Connectivity Map Batch 02 Random Load - CMAP32

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.83 0.47 % 93.68
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
vehicle					87.9447 1.55 % 93.2
vehicle					87.8347 1.38 % 93.23
HL60 perturbed by 1e-06microM of chlorpromazine					87.4569 2.11 % 92.67
vehicle					89.0348 0.47 % 94.28
MCF7 perturbed by 1.66e-05microM of phenformin					92.7156 0.02 % 96.35
HL60 perturbed by 1.38e-05microM of Prestwick-642					91.5831 0.03 % 95.78
HL60 perturbed by 7.8e-06microM of gossypol					90.8933 0.04 % 95.43
HL60 perturbed by 1.04e-05microM of palmatine					91.5911 1.62 % 94.99
vehicle					89.1024 1.61 % 93.75
HL60 perturbed by 9e-06microM of econazole					91.3633 0.01 % 95.68
vehicle					91.5665 0.39 % 95.59
HL60 perturbed by 2.2e-05microM of mephenesin					91.8285 0.12 % 95.85
HL60 perturbed by 1.74e-05microM of kawain					91.0884 6.35 % 92.37
PC3 perturbed by 9.6e-06microM of naltrexone					87.9657 2.05 % 92.96
MCF7 perturbed by 1.2e-05microM of isoxicam					92.2673 0.03 % 96.12
vehicle					89.8674 0.31 % 94.78
HL60 perturbed by 1.4e-05microM of piperine					90.3895 0.03 % 95.18
HL60 perturbed by 2.28e-05microM of N-acetyl-L-aspartic acid					89.4722 2.79 % 93.34
HL60 perturbed by 1.04e-05microM of benfluorex					90.2707 0.5 % 94.89
PC3 perturbed by 1.7e-05microM of carbamazepine					86.5016 4.86 % 90.82
PC3 perturbed by 1.12e-05microM of homatropine					89.4337 0.07 % 94.68
HL60 perturbed by 6.6e-06microM of benzonatate					87.4172 1.52 % 92.95
HL60 perturbed by 1.18e-05microM of tenoxicam					89.5796 0.9 % 94.34
HL60 perturbed by 2.8e-05microM of trimethadione					90.8977 0.1 % 95.4
vehicle					91.0007 0.09 % 95.46
HL60 perturbed by 1.78e-05microM of selegiline					90.7308 0.09 % 95.32
HL60 perturbed by 3.14e-05microM of 6-azathymine					90.344 0.12 % 95.11
MCF7 perturbed by 6.2e-06microM of thioproperazine					92.1802 0.75 % 95.71
MCF7 perturbed by 1.3e-05microM of nimesulide					91.9021 1.47 % 95.22
MCF7 perturbed by 1.02e-05microM of chlorphenamine					91.6399 1.06 % 95.29
MCF7 perturbed by 1.66e-05microM of levamisole					92.0581 1.18 % 95.44
HL60 perturbed by 1.42e-05microM of ramifenazone					89.8685 0.01 % 94.93
HL60 perturbed by 8.2e-06microM of cefmetazole					88.1513 0 % 94.07
HL60 perturbed by 4.8e-06microM of spiramycin					90.8704 0.04 % 95.42
vehicle					89.3737 4.69 % 92.34
MCF7 perturbed by 6.6e-06microM of hesperidin					91.7298 0.03 % 95.85
vehicle					92.8859 0.13 % 96.38
vehicle					88.8455 3.76 % 92.54
MCF7 perturbed by 8.6e-06microM of moracizine					90.4587 5.33 % 92.57
vehicle					89.4675 4.05 % 92.71
MCF7 perturbed by 8.8e-06microM of repaglinide					88.7154 3.69 % 92.51
HL60 perturbed by 5e-05microM of valproic acid					89.6117 0.37 % 94.62
HL60 perturbed by 1e-04microM of acetylsalicylic acid					89.9477 0.01 % 94.97
MCF7 perturbed by 2.02e-05microM of nitrofural					92.1688 0 % 96.08
MCF7 perturbed by 4.8e-06microM of mebhydrolin					90.2039 0.01 % 95.1
MCF7 perturbed by 2.14e-05microM of carbimazole					90.1174 0.03 % 95.04
MCF7 perturbed by 1.16e-05microM of corticosterone					91.2959 0.01 % 95.64
MCF7 perturbed by 8.8e-06microM of methylergometrine					91.4396 4.34 % 93.55
PC3 perturbed by 1.28e-05microM of heliotrine					89.9126 3.18 % 93.37
