Connectivity Map Batch 02 Random Load - CMAP21

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	86.49 2.22 % 92.14
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-05microM of troglitazone					86.6601 1.17 % 92.74
HL60 perturbed by 1e-05microM of prochlorperazine					86.4907 1.03 % 92.73
HL60 perturbed by 1e-06microM of tanespimycin					88.3076 0.47 % 93.92
HL60 perturbed by 1e-07microM of sirolimus					88.8377 2.22 % 93.31
vehicle					93.3337 0 % 96.67
MCF7 perturbed by 1.18e-05microM of danazol					93.1359 0.01 % 96.57
vehicle					92.4915 0.02 % 96.24
MCF7 perturbed by 9e-06microM of glipizide					93.1661 0 % 96.58
HL60 perturbed by 1e-07microM of trichostatin A					89.851 0.34 % 94.76
HL60 perturbed by 1.2e-05microM of metamizole sodium					90.9877 0.06 % 95.46
HL60 perturbed by 9.8e-06microM of trazodone					91.8623 0.12 % 95.87
HL60 perturbed by 1.16e-05microM of difenidol					91.706 0.02 % 95.84
PC3 perturbed by 2.54e-05microM of tranexamic acid					88.4487 0.85 % 93.8
PC3 perturbed by 9.2e-06microM of aztreonam					89.2156 1.22 % 94
vehicle					88.0519 0.86 % 93.59
MCF7 perturbed by 1.74e-05microM of naproxen					92.6136 0 % 96.31
MCF7 perturbed by 1.62e-05microM of dapsone					92.6919 0 % 96.35
MCF7 perturbed by 2.42e-05microM of metformin					93.1691 0 % 96.58
MCF7 perturbed by 1.7e-05microM of carbamazepine					92.4355 0.27 % 96.08
MCF7 perturbed by 1e-07microM of estradiol					93.2198 0.05 % 96.58
HL60 perturbed by 7.8e-06microM of flupentixol					90.09 3.1 % 93.5
HL60 perturbed by 1.54e-05microM of carisoprodol					90.8126 0.17 % 95.32
PC3 perturbed by 1.38e-05microM of diphenhydramine					89.8172 0.9 % 94.46
PC3 perturbed by 1.28e-05microM of amitriptyline					88.0482 4.97 % 91.54
PC3 perturbed by 2.2e-05microM of heptaminol					89.5447 2 % 93.77
PC3 perturbed by 2.7e-05microM of betazole					89.1686 0 % 94.58
HL60 perturbed by 2.7e-05microM of betazole					85.3863 3.37 % 91.01
HL60 perturbed by 1.58e-05microM of diprophylline					88.8815 3.27 % 92.81
HL60 perturbed by 8.2e-06microM of dicloxacillin					90.2262 1.81 % 94.21
HL60 perturbed by 1.86e-05microM of niridazole					90.6485 0.14 % 95.26
MCF7 perturbed by 1.34e-05microM of disulfiram					91.7694 0.42 % 95.68
HL60 perturbed by 1.6e-05microM of sulfapyridine					91.2493 1.05 % 95.1
vehicle					91.2234 0.04 % 95.59
HL60 perturbed by 6.4e-06microM of tetrandrine					89.6687 2.29 % 93.69
HL60 perturbed by 1.06e-05microM of fluorometholone					91.3906 0.07 % 95.66
HL60 perturbed by 1.28e-05microM of levonorgestrel					87.6542 21.69 % 82.98
MCF7 perturbed by 1.5e-05microM of anisomycin					90.6075 0.7 % 94.95
MCF7 perturbed by 9e-06microM of levomepromazine					91.6602 0.01 % 95.83
MCF7 perturbed by 1.3e-05microM of butacaine					91.9289 0.87 % 95.53
