Connectivity Map Batch 02 Random Load - CMAP23

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	92.9 0.05 % 96.42
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of LY-294002					88.9004 0.32 % 94.29
MCF7 perturbed by 1e-05microM of perphenazine					92.9016 0.03 % 96.43
MCF7 perturbed by 5.4e-06microM of bromocriptine					92.9519 0 % 96.48
MCF7 perturbed by 2.2e-05microM of mephenesin					92.9866 0.05 % 96.47
HL60 perturbed by 1.26e-05microM of diphenylpyraline					90.602 0.03 % 95.29
vehicle					89.2325 0.31 % 94.46
HL60 perturbed by 1.82e-05microM of harman					90.3536 0.03 % 95.16
HL60 perturbed by 2.3e-05microM of gramine					90.7905 0.11 % 95.34
HL60 perturbed by 1.7e-05microM of isosorbide					90.6289 0.02 % 95.31
HL60 perturbed by 1.14e-05microM of retrorsine					91.0754 0.03 % 95.52
HL60 perturbed by 1.86e-05microM of mexiletine					91.5294 2.13 % 94.7
HL60 perturbed by 1.58e-05microM of ketoprofen					91.5727 0.53 % 95.52
HL60 perturbed by 1.68e-05microM of nitrofurantoin					91.561 1.02 % 95.27
PC3 perturbed by 1.64e-05microM of hydrastinine					85.6312 3 % 91.32
PC3 perturbed by 1.26e-05microM of mefexamide					88.5006 2.05 % 93.23
PC3 perturbed by 1.42e-05microM of xylometazoline					87.2574 6.84 % 90.21
vehicle					90.91 0.19 % 95.36
MCF7 perturbed by 1e-07microM of trichostatin A					92.4599 0 % 96.23
vehicle					93.1932 0.05 % 96.57
HL60 perturbed by 1.36e-05microM of N-acetylmuramic acid					89.6296 0.74 % 94.45
HL60 perturbed by 1.08e-05microM of dextromethorphan					89.4763 0.81 % 94.33
HL60 perturbed by 1.08e-05microM of SR-95531					90.4208 0.03 % 95.2
HL60 perturbed by 1.62e-05microM of dapsone					89.3293 0.05 % 94.64
HL60 perturbed by 1.12e-05microM of chlorpromazine					89.8337 3.74 % 93.05
vehicle					88.8576 0.84 % 94.01
HL60 perturbed by 4.8e-06microM of rifampicin					90.6815 0.03 % 95.33
HL60 perturbed by 6e-06microM of cephaeline					88.2789 0.2 % 94.04
HL60 perturbed by 2.22e-05microM of L-methionine sulfoximine					90.4483 0.34 % 95.06
MCF7 perturbed by 1.54e-05microM of oxolinic acid					92.125 1.24 % 95.44
MCF7 perturbed by 9.6e-06microM of isoconazole					92.2038 1.39 % 95.4
MCF7 perturbed by 1.26e-05microM of norfloxacin					92.6144 1.45 % 95.58
MCF7 perturbed by 2.9e-05microM of pentetrazol					92.8652 1.49 % 95.69
HL60 perturbed by 4.8e-06microM of abamectin					88.7764 0.93 % 93.92
HL60 perturbed by 1.12e-05microM of napelline					90.4768 6.93 % 91.77
MCF7 perturbed by 1.24e-05microM of ritodrine					92.9002 0.07 % 96.42
MCF7 perturbed by 5.2e-06microM of iopamidol					91.7828 0.04 % 95.87
MCF7 perturbed by 8.2e-06microM of azlocillin					91.307 0.1 % 95.61
MCF7 perturbed by 1e-07microM of trichostatin A					90.216 0.13 % 95.04
MCF7 perturbed by 1.52e-05microM of cinoxacin					90.5774 3.91 % 93.33
MCF7 perturbed by 8e-06microM of fluocinonide					89.9258 0.01 % 94.96
MCF7 perturbed by 3.08e-05microM of mevalolactone					92.4016 0 % 96.2
vehicle					90.4808 4.12 % 93.18
HL60 perturbed by 1.84e-05microM of securinine					89.3078 0.67 % 94.32
vehicle					90.4597 2.44 % 94.01
vehicle					89.1945 0.15 % 94.52
HL60 perturbed by 1e-06microM of tanespimycin					89.0575 1.14 % 93.96
HL60 perturbed by 2.32e-05microM of sulfanilamide					91.1168 0.05 % 95.53
HL60 perturbed by 1.2e-05microM of isoetarine					89.1334 0.58 % 94.28
