Connectivity Map Batch 02 Random Load - CMAP30

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	200
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.74 4.3 % 91.72
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of genistein					86.9272 0.22 % 93.35
PC3 perturbed by 1e-05microM of trifluoperazine					87.7423 0.79 % 93.47
vehicle					88.0112 0.49 % 93.76
HL60 perturbed by 1e-06microM of nordihydroguaiaretic acid					86.4027 4.3 % 91.05
MCF7 perturbed by 1.18e-05microM of lisuride					92.1238 0 % 96.06
MCF7 perturbed by 1.56e-05microM of sulfathiazole					92.655 0.27 % 96.2
MCF7 perturbed by 1.18e-05microM of metoclopramide					92.4833 0.18 % 96.15
HL60 perturbed by 2.74e-05microM of myosmine					90.7842 0.05 % 95.37
HL60 perturbed by 1.24e-05microM of lycorine					89.5092 0.06 % 94.73
HL60 perturbed by 1.18e-05microM of disopyramide					90.603 0.02 % 95.29
HL60 perturbed by 1.2e-05microM of proglumide					90.7645 3.54 % 93.61
HL60 perturbed by 1.34e-05microM of isotretinoin					90.1006 0.05 % 95.02
HL60 perturbed by 1.48e-05microM of riluzole					91.2 0.07 % 95.56
PC3 perturbed by 8.8e-06microM of ursolic acid					88.3802 1.3 % 93.54
PC3 perturbed by 1.02e-05microM of picotamide					86.818 2.12 % 92.35
PC3 perturbed by 1.34e-05microM of fenspiride					87.6132 3.26 % 92.18
PC3 perturbed by 2.36e-05microM of chlorzoxazone					88.2236 1.54 % 93.34
PC3 perturbed by 8.8e-06microM of astemizole					86.8528 4.03 % 91.41
PC3 perturbed by 1.26e-05microM of norfloxacin					88.7952 1.75 % 93.52
HL60 perturbed by 1.16e-05microM of testosterone					89.7447 1.96 % 93.89
HL60 perturbed by 8.8e-06microM of cefixime					89.4875 3.06 % 93.22
HL60 perturbed by 1.14e-05microM of adiphenine					89.9579 0.04 % 94.96
HL60 perturbed by 1.18e-05microM of hexetidine					89.5822 0.29 % 94.65
HL60 perturbed by 3.1e-05microM of vigabatrin					89.8575 0.19 % 94.83
HL60 perturbed by 7.6e-06microM of ceforanide					89.3834 0.09 % 94.65
HL60 perturbed by 1.04e-05microM of cefaclor					88.5464 0.53 % 94.01
MCF7 perturbed by 1.66e-05microM of methocarbamol					92.2329 0.58 % 95.83
vehicle					91.6561 0.36 % 95.65
vehicle					92.5531 0.33 % 96.11
MCF7 perturbed by 1.14e-05microM of ranitidine					92.1086 0.75 % 95.68
HL60 perturbed by 6.8e-06microM of alexidine					85.5237 0.37 % 92.57
MCF7 perturbed by 1.46e-05microM of estradiol					89.1406 0.02 % 94.56
MCF7 perturbed by 2.14e-05microM of amrinone					89.6122 0.03 % 94.79
MCF7 perturbed by 1.1e-05microM of furaltadone					91.8393 0 % 95.92
MCF7 perturbed by 1.28e-05microM of zomepirac					88.8523 1 % 93.93
vehicle					90.7111 0.3 % 95.2
MCF7 perturbed by 1.36e-05microM of S-propranolol					88.612 3.9 % 92.35
HL60 perturbed by 1e-05microM of LY-294002					88.038 5.41 % 91.31
vehicle					89.6468 0.43 % 94.61
MCF7 perturbed by 8.8e-06microM of primaquine					89.3145 0.28 % 94.52
MCF7 perturbed by 1.02e-05microM of pirenperone					92.201 0 % 96.1
MCF7 perturbed by 7.4e-06microM of fusidic acid					91.6465 4.38 % 93.63
MCF7 perturbed by 1.32e-05microM of desipramine					90.9575 4.47 % 93.25
vehicle					92.2368 0.35 % 95.95
PC3 perturbed by 1.08e-05microM of finasteride					87.7897 3.53 % 92.13
PC3 perturbed by 1.26e-05microM of phentolamine					87.6389 1 % 93.32
MCF7 perturbed by 1.58e-05microM of ketoprofen					85.7967 1.94 % 91.93
MCF7 perturbed by 1.18e-05microM of isocorydine					88.3712 2.9 % 92.74
MCF7 perturbed by 7.4e-06microM of Prestwick-692					88.6215 0 % 94.31
