Connectivity Map Batch 02 Random Load - CMAP25

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	89.38 0.11 % 94.64
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-08microM of wortmannin					87.4048 1.83 % 92.79
PC3 perturbed by 1e-08microM of fulvestrant					89.3836 0.17 % 94.61
HL60 perturbed by 1e-05microM of haloperidol					88.9307 0.55 % 94.19
HL60 perturbed by 1e-04microM of acetylsalicylic acid					90.7311 0.11 % 95.31
vehicle					89.8624 0.03 % 94.92
MCF7 perturbed by 1.44e-05microM of ethambutol					92.7102 0 % 96.36
MCF7 perturbed by 1.02e-05microM of doxylamine					92.623 0.21 % 96.21
MCF7 perturbed by 5e-06microM of oleandomycin					92.9707 0.14 % 96.42
MCF7 perturbed by 1.28e-05microM of amoxapine					92.5953 0.06 % 96.27
MCF7 perturbed by 1.38e-05microM of nefopam					92.5363 0 % 96.27
MCF7 perturbed by 1.1e-05microM of tiapride					92.5512 0.59 % 95.98
HL60 perturbed by 1.12e-05microM of benzamil					90.5299 0.03 % 95.25
HL60 perturbed by 1e-07microM of trichostatin A					90.7185 3.41 % 93.65
HL60 perturbed by 1.7e-05microM of phenelzine					91.2598 1.8 % 94.73
HL60 perturbed by 1.7e-05microM of dropropizine					91.2208 0.14 % 95.54
HL60 perturbed by 1.1e-05microM of cortisone					89.9878 1.45 % 94.27
HL60 perturbed by 1.46e-05microM of nalidixic acid					91.1841 0.02 % 95.58
PC3 perturbed by 1.38e-05microM of midodrine					88.4731 0.95 % 93.76
PC3 perturbed by 1.82e-05microM of ornidazole					87.5229 1.74 % 92.89
PC3 perturbed by 1.78e-05microM of etofylline					87.0102 2.3 % 92.36
vehicle					92.0017 0.11 % 95.94
MCF7 perturbed by 1e-06microM of nordihydroguaiaretic acid					92.2044 0.09 % 96.06
MCF7 perturbed by 1.46e-05microM of procaine					91.8564 0.2 % 95.83
MCF7 perturbed by 1e-06microM of fulvestrant					92.6753 0 % 96.34
MCF7 perturbed by 1.46e-05microM of meticrane					92.8946 0 % 96.45
HL60 perturbed by 8.4e-06microM of naftidrofuryl					89.335 0.23 % 94.55
HL60 perturbed by 1.66e-05microM of mefenamic acid					89.671 5.88 % 91.89
PC3 perturbed by 1.16e-05microM of nifedipine					89.8443 0.04 % 94.9
PC3 perturbed by 1.12e-05microM of sulindac					87.4914 0.68 % 93.4
PC3 perturbed by 1.7e-05microM of epirizole					89.2233 1 % 94.11
vehicle					89.7984 0.04 % 94.88
HL60 perturbed by 1.32e-05microM of neostigmine bromide					89.775 0.12 % 94.83
MCF7 perturbed by 1.64e-05microM of hydrastinine					92.7116 0.53 % 96.09
vehicle					92.8508 0.48 % 96.18
MCF7 perturbed by 1.04e-05microM of metampicillin					92.4715 0.36 % 96.05
MCF7 perturbed by 4.4e-06microM of gallamine triethiodide					92.5196 0.38 % 96.07
MCF7 perturbed by 1.12e-05microM of pyrantel					92.8601 0.57 % 96.14
MCF7 perturbed by 1.4e-05microM of etodolac					92.4573 0.71 % 95.87
vehicle					88.5678 0.03 % 94.27
