Connectivity Map Batch 02 Random Load - CMAP29

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	86.49 0.27 % 93.11
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of rosiglitazone					89.682 0.08 % 94.8
HL60 perturbed by 1e-06microM of geldanamycin					86.4935 1.84 % 92.33
PC3 perturbed by 1e-07microM of sirolimus					89.4054 0.28 % 94.56
PC3 perturbed by 5e-05microM of valproic acid					89.2998 0.27 % 94.52
PC3 perturbed by 1e-05microM of haloperidol					90.4435 0.14 % 95.15
MCF7 perturbed by 1.08e-05microM of acebutolol					93.5414 0.58 % 96.48
MCF7 perturbed by 4.8e-06microM of josamycin					93.1952 0.01 % 96.59
MCF7 perturbed by 1.88e-05microM of baclofen					92.3567 0 % 96.18
MCF7 perturbed by 1.98e-05microM of edrophonium chloride					92.7366 0.24 % 96.25
MCF7 perturbed by 1.1e-05microM of metolazone					92.2471 0 % 96.12
HL60 perturbed by 5e-06microM of protoveratrine A					90.7752 0.34 % 95.22
HL60 perturbed by 1.06e-05microM of famprofazone					91.6431 0.05 % 95.8
PC3 perturbed by 1.66e-05microM of methocarbamol					87.5154 2.16 % 92.68
PC3 perturbed by 1e-05microM of scopolamine N-oxide					87.3576 1.34 % 93.01
PC3 perturbed by 9.6e-06microM of isoconazole					86.8798 1.16 % 92.86
vehicle					86.9123 1.67 % 92.62
PC3 perturbed by 6.4e-06microM of tiratricol					88.7977 1.57 % 93.62
PC3 perturbed by 4.6e-06microM of ivermectin					87.6696 1.79 % 92.94
MCF7 perturbed by 1.12e-05microM of thiamphenicol					92.0386 0.06 % 95.99
vehicle					92.1309 0.37 % 95.88
MCF7 perturbed by 1e-07microM of trichostatin A					92.3951 0.01 % 96.19
HL60 perturbed by 1.46e-05microM of procaine					85.9923 2.76 % 91.62
HL60 perturbed by 1.48e-05microM of pilocarpine					90.3011 0.2 % 95.05
HL60 perturbed by 2.4e-06microM of thiostrepton					91.0851 0.93 % 95.08
vehicle					92.6561 0.3 % 96.18
MCF7 perturbed by 8.4e-06microM of cefotaxime					92.0215 2.12 % 94.95
MCF7 perturbed by 1e-05microM of scopolamine N-oxide					92.6953 0.02 % 96.34
HL60 perturbed by 5e-06microM of atractyloside					89.8375 0.04 % 94.9
HL60 perturbed by 8.4e-06microM of cefazolin					90.8171 0.12 % 95.35
HL60 perturbed by 1.34e-05microM of sulfadimidine					89.7545 8.02 % 90.87
HL60 perturbed by 8.4e-06microM of flecainide					87.0999 3.41 % 91.84
HL60 perturbed by 1.1e-05microM of cloperastine					91.3624 1.82 % 94.77
HL60 perturbed by 1.54e-05microM of skimmianine					89.8622 5.55 % 92.16
MCF7 perturbed by 1.1e-05microM of cefalexin					93.5264 0.03 % 96.75
MCF7 perturbed by 9.2e-06microM of hecogenin					90.1838 0.05 % 95.07
MCF7 perturbed by 7.4e-06microM of levopropoxyphene					91.4232 2.36 % 94.53
MCF7 perturbed by 1e-07microM of trichostatin A					90.378 3.82 % 93.28
MCF7 perturbed by 8.8e-06microM of levocabastine					89.5842 4.55 % 92.52
MCF7 perturbed by 6e-06microM of natamycin					90.7263 2.39 % 94.17
HL60 perturbed by 9e-06microM of cefapirin					89.8892 0.12 % 94.88
HL60 perturbed by 0.001microM of valproic acid					89.5497 1.46 % 94.04
vehicle					92.8228 0.01 % 96.41
vehicle					89.2207 0.01 % 94.61
MCF7 perturbed by 1.1e-05microM of bisacodyl					91.0001 0.23 % 95.38
MCF7 perturbed by 2.2e-05microM of carcinine					90.3879 0.19 % 95.1
MCF7 perturbed by 8.6e-06microM of glycocholic acid					91.6545 6.85 % 92.4
MCF7 perturbed by 1.66e-05microM of idazoxan					91.7564 6.58 % 92.59
vehicle					92.5088 5.09 % 93.71
