Connectivity Map Batch 02 Random Load - CMAP33

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.25 0.15 % 93.55
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-07microM of sirolimus					89.6594 0.29 % 94.69
HL60 perturbed by 1e-06microM of trichostatin A					87.2453 2.25 % 92.5
vehicle					93.3331 0.28 % 96.52
MCF7 perturbed by 1.3e-05microM of orphenadrine					93.0122 0.15 % 96.43
MCF7 perturbed by 1.58e-05microM of sulfamethoxazole					92.6546 2.39 % 95.13
HL60 perturbed by 1.12e-05microM of succinylsulfathiazole					90.7085 3.29 % 93.71
HL60 perturbed by 1.3e-05microM of pempidine					90.5842 0.42 % 95.08
PC3 perturbed by 1.96e-05microM of ampyrone					88.7658 3.58 % 92.59
PC3 perturbed by 1.44e-05microM of iproniazid					88.2132 2.51 % 92.85
PC3 perturbed by 9.6e-06microM of mefloquine					87.5478 9.62 % 88.96
MCF7 perturbed by 1e-08microM of wortmannin					92.6742 0 % 96.34
MCF7 perturbed by 1e-05microM of trifluoperazine					92.6955 0.65 % 96.02
MCF7 perturbed by 1.7e-05microM of epirizole					91.9122 0.27 % 95.82
HL60 perturbed by 1.78e-05microM of 3-hydroxy-DL-kynurenine					90.0214 6.69 % 91.67
HL60 perturbed by 1.12e-05microM of chlorogenic acid					89.6637 2.59 % 93.54
HL60 perturbed by 4.8e-06microM of mebhydrolin					89.4606 0.73 % 94.36
vehicle					90.1069 1.03 % 94.54
HL60 perturbed by 4e-06microM of Chicago Sky Blue 6B					90.6195 1.31 % 94.65
HL60 perturbed by 1.12e-05microM of lactobionic acid					89.7316 0.31 % 94.71
PC3 perturbed by 1.24e-05microM of acetohexamide					85.8326 3.17 % 91.33
PC3 perturbed by 1.2e-05microM of hydroflumethiazide					75.7981 1.67 % 87.06
PC3 perturbed by 1.26e-05microM of moxisylyte					90.2092 0.04 % 95.08
PC3 perturbed by 1.56e-05microM of metrifonate					87.3806 0.07 % 93.65
HL60 perturbed by 1.16e-05microM of fluoxetine					90.7374 0.6 % 95.07
HL60 perturbed by 8.6e-06microM of cetirizine					90.4833 0.2 % 95.14
MCF7 perturbed by 9.8e-06microM of carbinoxamine					89.3479 0.01 % 94.67
MCF7 perturbed by 2.32e-05microM of sulfanilamide					89.2044 0.19 % 94.51
MCF7 perturbed by 1.02e-05microM of proadifen					92.2806 0.15 % 96.06
MCF7 perturbed by 2.04e-05microM of bethanechol					90.5805 4.48 % 93.05
MCF7 perturbed by 9e-06microM of betulin					91.0613 5.11 % 92.98
MCF7 perturbed by 1.9e-05microM of milrinone					90.0703 4.04 % 93.02
HL60 perturbed by 1e-08microM of wortmannin					89.7903 2.83 % 93.48
HL60 perturbed by 1e-05microM of troglitazone					89.5159 3.56 % 92.98
HL60 perturbed by 1e-06microM of tanespimycin					90.7492 3.06 % 93.84
vehicle					90.4961 0.17 % 95.16
MCF7 perturbed by 2.18e-05microM of carbachol					92.7958 8.06 % 92.37
vehicle					93.2836 1.5 % 95.89
MCF7 perturbed by 1.04e-05microM of benfluorex					91.7523 2.76 % 94.5