vehicle					90.5653 3.77 % 93.4
MCF7 perturbed by 1.1e-05microM of dorzolamide					88.5238 4.67 % 91.93
MCF7 perturbed by 3.4e-06microM of pyrvinium					90.2115 3.13 % 93.54
MCF7 perturbed by 9.6e-06microM of cyproterone					89.6312 5.15 % 92.24
MCF7 perturbed by 1.28e-05microM of sulfadoxine					91.6978 2.31 % 94.7
vehicle					89.5953 0.2 % 94.7
HL60 perturbed by 1.14e-05microM of drofenine					89.23 1.63 % 93.8
MCF7 perturbed by 1e-05microM of SR-95639A					90.7197 0.13 % 95.29
MCF7 perturbed by 1e-05microM of ergocalciferol					89.1206 0.01 % 94.56
MCF7 perturbed by 9.8e-06microM of ginkgolide A					87.997 0.8 % 93.6
MCF7 perturbed by 8.6e-06microM of meclozine					91.3856 0.09 % 95.65
MCF7 perturbed by 1.5e-05microM of anisomycin					90.2576 4.55 % 92.86
MCF7 perturbed by 1.08e-05microM of ciprofloxacin					92.2328 3.87 % 94.18
MCF7 perturbed by 6.2e-06microM of aconitine					90.9943 0 % 95.5
MCF7 perturbed by 1.36e-05microM of picrotoxinin					90.4119 4.08 % 93.17
vehicle					91.4147 3.39 % 94.01
MCF7 perturbed by 1.82e-05microM of xylazine					88.7454 9.08 % 89.83
MCF7 perturbed by 1.78e-05microM of 3-hydroxy-DL-kynurenine					92.125 0.09 % 96.02
MCF7 perturbed by 1.22e-05microM of clozapine					92.6985 1.39 % 95.66
MCF7 perturbed by 7.8e-06microM of probucol					92.5218 0.47 % 96.03
MCF7 perturbed by 1e-06microM of chlorpromazine					93.2396 0.5 % 96.37
vehicle					92.749 0.14 % 96.31
MCF7 perturbed by 1.22e-05microM of diloxanide					91.9591 0.96 % 95.5
MCF7 perturbed by 1.08e-05microM of acebutolol					92.5826 2.1 % 95.24
MCF7 perturbed by 9.6e-06microM of miconazole					93.2547 2.09 % 95.58
MCF7 perturbed by 9.2e-06microM of benzthiazide					92.5855 0.26 % 96.16
MCF7 perturbed by 1.22e-05microM of velnacrine					91.4348 1.15 % 95.14
MCF7 perturbed by 1.12e-05microM of lactobionic acid					92.6446 0.49 % 96.08
MCF7 perturbed by 1.26e-05microM of thioguanosine					92.7659 0.4 % 96.18
MCF7 perturbed by 1.36e-05microM of propranolol					92.052 0.14 % 95.95
MCF7 perturbed by 1.1e-05microM of (+)-isoprenaline					92.8596 0 % 96.43
MCF7 perturbed by 1.06e-05microM of trichlormethiazide					92.9361 0.01 % 96.47
MCF7 perturbed by 2.28e-05microM of N-acetyl-L-aspartic acid					92.4505 0.08 % 96.18
MCF7 perturbed by 2.3e-05microM of gramine					92.1291 0 % 96.06
MCF7 perturbed by 1.34e-05microM of ticlopidine					92.1199 2.82 % 94.65
MCF7 perturbed by 1.5e-05microM of pronetalol					90.6986 0.25 % 95.22
MCF7 perturbed by 8.4e-06microM of metacycline					90.546 0.73 % 94.91
MCF7 perturbed by 1e-06microM of PHA-00851261E					91.6609 0.52 % 95.57
PC3 perturbed by 1e-07microM of trichostatin A					90.3074 0.01 % 95.15
PC3 perturbed by 9.2e-06microM of fludroxycortide					89.1171 0 % 94.56