HL60 perturbed by 1e-07microM of sirolimus					90.64 0.1 % 95.27
HL60 perturbed by 7.2e-06microM of ribostamycin					90.5733 0.02 % 95.27
MCF7 perturbed by 1.16e-05microM of buflomedil					89.7883 2.98 % 93.4
MCF7 perturbed by 1e-07microM of trichostatin A					89.9986 0.01 % 94.99
MCF7 perturbed by 1.48e-05microM of apigenin					89.9244 3.16 % 93.38
MCF7 perturbed by 2.02e-05microM of nitrofural					91.052 4.34 % 93.35
MCF7 perturbed by 1.24e-05microM of cyproheptadine					91.8861 6.29 % 92.8
PC3 perturbed by 1.3e-05microM of foliosidine					88.7595 1.96 % 93.4
PC3 perturbed by 1.2e-05microM of proglumide					88.856 1.39 % 93.73
PC3 perturbed by 1.4e-05microM of sulfachlorpyridazine					87.4627 0.2 % 93.63
PC3 perturbed by 1.84e-05microM of ethoxyquin					90.9665 0.03 % 95.47
PC3 perturbed by 1.16e-05microM of bromopride					88.9884 1.29 % 93.85
MCF7 perturbed by 1.38e-05microM of Prestwick-642					90.1942 0.39 % 94.9
vehicle					90.4514 1.35 % 94.55
MCF7 perturbed by 1.16e-05microM of trimethylcolchicinic acid					90.8123 1.32 % 94.75
vehicle					90.9089 4.18 % 93.37
MCF7 perturbed by 1.06e-05microM of papaverine					88.9681 2.69 % 93.14
vehicle					90.7729 0.28 % 95.25
vehicle					92.0983 0.22 % 95.94
MCF7 perturbed by 1.5e-05microM of sulfafurazole					92.4731 0.7 % 95.88
MCF7 perturbed by 1e-07microM of sirolimus					92.1355 0.03 % 96.05
MCF7 perturbed by 6e-06microM of Prestwick-682					91.1069 0.72 % 95.19
MCF7 perturbed by 1.22e-05microM of Prestwick-857					91.4527 2.19 % 94.63
MCF7 perturbed by 8.2e-06microM of glimepiride					91.391 1.21 % 95.09
MCF7 perturbed by 8.2e-06microM of dicloxacillin					91.7151 0.9 % 95.41
MCF7 perturbed by 7.4e-06microM of apramycin					92.1458 1.62 % 95.26
MCF7 perturbed by 1.54e-05microM of carisoprodol					92.209 1.43 % 95.39
vehicle					91.1023 0.06 % 95.52
vehicle					92.337 0.01 % 96.16
MCF7 perturbed by 1.18e-05microM of canadine					90.2038 2.45 % 93.88
MCF7 perturbed by 1.18e-05microM of trihexyphenidyl					90.461 0.37 % 95.04
MCF7 perturbed by 1.22e-05microM of levobunolol					91.6666 1.12 % 95.27
MCF7 perturbed by 5e-06microM of metrizamide					90.7154 3.4 % 93.66
MCF7 perturbed by 2.34e-05microM of propylthiouracil					90.761 0.98 % 94.89
MCF7 perturbed by 2.24e-05microM of fusaric acid					90.8533 1.41 % 94.72
MCF7 perturbed by 3.14e-05microM of 6-azathymine					90.3773 1.12 % 94.63
MCF7 perturbed by 1.06e-05microM of indapamide					90.9266 2.49 % 94.22
MCF7 perturbed by 9.2e-06microM of flunisolide					86.5703 4.56 % 91.01
PC3 perturbed by 1.4e-05microM of tropicamide					89.7889 0.03 % 94.88
PC3 perturbed by 1.48e-05microM of riluzole					87.1881 0.01 % 93.59
HL60 perturbed by 8.2e-06microM of isometheptene					90.3239 0.02 % 95.15
HL60 perturbed by 1.32e-05microM of pipemidic acid					90.0593 3.45 % 93.31
HL60 perturbed by 1.18e-05microM of terguride					90.6112 0.02 % 95.3
HL60 perturbed by 9.8e-06microM of remoxipride					90.8167 0.12 % 95.35
vehicle					91.01 0.02 % 95.49
MCF7 perturbed by 1.86e-05microM of 10-methoxyharmalan					91.8113 0.71 % 95.55
MCF7 perturbed by 7.6e-06microM of orciprenaline					90.7163 1.46 % 94.63
vehicle					91.2381 1.35 % 94.94
PC3 perturbed by 2.52e-05microM of citiolone					91.1174 2.96 % 94.08
PC3 perturbed by 1.38e-05microM of Prestwick-691					88.4617 1.69 % 93.39