PC3 perturbed by 1.56e-05microM of prilocaine					88.7253 5.01 % 91.86
PC3 perturbed by 1.58e-05microM of ketoprofen					90.4845 0.1 % 95.19
PC3 perturbed by 8.6e-06microM of methylbenzethonium chloride					90.2332 0.56 % 94.83
PC3 perturbed by 2.04e-05microM of hydralazine					91.1104 0.29 % 95.41
PC3 perturbed by 1.16e-05microM of medrysone					89.001 3.89 % 92.55
MCF7 perturbed by 1e-05microM of 0179445-0000					87.2307 3.87 % 91.68
MCF7 perturbed by 1.38e-05microM of nefopam					88.281 1 % 93.64
MCF7 perturbed by 1.18e-05microM of convolamine					91.2178 0 % 95.61
MCF7 perturbed by 9.2e-06microM of vitexin					91.102 2.83 % 94.13
MCF7 perturbed by 1.38e-05microM of Prestwick-691					89.9758 0 % 94.99
MCF7 perturbed by 1.16e-05microM of calycanthine					89.5708 1.39 % 94.09
MCF7 perturbed by 1.22e-05microM of monocrotaline					91.5855 0.09 % 95.75
MCF7 perturbed by 1.94e-05microM of pyridoxine					91.6633 2.61 % 94.53
MCF7 perturbed by 1.16e-05microM of testosterone					92.3654 1.53 % 95.42
MCF7 perturbed by 1.28e-05microM of clenbuterol					92.6402 1.75 % 95.45
MCF7 perturbed by 1e-05microM of prochlorperazine					92.9189 0.31 % 96.3
MCF7 perturbed by 8e-06microM of harpagoside					92.28 1.57 % 95.36
MCF7 perturbed by 9.6e-06microM of bretylium tosilate					92.499 1.6 % 95.45
MCF7 perturbed by 1.14e-05microM of retrorsine					92.2259 2.18 % 95.02
MCF7 perturbed by 9.2e-06microM of oxolamine					92.6581 0.03 % 96.32
MCF7 perturbed by 9.2e-06microM of benzthiazide					93.048 0 % 96.52
MCF7 perturbed by 7e-06microM of cefotetan					89.9149 2.69 % 93.61
MCF7 perturbed by 1.24e-05microM of etifenin					92.6312 4.28 % 94.18
PC3 perturbed by 1.52e-05microM of sulfamerazine					91.742 0 % 95.87
HL60 perturbed by 2.26e-05microM of Prestwick-972					90.8813 0.02 % 95.43
HL60 perturbed by 8.4e-06microM of rilmenidine					90.8738 0.69 % 95.09
HL60 perturbed by 1.2e-05microM of alfaxalone					91.0786 0.92 % 95.08
HL60 perturbed by 8.4e-06microM of fluspirilene					91.1599 0.03 % 95.57
vehicle					91.2355 2.56 % 94.34
HL60 perturbed by 3.1e-05microM of nipecotic acid					91.4034 0.03 % 95.69
MCF7 perturbed by 1.18e-05microM of quercetin					91.8958 0.8 % 95.55
MCF7 perturbed by 9.8e-06microM of lovastatin					92.1278 0.64 % 95.75
MCF7 perturbed by 1.06e-05microM of clorsulon					92.5177 0.69 % 95.92
MCF7 perturbed by 4.8e-06microM of dirithromycin					93.1762 0.51 % 96.33
MCF7 perturbed by 1.2e-05microM of dosulepin					92.5425 0.61 % 95.97
PC3 perturbed by 1.5e-05microM of diethylstilbestrol					92.7145 2.47 % 95.12
PC3 perturbed by 3.2e-06microM of beta-escin					92.6019 1.59 % 95.5
PC3 perturbed by 4.8e-06microM of spiramycin					91.455 0.55 % 95.45
PC3 perturbed by 9e-06microM of Prestwick-1100					92.3181 1.12 % 95.6
PC3 perturbed by 1.24e-05microM of mycophenolic acid					90.9881 0.94 % 95.02