vehicle					87.3357 0.19 % 93.58
PC3 perturbed by 1.58e-05microM of sulfamethoxazole					89.1232 4.94 % 92.09
HL60 perturbed by 1.04e-05microM of megestrol					90.7718 0.13 % 95.32
HL60 perturbed by 1e-07microM of trichostatin A					91.0246 0.04 % 95.49
MCF7 perturbed by 1.46e-05microM of nifuroxazide					91.3064 3.05 % 94.13
MCF7 perturbed by 1.54e-05microM of norcyclobenzaprine					91.207 3.96 % 93.62
MCF7 perturbed by 1.8e-05microM of phenindione					91.504 1.35 % 95.08
PC3 perturbed by 1.86e-05microM of mexiletine					91.4586 0.4 % 95.53
PC3 perturbed by 1e-06microM of 0317956-0000					92.7995 0.12 % 96.34
PC3 perturbed by 1.22e-05microM of eucatropine					91.4061 0.28 % 95.56
PC3 perturbed by 7.8e-06microM of eldeline					91.9414 0.23 % 95.86
vehicle					90.3852 2.11 % 94.14
PC3 perturbed by 2.1e-05microM of tetroquinone					91.3971 0.78 % 95.31
PC3 perturbed by 1e-07microM of trichostatin A					90.1904 0.38 % 94.91
PC3 perturbed by 1.82e-05microM of xylazine					87.6949 0.73 % 93.48
MCF7 perturbed by 9.4e-06microM of ketotifen					92.1647 2.24 % 94.96
vehicle					92.8169 5.09 % 93.86
MCF7 perturbed by 1.5e-05microM of sulfafurazole					93.236 2.22 % 95.51
MCF7 perturbed by 1e-07microM of trichostatin A					92.2413 10.55 % 90.84
PC3 perturbed by 2.42e-05microM of benzocaine					91.9274 2.59 % 94.67
PC3 perturbed by 1.12e-05microM of idoxuridine					90.5243 1.17 % 94.68
PC3 perturbed by 1.48e-05microM of meptazinol					89.8587 0.88 % 94.49
HL60 perturbed by 2.32e-05microM of 2-aminobenzenesulfonamide					91.0756 3.59 % 93.74
HL60 perturbed by 1.18e-05microM of scopolamine					91.1835 6.2 % 92.49
HL60 perturbed by 1.36e-05microM of propranolol					91.3871 1.39 % 95
HL60 perturbed by 1.02e-05microM of digoxigenin					89.658 7.53 % 91.06
HL60 perturbed by 1.1e-05microM of (+)-isoprenaline					90.6935 4.48 % 93.11
vehicle					91.0574 1 % 95.03
HL60 perturbed by 9.6e-06microM of simvastatin					91.1037 4.74 % 93.18
vehicle					91.0591 0.74 % 95.16
HL60 perturbed by 2.12e-05microM of 3-acetylcoumarin					91.043 1.17 % 94.94
HL60 perturbed by 5e-06microM of ioversol					91.5523 2.1 % 94.73
MCF7 perturbed by 1.2e-05microM of proglumide					91.0238 0.59 % 95.22
MCF7 perturbed by 3.2e-06microM of beta-escin					91.3876 0.88 % 95.25
MCF7 perturbed by 3.92e-05microM of levcycloserine					91.8496 0.44 % 95.71
HL60 perturbed by 1.08e-05microM of rimexolone					90.6205 4.29 % 93.16
HL60 perturbed by 1.2e-05microM of piribedil					90.0188 5 % 92.51
MCF7 perturbed by 1.28e-05microM of molindone					91.4114 0.16 % 95.62
MCF7 perturbed by 1.24e-05microM of procyclidine					92.3848 0.8 % 95.79
MCF7 perturbed by 1.02e-05microM of corynanthine					91.3979 0 % 95.7
PC3 perturbed by 7.6e-06microM of deptropine					89.4921 1.51 % 93.99
