96.14
MCF7 perturbed by 7e-06microM of alpha-ergocryptine					92.3485 0.05 % 96.15
HL60 perturbed by 8.8e-06microM of Prestwick-1083					90.1571 13.22 % 88.47
HL60 perturbed by 1.84e-05microM of etilefrine					91.5143 1 % 95.26
HL60 perturbed by 9e-06microM of betulin					91.3584 0.56 % 95.4
MCF7 perturbed by 1.92e-05microM of minoxidil					92.5782 2.1 % 95.24
MCF7 perturbed by 1.28e-05microM of mestranol					92.0007 2.22 % 94.89
MCF7 perturbed by 1.36e-05microM of canavanine					92.0649 1.71 % 95.18
MCF7 perturbed by 1.08e-05microM of SR-95531					90.5191 2.51 % 94.01
PC3 perturbed by 1.22e-05microM of cyclic adenosine monophosphate					91.9423 1.6 % 95.17
PC3 perturbed by 1.32e-05microM of cyclizine					92.3382 2.08 % 95.13
PC3 perturbed by 1.36e-05microM of Prestwick-920					89.1435 2.25 % 93.45
PC3 perturbed by 1.48e-05microM of todralazine					91.1239 2.1 % 94.51
PC3 perturbed by 1.34e-05microM of adrenosterone					90.9713 1.83 % 94.57
PC3 perturbed by 1.96e-05microM of 3-acetamidocoumarin					91.9779 1.19 % 95.39
PC3 perturbed by 1.48e-05microM of lidocaine					92.5012 0.69 % 95.9
PC3 perturbed by 2.68e-05microM of 2-6-dimethylpiperidine					92.0748 0.26 % 95.91
MCF7 perturbed by 2.6e-06microM of vancomycin					93.308 0 % 96.65
PC3 perturbed by 1.24e-05microM of ritodrine					92.6965 1.04 % 95.83
vehicle					92.5263 0.64 % 95.94
PC3 perturbed by 2.06e-05microM of butyl hydroxybenzoate					92.7413 1.82 % 95.46
MCF7 perturbed by 8.4e-06microM of cefazolin					92.4824 1.14 % 95.67
PC3 perturbed by 1e-05microM of genistein					92.3238 1.06 % 95.63
vehicle					92.8093 1.17 % 95.82
PC3 perturbed by 1e-05microM of thioridazine					92.9859 1.88 % 95.55
PC3 perturbed by 0.001microM of valproic acid					92.6584 0.8 % 95.93
PC3 perturbed by 9.2e-06microM of benzthiazide					92.6937 0.08 % 96.31
PC3 perturbed by 1.5e-05microM of anisomycin					89.4573 1.01 % 94.22
PC3 perturbed by 6.6e-06microM of oxantel					92.1664 1.01 % 95.58
MCF7 perturbed by 4.4e-06microM of amphotericin B					93.3852 0.01 % 96.69
vehicle					93.69 0.48 % 96.61
MCF7 perturbed by 1.2e-05microM of piribedil					92.3242 0.32 % 96
MCF7 perturbed by 8e-06microM of minocycline					92.238 2.36 % 94.94
MCF7 perturbed by 1.04e-05microM of metampicillin					90.9431 0.1 % 95.42
MCF7 perturbed by 9.6e-06microM of prenylamine					92.3827 0.29 % 96.05
MCF7 perturbed by 1.54e-05microM of flumequine					91.9403 0.05 % 95.94
MCF7 perturbed by 1.8e-05microM of bufexamac					92.37 0.87 % 95.75
MCF7 perturbed by 1.48e-05microM of todralazine					92.3063 0.5 % 95.91
vehicle					91.2282 0.84 % 95.19
PC3 perturbed by 2.8e-06microM of dihydrostreptomycin					92.1106 0.98 % 95.57
PC3 perturbed by 2.1e-05microM of cytisine					92.6355 0.76 % 95.94
PC3 perturbed by 1.42e-05microM of sulfametoxydiazine					92.1596 2.54 % 94.81
PC3 perturbed by 9.6e-06microM of naltrexone					91.6523 0.56 % 95.55
MCF7 perturbed by 1.9e-05microM of altretamine					88.6234 7.29 % 90.67