MCF7 perturbed by 8.4e-06microM of metitepine					92.5598 2.12 % 95.22
MCF7 perturbed by 7e-06microM of hemicholinium					93.1919 2.07 % 95.56
PC3 perturbed by 1.12e-05microM of succinylsulfathiazole					91.741 3.11 % 94.32
PC3 perturbed by 1.5e-05microM of zardaverine					91.009 1.73 % 94.64
PC3 perturbed by 1.3e-05microM of quinisocaine					92.0806 0.27 % 95.91
HL60 perturbed by 2.6e-06microM of iodixanol					91.0519 5.39 % 92.83
HL60 perturbed by 5e-06microM of xamoterol					90.8842 2.63 % 94.13
HL60 perturbed by 9.2e-06microM of ethaverine					91.1831 2.59 % 94.3
HL60 perturbed by 7.6e-06microM of rolitetracycline					91.2733 1.22 % 95.03
HL60 perturbed by 2.64e-05microM of paracetamol					91.5709 5.56 % 93.01
MCF7 perturbed by 1.06e-05microM of lithocholic acid					91.8893 0.86 % 95.51
MCF7 perturbed by 9.6e-06microM of mepenzolate bromide					91.857 2.9 % 94.48
MCF7 perturbed by 1.34e-05microM of nialamide					92.3634 0.52 % 95.92
HL60 perturbed by 1.96e-05microM of Prestwick-1103					91.2226 2.49 % 94.37
HL60 perturbed by 1.22e-05microM of cyclic adenosine monophosphate					91.2824 0.03 % 95.63
HL60 perturbed by 1.3e-05microM of epitiostanol					91.5724 0.07 % 95.75
MCF7 perturbed by 2.42e-05microM of benzocaine					92.1181 2.13 % 94.99
MCF7 perturbed by 4.8e-06microM of mebhydrolin					92.3965 2.36 % 95.02
MCF7 perturbed by 1.54e-05microM of norcyclobenzaprine					91.8035 0.44 % 95.68
MCF7 perturbed by 4.8e-06microM of roxithromycin					90.9131 2.79 % 94.06
PC3 perturbed by 9.4e-06microM of pizotifen					90.8005 1.94 % 94.43
PC3 perturbed by 1.46e-05microM of naringenin					90.7732 0.64 % 95.07
PC3 perturbed by 5.6e-06microM of paromomycin					91.9623 1.02 % 95.47
PC3 perturbed by 1.02e-05microM of diphemanil metilsulfate					91.9387 1.23 % 95.36
PC3 perturbed by 2.02e-05microM of levodopa					92.6725 0.04 % 96.32
MCF7 perturbed by 1.02e-05microM of diphemanil metilsulfate					91.5059 0 % 95.75
MCF7 perturbed by 1.98e-05microM of tiabendazole					93.4025 0.04 % 96.68
vehicle					92.5941 0.2 % 96.2
MCF7 perturbed by 1.52e-05microM of etamsylate					93.4091 0.01 % 96.7
PC3 perturbed by 1.88e-05microM of serotonin					92.7684 0.3 % 96.23
PC3 perturbed by 1.38e-05microM of epiandrosterone					92.543 0.2 % 96.17
PC3 perturbed by 1.5e-05microM of sulfafurazole					92.1014 1.13 % 95.49
PC3 perturbed by 1.3e-05microM of capsaicin					91.7218 2.15 % 94.78
PC3 perturbed by 4e-06microM of tyloxapol					91.0108 1.47 % 94.77
vehicle					91.5057 1.87 % 94.82
MCF7 perturbed by 1.26e-05microM of diphenylpyraline					92.2134 1.09 % 95.56
MCF7 perturbed by 1.16e-05microM of Prestwick-665					90.8002 1.2 % 94.8
vehicle					91.7233 2.15 % 94.79
PC3 perturbed by 1e-07microM of sirolimus					91.9678 0.34 % 95.81