PC3 perturbed by 2.42e-05microM of metformin					91.0602 1.94 % 94.56
PC3 perturbed by 1.12e-05microM of sulindac					90.6309 1.93 % 94.35
PC3 perturbed by 1.8e-05microM of bufexamac					89.2482 2.19 % 93.53
PC3 perturbed by 1e-07microM of trichostatin A					90.0027 1.14 % 94.43
PC3 perturbed by 1.16e-05microM of dicycloverine					92.5821 0.02 % 96.28
PC3 perturbed by 1.3e-05microM of orphenadrine					90.8201 0.58 % 95.12
PC3 perturbed by 1.38e-05microM of quinethazone					90.8612 0.01 % 95.42
MCF7 perturbed by 5.4e-06microM of alcuronium chloride					92.7773 0.01 % 96.38
MCF7 perturbed by 1.62e-05microM of santonin					93.054 0.14 % 96.45
PC3 perturbed by 1.06e-05microM of droperidol					92.7643 1.71 % 95.53
PC3 perturbed by 7.6e-06microM of ketoconazole					92.1222 0.27 % 95.93
PC3 perturbed by 6.8e-06microM of tonzonium bromide					91.5468 1.1 % 95.22
PC3 perturbed by 3.1e-05microM of dimethadione					92.25 0.26 % 95.99
vehicle					92.4486 0.2 % 96.12
MCF7 perturbed by 1.68e-05microM of salbutamol					91.0594 0.3 % 95.38
MCF7 perturbed by 1.36e-05microM of mebendazole					91.4487 0.56 % 95.45
PC3 perturbed by 1e-06microM of trichostatin A					92.1023 0.33 % 95.89
PC3 perturbed by 1.62e-05microM of (-)-isoprenaline					92.6675 0.96 % 95.86
PC3 perturbed by 7.8e-06microM of clofilium tosylate					91.9123 0.14 % 95.88
vehicle					92.3329 0 % 96.16
PC3 perturbed by 1.46e-05microM of methyldopate					91.4728 0 % 95.74
PC3 perturbed by 6.8e-06microM of etoposide					92.4353 0.16 % 96.14
PC3 perturbed by 1.5e-05microM of ciclopirox					91.9274 0.01 % 95.96
PC3 perturbed by 8.2e-06microM of dicloxacillin					92.5538 0 % 96.28
PC3 perturbed by 1.94e-05microM of dexibuprofen					91.397 0.11 % 95.64
PC3 perturbed by 2.24e-05microM of propofol					92.2411 0.18 % 96.03
PC3 perturbed by 9.4e-06microM of buspirone					92.4469 0.22 % 96.12
PC3 perturbed by 1.32e-05microM of desipramine					91.3625 0.85 % 95.26
MCF7 perturbed by 2.38e-05microM of zoxazolamine					93.561 0.04 % 96.76
PC3 perturbed by 9.8e-06microM of piperacetazine					91.2937 2.53 % 94.38
PC3 perturbed by 6.4e-06microM of tetrandrine					91.666 0.23 % 95.72
PC3 perturbed by 1e-07microM of trichostatin A					91.2903 0.64 % 95.32
PC3 perturbed by 1.74e-05microM of diazoxide					91.4789 0.15 % 95.66
PC3 perturbed by 1.6e-05microM of harmine					91.134 3.95 % 93.59
PC3 perturbed by 2.54e-05microM of tranexamic acid					91.8895 0.01 % 95.94
PC3 perturbed by 1.84e-05microM of mephenytoin					92.1145 0.98 % 95.57
PC3 perturbed by 1.34e-05microM of disulfiram					92.5601 0.01 % 96.28
vehicle					90.9026 0.1 % 95.4
MCF7 perturbed by 1.24e-05microM of ritodrine					88.9694 1.61 % 93.68
MCF7 perturbed by 1e-07microM of sirolimus					90.2537 0.63 % 94.81
