Connectivity Map Batch 02 Random Load - CMAP20

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	88.04 0.82 % 93.61
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-07microM of sirolimus					88.8442 1.11 % 93.87
PC3 perturbed by 1e-06microM of tanespimycin					88.0351 0.33 % 93.85
HL60 perturbed by 1e-07microM of alvespimycin					89.7546 3.51 % 93.12
MCF7 perturbed by 1.92e-05microM of minoxidil					93.929 0.82 % 96.56
MCF7 perturbed by 1.12e-05microM of pheniramine					93.169 0.74 % 96.22
MCF7 perturbed by 1.32e-05microM of amiloride					93.2919 0.06 % 96.62
vehicle					93.7903 0 % 96.89
MCF7 perturbed by 1.56e-05microM of prilocaine					93.636 0.09 % 96.77
vehicle					92.9308 0.78 % 96.08
MCF7 perturbed by 1.1e-05microM of ofloxacin					93.9234 0.31 % 96.81
HL60 perturbed by 1.16e-05microM of trimethylcolchicinic acid					91.2824 0.03 % 95.62
HL60 perturbed by 9.4e-06microM of fludrocortisone					92.2715 0.17 % 96.05
HL60 perturbed by 1.12e-05microM of indometacin					92.1065 0.83 % 95.64
vehicle					92.4218 0.67 % 95.88
HL60 perturbed by 1e-07microM of trichostatin A					89.4118 4.23 % 92.59
vehicle					88.9113 2.95 % 92.98
PC3 perturbed by 1.32e-05microM of nocodazole					85.5251 8.09 % 88.72
vehicle					86.9268 3.57 % 91.68
MCF7 perturbed by 1e-05microM of prochlorperazine					92.7631 0.09 % 96.34
MCF7 perturbed by 6.6e-06microM of benzonatate					92.2357 0 % 96.12
HL60 perturbed by 1.18e-05microM of suloctidil					89.1201 2.02 % 93.55
HL60 perturbed by 1.1e-05microM of cefalexin					90.3738 2.15 % 94.11
PC3 perturbed by 1.28e-05microM of sulfaphenazole					89.7798 0.06 % 94.86
HL60 perturbed by 7.6e-06microM of terconazole					90.9547 0.14 % 95.4
HL60 perturbed by 7.6e-06microM of orciprenaline					90.9065 0.04 % 95.43
HL60 perturbed by 8.6e-06microM of tobramycin					91.4035 0.1 % 95.65
HL60 perturbed by 1.28e-05microM of tolazamide					91.5693 0.53 % 95.52
MCF7 perturbed by 1.32e-05microM of mianserin					92.4816 2.01 % 95.23
HL60 perturbed by 1.28e-05microM of sulfadimethoxine					90.9841 0.02 % 95.48
HL60 perturbed by 9.2e-06microM of suxibuzone					88.8415 1.69 % 93.58
MCF7 perturbed by 1.22e-05microM of clozapine					93.8489 0.27 % 96.79
MCF7 perturbed by 1e-07microM of trichostatin A					93.7279 0.06 % 96.83
vehicle					93.6565 0 % 96.83
MCF7 perturbed by 9.2e-06microM of clidinium bromide					90.2227 0.1 % 95.06
MCF7 perturbed by 1.72e-05microM of isocarboxazid					92.3102 0.74 % 95.79
MCF7 perturbed by 9.6e-06microM of ramipril					90.8094 5.91 % 92.45
MCF7 perturbed by 1.14e-05microM of tridihexethyl					89.8553 5.04 % 92.41
MCF7 perturbed by 1.14e-05microM of torasemide					87.6308 5.76 % 90.94
HL60 perturbed by 1e-05microM of genistein					90.0656 3.4 % 93.33
HL60 perturbed by 1e-08microM of fulvestrant					90.9695 1.87 % 94.55
HL60 perturbed by 8.8e-06microM of cefoxitin					91.1269 3.89 % 93.62
HL60 perturbed by 1e-05microM of thioridazine					91.3084 8.55 % 91.38
HL60 perturbed by 1e-06microM of tanespimycin					90.6247 3.5 % 93.56
HL60 perturbed by 1.46e-05microM of ebselen					91.8207 2.76 % 94.53
HL60 perturbed by 1e-08microM of alpha-estradiol					91.2279 2.86 % 94.18
HL60 perturbed by 1e-05microM of haloperidol					90.6344 0.08 % 95.28
MCF7 perturbed by 1.28e-05microM of cyclobenzaprine					93.0099 0 % 96.5
MCF7 perturbed by 3e-06microM of cyanocobalamin					91.1559 0.38 % 95.39