MCF7 perturbed by 9.4e-06microM of urapidil					92.8654 3.82 % 94.52
MCF7 perturbed by 3.1e-05microM of flucytosine					92.0232 7.67 % 92.18
MCF7 perturbed by 8.4e-06microM of naftidrofuryl					93.153 0.8 % 96.17
vehicle					89.7426 0.59 % 94.58
MCF7 perturbed by 5e-06microM of protoveratrine A					91.6167 3.13 % 94.24
MCF7 perturbed by 1.06e-05microM of haloperidol					92.403 0.61 % 95.9
MCF7 perturbed by 1e-06microM of tanespimycin					91.463 1.2 % 95.13
MCF7 perturbed by 1e-07microM of monorden					92.325 0.42 % 95.95
vehicle					92.6986 0 % 96.35
MCF7 perturbed by 9.6e-06microM of bretylium tosilate					92.2352 0.45 % 95.9
MCF7 perturbed by 1.96e-05microM of 4-hydroxyphenazone					92.7217 0 % 96.36
MCF7 perturbed by 9.8e-06microM of ginkgolide A					92.3901 0 % 96.2
MCF7 perturbed by 2.1e-05microM of tetroquinone					92.209 0.58 % 95.81
MCF7 perturbed by 2.24e-05microM of phenacetin					92.4191 0.7 % 95.86
MCF7 perturbed by 1.4e-05microM of acacetin					90.1648 1.38 % 94.39
MCF7 perturbed by 6e-06microM of deferoxamine					89.9857 3.25 % 93.37
vehicle					89.2862 3.37 % 92.96
PC3 perturbed by 1.28e-05microM of sulfadimethoxine					89.4988 2.14 % 93.68
PC3 perturbed by 7.8e-06microM of calcium folinate					90.2496 1.4 % 94.43
vehicle					90.3983 0.09 % 95.15
PC3 perturbed by 7.4e-06microM of pentolonium					91.0051 0 % 95.5
PC3 perturbed by 8e-06microM of demeclocycline					90.7295 0 % 95.36
HL60 perturbed by 2.04e-05microM of cantharidin					90.5233 3.33 % 93.6
HL60 perturbed by 2.06e-05microM of aminohippuric acid					90.9993 2 % 94.5
HL60 perturbed by 1.2e-05microM of proxymetacaine					91.166 0.03 % 95.57
MCF7 perturbed by 1.78e-05microM of selegiline					92.5287 0.77 % 95.88
PC3 perturbed by 1.12e-05microM of vincamine					91.4978 0.27 % 95.61
PC3 perturbed by 1.2e-05microM of proglumide					92.4055 0.7 % 95.85
vehicle					92.5543 0.39 % 96.08
PC3 perturbed by 9.8e-06microM of ginkgolide A					91.1608 0.13 % 95.51
PC3 perturbed by 5e-06microM of metrizamide					91.2742 1.42 % 94.93
MCF7 perturbed by 7.8e-06microM of fluphenazine					92.7409 7.76 % 92.49
MCF7 perturbed by 1.04e-05microM of brinzolamide					92.2242 2.14 % 95.04
MCF7 perturbed by 1.32e-05microM of antazoline					92.8514 3.22 % 94.82
MCF7 perturbed by 1.08e-05microM of c1arizine					92.6042 5.43 % 93.59
vehicle					91.0902 4.62 % 93.24
HL60 perturbed by 1.26e-05microM of tolmetin					91.2763 7.07 % 92.1
HL60 perturbed by 1.96e-05microM of crotamiton					91.1384 2.14 % 94.5
HL60 perturbed by 3.5e-05microM of Prestwick-860					90.4852 6.54 % 91.97
HL60 perturbed by 9.8e-06microM of spectinomycin					91.3535 6.54 % 92.4
MCF7 perturbed by 1.38e-05microM of quinethazone					92.5012 0.55 % 95.98
HL60 perturbed by 1.14e-05microM of torasemide					90.831 4.13 % 93.35
HL60 perturbed by 1.48e-05microM of meptazinol					91.1768 0.07 % 95.55
HL60 perturbed by 9.2e-06microM of Prestwick-984					91.4645 0.24 % 95.61
MCF7 perturbed by 1.4e-05microM of piperine					91.1671 2.42 % 94.37
MCF7 perturbed by 8.6e-06microM of cetirizine					91.4162 0.38 % 95.52
vehicle					91.1678 1.13 % 95.02
PC3 perturbed by 1.52e-05microM of roxarsone					91.0228 1.57 % 94.73
PC3 perturbed by 3.6e-06microM of adipiodone					91.5457 1.48 % 95.03
PC3 perturbed by 1e-05microM of CP-690334-01					91.7517 0.47 % 95.64
