Connectivity Map Batch 02 Random Load - CMAP27

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	94.11 0.03 % 97.04
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
vehicle					87.8228 0.05 % 93.89
MCF7 perturbed by 2.12e-05microM of phenazone					94.1054 2.09 % 96.01
MCF7 perturbed by 1.58e-05microM of fenbufen					92.2021 1.85 % 95.18
HL60 perturbed by 6e-06microM of Prestwick-682					90.7304 0.03 % 95.35
HL60 perturbed by 1.22e-05microM of boldine					90.5042 0.38 % 95.06
vehicle					90.7231 0.06 % 95.33
HL60 perturbed by 1.1e-05microM of bumetanide					91.3123 1.23 % 95.04
HL60 perturbed by 1.1e-05microM of tiapride					92.2001 1.36 % 95.42
PC3 perturbed by 1e-07microM of trichostatin A					89.4627 1.28 % 94.09
MCF7 perturbed by 1.14e-05microM of adiphenine					93.1704 0 % 96.59
MCF7 perturbed by 1e-06microM of trichostatin A					92.4773 0 % 96.24
MCF7 perturbed by 1.58e-05microM of sulfacetamide					92.8983 0 % 96.45
MCF7 perturbed by 1.66e-05microM of mefenamic acid					93.1495 0.12 % 96.51
MCF7 perturbed by 1e-06microM of chlorpromazine					92.8354 0.13 % 96.35
MCF7 perturbed by 1.56e-05microM of metrifonate					92.6934 0.01 % 96.34
MCF7 perturbed by 1e-04microM of acetylsalicylic acid					93.4882 0 % 96.74
vehicle					89.8325 0.06 % 94.88
PC3 perturbed by 1.62e-05microM of dapsone					90.4034 0.01 % 95.2
PC3 perturbed by 1e-07microM of trichostatin A					88.9593 0.09 % 94.43
HL60 perturbed by 2.6e-06microM of vancomycin					89.6955 0.37 % 94.66
HL60 perturbed by 1.26e-05microM of pregnenolone					90.8919 0.09 % 95.4
HL60 perturbed by 1e-05microM of ergocalciferol					91.0136 0.2 % 95.41
HL60 perturbed by 1.98e-05microM of tiabendazole					90.2611 0.19 % 95.04
HL60 perturbed by 1.16e-05microM of omeprazole					89.6063 1.96 % 93.82
MCF7 perturbed by 1e-05microM of canrenoic acid					93.4304 0.11 % 96.66
MCF7 perturbed by 1e-07microM of trichostatin A					92.2762 0.32 % 95.98
MCF7 perturbed by 1.54e-05microM of thalidomide					91.731 0.87 % 95.43
MCF7 perturbed by 9.6e-06microM of naltrexone					93.7447 0.47 % 96.64
MCF7 perturbed by 4.6e-06microM of ivermectin					93.4331 0.65 % 96.39
MCF7 perturbed by 1.2e-05microM of piroxicam					93.63 0.75 % 96.44
HL60 perturbed by 3.5e-05microM of thiamazole					90.9561 0.28 % 95.34
HL60 perturbed by 8.6e-06microM of delsoline					90.893 0.93 % 94.98
HL60 perturbed by 2.44e-05microM of ricinine					90.7779 1.27 % 94.76
MCF7 perturbed by 9e-06microM of bisoprolol					93.6237 0.18 % 96.72
MCF7 perturbed by 1.42e-05microM of guanfacine					93.7374 0.13 % 96.8
MCF7 perturbed by 1.06e-05microM of lithocholic acid					90.4398 0.34 % 95.05
MCF7 perturbed by 4.8e-06microM of spiramycin					92.6193 0.01 % 96.31
MCF7 perturbed by 1.2e-05microM of isoetarine					90.7213 0.01 % 95.36
MCF7 perturbed by 1.1e-05microM of piretanide					91.7218 3.47 % 94.13
MCF7 perturbed by 9.6e-06microM of methanthelinium bromide					90.5587 2.35 % 94.1
MCF7 perturbed by 1.38e-05microM of ciprofibrate					89.2905 3.06 % 93.12
vehicle					90.4016 4.89 % 92.75
MCF7 perturbed by 1.52e-05microM of ozagrel					91.0327 4.79 % 93.12
HL60 perturbed by 1.5e-05microM of vidarabine					90.5375 0.69 % 94.92
vehicle					92.1433 0 % 96.07
MCF7 perturbed by 1.08e-05microM of SR-95531					92.2575 0 % 96.13
MCF7 perturbed by 1.46e-05microM of estradiol					91.8249 6.9 % 92.46
