Connectivity Map Batch 02 Random Load - CMAP24

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	86.16 0.52 % 92.82
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of haloperidol					88.6882 0.43 % 94.13
HL60 perturbed by 1e-05microM of 15-delta prostaglandin J2					86.1559 4.27 % 90.94
HL60 perturbed by 5e-05microM of valproic acid					86.5595 1.57 % 92.5
vehicle					91.3134 0.52 % 95.39
MCF7 perturbed by 1.12e-05microM of idoxuridine					93.6195 0.16 % 96.73
MCF7 perturbed by 1.16e-05microM of dicycloverine					92.8007 0.16 % 96.32
MCF7 perturbed by 1e-07microM of trichostatin A					92.944 0.3 % 96.32
vehicle					93.5149 0.37 % 96.57
MCF7 perturbed by 1.18e-05microM of dantrolene					93.2207 0.34 % 96.44
vehicle					93.729 0 % 96.86
MCF7 perturbed by 1.48e-05microM of riluzole					93.6955 0.02 % 96.84
HL60 perturbed by 1.18e-05microM of chlorcyclizine					90.1952 0.05 % 95.07
HL60 perturbed by 1.16e-05microM of Prestwick-665					91.3307 0.11 % 95.61
HL60 perturbed by 1.06e-05microM of indapamide					91.2782 3.79 % 93.74
HL60 perturbed by 1.58e-05microM of fenbufen					91.6226 0.85 % 95.39
HL60 perturbed by 1.4e-05microM of tropicamide					91.542 5.65 % 92.94
HL60 perturbed by 1.1e-05microM of ofloxacin					91.5617 0.34 % 95.61
PC3 perturbed by 2.6e-06microM of gentamicin					88.326 2.45 % 92.94
vehicle					92.8494 0.02 % 96.42
vehicle					93.1749 0 % 96.59
HL60 perturbed by 1.5e-05microM of anisomycin					87.5805 1 % 93.29
HL60 perturbed by 2.24e-05microM of fusaric acid					90.4417 0.14 % 95.15
HL60 perturbed by 1.34e-05microM of noretynodrel					87.6974 1.82 % 92.94
PC3 perturbed by 1.94e-05microM of dexpanthenol					89.7618 0.96 % 94.4
MCF7 perturbed by 1.38e-05microM of midodrine					93.2235 0.82 % 96.2
MCF7 perturbed by 3e-06microM of dihydroergotamine					92.1528 0.73 % 95.71
MCF7 perturbed by 2.8e-06microM of dihydrostreptomycin					92.641 0.53 % 96.05
MCF7 perturbed by 1.14e-05microM of acenocoumarol					92.5627 1.26 % 95.65
MCF7 perturbed by 8.4e-06microM of alverine					92.5819 1.08 % 95.75
vehicle					92.4411 0.33 % 96.05
MCF7 perturbed by 7.4e-06microM of fusidic acid					92.9643 0 % 96.48
MCF7 perturbed by 2.38e-05microM of zoxazolamine					93.3784 0.02 % 96.68
MCF7 perturbed by 2.02e-05microM of guaifenesin					90.6544 0.27 % 95.19
MCF7 perturbed by 1.56e-05microM of quinpirole					92.1755 2.4 % 94.89
MCF7 perturbed by 5.2e-06microM of viomycin					91.5842 3.25 % 94.17
MCF7 perturbed by 1.12e-05microM of benzylpenicillin					90.5223 4.32 % 93.1
vehicle					91.7463 2.84 % 94.45
MCF7 perturbed by 9.8e-06microM of piperacetazine					91.6571 2.2 % 94.73
MCF7 perturbed by 5.2e-06microM of saquinavir					88.4035 4.91 % 91.75
MCF7 perturbed by 1.62e-05microM of Prestwick-1084					91.9984 2.42 % 94.79
HL60 perturbed by 1.7e-05microM of methazolamide					89.8265 7.81 % 91.01
HL60 perturbed by 1.42e-05microM of cicloheximide					89.1017 3.26 % 92.92
MCF7 perturbed by 1.22e-05microM of carteolol					91.1561 0.07 % 95.55
MCF7 perturbed by 1.58e-05microM of lysergol					90.772 0.02 % 95.37
MCF7 perturbed by 7.4e-06microM of puromycin					90.9396 7.12 % 91.91
PC3 perturbed by 8.4e-06microM of Prestwick-664					88.2575 0.3 % 93.98
PC3 perturbed by 7.2e-06microM of fenoprofen					90.4895 3.43 % 93.53
MCF7 perturbed by 9.8e-06microM of flumetasone					88.8865 1.05 % 93.92
vehicle					91.4301 3.02 % 94.21
MCF7 perturbed by 1.36e-05microM of cinchonidine					91.4134 0 % 95.71