MCF7 perturbed by 1e-06microM of fulvestrant					92.188 0.08 % 96.05
MCF7 perturbed by 8.6e-06microM of mebeverine					89.8257 3 % 93.41
MCF7 perturbed by 2.14e-05microM of amrinone					90.293 3.86 % 93.22
MCF7 perturbed by 1.22e-05microM of monocrotaline					91.7177 2.65 % 94.53
MCF7 perturbed by 8.8e-06microM of astemizole					90.7149 0 % 95.36
MCF7 perturbed by 1.1e-05microM of labetalol					89.0679 0.43 % 94.32
MCF7 perturbed by 1.56e-05microM of metrifonate					93.0583 0.01 % 96.53
MCF7 perturbed by 1.52e-05microM of ozagrel					91.6939 0 % 95.85
vehicle					92.4237 9.4 % 91.51
vehicle					93.625 0.38 % 96.62
MCF7 perturbed by 1.54e-05microM of skimmianine					93.4302 0.54 % 96.45
PC3 perturbed by 1e-07microM of trichostatin A					90.8704 3.24 % 93.82
PC3 perturbed by 9.6e-06microM of coralyne					90.7511 3.24 % 93.75
vehicle					90.7061 3.19 % 93.76
PC3 perturbed by 1e-05microM of C-75					92.5444 0 % 96.27
MCF7 perturbed by 1.18e-05microM of chlorcyclizine					92.7782 0.1 % 96.34
MCF7 perturbed by 7.6e-06microM of alclometasone					92.4866 0.01 % 96.24
MCF7 perturbed by 1.04e-05microM of altizide					91.7477 0 % 95.87
MCF7 perturbed by 1e-05microM of genistein					83.7888 1.03 % 91.38
MCF7 perturbed by 1e-05microM of trifluoperazine					82.9379 1.31 % 90.81
MCF7 perturbed by 1.22e-05microM of dyclonine					80.4777 2.06 % 89.21
MCF7 perturbed by 1e-05microM of vorinostat					80.5234 1.19 % 89.67
MCF7 perturbed by 1e-07microM of estradiol					82.5432 0.97 % 90.79
MCF7 perturbed by 1.9e-05microM of altretamine					92.8078 0 % 96.4
MCF7 perturbed by 1.94e-05microM of pyridoxine					82.9999 4.31 % 89.34
PC3 perturbed by 1.96e-05microM of mecamylamine					80.486 2.41 % 89.04
PC3 perturbed by 8.2e-06microM of cefamandole					75.2473 0.16 % 87.54
MCF7 perturbed by 7.6e-06microM of proscillaridin					75.3036 1.18 % 87.06
PC3 perturbed by 1.1e-05microM of clemizole					77.4246 0.41 % 88.5
MCF7 perturbed by 1e-06microM of SB-203580					78.354 0.89 % 88.73
PC3 perturbed by 1e-05microM of SC-19220					75.5094 0.27 % 87.62
PC3 perturbed by 1e-05microM of AR-A014418					77.1248 0.04 % 88.54
MCF7 perturbed by 5e-07microM of 6-bromoindirubin-3'-oxime					77.9666 0.06 % 88.96
vehicle					81.1915 0.17 % 90.51
MCF7 perturbed by 9e-06microM of betulin					80.0924 0.12 % 89.99
MCF7 perturbed by 9.6e-06microM of bromperidol					79.7991 0.84 % 89.48
MCF7 perturbed by 9.4e-06microM of flavoxate					78.7696 0.07 % 89.35
MCF7 perturbed by 1e-06microM of fulvestrant					82.1621 2.53 % 89.82
PC3 perturbed by 1e-05microM of CP-319743					83.0079 2.32 % 90.34
MCF7 perturbed by 1e-05microM of CP-863187					79.8589 4.37 % 87.74
MCF7 perturbed by 1e-05microM of pioglitazone					80.8243 4.89 % 87.97