MCF7 perturbed by 1.12e-05microM of florfenicol					92.4407 6.58 % 92.93
MCF7 perturbed by 1.58e-05microM of tacrine					93.4297 1.23 % 96.1
MCF7 perturbed by 1.5e-05microM of zidovudine					92.1111 8.29 % 91.91
PC3 perturbed by 2.52e-05microM of betonicine					90.9105 3.55 % 93.68
PC3 perturbed by 8e-06microM of fluocinonide					90.082 1.51 % 94.29
PC3 perturbed by 9.4e-06microM of bendroflumethiazide					89.1099 0.29 % 94.41
PC3 perturbed by 8e-06microM of demeclocycline					88.6632 3.86 % 92.4
vehicle					89.1135 1.07 % 94.02
MCF7 perturbed by 6e-06microM of Prestwick-682					90.7515 0.02 % 95.37
vehicle					90.966 0 % 95.48
MCF7 perturbed by 1.06e-05microM of riboflavin					91.526 0.15 % 95.69
MCF7 perturbed by 1.26e-05microM of piperlongumine					92.5411 4.31 % 94.12
MCF7 perturbed by 1.64e-05microM of flurbiprofen					93.0569 1.29 % 95.88
MCF7 perturbed by 1.44e-05microM of azathioprine					93.1464 0.69 % 96.23
MCF7 perturbed by 8e-06microM of dipyridamole					93.3004 0.28 % 96.51
vehicle					93.3352 1.29 % 96.03
MCF7 perturbed by 2.06e-05microM of butyl hydroxybenzoate					92.3506 1.85 % 95.25
MCF7 perturbed by 1.3e-05microM of nadolol					92.0382 0.04 % 96
MCF7 perturbed by 6.6e-06microM of reserpine					93.541 0.14 % 96.7
MCF7 perturbed by 3.1e-05microM of dimethadione					93.2428 0.33 % 96.46
MCF7 perturbed by 1e-05microM of phthalylsulfathiazole					92.4696 0 % 96.23
vehicle					92.9468 1.53 % 95.71
MCF7 perturbed by 1.86e-05microM of memantine					92.4564 0.13 % 96.16
MCF7 perturbed by 1.44e-05microM of oxamniquine					92.7791 0.05 % 96.36
MCF7 perturbed by 1.54e-05microM of carbarsone					92.1039 1.36 % 95.37
MCF7 perturbed by 1.82e-05microM of xylazine					89.7997 1.99 % 93.9
MCF7 perturbed by 4.8e-06microM of spiramycin					91.1069 5.59 % 92.76
PC3 perturbed by 1e-05microM of Prestwick-675					90.6495 0.57 % 95.04
vehicle					90.8906 0.07 % 95.41
HL60 perturbed by 1.64e-05microM of ribavirin					90.7403 0.08 % 95.33
vehicle					89.8703 0.04 % 94.91
HL60 perturbed by 1.1e-05microM of nitrendipine					91.3495 1.07 % 95.14
HL60 perturbed by 7.4e-06microM of halofantrine					91.0334 0.04 % 95.5
HL60 perturbed by 1.34e-05microM of protriptyline					91.2945 1.08 % 95.11
HL60 perturbed by 4e-06microM of tyloxapol					91.4098 0.05 % 95.68
HL60 perturbed by 1.34e-05microM of adrenosterone					91.2541 0.07 % 95.59
MCF7 perturbed by 8.2e-06microM of Prestwick-559					92.131 2.85 % 94.64
MCF7 perturbed by 1.72e-05microM of betahistine					92.2661 0.36 % 95.95
MCF7 perturbed by 2.22e-05microM of L-methionine sulfoximine					91.665 1.36 % 95.15
PC3 perturbed by 1.18e-05microM of dantrolene					92.4731 0.22 % 96.13
PC3 perturbed by 1e-06microM of paroxetine					92.6353 0.23 % 96.2
PC3 perturbed by 1.7e-05microM of phenelzine					92.3299 1.07 % 95.63
PC3 perturbed by 1.24e-05microM of promazine					90.9823 0.35 % 95.31
PC3 perturbed by 3.92e-05microM of levcycloserine					92.3609 0.03 % 96.17
PC3 perturbed by 1.18e-05microM of trihexyphenidyl					90.5884 0.14 % 95.23
PC3 perturbed by 1.22e-05microM of levobunolol					91.6558 0.08 % 95.79
PC3 perturbed by 1.44e-05microM of ethambutol					91.3189 0 % 95.66
MCF7 perturbed by 1.46e-05microM of chlormezanone					93.1931 2.23 % 95.48
MCF7 perturbed by 1.28e-05microM of praziquantel					92.8967 7.79 % 92.55
PC3 perturbed by 1.86e-05microM of sulfaguanidine					92.1529 14.76 % 88.7