PC3 perturbed by 5.4e-06microM of pancuronium bromide					92.0798 0.19 % 95.94
vehicle					91.4485 1.15 % 95.15
MCF7 perturbed by 5.6e-06microM of paromomycin					93.1024 0.01 % 96.55
MCF7 perturbed by 1.5e-05microM of diethylstilbestrol					91.9623 0 % 95.98
MCF7 perturbed by 1.48e-05microM of tolbutamide					92.6957 0 % 96.35
vehicle					91.9297 0 % 95.96
MCF7 perturbed by 6.4e-06microM of resc1amine					92.7323 0 % 96.37
PC3 perturbed by 6.8e-06microM of kanamycin					92.0441 0.51 % 95.77
PC3 perturbed by 2.32e-05microM of menadione					92.0214 0.98 % 95.52
PC3 perturbed by 1.1e-05microM of cefalexin					92.281 0.15 % 96.07
PC3 perturbed by 5.4e-06microM of bromocriptine					92.3151 0.95 % 95.68
MCF7 perturbed by 1.1e-05microM of ofloxacin			Image:5500024031723100807772.F01.CEL probe-variance.png		92.1027 0.66 % 95.72
MCF7 perturbed by 7.2e-06microM of fenoprofen					92.9618 0.09 % 96.43
PC3 perturbed by 1e-08microM of wortmannin					92.0529 0.19 % 95.93
PC3 perturbed by 5.8e-06microM of metoprolol					92.3768 0.23 % 96.07
vehicle					91.4326 0.49 % 95.47
PC3 perturbed by 1e-08microM of fulvestrant					92.8289 0.04 % 96.39
PC3 perturbed by 1e-05microM of troglitazone					92.0485 0.05 % 96
PC3 perturbed by 1.18e-05microM of atropine oxide					89.7379 3.83 % 92.95
PC3 perturbed by 1.1e-05microM of labetalol					91.1352 0.02 % 95.56
PC3 perturbed by 9.6e-06microM of miconazole					92.6175 0 % 96.31
PC3 perturbed by 9.2e-06microM of dl-alpha tocopherol					92.3041 0.01 % 96.15
PC3 perturbed by 1.16e-05microM of omeprazole					91.4965 0.09 % 95.7
PC3 perturbed by 4.6e-06microM of paclitaxel					90.0872 0.33 % 94.88
PC3 perturbed by 7.2e-06microM of cefotiam					91.2336 0.5 % 95.37
PC3 perturbed by 7.4e-06microM of puromycin					89.9958 0.13 % 94.93
vehicle					92.4565 0.04 % 96.21
PC3 perturbed by 1e-07microM of trichostatin A					91.8495 0.31 % 95.77
PC3 perturbed by 7.6e-06microM of rolitetracycline					91.6899 0.58 % 95.55
MCF7 perturbed by 2.32e-05microM of pralidoxime					92.0108 0.13 % 95.94
MCF7 perturbed by 1.18e-05microM of dobutamine					92.808 0.01 % 96.4
PC3 perturbed by 7.8e-06microM of bucladesine					91.2665 5.07 % 93.1
PC3 perturbed by 9.4e-06microM of terazosin					92.1432 0.27 % 95.94
vehicle					91.5636 1.01 % 95.28
PC3 perturbed by 1.5e-05microM of vidarabine					91.5716 0.99 % 95.29
PC3 perturbed by 1.06e-05microM of quinidine					93.0715 0.24 % 96.42
PC3 perturbed by 2.04e-05microM of methacholine chloride					92.8266 0.18 % 96.32
MCF7 perturbed by 5e-06microM of oleandomycin					92.6237 1.8 % 95.41
PC3 perturbed by 1e-06microM of rotenone					92.789 0.03 % 96.38
PC3 perturbed by 1e-04microM of H-7					92.1184 0.53 % 95.79
MCF7 perturbed by 1e-08microM of estradiol					91.7789 1.15 % 95.32
MCF7 perturbed by 1e-05microM of fluphenazine					92.575 0.04 % 96.27
MCF7 perturbed by 1e-06microM of tanespimycin					92.2773 0.27 % 96.01
MCF7 perturbed by 2.4e-05microM of pyrithyldione					91.7979 0.98 % 95.41
MCF7 perturbed by 1.2e-05microM of furosemide					90.0735 2.45 % 93.81
MCF7 perturbed by 1.58e-05microM of naproxen					90.7526 1.91 % 94.42
MCF7 perturbed by 1.02e-05microM of chlorphenamine					92.5416 0.11 % 96.22
MCF7 perturbed by 9.2e-06microM of estropipate					90.6847 0 % 95.34
vehicle					92.6068 0 % 96.3
MCF7 perturbed by 1e-05microM of pheneticillin					93.2362 2.84 % 95.2