HL60 perturbed by 2.02e-05microM of guaifenesin					90.1078 4.07 % 93.02
HL60 perturbed by 7e-06microM of alpha-ergocryptine					87.0009 0.19 % 93.41
HL60 perturbed by 1.86e-05microM of etanidazole					90.0065 0.98 % 94.51
MCF7 perturbed by 1.38e-05microM of androsterone					92.1884 1.51 % 95.34
MCF7 perturbed by 1e-05microM of bepridil					92.8896 0.02 % 96.43
vehicle					91.0913 0.01 % 95.54
MCF7 perturbed by 1.2e-05microM of Prestwick-1082					90.8635 3.55 % 93.66
MCF7 perturbed by 1.56e-05microM of procarbazine					88.1694 5.86 % 91.16
HL60 perturbed by 1e-05microM of trifluoperazine					88.506 3.3 % 92.6
HL60 perturbed by 1.16e-05microM of bergenin					89.1933 0.04 % 94.58
HL60 perturbed by 8.2e-06microM of azlocillin					90.2368 0.37 % 94.93
HL60 perturbed by 1e-07microM of sirolimus					89.005 2.52 % 93.24
HL60 perturbed by 1e-07microM of trichostatin A					90.4075 0.04 % 95.18
HL60 perturbed by 1e-07microM of LY-294002					89.3938 0.31 % 94.54
MCF7 perturbed by 5.8e-06microM of meclocycline					89.5006 0.01 % 94.75
MCF7 perturbed by 1.54e-05microM of carbarsone					90.6288 0.85 % 94.89
MCF7 perturbed by 1.22e-05microM of desoxycortone					90.7865 11.68 % 89.55
MCF7 perturbed by 3.24e-05microM of nicotinic acid					92.2683 2.72 % 94.77
PC3 perturbed by 1.18e-05microM of dantrolene					88.793 0.06 % 94.36
PC3 perturbed by 4e-06microM of lanatoside C					88.421 1.02 % 93.7
PC3 perturbed by 9.8e-06microM of flumetasone					88.0238 4.07 % 91.98
vehicle					87.1597 2.83 % 92.16
PC3 perturbed by 1.06e-05microM of famprofazone					90.6576 0.22 % 95.22
PC3 perturbed by 1.28e-05microM of levonorgestrel					89.1304 4.21 % 92.46
MCF7 perturbed by 1e-05microM of clozapine					91.8378 2.17 % 94.83
MCF7 perturbed by 1e-06microM of tanespimycin					91.1726 0.72 % 95.23
MCF7 perturbed by 1e-08microM of alpha-estradiol					92.061 0.29 % 95.88
MCF7 perturbed by 1.46e-05microM of methyldopate					90.843 1.22 % 94.81
vehicle					92.2344 1.09 % 95.57
MCF7 perturbed by 9.8e-06microM of trimipramine					90.203 0.12 % 95.04
MCF7 perturbed by 1.6e-05microM of etidronic acid					90.3545 0.07 % 95.14
vehicle					89.9966 4.59 % 92.7
MCF7 perturbed by 9.6e-06microM of decamethonium bromide					91.9661 0.17 % 95.9
MCF7 perturbed by 2.22e-05microM of L-methionine sulfoximine					89.5707 3.9 % 92.84
MCF7 perturbed by 1.06e-05microM of famprofazone					88.3355 2.09 % 93.13
MCF7 perturbed by 1.3e-05microM of pempidine					85.8431 5.51 % 90.17
PC3 perturbed by 1e-05microM of PNU-0230031					88.6362 0 % 94.32
PC3 perturbed by 1.28e-05microM of levonorgestrel					88.4001 0 % 94.2
MCF7 perturbed by 1.12e-05microM of laudanosine					92.0629 1.34 % 95.36
PC3 perturbed by 1e-06microM of CP-690334-01					91.2097 0.4 % 95.41