MCF7 perturbed by 1.64e-05microM of biotin					91.8715 0 % 95.94
MCF7 perturbed by 1.84e-05microM of primidone					91.8727 6.43 % 92.72
MCF7 perturbed by 5e-06microM of xamoterol					93.301 2.61 % 95.35
MCF7 perturbed by 7.6e-06microM of ceforanide					93.6377 2.25 % 95.69
MCF7 perturbed by 1.92e-05microM of moroxydine					92.5777 4.1 % 94.24
MCF7 perturbed by 9e-06microM of bisoprolol					93.4348 1.46 % 95.99
MCF7 perturbed by 9.2e-06microM of ethaverine					93.8945 3.85 % 95.02
MCF7 perturbed by 6.6e-06microM of oxantel					93.3806 0.69 % 96.34
MCF7 perturbed by 9e-06microM of debrisoquine					92.8146 1.35 % 95.73
MCF7 perturbed by 7.6e-06microM of rolitetracycline					92.7602 5.03 % 93.87
PC3 perturbed by 1e-05microM of 0179445-0000					90.6966 0.66 % 95.02
PC3 perturbed by 9.6e-06microM of mepenzolate bromide					89.099 1.36 % 93.87
MCF7 perturbed by 1e-06microM of 0179445-0000					89.3513 9.9 % 89.73
vehicle					92.0503 0 % 96.03
MCF7 perturbed by 9.4e-06microM of hydroquinine					92.0958 0.1 % 96
MCF7 perturbed by 1.22e-05microM of boldine					92.4239 5.17 % 93.63
vehicle					90.867 2.54 % 94.17
MCF7 perturbed by 2.12e-05microM of 3-acetylcoumarin					92.6289 0.45 % 96.09
MCF7 perturbed by 1e-06microM of fulvestrant					93.4619 0.08 % 96.69
MCF7 perturbed by 1.64e-05microM of azacitidine					92.7867 1.3 % 95.74
MCF7 perturbed by 1.54e-05microM of tiaprofenic acid					92.0998 2.75 % 94.68
MCF7 perturbed by 9.2e-06microM of fluvoxamine					92.7759 2.16 % 95.31
MCF7 perturbed by 1e-05microM of PHA-00851261E					91.5878 3.03 % 94.28
PC3 perturbed by 1.66e-05microM of phenformin					90.166 0 % 95.08
vehicle					91.3374 1.45 % 94.94
HL60 perturbed by 9.6e-06microM of prazosin					91.065 2.26 % 94.4
HL60 perturbed by 1.66e-05microM of idazoxan					91.9867 0.08 % 95.95
vehicle					91.4509 0.11 % 95.67
vehicle					92.6427 0.81 % 95.92
MCF7 perturbed by 1.62e-05microM of parthenolide					92.0256 1.17 % 95.43
MCF7 perturbed by 6.8e-06microM of pentamidine					92.0404 0.71 % 95.66
PC3 perturbed by 1e-06microM of PHA-00851261E					91.3815 3.16 % 94.11
PC3 perturbed by 1.3e-05microM of orphenadrine					91.9559 2.54 % 94.71
PC3 perturbed by 1.16e-05microM of corticosterone					90.209 2.65 % 93.78
MCF7 perturbed by 8.2e-06microM of lidoflazine					92.9018 2.68 % 95.11
vehicle					92.1206 3.21 % 94.46
MCF7 perturbed by 1e-05microM of colchicine					94.0836 2.1 % 95.99
MCF7 perturbed by 1.44e-05microM of chlorpropamide					94.0335 2.1 % 95.97
PC3 perturbed by 1.9e-05microM of zalcitabine					90.7636 21.34 % 84.71
PC3 perturbed by 1.56e-05microM of sulfathiazole					90.3677 2.12 % 94.12
HL60 perturbed by 1.3e-05microM of nadolol					91.7696 4.67 % 93.55
HL60 perturbed by 4.8e-06microM of roxithromycin					91.7116 3.18 % 94.27
vehicle					92.3401 1.15 % 95.6
HL60 perturbed by 1.32e-05microM of diclofenamide					92.0217 3.96 % 94.03
vehicle					87.5838 7.84 % 89.87
MCF7 perturbed by 1e-06microM of 0317956-0000					92.5962 1.08 % 95.76
MCF7 perturbed by 6e-06microM of deferoxamine					93.2944 0.49 % 96.4
MCF7 perturbed by 1.3e-05microM of orphenadrine					92.7073 0.08 % 96.31
MCF7 perturbed by 1.2e-05microM of metamizole sodium					93.0639 0.71 % 96.18
MCF7 perturbed by 2.52e-05microM of citiolone					92.5652 2.72 % 94.92
vehicle					92.0224 1.01 % 95.51
HL60 perturbed by 1.2e-05microM of sanguinarine					90.8325 12.55 % 89.14