PC3 perturbed by 1e-07microM of trichostatin A					89.2857 1.75 % 93.77
MCF7 perturbed by 6.8e-06microM of etoposide					91.1716 2.2 % 94.49
MCF7 perturbed by 1.28e-05microM of clenbuterol					92.3814 2.12 % 95.13
MCF7 perturbed by 7.8e-06microM of clofilium tosylate					91.8959 4.19 % 93.85
PC3 perturbed by 1.38e-05microM of (+/-)-catechin					91.2377 1.43 % 94.9
PC3 perturbed by 9.6e-06microM of simvastatin					90.9699 1.33 % 94.82
PC3 perturbed by 1.08e-05microM of minaprine					90.2251 2.72 % 93.75
PC3 perturbed by 1.16e-05microM of gibberellic acid					88.0289 2.35 % 92.84
HL60 perturbed by 2.24e-05microM of propofol					91.3453 2.8 % 94.27
HL60 perturbed by 1.14e-05microM of profenamine					91.1757 2.25 % 94.46
HL60 perturbed by 8.8e-06microM of nafcillin					91.1782 0.43 % 95.37
vehicle					90.2455 1.46 % 94.39
MCF7 perturbed by 1.34e-05microM of sulfadimidine					91.5261 1.17 % 95.18
vehicle					91.6714 1.7 % 94.98
MCF7 perturbed by 1.52e-05microM of homosalate					91.6108 0.94 % 95.34
MCF7 perturbed by 1.06e-05microM of famprofazone					91.7132 2.1 % 94.81
MCF7 perturbed by 1e-07microM of trichostatin A					91.9207 0.39 % 95.77
vehicle					90.8775 5.69 % 92.59
HL60 perturbed by 8.4e-06microM of metacycline					91.3069 0.07 % 95.62
HL60 perturbed by 1.38e-05microM of proguanil					91.3164 0.04 % 95.64
MCF7 perturbed by 4.4e-06microM of nystatin					91.4128 0.71 % 95.35
MCF7 perturbed by 1.06e-05microM of digitoxigenin					91.6896 0.42 % 95.63
MCF7 perturbed by 5.8e-06microM of pepstatin					90.9806 1.73 % 94.63
PC3 perturbed by 1.54e-05microM of flumequine					88.7825 2.83 % 92.98
PC3 perturbed by 1.76e-05microM of resveratrol					90.6714 2.52 % 94.08
PC3 perturbed by 1.38e-05microM of Prestwick-642					90.3127 1.05 % 94.63
PC3 perturbed by 6.8e-06microM of pentamidine					89.7418 3.13 % 93.31
vehicle					92.5836 0.02 % 96.28
MCF7 perturbed by 1.32e-05microM of chlorambucil					90.7128 0.51 % 95.1
vehicle					92.1152 1.3 % 95.41
MCF7 perturbed by 5e-06microM of atractyloside					92.2718 0.56 % 95.85
MCF7 perturbed by 1.18e-05microM of metoclopramide					92.256 0.89 % 95.68
vehicle					91.6734 1.78 % 94.95
MCF7 perturbed by 1.28e-05microM of levonorgestrel					92.5452 1.22 % 95.66
PC3 perturbed by 1.18e-05microM of isocorydine					91.611 0.04 % 95.79
PC3 perturbed by 1.24e-05microM of oxyphenbutazone					92.0082 0.1 % 95.95
PC3 perturbed by 1e-05microM of trifluoperazine					91.6081 1.62 % 94.99
PC3 perturbed by 0.0002microM of valproic acid					92.0194 2.95 % 94.53
vehicle					91.9699 0.05 % 95.96
PC3 perturbed by 2.22e-05microM of theobromine					91.5129 0.05 % 95.73
PC3 perturbed by 1e-05microM of metergoline					91.0333 1.87 % 94.58
MCF7 perturbed by 9.6e-06microM of aminophylline					93.2409 0.02 % 96.61
PC3 perturbed by 1.5e-05microM of streptozocin					90.7651 1.23 % 94.77
PC3 perturbed by 8.4e-06microM of cefotaxime					90.7508 0.06 % 95.35
PC3 perturbed by 1.38e-05microM of estriol					90.5862 2.03 % 94.28
PC3 perturbed by 9.2e-06microM of hecogenin					90.2127 1.04 % 94.59
vehicle					91.5057 0.38 % 95.56
MCF7 perturbed by 1.22e-05microM of cyclic adenosine monophosphate					90.9865 0.27 % 95.36
MCF7 perturbed by 1.18e-05microM of trimetazidine					91.3449 3.1 % 94.12
MCF7 perturbed by 2.12e-05microM of phensuximide					91.6976 0.26 % 95.72
MCF7 perturbed by 1.7e-05microM of carbamazepine					91.2406 0.45 % 95.39