MCF7 perturbed by 2.1e-05microM of cytisine					89.903 2.27 % 93.81
MCF7 perturbed by 1e-05microM of haloperidol					91.2714 0.73 % 95.27
MCF7 perturbed by 8.4e-06microM of clofazimine					91.6532 0.74 % 95.46
vehicle					91.9873 0.15 % 95.92
MCF7 perturbed by 1e-04microM of acetylsalicylic acid					92.837 0.49 % 96.17
MCF7 perturbed by 1.1e-05microM of naloxone					92.9653 0.03 % 96.47
MCF7 perturbed by 9.2e-06microM of fursultiamine					92.8725 8.47 % 92.2
MCF7 perturbed by 2.58e-05microM of bemegride					92.3781 0.5 % 95.94
MCF7 perturbed by 1.16e-05microM of omeprazole					91.4857 4.34 % 93.57
MCF7 perturbed by 6.6e-06microM of carbenoxolone					90.4274 0.68 % 94.87
MCF7 perturbed by 1.18e-05microM of esculin					92.3229 0.37 % 95.98
MCF7 perturbed by 9.6e-06microM of aminophylline					92.5334 0.06 % 96.24
MCF7 perturbed by 9.2e-06microM of fluvastatin					92.2426 0 % 96.12
MCF7 perturbed by 7.4e-06microM of doxazosin					90.8819 0 % 95.44
MCF7 perturbed by 1.54e-05microM of suprofen					92.4159 0.65 % 95.88
MCF7 perturbed by 1.86e-05microM of mexiletine			Image:5500024030403071907258.B10.CEL probe-variance.png		89.5792 2.19 % 93.7
MCF7 perturbed by 1.2e-05microM of metamizole sodium					91.714 1.82 % 94.95
PC3 perturbed by 1.38e-05microM of nefopam					88.6087 0 % 94.3
PC3 perturbed by 6e-06microM of dilazep					89.9993 0.75 % 94.62
HL60 perturbed by 1.04e-05microM of etynodiol					90.1083 0.21 % 94.95
HL60 perturbed by 1.24e-05microM of articaine					90.5599 0.33 % 95.12
HL60 perturbed by 7.6e-06microM of gliquidone					90.8824 0.04 % 95.42
HL60 perturbed by 1e-07microM of trichostatin A					91.0612 0.08 % 95.49
MCF7 perturbed by 1.5e-05microM of R-atenolol					91.7327 1.12 % 95.31
MCF7 perturbed by 1.24e-05microM of gliclazide					90.9981 2.35 % 94.32
PC3 perturbed by 1e-06microM of spiradoline					92.4976 0.08 % 96.21
PC3 perturbed by 1e-05microM of PHA-00851261E					92.305 0.1 % 96.1
PC3 perturbed by 1.2e-05microM of metamizole sodium					91.7806 0.22 % 95.78
PC3 perturbed by 1.38e-05microM of quinethazone					91.9693 0.7 % 95.64
PC3 perturbed by 1.12e-05microM of alprostadil					90.2434 0.06 % 95.09
PC3 perturbed by 9.6e-06microM of decamethonium bromide					91.8057 0.12 % 95.84
PC3 perturbed by 1.66e-05microM of moxonidine					91.0834 0.4 % 95.34
PC3 perturbed by 2.24e-05microM of fusaric acid					90.5953 0 % 95.3
PC3 perturbed by 3.14e-05microM of 6-azathymine					91.0521 0 % 95.52
MCF7 perturbed by 1.3e-05microM of clorgiline					93.0764 4.5 % 94.29
MCF7 perturbed by 7e-06microM of ketanserin					93.4928 2.03 % 95.73
PC3 perturbed by 1.36e-05microM of picrotoxinin					90.0821 9.76 % 90.16
vehicle					91.3646 7.42 % 91.97
PC3 perturbed by 3e-06microM of colistin					91.9148 0.04 % 95.94
PC3 perturbed by 7.6e-06microM of orciprenaline					91.6572 0.49 % 95.58
PC3 perturbed by 8.8e-06microM of cefalonium					89.0809 0.04 % 94.52
HL60 perturbed by 1.38e-05microM of (+/-)-catechin					90.8506 9.1 % 90.88
HL60 perturbed by 6.4e-06microM of novobiocin					90.7553 4.5 % 93.13
MCF7 perturbed by 1e-06microM of spiradoline					90.8182 0.65 % 95.08
MCF7 perturbed by 7.4e-06microM of helveticoside					90.7704 0.9 % 94.93
MCF7 perturbed by 1.44e-05microM of flutamide					92.2363 3.92 % 94.16
MCF7 perturbed by 1.14e-05microM of camptothecin					90.9239 4.3 % 93.31
MCF7 perturbed by 8.4e-06microM of flecainide					91.7688 3.37 % 94.2
