Connectivity Map Batch 02 Random Load - CMAP28

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	89.07 0.04 % 94.52
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-08microM of fulvestrant					88.468 0.34 % 94.06
HL60 perturbed by 1e-05microM of trifluoperazine					89.0663 0.28 % 94.39
PC3 perturbed by 0.001microM of valproic acid					87.7001 0.83 % 93.44
PC3 perturbed by 1e-08microM of alpha-estradiol					88.4755 0.04 % 94.22
MCF7 perturbed by 1e-07microM of trichostatin A					92.9729 0.07 % 96.45
MCF7 perturbed by 8.6e-06microM of oxetacaine					92.8295 0.76 % 96.04
MCF7 perturbed by 1.18e-05microM of isoxsuprine					93.2075 1.79 % 95.71
MCF7 perturbed by 8e-06microM of dipyridamole					91.1283 1.12 % 95.01
MCF7 perturbed by 1.62e-05microM of naphazoline					92.9477 0 % 96.47
vehicle					92.1321 0 % 96.07
MCF7 perturbed by 1.04e-05microM of lomefloxacin					92.1369 0.15 % 95.99
vehicle					91.105 0.02 % 95.54
HL60 perturbed by 8.6e-06microM of methylbenzethonium chloride					89.6679 0.03 % 94.82
HL60 perturbed by 1.12e-05microM of conessine					90.9783 0.1 % 95.44
HL60 perturbed by 8.2e-06microM of enalapril					91.3532 0.05 % 95.65
HL60 perturbed by 2.04e-05microM of hydralazine					91.3434 0.03 % 95.66
HL60 perturbed by 1.8e-05microM of bufexamac					90.9868 0.13 % 95.43
PC3 perturbed by 1e-05microM of canrenoic acid					86.3491 1.9 % 92.23
PC3 perturbed by 2.04e-05microM of pargyline					88.0842 1.67 % 93.21
PC3 perturbed by 1.74e-05microM of diazoxide					88.0221 0.81 % 93.61
PC3 perturbed by 1.18e-05microM of atropine oxide					86.4308 1.75 % 92.34
PC3 perturbed by 1.14e-05microM of ranitidine					87.9923 0.54 % 93.72
PC3 perturbed by 1.4e-05microM of etodolac					89.7629 1.03 % 94.37
vehicle					92.8073 0 % 96.4
MCF7 perturbed by 1e-05microM of LY-294002					92.4378 0 % 96.22
MCF7 perturbed by 1e-06microM of tretinoin					92.403 0 % 96.2
vehicle					92.3782 0.02 % 96.18
MCF7 perturbed by 1e-07microM of sirolimus					92.4996 0.8 % 95.85
HL60 perturbed by 5.4e-06microM of ouabain					89.6102 0.8 % 94.41
HL60 perturbed by 8.8e-06microM of betulinic acid					90.2655 0.12 % 95.07
vehicle					90.076 0.74 % 94.67
PC3 perturbed by 1.02e-05microM of triflupromazine					87.5716 3.7 % 91.94
HL60 perturbed by 1.16e-05microM of nifedipine					84.7737 8.52 % 88.13
HL60 perturbed by 1.8e-05microM of acetazolamide					87.4698 0.05 % 93.71
HL60 perturbed by 1.56e-05microM of metrifonate					86.7578 2.02 % 92.37
vehicle					90.1484 1.99 % 94.08
HL60 perturbed by 1e-07microM of trichostatin A					88.311 0.62 % 93.85
vehicle					90.6413 0.57 % 95.04
MCF7 perturbed by 1.44e-05microM of pentoxifylline					92.2356 0.01 % 96.12
HL60 perturbed by 1e-05microM of pheneticillin					90.0573 0.01 % 95.02
HL60 perturbed by 7.8e-06microM of calcium folinate					89.7492 0.09 % 94.83
vehicle					87.3943 0.56 % 93.42
HL60 perturbed by 2.06e-05microM of butamben					90.1044 0.01 % 95.05
MCF7 perturbed by 5.8e-06microM of monensin					90.6111 0 % 95.3
MCF7 perturbed by 7.6e-06microM of guanadrel					90.6665 0.18 % 95.24
vehicle					91.0389 0.11 % 95.47
MCF7 perturbed by 6e-06microM of thiethylperazine					91.0783 2.54 % 94.27
MCF7 perturbed by 3.92e-05microM of cycloserine					88.3402 3.17 % 92.59
MCF7 perturbed by 1.04e-05microM of meropenem					90.5924 3.08 % 93.76
MCF7 perturbed by 1e-07microM of trichostatin A					88.2957 5.84 % 91.23