vehicle					92.2118 1.47 % 95.37
PC3 perturbed by 7e-06microM of ketanserin					92.3193 0.58 % 95.87
PC3 perturbed by 1e-05microM of ergocalciferol					92.4681 0.48 % 95.99
PC3 perturbed by 2.62e-05microM of mesalazine					91.2848 1.86 % 94.71
PC3 perturbed by 1.18e-05microM of convolamine					91.8488 0.7 % 95.57
PC3 perturbed by 8.8e-06microM of repaglinide					91.3232 3.72 % 93.8
PC3 perturbed by 1.12e-05microM of nomifensine					90.1935 0.28 % 94.96
PC3 perturbed by 9.6e-06microM of isoconazole					90.7304 1.26 % 94.73
PC3 perturbed by 9.6e-06microM of tomatidine					91.6437 0.19 % 95.73
MCF7 perturbed by 1.24e-05microM of bupivacaine					92.1764 2.24 % 94.97
MCF7 perturbed by 1.6e-05microM of gemfibrozil					91.3338 0.11 % 95.61
MCF7 perturbed by 1.1e-05microM of prednisolone					92.143 0.11 % 96.02
MCF7 perturbed by 9e-06microM of telenzepine					92.3041 0.61 % 95.85
PC3 perturbed by 7.2e-06microM of terbutaline					90.4925 0.13 % 95.18
PC3 perturbed by 6e-06microM of propidium iodide					92.3418 0.42 % 95.96
PC3 perturbed by 1.48e-05microM of sulfamethizole					92.852 0.25 % 96.3
PC3 perturbed by 1.7e-05microM of methazolamide					92.794 1.28 % 95.75
PC3 perturbed by 1.38e-05microM of ciprofibrate					91.2003 0 % 95.6
vehicle					93.0727 0.53 % 96.27
MCF7 perturbed by 7.6e-06microM of vanoxerine					89.0929 2.5 % 93.29
vehicle					89.5507 0.64 % 94.45
MCF7 perturbed by 1e-07microM of valinomycin					92.7929 2.01 % 95.39
PC3 perturbed by 1e-06microM of tanespimycin					90.8013 0.47 % 95.17
PC3 perturbed by 1e-06microM of rotenone					91.7793 0.58 % 95.6
vehicle					92.8289 0.56 % 96.14
PC3 perturbed by 1e-06microM of fulvestrant					91.58 0.92 % 95.33
vehicle					92.8057 0.17 % 96.32
MCF7 perturbed by 1e-05microM of PF-00562151-00					92.7715 1.3 % 95.74
MCF7 perturbed by 1e-07microM of monorden					90.6842 0.25 % 95.22
MCF7 perturbed by 1e-07microM of trichostatin A					91.6125 0.09 % 95.76
vehicle					90.9063 1.28 % 94.81
MCF7 perturbed by 1.38e-05microM of midodrine					91.3423 2.33 % 94.51
MCF7 perturbed by 1.28e-05microM of zomepirac					92.3356 1.01 % 95.66
MCF7 perturbed by 2.2e-05microM of dacarbazine					92.8125 0.2 % 96.31
MCF7 perturbed by 1.64e-05microM of ribavirin					90.081 0.22 % 94.93
MCF7 perturbed by 1.54e-05microM of tiletamine					91.4137 0.08 % 95.67
MCF7 perturbed by 9.6e-06microM of hydrastine hydrochloride					93.1833 0.18 % 96.5
MCF7 perturbed by 3.1e-05microM of nipecotic acid					92.1837 0.09 % 96.05
MCF7 perturbed by 1.18e-05microM of dizocilpine					93.2946 2.28 % 95.51
MCF7 perturbed by 1.16e-05microM of fluorocurarine					93.5365 0.76 % 96.39
MCF7 perturbed by 1.34e-05microM of tretinoin					92.8637 4.41 % 94.23
HL60 perturbed by 1.4e-05microM of kaempferol					89.9001 3.3 % 93.3
