Connectivity Map Batch 02 Random Load - CMAP26

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	88.66 0.94 % 93.86
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-07microM of alvespimycin					86.2743 0.22 % 93.03
vehicle					88.6555 0.12 % 94.27
PC3 perturbed by 1e-06microM of tanespimycin					90.0242 0.09 % 94.97
MCF7 perturbed by 7.8e-06microM of chlortetracycline					93.5843 0.94 % 96.32
MCF7 perturbed by 1.86e-05microM of sulfaguanidine					93.6133 0.36 % 96.63
MCF7 perturbed by 1.32e-05microM of hesperetin					93.3819 1.4 % 95.99
MCF7 perturbed by 7.8e-06microM of loperamide					93.5662 0 % 96.78
MCF7 perturbed by 1.5e-05microM of azacyclonol					92.2282 0 % 96.11
MCF7 perturbed by 1.86e-05microM of mexiletine					93.375 0.2 % 96.59
vehicle					93.3668 0 % 96.68
MCF7 perturbed by 1.38e-05microM of trimethoprim					92.6097 0.08 % 96.27
MCF7 perturbed by 1.74e-05microM of kawain					92.4647 9.3 % 91.58
HL60 perturbed by 1.18e-05microM of canadine					91.0459 0.08 % 95.48
vehicle					91.2887 1 % 95.14
HL60 perturbed by 1.24e-05microM of promazine					91.5358 0.04 % 95.75
HL60 perturbed by 1.38e-05microM of nefopam					91.6556 0.19 % 95.73
vehicle					91.8515 0.2 % 95.83
HL60 perturbed by 1.34e-05microM of nortriptyline					91.1626 0.23 % 95.46
HL60 perturbed by 1.12e-05microM of griseofulvin					92.3988 0.23 % 96.08
HL60 perturbed by 9e-06microM of lisinopril					92.2262 0.49 % 95.87
PC3 perturbed by 2.92e-05microM of isoniazid					89.5373 2.91 % 93.31
PC3 perturbed by 1.14e-05microM of acenocoumarol					87.0285 3.96 % 91.54
PC3 perturbed by 1.6e-05microM of gemfibrozil					85.9777 4.14 % 90.92
vehicle					86.9854 7.4 % 89.79
PC3 perturbed by 1.72e-05microM of aminophenazone					88.1443 3.05 % 92.55
PC3 perturbed by 1.54e-05microM of oxolinic acid					89.3426 4.45 % 92.44
MCF7 perturbed by 1e-05microM of rosiglitazone					92.4225 0.04 % 96.19
MCF7 perturbed by 1e-06microM of geldanamycin					91.6746 0 % 95.84
MCF7 perturbed by 1.02e-05microM of triflupromazine					92.565 0 % 96.28
MCF7 perturbed by 1e-07microM of monorden					92.52 0 % 96.26
MCF7 perturbed by 1e-05microM of vorinostat					91.7341 0.07 % 95.83
MCF7 perturbed by 1.94e-05microM of dexpanthenol					92.4388 0 % 96.22
MCF7 perturbed by 1.12e-05microM of homatropine					92.9335 0.54 % 96.2
HL60 perturbed by 9.4e-06microM of buspirone					89.6743 2.23 % 93.72
HL60 perturbed by 2.38e-05microM of zoxazolamine					89.6236 1.26 % 94.18
PC3 perturbed by 1.58e-05microM of triamterene					89.6402 0.35 % 94.65
vehicle					87.6313 3.17 % 92.23
HL60 perturbed by 8.4e-06microM of dinoprost					91.8347 0.03 % 95.9
HL60 perturbed by 1.1e-05microM of atovaquone					91.5032 0.21 % 95.65
HL60 perturbed by 1.1e-05microM of bisacodyl					89.6198 0.55 % 94.53
HL60 perturbed by 5.2e-06microM of digoxin					91.2401 1.87 % 94.69
MCF7 perturbed by 1.3e-05microM of nifenazone					92.9656 0.32 % 96.32
MCF7 perturbed by 1.62e-05microM of chlorphenesin					92.8448 2.25 % 95.3
vehicle					91.8841 0.96 % 95.46
MCF7 perturbed by 1.72e-05microM of aminophenazone					92.1658 2.24 % 94.97
HL60 perturbed by 9.4e-06microM of terazosin					91.5901 0.26 % 95.66
HL60 perturbed by 7.2e-06microM of fenoprofen					89.9005 2.14 % 93.88
HL60 perturbed by 1.16e-05microM of medrysone					89.7397 33.9 % 77.92
MCF7 perturbed by 7.6e-06microM of ketoconazole					93.6959 0 % 96.85