HL60 perturbed by 1e-05microM of haloperidol					89.146 1.85 % 93.65
HL60 perturbed by 1e-05microM of vorinostat					89.3579 0.45 % 94.45
HL60 perturbed by 0.0002microM of valproic acid					90.5306 1.93 % 94.3
HL60 perturbed by 1.02e-05microM of pridinol					89.7936 0.8 % 94.5
HL60 perturbed by 1.42e-05microM of sulfametoxydiazine					88.385 3.04 % 92.67
MCF7 perturbed by 3.4e-06microM of ciclosporin					89.3749 0.23 % 94.57
MCF7 perturbed by 9.2e-06microM of brompheniramine					88.3984 0.58 % 93.91
MCF7 perturbed by 1.46e-05microM of 7-aminocephalosporanic acid					90.0354 0 % 95.02
MCF7 perturbed by 1.12e-05microM of lactobionic acid					92.3783 0.03 % 96.18
MCF7 perturbed by 1.36e-05microM of propranolol					92.1195 6.09 % 93.02
vehicle					91.1926 3.95 % 93.62
MCF7 perturbed by 1.32e-05microM of hesperetin					90.0874 10.96 % 89.56
MCF7 perturbed by 9.2e-06microM of fluvastatin					92.9987 0.76 % 96.12
MCF7 perturbed by 5.2e-06microM of digoxin					92.4339 1.69 % 95.37
MCF7 perturbed by 1.5e-05microM of (-)-atenolol					92.7162 1.78 % 95.47
MCF7 perturbed by 1.02e-05microM of betamethasone					91.4531 12.8 % 89.33
vehicle					89.7654 0.12 % 94.82
PC3 perturbed by 1.04e-05microM of lomefloxacin					90.2892 0.49 % 94.9
MCF7 perturbed by 2.52e-05microM of betonicine					87.8836 1.18 % 93.35
MCF7 perturbed by 1.06e-05microM of karakoline					87.2646 1.51 % 92.88
MCF7 perturbed by 1e-07microM of trichostatin A					90.2964 0.02 % 95.14
MCF7 perturbed by 6.2e-06microM of physostigmine					89.5312 3 % 93.27
MCF7 perturbed by 1.06e-05microM of lobeline					91.3534 6.97 % 92.19
MCF7 perturbed by 1.04e-05microM of palmatine					91.2122 0 % 95.61
MCF7 perturbed by 6.4e-06microM of co-dergocrine mesilate					89.5262 0 % 94.76
MCF7 perturbed by 2.22e-05microM of stachydrine					88.7516 0 % 94.38
MCF7 perturbed by 1.08e-05microM of galantamine					89.3407 2.26 % 93.54
MCF7 perturbed by 1e-05microM of LY-294002					92.0427 0.44 % 95.8
MCF7 perturbed by 1.9e-05microM of methyldopa					92.0881 0.3 % 95.89
MCF7 perturbed by 1e-06microM of trichostatin A					92.3086 0.42 % 95.94
MCF7 perturbed by 1.3e-05microM of clioquinol					92.1145 0.32 % 95.9
MCF7 perturbed by 1.24e-05microM of enoxacin					92.6047 0.72 % 95.94
MCF7 perturbed by 5.8e-06microM of amiodarone					92.6115 0.02 % 96.29
MCF7 perturbed by 1.3e-05microM of clorgiline					91.8644 0.88 % 95.49
MCF7 perturbed by 1.78e-05microM of furazolidone					91.0552 0 % 95.53
MCF7 perturbed by 2.6e-06microM of iodixanol					91.2768 2.48 % 94.4
MCF7 perturbed by 1.84e-05microM of primidone					90.8646 0 % 95.43
MCF7 perturbed by 4.8e-06microM of roxithromycin					92.8073 0 % 96.4
MCF7 perturbed by 1.12e-05microM of alprostadil					91.1797 1.07 % 95.05
vehicle					92.1592 0 % 96.08
MCF7 perturbed by 1.18e-05microM of amiprilose					91.8957 0.01 % 95.94
MCF7 perturbed by 1.22e-05microM of eucatropine					91.0356 0.34 % 95.35
MCF7 perturbed by 8.4e-06microM of flecainide					88.5855 1.85 % 93.37
vehicle					90.8764 0 % 95.44
vehicle					90.8932 0 % 95.45
PC3 perturbed by 1.58e-05microM of ketoprofen					90.0577 0 % 95.03
PC3 perturbed by 8.4e-06microM of Prestwick-664					89.3313 0 % 94.67
HL60 perturbed by 1.36e-05microM of Prestwick-920					90.9146 0.03 % 95.44
vehicle					90.9664 0.12 % 95.42
vehicle					91.436 1.8 % 94.82