PC3 perturbed by 5.8e-06microM of pepstatin					91.949 0.14 % 95.91
PC3 perturbed by 1.06e-05microM of trichlormethiazide					91.8126 1.52 % 95.15
PC3 perturbed by 1.84e-05microM of fosfosal					90.881 0.33 % 95.28
vehicle					91.5363 0.36 % 95.59
MCF7 perturbed by 1.34e-05microM of fenbendazole					92.2666 1.07 % 95.6
HL60 perturbed by 1.08e-05microM of loracarbef					91.3284 0.03 % 95.65
HL60 perturbed by 2.12e-05microM of phensuximide					91.6098 0.38 % 95.62
vehicle					91.3892 0.08 % 95.66
MCF7 perturbed by 1.6e-05microM of diflunisal					92.5962 0.77 % 95.91
vehicle					93.115 1.85 % 95.63
vehicle					93.208 0.19 % 96.51
MCF7 perturbed by 7.2e-06microM of emetine					91.0358 1.55 % 94.75
MCF7 perturbed by 1.56e-05microM of sulfathiazole					91.2276 0.53 % 95.35
MCF7 perturbed by 1.06e-05microM of cyclopenthiazide					89.4687 2.07 % 93.7
PC3 perturbed by 1.1e-05microM of bumetanide					91.6097 1.58 % 95.02
PC3 perturbed by 9.2e-06microM of aztreonam					90.4999 1.83 % 94.33
vehicle					90.0896 1.53 % 94.28
PC3 perturbed by 7e-06microM of alpha-ergocryptine					90.8992 0.27 % 95.31
MCF7 perturbed by 1e-06microM of paroxetine					92.5204 0 % 96.26
MCF7 perturbed by 1.52e-05microM of homosalate					91.9187 0 % 95.96
MCF7 perturbed by 1.62e-05microM of parbendazole					93.5181 0 % 96.76
MCF7 perturbed by 1.38e-05microM of piromidic acid					93.896 0.74 % 96.58
MCF7 perturbed by 2.02e-05microM of levodopa					91.4685 0.09 % 95.69
PC3 perturbed by 1.88e-05microM of felbinac					91.4339 0.63 % 95.4
PC3 perturbed by 1.06e-05microM of haloperidol					92.0385 0.09 % 95.98
PC3 perturbed by 1.02e-05microM of pirenperone					92.6149 0.11 % 96.25
PC3 perturbed by 1.42e-05microM of guanfacine					92.7694 0.03 % 96.37
MCF7 perturbed by 7.6e-06microM of guanadrel					92.3814 0.34 % 96.02
MCF7 perturbed by 1e-05microM of 0175029-0000					90.7357 3.11 % 93.81
MCF7 perturbed by 1e-06microM of 0179445-0000					93.2614 0.45 % 96.41
MCF7 perturbed by 1.7e-05microM of isosorbide					93.5405 0 % 96.77
PC3 perturbed by 1e-08microM of estradiol					92.7238 2.28 % 95.22
PC3 perturbed by 9.2e-06microM of clidinium bromide					93.1128 1.85 % 95.63
PC3 perturbed by 1e-07microM of trichostatin A					92.7339 0 % 96.37
PC3 perturbed by 7.4e-06microM of doxazosin					92.2564 0.06 % 96.1
vehicle					93.4094 0 % 96.7
MCF7 perturbed by 1.18e-05microM of esculin					94.0127 0.29 % 96.86
MCF7 perturbed by 1.72e-05microM of melatonin					92.0632 0.01 % 96.03
PC3 perturbed by 1.14e-05microM of acenocoumarol					91.0259 1.52 % 94.75
vehicle					91.5463 4.65 % 93.45
vehicle					92.0155 0.07 % 95.97
PC3 perturbed by 1.02e-05microM of proadifen					91.7299 0.56 % 95.59
PC3 perturbed by 1.28e-05microM of sulfadoxine					91.4535 0.12 % 95.67
MCF7 perturbed by 1.12e-05microM of chlorpromazine					92.7806 0.79 % 95.99
MCF7 perturbed by 9.2e-06microM of aztreonam					92.1612 0.39 % 95.88
PC3 perturbed by 8.2e-06microM of lidoflazine					92.6991 0.38 % 96.16
PC3 perturbed by 6e-06microM of thiethylperazine					91.2407 0.48 % 95.38
PC3 perturbed by 3.5e-05microM of chloropyrazine					92.2717 0.47 % 95.9
PC3 perturbed by 1.86e-05microM of etanidazole					92.8257 0.01 % 96.41
PC3 perturbed by 5.2e-06microM of saquinavir					93.0024 0 % 96.5
vehicle					92.7969 0.37 % 96.22
MCF7 perturbed by 1.96e-05microM of crotamiton					91.2779 5.88 % 92.7