vehicle					90.423 0.09 % 95.17
MCF7 perturbed by 7e-06microM of iopanoic acid					90.8043 4.75 % 93.03
MCF7 perturbed by 7.8e-06microM of talampicillin					89.699 4.89 % 92.4
HL60 perturbed by 7.8e-06microM of raloxifene					90.0678 6.43 % 91.82
HL60 perturbed by 1e-05microM of prochlorperazine					90.5743 0.07 % 95.25
vehicle					91.2636 0.06 % 95.6
MCF7 perturbed by 8e-06microM of calcium pantothenate					89.9014 0.17 % 94.87
MCF7 perturbed by 1e-07microM of trichostatin A					91.2468 0.36 % 95.44
MCF7 perturbed by 6.6e-06microM of naringin					90.4161 0.26 % 95.08
MCF7 perturbed by 6.6e-06microM of hesperidin					92.6697 9.13 % 91.77
MCF7 perturbed by 9.4e-06microM of buspirone					93.3017 4.18 % 94.56
PC3 perturbed by 1.28e-05microM of ethisterone					91.8851 1.44 % 95.22
vehicle					91.1739 1.71 % 94.73
vehicle					91.5358 1.25 % 95.14
PC3 perturbed by 1.06e-05microM of karakoline					91.8484 1.52 % 95.16
PC3 perturbed by 1.22e-05microM of eucatropine					89.9553 0.65 % 94.65
MCF7 perturbed by 1.26e-05microM of diphenylpyraline					87.5517 2.4 % 92.58
MCF7 perturbed by 2.74e-05microM of myosmine					88.5702 1.96 % 93.3
MCF7 perturbed by 1.28e-05microM of heliotrine					89.3554 2.91 % 93.22
MCF7 perturbed by 8e-06microM of demeclocycline					88.8978 2.66 % 93.12
MCF7 perturbed by 2.42e-05microM of benzocaine					90.1296 0.02 % 95.06
MCF7 perturbed by 1.2e-05microM of seneciphylline					92.6082 5.59 % 93.51
MCF7 perturbed by 7.8e-06microM of loperamide					92.319 2.15 % 95.08
MCF7 perturbed by 1e-05microM of haloperidol					92.7742 0.95 % 95.91
MCF7 perturbed by 9.4e-06microM of alfuzosin					92.1886 0.6 % 95.79
MCF7 perturbed by 5.8e-06microM of meclocycline					92.5345 2.42 % 95.06
MCF7 perturbed by 6.6e-06microM of lasalocid					92.5457 0.13 % 96.21
MCF7 perturbed by 2e-05microM of monobenzone					92.9326 0.03 % 96.45
MCF7 perturbed by 1.02e-05microM of pentetic acid					92.3985 0.03 % 96.18
MCF7 perturbed by 4.2e-06microM of benzathine benzylpenicillin					92.1187 3.14 % 94.49
MCF7 perturbed by 8e-06microM of fluticasone					92.1586 7.36 % 92.4
MCF7 perturbed by 1.26e-05microM of tolmetin					93.1081 1.49 % 95.81
MCF7 perturbed by 1.48e-05microM of amylocaine					91.3593 3.33 % 94.01
MCF7 perturbed by 1.38e-05microM of Prestwick-691					92.5788 1.72 % 95.43
MCF7 perturbed by 8.6e-06microM of tobramycin					92.6603 0.87 % 95.9
MCF7 perturbed by 1.16e-05microM of cinchocaine					92.0603 2.34 % 94.86
MCF7 perturbed by 1.78e-05microM of selegiline					92.7545 0.89 % 95.93
PC3 perturbed by 9e-06microM of levomepromazine					90.0398 2.11 % 93.97
PC3 perturbed by 6.8e-06microM of alexidine					90.8838 3.7 % 93.59
PC3 perturbed by 1e-05microM of PNU-0251126					89.6459 2.57 % 93.54
PC3 perturbed by 1e-06microM of PNU-0230031					91.2395 0 % 95.62
PC3 perturbed by 1.1e-05microM of ofloxacin					90.1474 0 % 95.07
PC3 perturbed by 1.12e-05microM of griseofulvin					89.5698 6.53 % 91.52
vehicle					90.3004 0.16 % 95.07
HL60 perturbed by 1.54e-05microM of tiletamine					91.4225 0.3 % 95.56
HL60 perturbed by 2.24e-05microM of esculetin					91.4512 0.04 % 95.71
HL60 perturbed by 2.32e-05microM of pralidoxime					91.2621 0.03 % 95.62
MCF7 perturbed by 1.02e-05microM of raubasine					92.5474 0.77 % 95.89
MCF7 perturbed by 1e-07microM of trichostatin A					91.4648 2.23 % 94.62
MCF7 perturbed by 1.24e-05microM of etifenin					91.0058 2.23 % 94.39