PC3 perturbed by 1.2e-05microM of metamizole sodium					87.8021 2.3 % 92.75
vehicle					89.8962 3.43 % 93.23
MCF7 perturbed by 1.12e-05microM of benzamil					88.0295 0.33 % 93.85
MCF7 perturbed by 1.66e-05microM of phenformin					87.0041 0.03 % 93.49
MCF7 perturbed by 2.2e-05microM of dacarbazine					91.1579 1.43 % 94.86
MCF7 perturbed by 1e-05microM of fluphenazine					91.9957 0.26 % 95.87
vehicle					91.6309 0.66 % 95.49
MCF7 perturbed by 8.6e-06microM of meclozine					92.379 0.07 % 96.15
MCF7 perturbed by 1.48e-05microM of arcaine					91.7847 1.03 % 95.38
MCF7 perturbed by 9.4e-06microM of benzbromarone					91.4584 2.48 % 94.49
MCF7 perturbed by 1.16e-05microM of metixene					91.6075 0.19 % 95.71
MCF7 perturbed by 4e-06microM of Chicago Sky Blue 6B					92.2848 0.67 % 95.81
vehicle					91.8969 0.4 % 95.75
MCF7 perturbed by 9.2e-06microM of dl-alpha tocopherol					92.2472 2.11 % 95.07
MCF7 perturbed by 1.28e-05microM of progesterone					91.1352 0.76 % 95.19
MCF7 perturbed by 1.54e-05microM of suprofen					92.085 0.42 % 95.83
MCF7 perturbed by 2.24e-05microM of propofol					91.7132 0 % 95.86
MCF7 perturbed by 1.5e-05microM of equilin					90.3319 0 % 95.17
MCF7 perturbed by 4.6e-06microM of solanine					91.4362 0.96 % 95.24
vehicle					92.1302 1.17 % 95.48
MCF7 perturbed by 1e-05microM of 0317956-0000					90.0292 3.08 % 93.47
PC3 perturbed by 1.18e-05microM of metoclopramide					90.2869 0 % 95.14
PC3 perturbed by 1.38e-05microM of trimethoprim					90.5974 0.74 % 94.93
vehicle					91.0085 4.08 % 93.46
vehicle					91.2806 0.02 % 95.63
HL60 perturbed by 1.1e-05microM of atropine methonitrate					91.1698 0.03 % 95.57
HL60 perturbed by 3.1e-05microM of flucytosine					91.0997 0.02 % 95.54
HL60 perturbed by 1.58e-05microM of chrysin					90.5032 0.95 % 94.78
MCF7 perturbed by 1.62e-05microM of triflusal					91.46 0.64 % 95.41
PC3 perturbed by 1e-07microM of trichostatin A					91.1757 0.61 % 95.29
PC3 perturbed by 4.6e-06microM of solanine					89.726 1.07 % 94.33
PC3 perturbed by 1.16e-05microM of oxybuprocaine					91.0294 0.81 % 95.11
vehicle					91.396 3.26 % 94.07
vehicle					92.1589 5.98 % 93.09
MCF7 perturbed by 1.2e-05microM of furosemide					91.8623 5.8 % 93.03
MCF7 perturbed by 8.8e-06microM of methylergometrine					92.449 2.75 % 94.85
MCF7 perturbed by 8e-06microM of oxytetracycline					92.8794 5.13 % 93.88
MCF7 perturbed by 1.5e-05microM of zidovudine					91.8715 2.13 % 94.87
MCF7 perturbed by 8e-06microM of glibenclamide					92.8106 4.07 % 94.37
vehicle					91.3879 10.27 % 90.56
PC3 perturbed by 1.18e-05microM of quercetin					91.5208 2.71 % 94.4
PC3 perturbed by 1.28e-05microM of molindone					90.5747 0.86 % 94.86
vehicle					91.6203 1.18 % 95.22
PC3 perturbed by 1.36e-05microM of canavanine					90.0421 1.35 % 94.35
HL60 perturbed by 2.22e-05microM of caffeic acid					91.0815 1.08 % 95
HL60 perturbed by 2e-05microM of monobenzone					91.1162 2.83 % 94.15
MCF7 perturbed by 1.26e-05microM of phentolamine					89.9774 0.39 % 94.8
MCF7 perturbed by 1e-06microM of withaferin A					90.7761 0.71 % 95.03
MCF7 perturbed by 2.68e-05microM of 2-6-dimethylpiperidine					91.4337 0.02 % 95.7
MCF7 perturbed by 1.1e-05microM of furaltadone					92.1108 2.5 % 94.8
MCF7 perturbed by 1.22e-05microM of eucatropine					91.6019 0.67 % 95.46
