Connectivity Map Batch 02 Random Load - CMAP19

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	86.28 0.11 % 93.08
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 0.0005microM of valproic acid					85.3256 7.74 % 88.79
PC3 perturbed by 1e-05microM of thioridazine					86.2763 1.06 % 92.61
PC3 perturbed by 1e-06microM of geldanamycin					90.7143 0 % 95.36
PC3 perturbed by 0.0002microM of valproic acid					88.0787 0.11 % 93.99
HL60 perturbed by 1e-07microM of estradiol					89.8526 0.15 % 94.85
PC3 perturbed by 1e-06microM of tretinoin					90.458 0 % 95.23
MCF7 perturbed by 1.4e-05microM of lynestrenol					93.7258 0.14 % 96.79
MCF7 perturbed by 1.72e-05microM of captopril					93.1021 1.07 % 96.02
MCF7 perturbed by 1e-05microM of ampicillin					92.7106 0 % 96.36
MCF7 perturbed by 1.18e-05microM of sulpiride					93.6881 0.31 % 96.69
HL60 perturbed by 1.3e-05microM of quinisocaine					91.4354 0.03 % 95.7
HL60 perturbed by 1.36e-05microM of cinchonine					90.6852 0.19 % 95.25
HL60 perturbed by 6.4e-06microM of co-dergocrine mesilate					90.8635 0.06 % 95.4
HL60 perturbed by 1.08e-05microM of galantamine					90.8475 0.14 % 95.35
HL60 perturbed by 7.8e-06microM of eldeline					91.5986 0.03 % 95.78
HL60 perturbed by 1.18e-05microM of dantrolene					91.4825 4.81 % 93.34
HL60 perturbed by 1.24e-05microM of bupivacaine					91.7564 0.05 % 95.85
HL60 perturbed by 8.6e-06microM of dimenhydrinate					91.8747 0.18 % 95.85
PC3 perturbed by 8.4e-06microM of tetracycline					87.9338 1.44 % 93.25
MCF7 perturbed by 1e-05microM of genistein					93.3408 0 % 96.67
MCF7 perturbed by 5e-05microM of valproic acid					92.3443 0.12 % 96.11
HL60 perturbed by 7.4e-06microM of fusidic acid					89.8008 0.67 % 94.57
HL60 perturbed by 7.6e-06microM of pentoxyverine					89.7388 4.27 % 92.74
PC3 perturbed by 1.74e-05microM of naproxen					86.4319 1.77 % 92.33
PC3 perturbed by 1.8e-05microM of acetazolamide					89.4551 1.48 % 93.99
HL60 perturbed by 1.18e-05microM of quercetin					90.3161 0.03 % 95.14
HL60 perturbed by 1.5e-05microM of R-atenolol					90.4086 0.05 % 95.18
HL60 perturbed by 1.04e-05microM of benperidol					90.3789 0.24 % 95.07
vehicle					90.2449 0.44 % 94.9
MCF7 perturbed by 1.32e-05microM of nocodazole					92.8924 0.84 % 96.03
vehicle					92.8573 0.57 % 96.14
MCF7 perturbed by 6.4e-06microM of tiratricol					92.9489 0.25 % 96.35
MCF7 perturbed by 1.18e-05microM of suloctidil					92.9908 0.12 % 96.43
MCF7 perturbed by 6.6e-06microM of clomifene					92.804 0.62 % 96.09
MCF7 perturbed by 5e-06microM of merbromin					91.5362 0.09 % 95.72
MCF7 perturbed by 7.8e-06microM of calcium folinate					91.1316 0.15 % 95.49
MCF7 perturbed by 1.62e-05microM of tinidazole					90.8182 0 % 95.41
MCF7 perturbed by 8.4e-06microM of flecainide					89.4094 0.05 % 94.68
MCF7 perturbed by 1.22e-05microM of cyclic adenosine monophosphate					91.3335 3.22 % 94.06
MCF7 perturbed by 3.5e-05microM of chloropyrazine					92.0004 3.21 % 94.39
MCF7 perturbed by 1.52e-05microM of roxarsone					90.4296 3.67 % 93.38
HL60 perturbed by 1.42e-05microM of sulfamonomethoxine					89.918 7.44 % 91.24
HL60 perturbed by 5.4e-06microM of alimemazine					89.5288 5.68 % 91.92
HL60 perturbed by 9.2e-06microM of hecogenin					90.6294 0.13 % 95.25