MCF7 perturbed by 1e-07microM of trichostatin A					91.259 1.26 % 95
MCF7 perturbed by 3.5e-05microM of Prestwick-860					91.206 1.9 % 94.65
vehicle					91.7711 4.06 % 93.86
PC3 perturbed by 1e-05microM of AG-013608					91.97 0.46 % 95.76
vehicle					92.6514 0.12 % 96.27
MCF7 perturbed by 1e-08microM of estradiol					92.1335 2.3 % 94.92
vehicle					92.7351 0 % 96.37
vehicle					91.8314 0.75 % 95.54
MCF7 perturbed by 1e-05microM of rosiglitazone					92.8367 1.52 % 95.66
MCF7 perturbed by 9e-06microM of bephenium hydroxynaphthoate					92.7488 2.64 % 95.05
MCF7 perturbed by 1.14e-05microM of clomipramine					90.4491 2.23 % 94.11
MCF7 perturbed by 1.72e-05microM of aminophenazone					93.6455 0 % 96.82
MCF7 perturbed by 9e-06microM of econazole					93.5007 0.01 % 96.75
MCF7 perturbed by 9.8e-06microM of sulfinpyrazone					93.8424 1.15 % 96.35
MCF7 perturbed by 1.3e-05microM of butacaine					93.6556 2.96 % 95.35
HL60 perturbed by 7.4e-06microM of cefepime					88.2274 3.61 % 92.31
vehicle					90.1318 3.12 % 93.51
HL60 perturbed by 1e-08microM of alpha-estradiol					90.0925 3.95 % 93.07
HL60 perturbed by 1e-06microM of tanespimycin					88.4712 4.01 % 92.23
vehicle					91.5815 3.84 % 93.87
PC3 perturbed by 1.18e-05microM of terguride					91.0144 3.51 % 93.75
PC3 perturbed by 1.1e-05microM of amoxicillin					90.7302 3.8 % 93.46
PC3 perturbed by 5e-07microM of H-89					77.7487 5.64 % 86.05
PC3 perturbed by 1e-05microM of orlistat					92.5911 0 % 96.3
MCF7 perturbed by 1e-07microM of trichostatin A					92.4562 0.01 % 96.22
MCF7 perturbed by 1e-07microM of sirolimus					79.533 1.87 % 88.83
MCF7 perturbed by 7.8e-06microM of talampicillin					81.0544 4.2 % 88.43
MCF7 perturbed by 1e-07microM of sirolimus					82.6491 0.42 % 91.11
MCF7 perturbed by 1.08e-05microM of Prestwick-981					92.36 0.44 % 95.96
MCF7 perturbed by 6.8e-06microM of tonzonium bromide					92.1968 0 % 96.1
PC3 perturbed by 1.4e-05microM of STOCK1N-35874					90.4203 3.97 % 93.23
PC3 perturbed by 1e-05microM of 5155877					91.1224 3.75 % 93.68
MCF7 perturbed by 1e-05microM of AG-028671					92.6233 0.01 % 96.31
MCF7 perturbed by 1e-06microM of tanespimycin					84.114 5.65 % 89.23
MCF7 perturbed by 1e-06microM of tanespimycin					82.4803 8.48 % 87
vehicle					84.1263 2.96 % 90.58
MCF7 perturbed by 1.04e-05microM of meropenem					82.586 5.03 % 88.78
MCF7 perturbed by 8e-06microM of glibenclamide					84.8131 0.57 % 92.12
PC3 perturbed by 1.14e-05microM of adiphenine					82.693 0.68 % 91
vehicle					80.972 1.49 % 89.74
PC3 perturbed by 1.06e-05microM of ketorolac					81.4415 3.11 % 89.17
PC3 perturbed by 1.46e-05microM of meticrane					83.7713 2.08 % 90.84
PC3 perturbed by 9e-06microM of levomepromazine					77.7862 0.58 % 88.6
PC3 perturbed by 9.4e-06microM of mephentermine					75.7304 2.77 % 86.48
PC3 perturbed by 1.46e-05microM of nalidixic acid					74.7323 1.52 % 86.61
MCF7 perturbed by 1e-05microM of 0198306-0000					81.0194 0.08 % 90.47
MCF7 perturbed by 9.8e-06microM of pimethixene					78.2877 2.59 % 87.85
MCF7 perturbed by 1.94e-05microM of dexpanthenol					80.9415 0.06 % 90.44
MCF7 perturbed by 2.24e-05microM of esculetin					81.6304 0.04 % 90.8
vehicle					81.348 0.06 % 90.64
MCF7 perturbed by 1e-05microM of suramin sodium					80.1855 4.07 % 88.06
PC3 perturbed by 1e-05microM of BCB000039					80.9294 9.9 % 85.51