MCF7 perturbed by 1.5e-05microM of Prestwick-1080					91.4781 0 % 95.74
vehicle					89.2267 5.3 % 91.96
HL60 perturbed by 1.28e-05microM of molindone					90.5474 3.36 % 93.59
HL60 perturbed by 1.08e-05microM of etofenamate					90.9258 3.26 % 93.83
MCF7 perturbed by 1.18e-05microM of isoxsuprine					91.3014 0.79 % 95.26
PC3 perturbed by 2.04e-05microM of bethanechol					90.3524 2.06 % 94.15
PC3 perturbed by 1.62e-05microM of parthenolide					90.4968 2.06 % 94.22
PC3 perturbed by 1.18e-05microM of ciclacillin					90.0402 1.26 % 94.39
PC3 perturbed by 6.4e-06microM of novobiocin					91.4301 0.73 % 95.35
MCF7 perturbed by 2.02e-05microM of guaifenesin					92.4466 0.03 % 96.21
MCF7 perturbed by 1.18e-05microM of ciclacillin					92.32 0.04 % 96.14
MCF7 perturbed by 3e-06microM of cyanocobalamin					92.8106 0.02 % 96.4
MCF7 perturbed by 4.8e-06microM of rifabutin					91.7952 0 % 95.9
vehicle					92.2666 1.13 % 95.57
PC3 perturbed by 1.16e-05microM of testosterone					92.3032 0.65 % 95.83
vehicle					92.5436 0.37 % 96.08
PC3 perturbed by 1.44e-05microM of azathioprine					92.4741 0.54 % 95.97
PC3 perturbed by 2.12e-05microM of 3-acetylcoumarin					92.3715 0.99 % 95.69
PC3 perturbed by 1e-05microM of colchicine					92.012 1.2 % 95.41
PC3 perturbed by 5e-06microM of oleandomycin					91.2323 1.71 % 94.76
PC3 perturbed by 9.4e-06microM of alfuzosin					92.1455 0.52 % 95.81
vehicle					91.69 0.75 % 95.47
MCF7 perturbed by 1.38e-05microM of trimethoprim					90.7856 0.71 % 95.04
MCF7 perturbed by 1.52e-05microM of sulfamerazine					91.572 0.83 % 95.37
MCF7 perturbed by 6e-06microM of dilazep					91.5604 2.26 % 94.65
PC3 perturbed by 1e-06microM of fulvestrant					92.6855 0 % 96.34
PC3 perturbed by 6.6e-06microM of lasalocid					91.3542 0.01 % 95.67
PC3 perturbed by 9.6e-06microM of bretylium tosilate					92.0092 0 % 96
PC3 perturbed by 1.4e-05microM of harmaline					92.083 0.53 % 95.78
PC3 perturbed by 1e-07microM of trichostatin A					91.7734 0.75 % 95.51
vehicle					91.2314 0.02 % 95.61
PC3 perturbed by 1.48e-05microM of pilocarpine					92.2427 0.6 % 95.82
PC3 perturbed by 1.04e-05microM of felodipine					91.4993 1.1 % 95.2
PC3 perturbed by 1.14e-05microM of profenamine					91.1883 1.22 % 94.99
PC3 perturbed by 1.32e-05microM of neostigmine bromide					91.0763 5.04 % 93.02
vehicle					91.4764 2.04 % 94.72
PC3 perturbed by 1.14e-05microM of chlorprothixene					90.4141 5.29 % 92.56
PC3 perturbed by 5.2e-06microM of digoxin					88.8679 1.9 % 93.48
PC3 perturbed by 5e-06microM of ioversol					91.4996 1.21 % 95.14
MCF7 perturbed by 9.6e-06microM of nimodipine					91.1835 0.02 % 95.58
MCF7 perturbed by 1.74e-05microM of naproxen					91.6875 0 % 95.84
MCF7 perturbed by 9.8e-06microM of remoxipride					92.7812 0.58 % 96.1
vehicle					90.9689 0.51 % 95.23
vehicle					90.6835 0.37 % 95.16
PC3 perturbed by 9.2e-06microM of suxibuzone					90.8789 0.19 % 95.35
vehicle					91.7389 0.36 % 95.69
MCF7 perturbed by 1.12e-05microM of pyrantel					90.7135 0.02 % 95.35
PC3 perturbed by 7.8e-06microM of cromoglicic acid					92.5075 0.01 % 96.25
PC3 perturbed by 1.18e-05microM of dizocilpine					92.6189 0.05 % 96.28
PC3 perturbed by 9.4e-06microM of hydroquinine					91.8443 0.42 % 95.71
PC3 perturbed by 1.02e-05microM of spiperone					92.0568 1.67 % 95.19