HL60 perturbed by 8e-06microM of harpagoside					90.5935 0.27 % 95.16
HL60 perturbed by 3.2e-06microM of ioxaglic acid					90.3076 3.75 % 93.28
MCF7 perturbed by 9.6e-06microM of amantadine					91.7154 1.97 % 94.88
MCF7 perturbed by 1.18e-05microM of scopolamine					92.5552 1.59 % 95.48
MCF7 perturbed by 1.5e-05microM of zardaverine					91.6048 1.61 % 95
vehicle					90.9396 0.67 % 95.14
PC3 perturbed by 1.42e-05microM of niflumic acid					91.6946 0.12 % 95.79
PC3 perturbed by 1.14e-05microM of tridihexethyl					91.599 0.9 % 95.35
PC3 perturbed by 1.24e-05microM of gliclazide					91.2736 0.25 % 95.51
PC3 perturbed by 1.12e-05microM of pyrantel					89.1835 2.16 % 93.51
PC3 perturbed by 1e-06microM of spiradoline					91.4137 0.11 % 95.65
vehicle					91.3633 0.2 % 95.58
PC3 perturbed by 3e-06microM of cyanocobalamin					91.389 0.09 % 95.65
MCF7 perturbed by 7.6e-06microM of proscillaridin					92.4369 0.6 % 95.92
MCF7 perturbed by 1.12e-05microM of prednisone					90.5067 1.23 % 94.64
PC3 perturbed by 7.8e-06microM of loperamide					92.4156 0.06 % 96.18
PC3 perturbed by 7.8e-06microM of probucol					91.9776 0.04 % 95.97
PC3 perturbed by 1e-05microM of bepridil					91.8 2.03 % 94.89
vehicle					91.6366 0.21 % 95.71
MCF7 perturbed by 2.52e-05microM of betonicine					92.2602 1.26 % 95.5
MCF7 perturbed by 1e-05microM of PNU-0251126					93.0023 0.02 % 96.49
vehicle					92.1433 0.45 % 95.85
PC3 perturbed by 1e-05microM of 15-delta prostaglandin J2					92.0382 0.06 % 95.99
PC3 perturbed by 1.28e-05microM of zomepirac					91.6803 1.82 % 94.93
PC3 perturbed by 1e-07microM of sirolimus					92.297 0.01 % 96.15
PC3 perturbed by 7.8e-06microM of chlortetracycline					91.9815 0.43 % 95.77
MCF7 perturbed by 5.8e-06microM of cefoperazone					92.8447 0.04 % 96.4
vehicle					93.5099 0.54 % 96.48
MCF7 perturbed by 7.8e-06microM of nicardipine					93.4775 0.85 % 96.31
MCF7 perturbed by 1.04e-05microM of fenoterol					93.267 0.1 % 96.58
PC3 perturbed by 1.16e-05microM of benzydamine					91.0433 1.54 % 94.75
PC3 perturbed by 1.36e-05microM of dexpropranolol					91.5214 0.28 % 95.62
MCF7 perturbed by 1.1e-05microM of bumetanide					91.0444 1.9 % 94.57
MCF7 perturbed by 1.42e-05microM of flufenamic acid					91.0077 2.19 % 94.41
MCF7 perturbed by 1.52e-05microM of roxarsone					92.5383 0.04 % 96.25
vehicle					91.5366 1.16 % 95.19
PC3 perturbed by 5.6e-06microM of demecarium bromide					91.6306 1.01 % 95.31
vehicle					92.1382 0.45 % 95.85
PC3 perturbed by 1.44e-05microM of bupropion					92.3916 1.12 % 95.63
PC3 perturbed by 3.08e-05microM of mevalolactone					92.4621 0.15 % 96.16
MCF7 perturbed by 7.4e-06microM of domperidone					88.92 5.64 % 91.64
MCF7 perturbed by 6.8e-06microM of kanamycin					89.683 2.79 % 93.45
MCF7 perturbed by 1e-05microM of bepridil					92.3165 0.18 % 96.07
PC3 perturbed by 1e-05microM of thioridazine					91.6401 0.01 % 95.82
MCF7 perturbed by 1e-04microM of H-7					92.9004 0.5 % 96.2
vehicle					93.0835 0.02 % 96.53
PC3 perturbed by 1e-06microM of trichostatin A					91.3141 0.01 % 95.65
MCF7 perturbed by 1e-05microM of LY-294002					92.0232 0.06 % 95.98
MCF7 perturbed by 1.02e-05microM of pirenperone					91.7649 1.12 % 95.32
MCF7 perturbed by 1.3e-05microM of clioquinol					91.7711 0.82 % 95.47
MCF7 perturbed by 2.26e-05microM of cotinine					92.7441 0.37 % 96.19
vehicle					89.3223 0.47 % 94.42
MCF7 perturbed by 1.62e-05microM of pindolol					90.986 0.83 % 95.08