MCF7 perturbed by 9e-06microM of acepromazine					89.6926 3.22 % 93.24
MCF7 perturbed by 1.4e-05microM of harmaline					90.0006 3.54 % 93.23
MCF7 perturbed by 1.02e-05microM of pirenperone					90.9968 1.06 % 94.97
MCF7 perturbed by 1e-06microM of tanespimycin					91.482 1.03 % 95.22
MCF7 perturbed by 1.04e-05microM of palmatine					90.7336 6.25 % 92.24
MCF7 perturbed by 5.6e-06microM of paromomycin					91.41 0.25 % 95.58
MCF7 perturbed by 2.18e-05microM of carbachol					91.6158 0 % 95.81
vehicle					89.8262 0.05 % 94.89
MCF7 perturbed by 1.22e-05microM of niclosamide					91.6174 0.03 % 95.79
MCF7 perturbed by 1.24e-05microM of gelsemine					90.6154 0.12 % 95.25
MCF7 perturbed by 1.2e-05microM of proglumide					90.6864 2.08 % 94.3
MCF7 perturbed by 7.4e-06microM of helveticoside					88.925 0.52 % 94.2
MCF7 perturbed by 8e-06microM of fluocinonide					90.1138 2.46 % 93.83
MCF7 perturbed by 9.4e-06microM of bendroflumethiazide					90.2584 2.01 % 94.12
PC3 perturbed by 5e-06microM of merbromin					86.8303 0.01 % 93.41
PC3 perturbed by 1.26e-05microM of diphenylpyraline					89.6009 0.01 % 94.79
PC3 perturbed by 1.72e-05microM of isocarboxazid					87.4663 0 % 93.73
PC3 perturbed by 1.16e-05microM of bromopride					89.0658 0 % 94.53
HL60 perturbed by 1.22e-05microM of prasterone					89.8326 0.09 % 94.87
MCF7 perturbed by 9.2e-06microM of budesonide					90.709 2.26 % 94.22
vehicle					91.8771 0.72 % 95.58
PC3 perturbed by 1.62e-05microM of tinidazole					91.7389 0.58 % 95.58
PC3 perturbed by 9.2e-06microM of flunisolide					90.8215 0.64 % 95.09
PC3 perturbed by 9.6e-06microM of mepenzolate bromide					90.0303 0.92 % 94.55
PC3 perturbed by 8.8e-06microM of betulinic acid					89.9487 1.14 % 94.41
PC3 perturbed by 1.22e-05microM of carteolol					88.8912 0.58 % 94.15
PC3 perturbed by 9.2e-06microM of fluvoxamine					91.2571 0.36 % 95.45
MCF7 perturbed by 1.14e-05microM of fendiline					90.9705 2.51 % 94.23
MCF7 perturbed by 8.6e-06microM of amodiaquine					92.0578 7.51 % 92.28
MCF7 perturbed by 1.34e-05microM of tretinoin					92.2981 3.86 % 94.22
MCF7 perturbed by 1.1e-05microM of labetalol					92.331 4.79 % 93.77
vehicle					87.7519 3.4 % 92.18
PC3 perturbed by 9e-06microM of propantheline bromide					90.9316 1.29 % 94.82
PC3 perturbed by 1.4e-05microM of probenecid					89.5751 0.97 % 94.3
HL60 perturbed by 1.88e-05microM of felbinac					89.88 9.06 % 90.41
HL60 perturbed by 3.5e-05microM of Prestwick-864					90.6221 6.4 % 92.11
MCF7 perturbed by 1.62e-05microM of parbendazole					91.3667 0.29 % 95.54
HL60 perturbed by 4.2e-06microM of benzathine benzylpenicillin					88.8163 2.08 % 93.37
HL60 perturbed by 1.96e-05microM of 3-acetamidocoumarin					89.5352 0.16 % 94.69
HL60 perturbed by 9.6e-06microM of decamethonium bromide					89.3812 3.82 % 92.78
vehicle					89.5619 4.03 % 92.76
HL60 perturbed by 4.2e-06microM of asiaticoside					90.4684 0.17 % 95.15
MCF7 perturbed by 1.26e-05microM of amprolium					91.9316 0.75 % 95.59
MCF7 perturbed by 1.6e-05microM of pyrimethamine					91.7704 0.3 % 95.73
MCF7 perturbed by 1.64e-05microM of salsolidin					90.607 0.84 % 94.88
PC3 perturbed by 1.08e-05microM of loracarbef					90.1854 1.72 % 94.24
PC3 perturbed by 1.42e-05microM of flufenamic acid					88.4217 2.3 % 93.06
PC3 perturbed by 9e-06microM of denatonium benzoate					90.2744 1.97 % 94.15
PC3 perturbed by 1.08e-05microM of bicuculline					91.1746 2.77 % 94.2