PC3 perturbed by 1.48e-05microM of meprylcaine					91.0553 0.08 % 95.49
MCF7 perturbed by 1.06e-05microM of droperidol					87.6826 1.9 % 92.89
MCF7 perturbed by 1e-08microM of wortmannin					91.9223 0.01 % 95.96
MCF7 perturbed by 1.78e-05microM of 3-hydroxy-DL-kynurenine					90.0834 2.74 % 93.67
vehicle					90.2296 0.01 % 95.11
MCF7 perturbed by 5e-05microM of valproic acid					91.8162 0.37 % 95.72
MCF7 perturbed by 0.0002microM of valproic acid					91.7217 3.13 % 94.3
MCF7 perturbed by 1e-07microM of trichostatin A					88.5029 3.26 % 92.62
MCF7 perturbed by 7.2e-06microM of ribostamycin					90.4172 0.01 % 95.21
MCF7 perturbed by 1.34e-05microM of isotretinoin					92.5978 0.35 % 96.13
MCF7 perturbed by 1.68e-05microM of proxyphylline					91.0455 0.03 % 95.51
MCF7 perturbed by 4.4e-06microM of gallamine triethiodide					92.9762 3.46 % 94.76
HL60 perturbed by 2.8e-06microM of verteporfin					89.2888 3.8 % 92.75
HL60 perturbed by 1e-06microM of chlorpromazine					89.7008 3.31 % 93.19
PC3 perturbed by 1.52e-05microM of tolfenamic acid					90.2481 3.51 % 93.37
PC3 perturbed by 7.6e-06microM of dequalinium chloride					89.8617 4.35 % 92.76
PC3 perturbed by 1.76e-05microM of nabumetone					91.0909 3.38 % 93.86
MCF7 perturbed by 1e-06microM of fulvestrant					79.7757 1.1 % 89.34
vehicle					82.4227 1.59 % 90.42
PC3 perturbed by 1e-06microM of trichostatin A					74.536 4.1 % 85.22
vehicle					92.586 0.37 % 96.11
vehicle					92.3308 3.49 % 94.42
MCF7 perturbed by 1.6e-05microM of phenazopyridine					90.8378 0.04 % 95.4
MCF7 perturbed by 8.6e-06microM of methylbenzethonium chloride					92.2077 0.82 % 95.69
vehicle					92.381 0 % 96.19
MCF7 perturbed by 1.2e-05microM of hydroflumethiazide					80.9477 1.54 % 89.7
MCF7 perturbed by 1.08e-05microM of morantel					80.0707 1.97 % 89.05
MCF7 perturbed by 1e-05microM of haloperidol					83.1217 0.28 % 91.42
vehicle					90.9051 0.45 % 95.23
MCF7 perturbed by 1e-05microM of LY-294002					83.0509 4.58 % 89.23
vehicle					81.0743 1.84 % 89.62
MCF7 perturbed by 1.42e-05microM of ramifenazone					82.5043 0.73 % 90.88
MCF7 perturbed by 5.2e-06microM of iopamidol					85.4896 1.06 % 92.22
MCF7 perturbed by 9.8e-06microM of piperacetazine					83.3868 3.49 % 89.95
PC3 perturbed by 8.4e-06microM of pivmecillinam					81.6968 1.76 % 89.97
PC3 perturbed by 1.2e-05microM of isoxicam					84.0955 2 % 91.05
PC3 perturbed by 1.8e-05microM of phenindione					80.247 0.37 % 89.94
PC3 perturbed by 1.2e-05microM of dosulepin					84.9037 0.1 % 92.4
PC3 perturbed by 1.4e-05microM of alprenolol					75.6802 0.61 % 87.53
PC3 perturbed by 9e-06microM of cefapirin					75.7372 0.72 % 87.51
MCF7 perturbed by 1.12e-05microM of alprostadil					76.1302 0.08 % 88.02
PC3 perturbed by 8.6e-06microM of metaraminol					74.1094 0.36 % 86.87
PC3 perturbed by 1e-05microM of GW-8510					77.8227 3.85 % 86.99
PC3 perturbed by 1e-07microM of MG-262					79.169 0.02 % 89.57
MCF7 perturbed by 1.64e-05microM of pinacidil					82.3892 0.48 % 90.96
vehicle					77.9064 2.56 % 87.67
MCF7 perturbed by 1.34e-05microM of nortriptyline					77.993 0.83 % 88.58
vehicle					80.8962 0.17 % 90.36
PC3 perturbed by 1e-05microM of pioglitazone					81.8433 4.75 % 88.55
MCF7 perturbed by 1e-05microM of 16-phenyltetranorprostaglandin E2					81.6972 2.97 % 89.37