HL60 perturbed by 3.5e-05microM of chloropyrazine					89.9512 3.43 % 93.26
HL60 perturbed by 1.38e-05microM of ciprofibrate					89.4865 2.62 % 93.44
HL60 perturbed by 1e-05microM of vorinostat					91.2164 1.78 % 94.72
HL60 perturbed by 1e-07microM of LY-294002					90.9087 3.86 % 93.53
HL60 perturbed by 1e-06microM of tretinoin					90.798 0.35 % 95.22
PC3 perturbed by 3.1e-05microM of vigabatrin					90.7212 3.22 % 93.75
vehicle					91.678 3.27 % 94.2
PC3 perturbed by 1.88e-05microM of baclofen					90.5881 3.9 % 93.34
PC3 perturbed by 8.4e-06microM of trifluoperazine					91.0999 3.54 % 93.78
PC3 perturbed by 1.1e-05microM of metolazone					91.6291 3.83 % 93.9
vehicle					92.7081 1.71 % 95.5
PC3 perturbed by 1e-05microM of AG-013608					92.8127 0.28 % 96.27
PC3 perturbed by 1e-05microM of 3-nitropropionic acid					93.1806 0.01 % 96.58
MCF7 perturbed by 1.96e-05microM of ethotoin					92.2984 3.15 % 94.58
MCF7 perturbed by 8.4e-06microM of Prestwick-664					91.3389 0 % 95.67
MCF7 perturbed by 1.12e-05microM of laudanosine					84.0709 2.19 % 90.94
MCF7 perturbed by 1.42e-05microM of xylometazoline					81.2926 1.93 % 89.68
MCF7 perturbed by 1e-07microM of alvespimycin					81.9849 1.72 % 90.13
MCF7 perturbed by 1e-06microM of fulvestrant					82.3219 0.6 % 90.86
MCF7 perturbed by 9.4e-06microM of urapidil					91.4176 0.06 % 95.68
MCF7 perturbed by 3.1e-05microM of flucytosine					92.076 0.12 % 95.98
PC3 perturbed by 1e-05microM of PHA-00767505E					91.9016 2.71 % 94.6
MCF7 perturbed by 1e-05microM of clozapine					83.0115 2.44 % 90.29
MCF7 perturbed by 9e-06microM of folic acid					86.1632 2.74 % 91.71
MCF7 perturbed by 9.4e-06microM of mifepristone					82.3275 1.39 % 90.47
MCF7 perturbed by 8.2e-06microM of cefmetazole					82.9703 0.87 % 91.05
PC3 perturbed by 3.1e-05microM of nipecotic acid					81.0768 0.78 % 90.15
PC3 perturbed by 1.52e-05microM of ozagrel					84.7161 2.21 % 91.25
MCF7 perturbed by 8.6e-06microM of naftopidil					73.8624 2.22 % 85.82
PC3 perturbed by 1e-05microM of alsterpaullone					77.5446 1.91 % 87.82
PC3 perturbed by 1e-07microM of MG-262					75.7386 0.01 % 87.86
MCF7 perturbed by 1e-05microM of 0316684-0000					76.3507 6.9 % 84.72
PC3 perturbed by 1e-07microM of thapsigargin					76.0921 0.16 % 87.96
MCF7 perturbed by 1.22e-05microM of ajmaline					83.3903 0.01 % 91.69
MCF7 perturbed by 1.18e-05microM of thiamine					79.455 0.07 % 89.69
MCF7 perturbed by 8.6e-06microM of dimenhydrinate					83.0964 0.04 % 91.53
MCF7 perturbed by 1.32e-05microM of spaglumic acid					78.5393 0.33 % 89.1
vehicle					86.3351 2.26 % 92.04
MCF7 perturbed by 1e-05microM of CP-944629					81.8463 2.86 % 89.49
PC3 perturbed by 1e-05microM of CP-863187					79.7756 4.91 % 87.44
vehicle					80.676 5.55 % 87.56
MCF7 perturbed by 1e-06microM of fulvestrant					76.5718 4.9 % 85.83