MCF7 perturbed by 1.5e-05microM of ciclopirox					92.3901 0 % 96.19
vehicle					93.1898 0.15 % 96.52
MCF7 perturbed by 1.28e-05microM of progesterone					93.3596 0 % 96.68
MCF7 perturbed by 1.1e-05microM of adenosine phosphate					91.1566 16.47 % 87.35
MCF7 perturbed by 2.02e-05microM of mimosine					92.9674 2.45 % 95.26
MCF7 perturbed by 7e-06microM of hemicholinium					92.0151 4.52 % 93.75
PC3 perturbed by 1.3e-05microM of pempidine					90.822 0.1 % 95.36
MCF7 perturbed by 1.78e-05microM of 6-benzylaminopurine					87.5192 3.25 % 92.13
MCF7 perturbed by 1.44e-05microM of Prestwick-674					89.7755 0.19 % 94.79
vehicle					91.3184 0.03 % 95.64
MCF7 perturbed by 1e-05microM of thioridazine					92.4761 1 % 95.74
MCF7 perturbed by 1e-05microM of troglitazone					92.2212 0.67 % 95.78
MCF7 perturbed by 8.4e-06microM of lorglumide					91.9515 0.94 % 95.51
MCF7 perturbed by 6.6e-06microM of lasalocid					91.4887 0.51 % 95.49
MCF7 perturbed by 1.62e-05microM of methoxamine					92.4263 1.76 % 95.33
MCF7 perturbed by 1.1e-05microM of (+)-isoprenaline					93.0793 0.88 % 96.1
MCF7 perturbed by 1.22e-05microM of Prestwick-857					92.599 0.19 % 96.21
MCF7 perturbed by 2.1e-05microM of tetroquinone					91.3109 3.35 % 93.98
MCF7 perturbed by 8.6e-06microM of sulconazole					92.9612 0.38 % 96.29
vehicle					92.9282 0.49 % 96.22
MCF7 perturbed by 2.64e-05microM of paracetamol					92.0134 0 % 96.01
MCF7 perturbed by 1.22e-05microM of carteolol					92.3232 3.55 % 94.38
MCF7 perturbed by 1.26e-05microM of myricetin					92.7159 1.5 % 95.61
vehicle					91.9359 2.5 % 94.72
PC3 perturbed by 8.6e-06microM of metaraminol					90.6756 0.03 % 95.32
PC3 perturbed by 1.74e-05microM of kawain					90.883 0.02 % 95.43
vehicle					91.1556 0 % 95.58
PC3 perturbed by 1.42e-05microM of sulfamethoxypyridazine					91.5597 0 % 95.78
HL60 perturbed by 1.12e-05microM of florfenicol					91.118 0.03 % 95.55
HL60 perturbed by 1.68e-05microM of proxyphylline					91.1073 0.04 % 95.53
HL60 perturbed by 2.8e-06microM of bacitracin					88.9811 0.05 % 94.47
MCF7 perturbed by 1.32e-05microM of tetracaine					92.4173 0.64 % 95.89
MCF7 perturbed by 9.6e-06microM of hydrastine hydrochloride					92.2724 1.67 % 95.3
MCF7 perturbed by 7.8e-06microM of chloroquine					92.3446 0.63 % 95.85
MCF7 perturbed by 2.82e-05microM of piracetam					92.7766 0.07 % 96.35
PC3 perturbed by 8e-06microM of fluocinonide					91.9347 0.26 % 95.84
PC3 perturbed by 1.18e-05microM of ciclacillin					91.861 0.99 % 95.44
vehicle					91.4014 0.29 % 95.56
PC3 perturbed by 9.6e-06microM of solasodine					91.6598 0.37 % 95.64
PC3 perturbed by 9.8e-06microM of trimipramine					91.2951 0.16 % 95.57
PC3 perturbed by 6.4e-06microM of co-dergocrine mesilate					88.2244 0.86 % 93.68
vehicle					93.4571 2.84 % 95.31
MCF7 perturbed by 1.5e-05microM of albendazole					93.172 8.4 % 92.39
MCF7 perturbed by 1.16e-05microM of clotrimazole					93.3711 4.42 % 94.48
PC3 perturbed by 4.4e-06microM of nystatin					90.9874 4.31 % 93.34
PC3 perturbed by 1e-07microM of trichostatin A					90.8934 0.41 % 95.24
PC3 perturbed by 2.02e-05microM of theophylline					90.4719 0.14 % 95.16
HL60 perturbed by 1.84e-05microM of primidone					90.3831 5.73 % 92.33
vehicle					88.9962 5.35 % 91.82
HL60 perturbed by 1e-07microM of trichostatin A					90.9642 11.08 % 89.94