PC3 perturbed by 6e-06microM of deferoxamine					91.4981 1.04 % 95.23
PC3 perturbed by 1.32e-05microM of chlorambucil					91.7894 0.69 % 95.55
PC3 perturbed by 1.5e-05microM of pronetalol					89.9995 0.39 % 94.81
MCF7 perturbed by 7.6e-06microM of vanoxerine					91.2151 2.49 % 94.36
MCF7 perturbed by 8.6e-06microM of mebeverine					91.4608 3.45 % 94.01
MCF7 perturbed by 9.8e-06microM of sulfinpyrazone					91.5631 5.89 % 92.84
PC3 perturbed by 1.18e-05microM of isoxsuprine					90.8678 0.31 % 95.28
HL60 perturbed by 1.42e-05microM of indoprofen					90.432 4.34 % 93.05
HL60 perturbed by 1.56e-05microM of ganciclovir					91.0104 0.67 % 95.17
MCF7 perturbed by 1e-06microM of citalopram					90.793 0.45 % 95.17
vehicle					90.4718 3.06 % 93.71
HL60 perturbed by 5.4e-06microM of pancuronium bromide					90.8027 0.03 % 95.38
vehicle					90.7498 2 % 94.37
MCF7 perturbed by 1.5e-05microM of R-atenolol					91.2134 2.48 % 94.37
MCF7 perturbed by 1.16e-05microM of trimethylcolchicinic acid					91.3483 0.95 % 95.2
MCF7 perturbed by 9.6e-06microM of simvastatin					91.6438 1.16 % 95.24
MCF7 perturbed by 1.04e-05microM of benperidol					90.0582 1.71 % 94.17
MCF7 perturbed by 1e-07microM of trichostatin A					89.9426 5.16 % 92.39
MCF7 perturbed by 1.84e-05microM of fosfosal					90.818 0.09 % 95.36
PC3 perturbed by 2.12e-05microM of phensuximide					90.022 1.71 % 94.16
PC3 perturbed by 6.6e-06microM of iocetamic acid					90.8862 0.94 % 94.97
vehicle					91.5575 0.08 % 95.74
MCF7 perturbed by 1e-05microM of CP-690334-01					89.9206 0 % 94.96
MCF7 perturbed by 1e-05microM of PHA-00745360					90.4587 0.3 % 95.08
vehicle					90.9064 0 % 95.45
MCF7 perturbed by 1e-06microM of citalopram					92.4145 0 % 96.21
MCF7 perturbed by 1.22e-05microM of chloropyramine					92.1565 0.06 % 96.05
MCF7 perturbed by 1.24e-05microM of lycorine					91.0263 0 % 95.51
MCF7 perturbed by 1.18e-05microM of chlorcyclizine					92.3354 0 % 96.17
PC3 perturbed by 4.8e-06microM of iohexol					91.9681 0.18 % 95.89
PC3 perturbed by 1.64e-05microM of dioxybenzone					91.8689 0.09 % 95.89
PC3 perturbed by 8.8e-06microM of terguride					91.6955 1.1 % 95.3
MCF7 perturbed by 2.74e-05microM of myosmine					92.0318 0.49 % 95.77
PC3 perturbed by 0.0005microM of valproic acid					91.0004 0.05 % 95.48
vehicle					91.8783 1.23 % 95.32
PC3 perturbed by 1.54e-05microM of khellin					91.1641 0.01 % 95.57
PC3 perturbed by 3.24e-05microM of pyrazinamide					91.0368 0.04 % 95.5
PC3 perturbed by 9e-06microM of glipizide					91.1147 1.87 % 94.62
PC3 perturbed by 1.32e-05microM of hesperetin					91.2613 0.6 % 95.33
PC3 perturbed by 1.12e-05microM of florfenicol					91.7799 0.37 % 95.7
PC3 perturbed by 9e-06microM of debrisoquine					90.7828 1.52 % 94.63
MCF7 perturbed by 9.6e-06microM of acemetacin					91.4772 0.12 % 95.68