vehicle					90.6022 0.16 % 95.22
PC3 perturbed by 1.36e-05microM of oxaprozin					91.8126 0.44 % 95.69
PC3 perturbed by 1.12e-05microM of chlorogenic acid					90.3586 0.04 % 95.16
PC3 perturbed by 9.4e-06microM of trimethobenzamide					90.8945 0.38 % 95.26
PC3 perturbed by 2.8e-05microM of trimethadione					89.7997 0.16 % 94.82
MCF7 perturbed by 1.14e-05microM of clomipramine					92.0511 10.07 % 90.99
MCF7 perturbed by 1.16e-05microM of clopamide					92.0845 2.11 % 94.99
MCF7 perturbed by 9.4e-06microM of fipexide					92.3562 10.04 % 91.16
MCF7 perturbed by 1.34e-05microM of methapyrilene					92.9355 2.07 % 95.43
PC3 perturbed by 9.6e-06microM of amantadine					91.5226 3.54 % 93.99
PC3 perturbed by 2.12e-05microM of phenazone					91.8811 0.02 % 95.93
PC3 perturbed by 1.28e-05microM of cyclobenzaprine					91.8458 0.21 % 95.82
PC3 perturbed by 8.6e-06microM of oxetacaine					91.2218 0.22 % 95.5
PC3 perturbed by 1.42e-05microM of indoprofen					90.1951 0.58 % 94.81
PC3 perturbed by 1e-07microM of trichostatin A					88.7856 0.12 % 94.33
HL60 perturbed by 1.18e-05microM of esculin					90.787 1.09 % 94.85
MCF7 perturbed by 1e-05microM of CP-320650-01					88.7399 0.04 % 94.35
MCF7 perturbed by 1.62e-05microM of santonin					90.5823 0.05 % 95.26
HL60 perturbed by 1.06e-05microM of cyclopenthiazide					90.9421 0.04 % 95.45
vehicle					91.8835 1.4 % 95.24
MCF7 perturbed by 9.2e-06microM of zuclopenthixol					91.6742 1.92 % 94.87
PC3 perturbed by 1.64e-05microM of hydrastinine					89.8135 0.93 % 94.44
PC3 perturbed by 1.82e-05microM of ornidazole					90.2455 0.51 % 94.87
PC3 perturbed by 1.48e-05microM of tolbutamide					91.2119 0.1 % 95.55
PC3 perturbed by 1.62e-05microM of parbendazole					90.3094 0.74 % 94.79
PC3 perturbed by 1.7e-05microM of sparteine					91.5722 0.18 % 95.7
MCF7 perturbed by 1.36e-05microM of oxaprozin					92.8031 0.28 % 96.26
vehicle					91.3127 0.23 % 95.54
MCF7 perturbed by 8.2e-06microM of cefamandole					91.7581 0 % 95.88
MCF7 perturbed by 1e-05microM of glycopyrronium bromide					90.9988 0.21 % 95.4
MCF7 perturbed by 1.38e-05microM of nefopam					91.9475 0.12 % 95.91
PC3 perturbed by 1e-05microM of clozapine					91.356 0.45 % 95.45
PC3 perturbed by 1.62e-05microM of pindolol					91.9346 1.13 % 95.4
PC3 perturbed by 1e-06microM of tanespimycin					92.0567 1.34 % 95.36
PC3 perturbed by 1e-05microM of vorinostat					92.1063 1.99 % 95.06
PC3 perturbed by 1e-05microM of prochlorperazine					92.0242 1.05 % 95.49
PC3 perturbed by 9.2e-06microM of fursultiamine					92.2593 0.02 % 96.12
PC3 perturbed by 1.04e-05microM of cefaclor					91.5519 0 % 95.78
PC3 perturbed by 1.98e-05microM of edrophonium chloride					92.2244 0.42 % 95.9
PC3 perturbed by 1.32e-05microM of diclofenamide					91.3816 0.8 % 95.29
MCF7 perturbed by 8.4e-06microM of dinoprost					90.7888 0.11 % 95.34
PC3 perturbed by 6e-06microM of nadide					91.4065 0.29 % 95.56
PC3 perturbed by 1.28e-05microM of praziquantel					91.4332 1.13 % 95.15
vehicle					91.2544 0.03 % 95.61
MCF7 perturbed by 2.82e-05microM of piracetam					90.7567 0.98 % 94.89
PC3 perturbed by 8.2e-06microM of azlocillin					91.8753 0.01 % 95.93
PC3 perturbed by 1.06e-05microM of fluorometholone					92.1534 0.07 % 96.04
PC3 perturbed by 1e-08microM of estradiol					91.7701 0.11 % 95.83
MCF7 perturbed by 1e-05microM of pioglitazone					92.7367 0.05 % 96.34