vehicle					90.747 0.08 % 95.33
MCF7 perturbed by 1.36e-05microM of N-acetylmuramic acid					92.3608 1.77 % 95.29
MCF7 perturbed by 1.3e-05microM of orphenadrine					90.8854 0.42 % 95.23
vehicle					92.1853 0.06 % 96.06
PC3 perturbed by 1e-05microM of perphenazine					91.7774 0.27 % 95.76
PC3 perturbed by 1.3e-05microM of clioquinol					91.2202 0.53 % 95.34
PC3 perturbed by 7.6e-06microM of pentoxyverine					91.7626 0.75 % 95.51
MCF7 perturbed by 1e-05microM of 0173570-0000					91.3235 0.26 % 95.53
MCF7 perturbed by 9.2e-06microM of fludroxycortide					91.6734 0.66 % 95.51
MCF7 perturbed by 1.1e-05microM of clemizole					90.9189 1.85 % 94.53
PC3 perturbed by 9.2e-06microM of diperodon					90.1078 1.99 % 94.06
PC3 perturbed by 1e-05microM of LY-294002					91.4212 0.16 % 95.63
PC3 perturbed by 1.86e-05microM of kinetin					92.0751 0 % 96.04
PC3 perturbed by 8.8e-06microM of astemizole					91.7348 0.75 % 95.49
vehicle					91.5777 0.03 % 95.77
PC3 perturbed by 1.18e-05microM of (-)-MK-801					91.5673 0.07 % 95.75
PC3 perturbed by 1.12e-05microM of lactobionic acid					91.5715 0.08 % 95.75
vehicle					91.9783 0.42 % 95.78
PC3 perturbed by 7.6e-06microM of ceforanide					92.069 0.03 % 96.02
PC3 perturbed by 1.92e-05microM of moroxydine					91.5122 0.49 % 95.51
PC3 perturbed by 3.24e-05microM of nicotinic acid					91.2068 2.25 % 94.48
PC3 perturbed by 8.4e-06microM of naftidrofuryl					91.273 0.89 % 95.19
MCF7 perturbed by 1.34e-05microM of protriptyline					92.6419 0.03 % 96.3
PC3 perturbed by 5.4e-06microM of alimemazine					90.7635 3.54 % 93.61
PC3 perturbed by 1.32e-05microM of oxprenolol					90.4948 4.8 % 92.85
PC3 perturbed by 1.04e-05microM of meropenem					90.8696 1.41 % 94.73
PC3 perturbed by 6e-06microM of natamycin					90.6611 0.44 % 95.11
MCF7 perturbed by 7.4e-06microM of levopropoxyphene					90.2676 0.49 % 94.89
MCF7 perturbed by 1.64e-05microM of hydrastinine					88.2489 2.63 % 92.81
MCF7 perturbed by 1.66e-05microM of mefenamic acid					91.3764 0.23 % 95.57
MCF7 perturbed by 6.2e-06microM of ceftazidime					91.5795 1.16 % 95.21
PC3 perturbed by 1.54e-05microM of ifosfamide					91.2691 0.07 % 95.6
PC3 perturbed by 7.6e-06microM of alclometasone					91.4342 0.02 % 95.71
PC3 perturbed by 2.06e-05microM of butamben					92.1478 0.02 % 96.06
PC3 perturbed by 8.6e-06microM of amodiaquine					91.7084 0.12 % 95.79
vehicle					92.0413 1.08 % 95.48
PC3 perturbed by 1.54e-05microM of skimmianine					91.1301 0.01 % 95.56
MCF7 perturbed by 1e-06microM of trichostatin A					91.2772 0.32 % 95.48
MCF7 perturbed by 1e-05microM of AG-013608					91.6942 0.44 % 95.63
MCF7 perturbed by 1e-07microM of valinomycin					92.3465 0.38 % 95.98
vehicle					91.402 0.41 % 95.5
MCF7 perturbed by 1e-05microM of PF-00539745-00					91.1864 1.42 % 94.89
PC3 perturbed by 1e-05microM of PF-00539745-00					90.8519 1.55 % 94.65
PC3 perturbed by 1e-06microM of trichostatin A					86.6126 0.78 % 92.91
MCF7 perturbed by 1e-06microM of trichostatin A					88.508 0.86 % 93.82
MCF7 perturbed by 9.8e-06microM of thioperamide					88.9081 0.04 % 94.43
MCF7 perturbed by 1.02e-05microM of pentetic acid					90.6711 2.65 % 94.01
MCF7 perturbed by 1e-06microM of chlorpromazine					89.8931 2.96 % 93.47
MCF7 perturbed by 1e-05microM of phthalylsulfathiazole					91.2172 0.18 % 95.52
MCF7 perturbed by 9e-06microM of cefapirin					89.6977 1.82 % 93.94
MCF7 perturbed by 8.6e-06microM of clobetasol					91.5702 0.14 % 95.71