HL60 perturbed by 3.4e-06microM of pyrvinium					90.8657 5.27 % 92.8
HL60 perturbed by 1.16e-05microM of gibberellic acid					91.354 0.05 % 95.65
HL60 perturbed by 1e-07microM of trichostatin A					91.569 0.05 % 95.76
MCF7 perturbed by 8.8e-06microM of primaquine					91.8658 0.44 % 95.71
MCF7 perturbed by 2.6e-06microM of iodixanol					91.995 1.49 % 95.25
MCF7 perturbed by 1.9e-05microM of zalcitabine					90.8793 3.37 % 93.75
MCF7 perturbed by 1.28e-05microM of dydrogesterone					92.5408 3.15 % 94.69
MCF7 perturbed by 1.74e-05microM of tocainide					91.6741 2.76 % 94.46
PC3 perturbed by 1.6e-05microM of gemfibrozil					89.0245 3.06 % 92.98
PC3 perturbed by 1.54e-05microM of oxolinic acid					89.936 3.19 % 93.37
PC3 perturbed by 8.6e-06microM of pivampicillin					90.5752 2.6 % 93.99
PC3 perturbed by 3.2e-06microM of beta-escin					91.5108 1.06 % 95.23
PC3 perturbed by 9e-06microM of Prestwick-1100					91.4242 1.89 % 94.77
PC3 perturbed by 1.52e-05microM of etamsylate					91.2294 4.96 % 93.13
PC3 perturbed by 1e-07microM of trichostatin A					91.9709 0.03 % 95.97
MCF7 perturbed by 1e-06microM of withaferin A					93.179 0.02 % 96.58
MCF7 perturbed by 8e-06microM of bacampicillin					93.8339 0.1 % 96.87
MCF7 perturbed by 1.5e-05microM of Prestwick-1080					93.1002 0 % 96.55
MCF7 perturbed by 1.34e-05microM of nialamide					93.0505 0 % 96.53
PC3 perturbed by 1.38e-05microM of guanabenz					92.8527 1.52 % 95.66
PC3 perturbed by 1.28e-05microM of clenbuterol					92.3612 2.91 % 94.73
MCF7 perturbed by 1.78e-05microM of 6-benzylaminopurine					91.036 2.39 % 94.33
PC3 perturbed by 1e-05microM of LY-294002					92.8772 0.33 % 96.27
PC3 perturbed by 1.12e-05microM of benzylpenicillin					93.2174 2.36 % 95.43
vehicle					91.707 4.21 % 93.75
PC3 perturbed by 5e-05microM of valproic acid					92.6655 1.46 % 95.6
PC3 perturbed by 9.2e-06microM of pipenzolate bromide					92.0327 0.62 % 95.71
PC3 perturbed by 1.06e-05microM of riboflavin					92.6808 0.54 % 96.07
vehicle					92.983 3.47 % 94.76
PC3 perturbed by 5.4e-06microM of ouabain					92.4808 0.09 % 96.2
PC3 perturbed by 1.16e-05microM of metixene					92.6694 0.01 % 96.33
PC3 perturbed by 1.34e-05microM of hydrochlorothiazide					92.8937 0 % 96.45
PC3 perturbed by 1.22e-05microM of desoxycortone					92.3293 2.54 % 94.89
PC3 perturbed by 9e-06microM of bisoprolol					92.2727 2.68 % 94.79
MCF7 perturbed by 8.2e-06microM of clebopride					93.722 0.27 % 96.73
MCF7 perturbed by 1.88e-05microM of baclofen					93.8149 0.44 % 96.69
MCF7 perturbed by 5.2e-06microM of tubocurarine chloride					93.9246 0.94 % 96.49
MCF7 perturbed by 1e-05microM of sulfasalazine					94.0341 0.7 % 96.67
MCF7 perturbed by 6.6e-06microM of benzonatate					94.1934 0.39 % 96.9
MCF7 perturbed by 1.1e-05microM of metolazone					93.2698 0.05 % 96.61
PC3 perturbed by 1.4e-05microM of kaempferol					91.9857 0.33 % 95.83
PC3 perturbed by 1.42e-05microM of ramifenazone					92.0697 0.04 % 96.01
PC3 perturbed by 8.8e-06microM of ursolic acid					92.0277 0.03 % 96
PC3 perturbed by 2.1e-05microM of pseudopelletierine					92.1165 0.14 % 95.99
PC3 perturbed by 9.4e-06microM of ticarcillin					88.1692 1.25 % 93.46
PC3 perturbed by 4.8e-06microM of abamectin					92.0326 0.07 % 95.98
PC3 perturbed by 1.02e-05microM of Prestwick-689					92.005 0.02 % 95.99
PC3 perturbed by 1.9e-05microM of milrinone					91.9658 0.2 % 95.88
MCF7 perturbed by 1.46e-05microM of harmalol					92.5118 0.06 % 96.22