MCF7 perturbed by 1e-06microM of tanespimycin					89.606 1.13 % 94.24
MCF7 perturbed by 1.18e-05microM of chlortalidone					88.8939 2.3 % 93.3
MCF7 perturbed by 1.62e-05microM of (-)-isoprenaline					90.3146 0.75 % 94.78
MCF7 perturbed by 1e-05microM of canrenoic acid					91.613 1.03 % 95.29
MCF7 perturbed by 1.32e-05microM of antazoline					89.8426 2.23 % 93.81
MCF7 perturbed by 1.34e-05microM of nortriptyline					92.4375 0.06 % 96.19
MCF7 perturbed by 1.04e-05microM of homochlorcyclizine					92.7542 0 % 96.38
MCF7 perturbed by 8.2e-06microM of nicergoline					92.492 0.64 % 95.92
MCF7 perturbed by 1.5e-05microM of dienestrol					92.8882 0.21 % 96.34
HL60 perturbed by 1e-07microM of sirolimus					88.1071 3.88 % 92.12
vehicle					88.5506 4.2 % 92.18
HL60 perturbed by 1e-05microM of fluphenazine					89.8362 2.92 % 93.46
HL60 perturbed by 1e-08microM of fulvestrant					88.1781 3.3 % 92.44
HL60 perturbed by 1e-06microM of geldanamycin					87.7527 0.04 % 93.85
PC3 perturbed by 1.08e-05microM of nomegestrol					90.1869 2.87 % 93.66
PC3 perturbed by 2.7e-05microM of betazole					90.6265 3.34 % 93.64
PC3 perturbed by 1.2e-05microM of piribedil					91.1156 3.11 % 94
PC3 perturbed by 1e-06microM of fulvestrant					78.4729 1.64 % 88.42
MCF7 perturbed by 1e-04microM of carmustine					78.843 2.26 % 88.29
PC3 perturbed by 1e-06microM of SB-203580					75.5707 3.7 % 85.93
vehicle					92.5357 2.44 % 95.05
MCF7 perturbed by 6e-06microM of propidium iodide					90.9805 0.02 % 95.48
MCF7 perturbed by 1.06e-05microM of karakoline					91.6233 1.79 % 94.92
MCF7 perturbed by 8.8e-06microM of halcinonide					92.2187 0.01 % 96.1
MCF7 perturbed by 1.42e-05microM of artemisinin					84.7883 1.46 % 91.67
MCF7 perturbed by 1.36e-05microM of benserazide					90.0242 0.05 % 94.99
MCF7 perturbed by 1.02e-05microM of alfadolone					91.5488 0 % 95.77
vehicle					91.8949 0.01 % 95.94
vehicle					91.4846 0.05 % 95.72
MCF7 perturbed by 1.76e-05microM of nabumetone					91.4249 0.35 % 95.54
MCF7 perturbed by 1e-06microM of tanespimycin					78.6884 3.47 % 87.61
MCF7 perturbed by 1.36e-05microM of cinchonidine					82.3423 2.37 % 89.99
MCF7 perturbed by 9e-06microM of benzethonium chloride					82.0306 2.61 % 89.71
PC3 perturbed by 1.44e-05microM of pentoxifylline					83.0381 1.18 % 90.93
PC3 perturbed by 1.34e-05microM of isotretinoin					82.4475 0.82 % 90.82
vehicle					80.6082 1.55 % 89.53
PC3 perturbed by 1.4e-05microM of etodolac					85.3202 3.48 % 90.92
PC3 perturbed by 2.4e-05microM of pyrithyldione					78.0324 0.08 % 88.98
vehicle					76.4608 0.69 % 87.88
PC3 perturbed by 5e-06microM of atractyloside					75.6536 0.84 % 87.41
PC3 perturbed by 1e-07microM of trichostatin A					77.5727 0.2 % 88.69
MCF7 perturbed by 1.18e-05microM of tracazolate					74.8371 3.04 % 85.9
MCF7 perturbed by 9.6e-06microM of sitosterol					75.1212 0.24 % 87.44
PC3 perturbed by 1e-04microM of lomustine					78.2466 0.2 % 89.02
vehicle					77.3834 0.43 % 88.47
PC3 perturbed by 1e-06microM of trichostatin A					76.2902 0.2 % 88.05
MCF7 perturbed by 1e-05microM of GW-8510					77.1156 0.35 % 88.38
PC3 perturbed by 1e-06microM of trichostatin A					79.0559 0.02 % 89.52
MCF7 perturbed by 1.1e-05microM of bumetanide					85.1282 0.03 % 92.55
MCF7 perturbed by 1e-05microM of pioglitazone					81.8043 4.07 % 88.87
vehicle					85.0152 11.39 % 86.81
vehicle					80.2005 2.51 % 88.84