MCF7 perturbed by 1.08e-05microM of lansoprazole					91.0087 0 % 95.5
vehicle					92.3036 0.05 % 96.13
MCF7 perturbed by 9e-06microM of lincomycin					92.4308 0.03 % 96.2
MCF7 perturbed by 1e-07microM of trichostatin A					92.8031 0.22 % 96.29
MCF7 perturbed by 1.1e-05microM of dorzolamide					92.5319 0.62 % 95.96
HL60 perturbed by 1.2e-05microM of propoxycaine					86.62 3.41 % 91.61
PC3 perturbed by 4.4e-06microM of amphotericin B					90.2192 3.03 % 93.59
MCF7 perturbed by 5e-07microM of H-89					78.9357 1.68 % 88.63
PC3 perturbed by 1e-05microM of pioglitazone					79.3772 2.68 % 88.35
PC3 perturbed by 1e-06microM of fulvestrant					80.6783 2.18 % 89.25
MCF7 perturbed by 5.8e-06microM of metoprolol					90.1291 0 % 95.06
MCF7 perturbed by 9.2e-06microM of estropipate					90.2815 0 % 95.14
MCF7 perturbed by 1e-08microM of estradiol					85.7298 0.91 % 92.41
MCF7 perturbed by 1.12e-05microM of aceclofenac					83.5151 1.86 % 90.83
MCF7 perturbed by 1e-06microM of tanespimycin					82.9637 1.53 % 90.72
vehicle					82.6474 1.16 % 90.74
MCF7 perturbed by 1.34e-05microM of azapropazone					91.7855 0.01 % 95.89
MCF7 perturbed by 1.7e-05microM of Prestwick-983					91.6027 0.05 % 95.78
MCF7 perturbed by 8.8e-06microM of terguride					92.0663 0 % 96.03
MCF7 perturbed by 1.46e-05microM of rolipram					91.1061 0.22 % 95.44
MCF7 perturbed by 2.8e-06microM of bacitracin					88.2625 0.02 % 94.12
MCF7 perturbed by 1e-05microM of PHA-00767505E					90.7327 3.38 % 93.68
MCF7 perturbed by 1e-06microM of trichostatin A					89.9718 1.05 % 94.46
MCF7 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					91.2178 1.9 % 94.66
MCF7 perturbed by 1e-05microM of rosiglitazone					85.2923 1.29 % 92
MCF7 perturbed by 1e-07microM of monorden					82.5052 3.44 % 89.53
MCF7 perturbed by 1.28e-05microM of praziquantel					82.9136 1.36 % 90.78
MCF7 perturbed by 2.34e-05microM of gabapentin					83.1646 3.6 % 89.78
MCF7 perturbed by 2.18e-05microM of corbadrine					80.9663 1.74 % 89.62
MCF7 perturbed by 1.5e-05microM of albendazole					84.6905 0.23 % 92.23
PC3 perturbed by 5.6e-06microM of dihydroergocristine					82.9753 3.3 % 89.84
PC3 perturbed by 1.54e-05microM of tiletamine					81.6294 0.86 % 90.39
PC3 perturbed by 2.84e-05microM of ethosuximide					82.6255 1.31 % 90.66
PC3 perturbed by 8.4e-06microM of isopropamide iodide					75.5877 1 % 87.29
MCF7 perturbed by 1.46e-05microM of methyldopate					77.864 0.16 % 88.85
MCF7 perturbed by 9.2e-06microM of fluvoxamine					73.3783 4.94 % 84.22
MCF7 perturbed by 1.52e-05microM of etamsylate					76.8395 1.31 % 87.76
PC3 perturbed by 1e-05microM of 0316684-0000					78.0884 0.01 % 89.04
PC3 perturbed by 1e-05microM of MS-275					79.0606 0.02 % 89.52
MCF7 perturbed by 8.8e-06microM of cloxacillin					81.3525 0.11 % 90.62
vehicle					79.6633 1.21 % 89.23
MCF7 perturbed by 1.8e-05microM of acetazolamide					78.4399 1.08 % 88.68
MCF7 perturbed by 8.4e-06microM of flunarizine					81.2599 0.03 % 90.61
MCF7 perturbed by 2.36e-05microM of chlorzoxazone					77.877 0.59 % 88.64
MCF7 perturbed by 1.1e-05microM of cortisone					77.9775 0.12 % 88.93
MCF7 perturbed by 1e-06microM of daunorubicin					81.8773 4.79 % 88.54
MCF7 perturbed by 1e-06microM of IC-86621					79.69 3.67 % 88.01
vehicle					78.9327 4.39 % 87.27
PC3 perturbed by 1e-05microM of CP-319743					77.5669 7.68 % 84.94
MCF7 perturbed by 1e-04microM of semustine					78.8493 2.85 % 88
vehicle					80.3107 2.33 % 88.99