MCF7 perturbed by 2.1e-05microM of octopamine					92.8579 1.02 % 95.92
MCF7 perturbed by 9e-06microM of lisinopril					91.9936 0.04 % 95.98
MCF7 perturbed by 1.38e-05microM of proguanil					92.01 0.01 % 96
PC3 perturbed by 6.2e-06microM of thioproperazine					93.2756 1.5 % 95.89
PC3 perturbed by 1.22e-05microM of cyclopentolate					92.6189 0 % 96.31
MCF7 perturbed by 1.38e-05microM of guanabenz					91.7223 0.61 % 95.55
PC3 perturbed by 1e-05microM of PF-00562151-00					92.0255 1.15 % 95.44
vehicle					93.2222 2.32 % 95.45
PC3 perturbed by 1e-05microM of PF-00562151-00					92.6757 0.84 % 95.92
MCF7 perturbed by 7e-06microM of latamoxef					91.8705 0.04 % 95.92
MCF7 perturbed by 2.8e-06microM of verteporfin					92.7861 1.74 % 95.52
MCF7 perturbed by 1.38e-05microM of diphenhydramine			Image:5500024035735011708567.A03.CEL probe-variance.png		92.4959 0.04 % 96.23
MCF7 perturbed by 1.44e-05microM of pentoxifylline					92.5083 0.01 % 96.25
vehicle					93.4801 0.5 % 96.49
MCF7 perturbed by 1.16e-05microM of calycanthine					93.9038 0.03 % 96.94
MCF7 perturbed by 1.16e-05microM of clotrimazole					93.8548 0.93 % 96.46
HL60 perturbed by 1e-05microM of genistein					89.7077 4.23 % 92.74
HL60 perturbed by 1e-06microM of tanespimycin					90.8877 0.27 % 95.31
HL60 perturbed by 1.04e-05microM of meropenem					90.005 5 % 92.5
PC3 perturbed by 2.06e-05microM of aminohippuric acid					91.8815 3.73 % 94.08
PC3 perturbed by 8.4e-06microM of butoconazole					91.428 3.52 % 93.96
MCF7 perturbed by 1e-05microM of orlistat					78.9843 3.72 % 87.63
vehicle					75.9596 3.36 % 86.3
vehicle					93.1376 0.11 % 96.51
MCF7 perturbed by 1.26e-05microM of diphenylpyraline					92.7826 0 % 96.39
vehicle					92.5104 0 % 96.26
MCF7 perturbed by 4e-06microM of lanatoside C					93.2843 0 % 96.64
MCF7 perturbed by 1.16e-05microM of fluorocurarine					92.4967 0.02 % 96.24
MCF7 perturbed by 1e-07microM of trichostatin A					91.1923 0 % 95.6
MCF7 perturbed by 1.7e-05microM of isosorbide					93.8221 0 % 96.91
MCF7 perturbed by 1.24e-05microM of promazine					92.5694 0 % 96.28
vehicle					82.2788 0.87 % 90.71
MCF7 perturbed by 1.14e-05microM of adiphenine					83.6745 1.41 % 91.13
vehicle					81.5512 0.29 % 90.63
MCF7 perturbed by 1.64e-05microM of dioxybenzone					92.2911 0.91 % 95.69
MCF7 perturbed by 8.4e-06microM of flucloxacillin					92.8141 0.07 % 96.37
MCF7 perturbed by 1e-08microM of wortmannin					82.3641 2.99 % 89.69
vehicle					83.9277 3.57 % 90.18
MCF7 perturbed by 1e-07microM of alvespimycin					82.8225 2.68 % 90.07
vehicle					87.6595 2.49 % 92.59
MCF7 perturbed by 1e-07microM of trichostatin A					83.96 1 % 91.48
PC3 perturbed by 7.8e-06microM of talampicillin					78.4163 1 % 88.71
PC3 perturbed by 1.04e-05microM of homochlorcyclizine					84.5124 0.07 % 92.22
PC3 perturbed by 1.56e-05microM of metrifonate					80.697 3.28 % 88.71
MCF7 perturbed by 1.96e-05microM of 3-acetamidocoumarin					77.0708 0.59 % 88.24
vehicle					75.9529 0.01 % 87.97
vehicle					79.0736 0.05 % 89.51
MCF7 perturbed by 1e-04microM of lomustine					76.8041 0.04 % 88.38
PC3 perturbed by 1e-04microM of lomustine					74.9792 0.36 % 87.31
MCF7 perturbed by 8.4e-06microM of trifluoperazine					79.7226 1.16 % 89.28
PC3 perturbed by 1e-05microM of 16-phenyltetranorprostaglandin E2					77.2634 5.21 % 86.03
MCF7 perturbed by 1e-07microM of vinblastine					80.3004 2.95 % 88.67