MCF7 perturbed by 9.6e-06microM of prazosin					92.5923 0.01 % 96.29
MCF7 perturbed by 1.16e-05microM of clopamide					92.2239 0.16 % 96.03
MCF7 perturbed by 8.4e-06microM of trifluoperazine					93.0424 0 % 96.52
MCF7 perturbed by 2.64e-05microM of paracetamol					90.7587 0 % 95.38
PC3 perturbed by 1.48e-05microM of leflunomide					90.6085 3.95 % 93.33
PC3 perturbed by 1.02e-05microM of nalbuphine					90.7364 0.12 % 95.31
PC3 perturbed by 2.18e-05microM of corbadrine					90.7694 0.7 % 95.04
MCF7 perturbed by 7.6e-06microM of deptropine					90.9302 2.15 % 94.39
MCF7 perturbed by 1.62e-05microM of parthenolide					91.41 0.35 % 95.53
vehicle					91.5548 1.62 % 94.97
MCF7 perturbed by 1.28e-05microM of sulfaphenazole					90.3457 0.08 % 95.13
PC3 perturbed by 1e-07microM of trichostatin A					91.0176 0.24 % 95.39
PC3 perturbed by 1.06e-05microM of papaverine					88.7808 0.25 % 94.27
MCF7 perturbed by 1.88e-05microM of felbinac					90.3386 5.13 % 92.6
MCF7 perturbed by 1.06e-05microM of eticlopride					90.6759 4.6 % 93.04
MCF7 perturbed by 1e-05microM of perphenazine					91.4519 1.94 % 94.76
MCF7 perturbed by 9.8e-06microM of zimeldine					91.348 0.15 % 95.6
MCF7 perturbed by 1.5e-05microM of practolol					89.2584 1.25 % 94
MCF7 perturbed by 1e-06microM of rotenone					91.0129 1.51 % 94.75
MCF7 perturbed by 1e-06microM of trichostatin A					90.6833 0.08 % 95.3
MCF7 perturbed by 1e-05microM of clozapine					90.1334 0.38 % 94.88
MCF7 perturbed by 1e-05microM of LY-294002					91.7247 0.03 % 95.85
vehicle					91.7886 0.03 % 95.88
MCF7 perturbed by 8.8e-06microM of cefoxitin					90.0722 0.71 % 94.68
MCF7 perturbed by 1.6e-05microM of sulfapyridine					91.1481 1.58 % 94.78
MCF7 perturbed by 1.62e-05microM of Prestwick-1084					89.4604 2.78 % 93.34
MCF7 perturbed by 1.68e-05microM of tetryzoline					90.0357 0 % 95.02
MCF7 perturbed by 2.2e-05microM of heptaminol					91.1216 0 % 95.56
MCF7 perturbed by 1.02e-05microM of chenodeoxycholic acid					91.8782 0.17 % 95.86
MCF7 perturbed by 2.54e-05microM of tranexamic acid					92.3319 1.3 % 95.52
MCF7 perturbed by 1e-07microM of trichostatin A					91.7713 3.53 % 94.12
vehicle					92.8143 4.32 % 94.25
MCF7 perturbed by 1.7e-05microM of methazolamide					92.8781 4.98 % 93.95
HL60 perturbed by 1.22e-05microM of cyclopentolate					88.689 2.05 % 93.32
HL60 perturbed by 1e-05microM of haloperidol					87.0968 3.83 % 91.64
vehicle					90.2979 1.7 % 94.3
PC3 perturbed by 1.74e-05microM of naproxen					90.2903 1.9 % 94.19
PC3 perturbed by 1.76e-05microM of oxybenzone					90.5827 2.96 % 93.81
MCF7 perturbed by 5e-05microM of 5707885					92.5022 3.66 % 94.42
MCF7 perturbed by 1e-05microM of valdecoxib					92.5504 1.98 % 95.29
MCF7 perturbed by 1e-05microM of PF-00539758-00					92.8842 1.64 % 95.62