PC3 perturbed by 1.1e-05microM of dorzolamide					92.3078 0.16 % 96.08
PC3 perturbed by 6e-06microM of syrosingopine					91.0986 0.14 % 95.48
vehicle					90.8809 0.52 % 95.18
MCF7 perturbed by 1e-05microM of AG-013608					92.5107 2.15 % 95.18
vehicle					92.4923 1.69 % 95.4
MCF7 perturbed by 1.5e-05microM of sulfafurazole					92.6407 0.02 % 96.31
MCF7 perturbed by 1.1e-05microM of naloxone					91.5824 0.03 % 95.78
MCF7 perturbed by 1.2e-05microM of propoxycaine					89.7709 4.4 % 92.69
MCF7 perturbed by 1.58e-05microM of harmol					91.3486 0.03 % 95.66
MCF7 perturbed by 1.06e-05microM of ketorolac					90.7985 0 % 95.4
MCF7 perturbed by 1.26e-05microM of norfloxacin					91.2544 0.01 % 95.62
MCF7 perturbed by 1.76e-05microM of trioxysalen					92.7435 3.89 % 94.42
MCF7 perturbed by 1.46e-05microM of Prestwick-1085					92.9544 0.81 % 96.07
HL60 perturbed by 1e-07microM of trichostatin A					89.0252 3.18 % 92.92
HL60 perturbed by 1.46e-05microM of Prestwick-1085					88.5822 2.66 % 92.96
HL60 perturbed by 1e-05microM of prochlorperazine					89.9378 3.23 % 93.35
PC3 perturbed by 1.64e-05microM of pinacidil					89.9953 3.76 % 93.12
PC3 perturbed by 2e-05microM of STOCK1N-28457					80.3134 3.66 % 88.32
vehicle					80.2151 2.43 % 88.89
MCF7 perturbed by 1e-05microM of orlistat					92.775 1.51 % 95.63
MCF7 perturbed by 1.06e-05microM of Prestwick-685					91.1864 0.04 % 95.57
MCF7 perturbed by 1e-05microM of thioridazine					82.4769 2.9 % 89.79
MCF7 perturbed by 1e-06microM of trichostatin A					81.2526 1.64 % 89.8
MCF7 perturbed by 1e-06microM of tanespimycin					82.0242 1.78 % 90.12
MCF7 perturbed by 5e-05microM of valproic acid					81.1903 1.13 % 90.03
vehicle					83.3471 1.57 % 90.89
MCF7 perturbed by 1.54e-05microM of tiletamine					92.0645 0.54 % 95.76
MCF7 perturbed by 2e-05microM of 5194442					91.9717 0.64 % 95.67
MCF7 perturbed by 1e-06microM of tanespimycin					81.3985 1.93 % 89.73
MCF7 perturbed by 1e-07microM of sirolimus					84.4058 0.16 % 92.12
vehicle					82.8758 2.17 % 90.35
MCF7 perturbed by 1.74e-05microM of diazoxide					86.4243 0.24 % 93.09
MCF7 perturbed by 1.16e-05microM of benzydamine					84.5158 0.23 % 92.14
PC3 perturbed by 7.6e-06microM of gliquidone					82.4162 2 % 90.21
PC3 perturbed by 4.2e-06microM of asiaticoside					83.1273 0.43 % 91.35
PC3 perturbed by 1.54e-05microM of 1-4-chrysenequinone					75.387 2.3 % 86.54
PC3 perturbed by 1.02e-05microM of picotamide					76.3936 1.7 % 87.35
PC3 perturbed by 1.14e-05microM of drofenine					75.0202 0.96 % 87.03
PC3 perturbed by 6.8e-06microM of alexidine					76.6691 1.54 % 87.57
vehicle					75.994 2.37 % 86.81
PC3 perturbed by 1e-06microM of trichostatin A					77.8629 0.05 % 88.91
vehicle					78.1041 1.32 % 88.39
vehicle					81.7668 0.01 % 90.88
MCF7 perturbed by 1.64e-05microM of etomidate					79.5246 0.34 % 89.59
MCF7 perturbed by 1.72e-05microM of aminoglutethimide					81.0247 0.1 % 90.46
MCF7 perturbed by 1.66e-05microM of levamisole					78.0655 0.01 % 89.03
vehicle					83.6291 0.04 % 91.79
MCF7 perturbed by 1e-07microM of vinblastine					79.2644 6.36 % 86.45
MCF7 perturbed by 1e-06microM of daunorubicin					80.4204 6.39 % 87.02
vehicle					78.2344 5.44 % 86.4
PC3 perturbed by 1e-05microM of CP-944629					82.8593 2.51 % 90.18
MCF7 perturbed by 1e-05microM of CP-863187					82.1396 2.2 % 89.97