PC3 perturbed by 1e-07microM of valinomycin					92.0129 0.14 % 95.94
MCF7 perturbed by 1e-05microM of PF-00875133-00					92.9632 1.1 % 95.93
MCF7 perturbed by 1e-06microM of fulvestrant					91.9675 3 % 94.48
MCF7 perturbed by 1e-05microM of LY-294002					92.5995 0 % 96.3
PC3 perturbed by 1e-05microM of LY-294002					92.7471 0.13 % 96.31
MCF7 perturbed by 1.02e-05microM of digoxigenin					91.6041 0.82 % 95.39
MCF7 perturbed by 2.12e-05microM of 3-acetylcoumarin					91.2756 0.06 % 95.61
vehicle					90.9385 3.41 % 93.76
vehicle					91.4129 2.84 % 94.29
MCF7 perturbed by 7.6e-06microM of alclometasone					93.6803 3.48 % 95.1
vehicle					93.824 2.09 % 95.87
HL60 perturbed by 1.32e-05microM of oxprenolol					89.7289 4.45 % 92.64
HL60 perturbed by 1e-06microM of tanespimycin					90.3526 3.48 % 93.44
PC3 perturbed by 8.8e-06microM of methotrexate					91.703 3.59 % 94.06
PC3 perturbed by 5.2e-06microM of tubocurarine chloride					90.2394 4.14 % 93.05
vehicle					90.8123 2.94 % 93.94
MCF7 perturbed by 1e-06microM of trichostatin A					83.0845 2.25 % 90.42
vehicle					79.3961 2.95 % 88.22
PC3 perturbed by 1e-05microM of 3-nitropropionic acid					91.6057 0 % 95.8
MCF7 perturbed by 1.12e-05microM of benzamil					92.8514 0.01 % 96.42
MCF7 perturbed by 3.2e-06microM of beta-escin					92.5228 0 % 96.26
vehicle					92.6159 0 % 96.31
MCF7 perturbed by 6.4e-06microM of tetrandrine					93.4561 0 % 96.73
MCF7 perturbed by 9e-06microM of benzethonium chloride					92.6099 0.04 % 96.28
MCF7 perturbed by 1.2e-05microM of isoxicam					83.4115 2.17 % 90.62
MCF7 perturbed by 1.02e-05microM of ursodeoxycholic acid					92.6818 0.46 % 96.11
PC3 perturbed by 1e-05microM of PHA-00767505E					92.759 0.67 % 96.04
vehicle					92.9203 1.46 % 95.73
vehicle					92.4709 0.47 % 96
vehicle					91.3244 3.95 % 93.69
MCF7 perturbed by 1e-05microM of 16-16-dimethylprostaglandin E2					92.8002 0.72 % 96.04
MCF7 perturbed by 8.4e-06microM of cefotaxime					85.4383 0.37 % 92.53
MCF7 perturbed by 6e-06microM of nadide					84.1351 1.14 % 91.5
MCF7 perturbed by 5.8e-06microM of atropine					83.0216 5.08 % 88.97
PC3 perturbed by 2.2e-05microM of heptaminol					83.3343 1.82 % 90.76
PC3 perturbed by 9.6e-06microM of hydrastine hydrochloride					82.731 1.91 % 90.41
PC3 perturbed by 9e-06microM of econazole					84.6498 0.83 % 91.91
PC3 perturbed by 3.04e-05microM of aminocaproic acid					81.9547 5.29 % 88.33
PC3 perturbed by 2.4e-05microM of oxedrine					77.2136 1.88 % 87.67
PC3 perturbed by 1e-07microM of trichostatin A					78.3066 1.43 % 88.44
PC3 perturbed by 5.8e-06microM of monensin					76.6561 0.15 % 88.25
MCF7 perturbed by 8e-06microM of fluticasone					77.2848 0.54 % 88.37
PC3 perturbed by 8.8e-06microM of halcinonide					74.8461 1.17 % 86.84
MCF7 perturbed by 1.24e-05microM of bupivacaine					83.5253 0.94 % 91.29
vehicle					79.5622 1.68 % 88.94
vehicle					78.3145 0.08 % 89.12
vehicle					82.3425 2.54 % 89.9
vehicle					79.9229 3.11 % 88.41