MCF7 perturbed by 9.6e-06microM of bromperidol					91.4093 4.23 % 93.59
PC3 perturbed by 1e-06microM of PHA-00745360					92.3516 2.13 % 95.11
vehicle					92.1642 2.7 % 94.73
PC3 perturbed by 1.18e-05microM of tenoxicam					90.887 2.23 % 94.33
MCF7 perturbed by 9e-06microM of debrisoquine					94.0246 2.16 % 95.93
PC3 perturbed by 1.3e-05microM of tolnaftate					91.8369 16.61 % 87.61
PC3 perturbed by 8.8e-06microM of primaquine					90.877 12.64 % 89.12
PC3 perturbed by 1.2e-05microM of seneciphylline					92.3417 1.54 % 95.4
PC3 perturbed by 9.8e-06microM of spectinomycin					91.5164 1.62 % 94.95
HL60 perturbed by 1.22e-05microM of Prestwick-857					91.6608 3.51 % 94.08
HL60 perturbed by 1.22e-05microM of chloropyramine					91.4745 3.04 % 94.22
HL60 perturbed by 1.38e-05microM of piromidic acid					92.0201 2.67 % 94.67
MCF7 perturbed by 1.18e-05microM of dantrolene					91.2324 2.72 % 94.25
vehicle					92.2486 0.79 % 95.73
MCF7 perturbed by 1.96e-05microM of ethotoin					91.411 5.12 % 93.14
HL60 perturbed by 9.6e-06microM of gabexate					91.0723 0.04 % 95.52
HL60 perturbed by 7.6e-06microM of proscillaridin					90.5296 4.12 % 93.2
MCF7 perturbed by 2.2e-05microM of carcinine					91.0002 1.39 % 94.81
vehicle					90.9742 2.69 % 94.14
PC3 perturbed by 1.78e-05microM of etofylline					89.7305 2.78 % 93.48
PC3 perturbed by 1.36e-05microM of oxaprozin					90.9505 2.74 % 94.1
PC3 perturbed by 4.8e-06microM of rifabutin					91.4972 1.57 % 94.96
MCF7 perturbed by 7.6e-06microM of beclometasone					93.6899 0.02 % 96.84
MCF7 perturbed by 1.7e-05microM of sparteine					93.9369 0.14 % 96.9
vehicle					92.4174 1.04 % 95.69
PC3 perturbed by 1.06e-05microM of eticlopride					92.4281 3.11 % 94.66
MCF7 perturbed by 1e-07microM of trichostatin A					90.8527 1.04 % 94.91
MCF7 perturbed by 1.04e-05microM of lomefloxacin					91.4262 2.96 % 94.24
MCF7 perturbed by 1.28e-05microM of heliotrine					92.3241 2.32 % 95
PC3 perturbed by 1.2e-05microM of furosemide					92.3419 2.62 % 94.86
PC3 perturbed by 1.84e-05microM of securinine					92.1612 1.39 % 95.38
PC3 perturbed by 1e-07microM of LY-294002					92.6433 1.71 % 95.47
PC3 perturbed by 1.22e-05microM of diloxanide					92.719 0.3 % 96.21
PC3 perturbed by 1.48e-05microM of arcaine					92.7759 1.09 % 95.84
PC3 perturbed by 9.2e-06microM of oxolamine					93.1354 0.21 % 96.46
vehicle					93.0187 0.03 % 96.49
PC3 perturbed by 1.22e-05microM of velnacrine					92.4295 0.74 % 95.84
PC3 perturbed by 1.26e-05microM of nilutamide					92.5443 3.36 % 94.59
PC3 perturbed by 1e-07microM of trichostatin A					89.3763 1.87 % 93.75
PC3 perturbed by 7e-06microM of hemicholinium					92.2299 2.77 % 94.73
MCF7 perturbed by 1.18e-05microM of terguride					94.0256 0 % 97.01
PC3 perturbed by 1.02e-05microM of pridinol					92.0636 0.91 % 95.58
MCF7 perturbed by 1.08e-05microM of loracarbef					92.6252 0.48 % 96.07
MCF7 perturbed by 7e-06microM of thiocolchicoside					93.0739 0.8 % 96.14
vehicle					91.7101 0.57 % 95.57
MCF7 perturbed by 2.9e-05microM of pentetrazol					90.2736 0.67 % 94.8
PC3 perturbed by 1.5e-05microM of tremorine					92.8149 1.44 % 95.69
PC3 perturbed by 8.2e-06microM of nicergoline					93.2607 2.32 % 95.47
PC3 perturbed by 1.34e-05microM of guanethidine					93.0919 0.65 % 96.22
PC3 perturbed by 9.6e-06microM of mefloquine					91.972 0.04 % 95.97