MCF7 perturbed by 7.4e-06microM of helveticoside					91.8059 0.2 % 95.8
MCF7 perturbed by 1e-08microM of wortmannin					83.5736 0.49 % 91.54
MCF7 perturbed by 1e-05microM of rosiglitazone					83.642 0.52 % 91.56
MCF7 perturbed by 1.8e-05microM of etamivan					87.1735 1.47 % 92.85
MCF7 perturbed by 1e-05microM of prochlorperazine					80.8488 1.46 % 89.7
MCF7 perturbed by 2.04e-05microM of pargyline					81.5095 1.97 % 89.77
MCF7 perturbed by 1e-08microM of alpha-estradiol					80.8634 0.2 % 90.33
MCF7 perturbed by 3.04e-05microM of aminocaproic acid					91.9299 0.01 % 95.96
PC3 perturbed by 1e-05microM of AG-028671					91.4768 0.3 % 95.59
PC3 perturbed by 1e-05microM of PNU-0293363					89.422 4.38 % 92.52
MCF7 perturbed by 1e-06microM of nordihydroguaiaretic acid					82.6938 1.27 % 90.71
MCF7 perturbed by 1e-07microM of trichostatin A					84.1297 0.71 % 91.71
MCF7 perturbed by 9e-06microM of quipazine					84.704 1.61 % 91.55
MCF7 perturbed by 1e-07microM of trichostatin A					84.0531 1.66 % 91.2
MCF7 perturbed by 9.8e-06microM of strophanthidin					84.0093 0.62 % 91.69
MCF7 perturbed by 1.02e-05microM of Prestwick-689					85.2512 0.16 % 92.54
PC3 perturbed by 1.18e-05microM of meclofenamic acid					87.0719 3.46 % 91.8
PC3 perturbed by 1.12e-05microM of thiamphenicol					83.1558 1.09 % 91.03
vehicle					81.1724 1.05 % 90.06
PC3 perturbed by 1e-07microM of trichostatin A					82.0482 0.18 % 90.94
PC3 perturbed by 1.26e-05microM of norfloxacin					84.1173 7.91 % 88.1
PC3 perturbed by 8.6e-06microM of mebeverine					77.2664 0.09 % 88.59
PC3 perturbed by 1.6e-05microM of sulfapyridine					79.8017 0.06 % 89.87
PC3 perturbed by 3.92e-05microM of cycloserine					77.0839 0.56 % 88.26
PC3 perturbed by 7.8e-06microM of calcium folinate					78.6434 0.3 % 89.17
MCF7 perturbed by 1.86e-05microM of memantine					77.5601 0.04 % 88.76
MCF7 perturbed by 1.28e-05microM of molindone					75.7687 0.39 % 87.69
PC3 perturbed by 1.36e-05microM of mebendazole					75.414 1.07 % 87.17
PC3 perturbed by 6e-06microM of dilazep					77.3764 0.27 % 88.56
PC3 perturbed by 1.58e-05microM of sulfamethoxazole					78.0426 0.15 % 88.95
PC3 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					79.0324 0 % 89.52
MCF7 perturbed by 1e-05microM of PHA-00846566E					79.6333 0.05 % 89.79
MCF7 perturbed by 1.26e-05microM of mefexamide					83.6939 0.02 % 91.84
MCF7 perturbed by 1e-04microM of irinotecan					79.7779 4.72 % 87.53
vehicle					82.3438 2.58 % 89.88
PC3 perturbed by 1e-05microM of 15(S)-15-methylprostaglandin E2					79.3227 6.66 % 86.33
PC3 perturbed by 1e-06microM of trichostatin A					82.9827 2.4 % 90.29
PC3 perturbed by 1e-05microM of meteneprost					82.9793 2.22 % 90.38
PC3 perturbed by 1e-05microM of BCB000040					86.6105 2.84 % 91.89