MCF7 perturbed by 1.6e-05microM of phenazopyridine					93.144 3.68 % 94.73
MCF7 perturbed by 7.8e-06microM of raloxifene					93.4054 2.82 % 95.29
MCF7 perturbed by 1.34e-05microM of disulfiram					92.8623 0.77 % 96.05
HL60 perturbed by 1e-08microM of estradiol					87.4943 3.69 % 91.9
HL60 perturbed by 1.22e-05microM of ondansetron					88.9598 0.71 % 94.12
HL60 perturbed by 6e-06microM of thiethylperazine					88.39 3.53 % 92.43
HL60 perturbed by 9.6e-06microM of ramipril					88.9383 3.64 % 92.65
vehicle					90.4507 0.49 % 94.98
PC3 perturbed by 8.4e-06microM of dinoprost					91.1628 3.28 % 93.94
PC3 perturbed by 8.2e-06microM of clebopride					90.7246 3.49 % 93.62
PC3 perturbed by 1.58e-05microM of sulfacetamide					90.4448 3.84 % 93.3
PC3 perturbed by 1e-05microM of ampicillin					90.9599 3.39 % 93.78
vehicle					80.0127 1.87 % 89.07
PC3 perturbed by 1e-05microM of scriptaid					77.0737 2 % 87.54
PC3 perturbed by 1e-05microM of PF-00562151-00					77.1981 2.88 % 87.16
MCF7 perturbed by 1e-05microM of STOCK1N-35215					92.6877 0.25 % 96.22
MCF7 perturbed by 1e-05microM of pheneticillin					92.4393 0 % 96.22
vehicle					89.9086 0.19 % 94.86
MCF7 perturbed by 2.68e-05microM of 2-6-dimethylpiperidine					92.1622 0 % 96.08
MCF7 perturbed by 1.24e-05microM of lycorine					92.1881 0.02 % 96.08
MCF7 perturbed by 1.22e-05microM of pramocaine					92.0569 0.15 % 95.96
MCF7 perturbed by 1.02e-05microM of Prestwick-689					93.1967 0 % 96.6
MCF7 perturbed by 2.52e-05microM of citiolone					93.3305 0.1 % 96.61
vehicle					93.2525 0 % 96.62
MCF7 perturbed by 9.2e-06microM of flunisolide					91.8888 0 % 95.94
MCF7 perturbed by 1.3e-05microM of pempidine					92.0732 0.2 % 95.94
MCF7 perturbed by 1e-05microM of LY-294002					81.2585 4.74 % 88.26
MCF7 perturbed by 9.6e-06microM of prazosin					92.5267 0.01 % 96.26
MCF7 perturbed by 8.4e-06microM of rilmenidine					92.4224 0.06 % 96.18
MCF7 perturbed by 1.94e-05microM of trapidil					91.9105 0.02 % 95.95
vehicle					92.0331 0.08 % 95.97
MCF7 perturbed by 7.6e-06microM of gliquidone					92.5877 0 % 96.29
MCF7 perturbed by 1.1e-05microM of atropine methonitrate					91.7515 0 % 95.87
MCF7 perturbed by 2e-05microM of 5194442					92.4512 0.01 % 96.22
MCF7 perturbed by 1.08e-05microM of c1arizine					83.7511 1.42 % 91.16
MCF7 perturbed by 1.2e-05microM of isoetarine					83.0409 0.25 % 91.4
PC3 perturbed by 1.34e-05microM of nortriptyline					82.2538 0.31 % 90.97
PC3 perturbed by 1.62e-05microM of Prestwick-1084					77.0697 0.08 % 88.5
PC3 perturbed by 9.2e-06microM of fludroxycortide					74.5046 0.72 % 86.89
vehicle					76.6664 0.21 % 88.23
vehicle					78.9223 0.14 % 89.39
vehicle					75.8352 0.24 % 87.8
vehicle					75.754 1.22 % 87.27
MCF7 perturbed by 1.42e-05microM of niflumic acid					81.4861 0.6 % 90.44
MCF7 perturbed by 9.8e-06microM of risperidone					78.8157 0.3 % 89.26
MCF7 perturbed by 4.8e-06microM of dirithromycin					80.5408 0.07 % 90.24
vehicle					77.9221 4.56 % 86.68
PC3 perturbed by 1e-05microM of CP-645525-01					77.6052 6.96 % 85.32
PC3 perturbed by 1e-05microM of suramin sodium					79.5833 3.21 % 88.19
PC3 perturbed by 1e-06microM of fulvestrant					83.5854 3.86 % 89.86
MCF7 perturbed by 1e-06microM of IC-86621					78.8312 2.87 % 87.98
MCF7 perturbed by 1e-06microM of trichostatin A					81.4661 2.61 % 89.43
PC3 perturbed by 1e-07microM of vinblastine					79.8403 2.57 % 88.64