MCF7 perturbed by 3.1e-05microM of dimethadione					92.3703 0.04 % 96.17
vehicle					92.5647 2.14 % 95.21
PC3 perturbed by 1e-07microM of sirolimus					92.4117 2.49 % 94.96
MCF7 perturbed by 1e-08microM of fulvestrant					93.1902 0.32 % 96.44
MCF7 perturbed by 1e-05microM of vorinostat					92.2883 0.27 % 96.01
MCF7 perturbed by 0.001microM of valproic acid					90.7778 1.77 % 94.5
vehicle					91.6523 2.84 % 94.41
MCF7 perturbed by 1.32e-05microM of nocodazole					92.1416 3.25 % 94.45
MCF7 perturbed by 1.24e-05microM of sulfaquinoxaline					92.6187 0.62 % 96
MCF7 perturbed by 5.4e-06microM of butirosin					93.3326 0 % 96.67
vehicle					93.4273 0.13 % 96.65
MCF7 perturbed by 1.84e-05microM of mephenytoin					93.7093 2.34 % 95.68
MCF7 perturbed by 8.6e-06microM of amodiaquine					93.5762 0.61 % 96.48
MCF7 perturbed by 1.52e-05microM of cinoxacin					93.7439 0.03 % 96.86
MCF7 perturbed by 6e-06microM of syrosingopine					93.6956 0.51 % 96.59
HL60 perturbed by 1e-05microM of rosiglitazone					91.7072 2.33 % 94.69
HL60 perturbed by 1.38e-05microM of estriol					90.2911 4.97 % 92.66
HL60 perturbed by 1.36e-05microM of dexpropranolol					89.4356 4.84 % 92.3
HL60 perturbed by 1.48e-05microM of meprylcaine					87.7226 3.33 % 92.2
PC3 perturbed by 9.6e-06microM of acemetacin					91.6136 2.58 % 94.52
PC3 perturbed by 8.6e-06microM of dimenhydrinate					91.0461 3.63 % 93.71
PC3 perturbed by 1.26e-05microM of doxepin					90.6769 3.67 % 93.5
PC3 perturbed by 8.4e-06microM of tribenoside					91.1463 3.47 % 93.84
MCF7 perturbed by 3.8e-05microM of BAS-012416453					79.9741 2.71 % 88.63
MCF7 perturbed by 1e-05microM of scriptaid					82.7033 2.78 % 89.96
MCF7 perturbed by 1e-05microM of 0297417-0002B					76.8837 4.55 % 86.17
PC3 perturbed by 5e-07microM of H-89					78.568 2.08 % 88.25
MCF7 perturbed by 1e-05microM of PF-01378883-00					93.0093 4.1 % 94.45
PC3 perturbed by 1e-05microM of valdecoxib					93.4007 0.41 % 96.5
vehicle					93.278 1.09 % 96.09
MCF7 perturbed by 1.86e-05microM of etanidazole					93.4064 0 % 96.7
MCF7 perturbed by 1.86e-05microM of kinetin					93.5423 0 % 96.77
MCF7 perturbed by 1e-05microM of fluphenazine					81.4776 2.48 % 89.5
MCF7 perturbed by 1.24e-05microM of pirlindole					92.3031 0.07 % 96.12
MCF7 perturbed by 1.36e-05microM of Prestwick-920					90.4967 0.83 % 94.83
MCF7 perturbed by 3.6e-06microM of adipiodone					92.3637 0.05 % 96.16
vehicle					91.9956 3.01 % 94.49
PC3 perturbed by 1e-05microM of PNU-0293363					90.9631 4.95 % 93.01
PC3 perturbed by 1e-06microM of Gly-His-Lys					92.3626 0.46 % 95.95
MCF7 perturbed by 1e-05microM of PHA-00767505E					92.4496 0.56 % 95.94
MCF7 perturbed by 1e-06microM of tretinoin					81.1607 2.64 % 89.26
vehicle					85.9416 0.66 % 92.64
MCF7 perturbed by 1.5e-05microM of vidarabine					83.9722 0.1 % 91.93
vehicle					74.4716 1.98 % 86.24
PC3 perturbed by 1.16e-05microM of Prestwick-665					73.9059 4.17 % 84.87
PC3 perturbed by 1.74e-05microM of kawain					73.9995 2.76 % 85.62
PC3 perturbed by 1e-05microM of PHA-00846566E					78.444 0.06 % 89.19
MCF7 perturbed by 1e-05microM of GW-8510					77.3917 3.38 % 87.01
MCF7 perturbed by 1e-05microM of 0198306-0000					76.8078 1.44 % 87.68
PC3 perturbed by 1e-05microM of AR-A014418					76.5547 0.08 % 88.24
MCF7 perturbed by 1.56e-05microM of quinpirole					83.4039 0.08 % 91.66
MCF7 perturbed by 1e-07microM of trichostatin A					81.9515 0.04 % 90.96