MCF7 perturbed by 1.1e-05microM of piretanide					91.0567 1.83 % 94.61
MCF7 perturbed by 1e-07microM of trichostatin A					91.6017 0.11 % 95.74
MCF7 perturbed by 1.48e-05microM of sulfamethizole					93.6502 2.07 % 95.79
MCF7 perturbed by 2.44e-05microM of ricinine					93.3289 3.04 % 95.14
HL60 perturbed by 1.1e-05microM of piretanide					88.9197 3.52 % 92.7
vehicle					90.1295 0.25 % 94.94
vehicle					90.3263 4.25 % 93.04
PC3 perturbed by 8.4e-06microM of metitepine					90.5806 3.49 % 93.54
PC3 perturbed by 9.2e-06microM of budesonide					89.8302 4.08 % 92.88
vehicle					90.6753 3.12 % 93.78
PC3 perturbed by 1e-05microM of PF-00562151-00					81.9199 3.01 % 89.46
MCF7 perturbed by 1e-06microM of trichostatin A					92.6808 0.09 % 96.3
MCF7 perturbed by 1.48e-05microM of leflunomide					92.0718 0 % 96.04
MCF7 perturbed by 8.2e-06microM of cefmetazole					91.9456 0.12 % 95.91
MCF7 perturbed by 1.52e-05microM of sulfamerazine					92.2548 3.28 % 94.49
MCF7 perturbed by 9.6e-06microM of solasodine					91.6347 3.18 % 94.23
MCF7 perturbed by 1.54e-05microM of skimmianine					92.8782 0 % 96.44
MCF7 perturbed by 1e-05microM of 15-delta prostaglandin J2					81.9219 2.52 % 89.7
MCF7 perturbed by 1e-05microM of troglitazone					81.908 1.34 % 90.29
MCF7 perturbed by 0.001microM of valproic acid					80.3966 1.75 % 89.33
MCF7 perturbed by 8.8e-06microM of levocabastine					80.9655 1.42 % 89.77
MCF7 perturbed by 1e-07microM of trichostatin A					84.8424 1 % 91.92
MCF7 perturbed by 9e-06microM of bephenium hydroxynaphthoate					92.9313 0 % 96.47
MCF7 perturbed by 1.2e-05microM of proxymetacaine					92.0485 0.01 % 96.02
vehicle					90.7145 0.1 % 95.31
MCF7 perturbed by 1e-05microM of dinoprostone					91.1698 3.01 % 94.08
PC3 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					89.758 4.15 % 92.8
MCF7 perturbed by 1e-05microM of dinoprostone					92.0713 0.26 % 95.9
MCF7 perturbed by 1e-07microM of sirolimus					86.0544 2.17 % 91.94
MCF7 perturbed by 1e-05microM of fluphenazine					83.6169 9.08 % 87.27
MCF7 perturbed by 1e-05microM of LY-294002					85.5014 4.03 % 90.73
MCF7 perturbed by 1.32e-05microM of oxprenolol					84.5398 2.57 % 90.99
MCF7 perturbed by 9.6e-06microM of isoconazole					85.693 0.51 % 92.59
PC3 perturbed by 1.02e-05microM of alfadolone					81.7551 4.62 % 88.57
PC3 perturbed by 1.06e-05microM of clorsulon					83.6741 3.09 % 90.29
PC3 perturbed by 1.32e-05microM of antazoline					75.2209 0.08 % 87.57
MCF7 perturbed by 5.4e-06microM of pancuronium bromide					76.372 0.26 % 88.06
MCF7 perturbed by 1.16e-05microM of gibberellic acid					77.8482 0.18 % 88.83
MCF7 perturbed by 9.2e-06microM of Prestwick-984					77.9115 0.33 % 88.79
MCF7 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					81.2893 0.01 % 90.64
MCF7 perturbed by 1e-05microM of alsterpaullone					80.0234 4.45 % 87.79
vehicle					77.1785 0.1 % 88.54
PC3 perturbed by 1e-05microM of pioglitazone					82.193 0.54 % 90.83
PC3 perturbed by 1e-06microM of fulvestrant					77.0676 0.02 % 88.52
PC3 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					78.8914 0.76 % 89.07
MCF7 perturbed by 1.18e-05microM of disopyramide					83.871 2.45 % 90.71
MCF7 perturbed by 3.2e-06microM of atracurium besilate					80.4696 0.24 % 90.11
MCF7 perturbed by 9e-06microM of lincomycin					80.9579 0.08 % 90.44
PC3 perturbed by 1e-05microM of BCB000040					79.6978 2.99 % 88.36
PC3 perturbed by 1e-05microM of CP-863187					82.2512 2.62 % 89.82