MCF7 perturbed by 1e-06microM of PHA-00745360					90.7484 0.66 % 95.04
MCF7 perturbed by 1.5e-05microM of diethylstilbestrol					91.9238 1.05 % 95.43
MCF7 perturbed by 3.5e-05microM of thiamazole					91.7798 0.23 % 95.78
HL60 perturbed by 1.64e-05microM of etomidate					90.7729 3.06 % 93.86
HL60 perturbed by 7.8e-06microM of talampicillin					90.0113 5.15 % 92.43
HL60 perturbed by 8.4e-06microM of tribenoside					90.4783 0.08 % 95.2
MCF7 perturbed by 3e-06microM of colistin					92.5258 1.74 % 95.39
vehicle					91.5952 1.68 % 94.96
MCF7 perturbed by 1.06e-05microM of trichlormethiazide					91.7252 2.1 % 94.81
MCF7 perturbed by 1.4e-05microM of probenecid					91.6948 0.32 % 95.69
PC3 perturbed by 1.02e-05microM of perhexiline					89.8312 0.66 % 94.59
PC3 perturbed by 1.02e-05microM of diethylcarbamazine					89.1136 2.48 % 93.32
PC3 perturbed by 1.12e-05microM of homatropine					89.9091 1.99 % 93.96
PC3 perturbed by 2.52e-05microM of allantoin					88.4283 2.14 % 93.15
PC3 perturbed by 1.24e-05microM of chloramphenicol					90.324 1.68 % 94.32
PC3 perturbed by 1e-06microM of citalopram					91.7308 0.11 % 95.81
PC3 perturbed by 1e-06microM of paroxetine					91.5065 0.25 % 95.63
PC3 perturbed by 1.66e-05microM of tetramisole					91.3544 0.03 % 95.66
PC3 perturbed by 1.34e-05microM of fenbendazole					89.9722 0.3 % 94.84
PC3 perturbed by 1.32e-05microM of chlorambucil					91.9601 0.06 % 95.95
MCF7 perturbed by 2.4e-05microM of ethionamide					93.3183 0.65 % 96.33
MCF7 perturbed by 1.06e-05microM of lithocholic acid					92.9355 0.01 % 96.46
vehicle					92.4231 0.01 % 96.21
MCF7 perturbed by 1.18e-05microM of sulpiride					90.5382 0.05 % 95.24
MCF7 perturbed by 1.3e-05microM of foliosidine					91.7344 0.96 % 95.38
MCF7 perturbed by 1.06e-05microM of Prestwick-685					91.1507 1.1 % 95.03
MCF7 perturbed by 1.42e-05microM of sulfamethoxypyridazine					91.7122 0.69 % 95.51
vehicle					92.3903 0.46 % 95.96
MCF7 perturbed by 1.58e-05microM of sulfamethoxazole					92.5865 0.49 % 96.05
PC3 perturbed by 1e-05microM of haloperidol					91.4868 0.01 % 95.74
PC3 perturbed by 9e-06microM of acepromazine					92.5217 0.98 % 95.77
vehicle					91.9119 1.26 % 95.32
PC3 perturbed by 4e-06microM of Chicago Sky Blue 6B					92.0604 0.01 % 96.02
PC3 perturbed by 1.86e-05microM of methoxsalen					91.7203 0.06 % 95.83
PC3 perturbed by 8.8e-06microM of methotrexate					92.4415 0.46 % 95.99
PC3 perturbed by 1.62e-05microM of naphazoline					91.8194 0.38 % 95.72
PC3 perturbed by 1.28e-05microM of progesterone					90.9351 0.75 % 95.09
vehicle					92.6076 1.01 % 95.8
MCF7 perturbed by 1.7e-05microM of arecoline					93.2412 0.05 % 96.6
MCF7 perturbed by 1.44e-05microM of iproniazid					93.1457 1.35 % 95.9
MCF7 perturbed by 1e-07microM of trichostatin A					93.349 0.05 % 96.65
MCF7 perturbed by 9.2e-06microM of budesonide					93.7907 0.2 % 96.8
PC3 perturbed by 1.2e-05microM of isoetarine					91.2866 2.85 % 94.22
MCF7 perturbed by 2.52e-05microM of allantoin					92.2723 0.07 % 96.1
PC3 perturbed by 8.4e-06microM of tetracycline					91.8122 0 % 95.91
vehicle					92.5135 0.04 % 96.24
PC3 perturbed by 6.2e-06microM of physostigmine					91.9819 0 % 95.99
PC3 perturbed by 1.42e-05microM of cicloheximide					91.9642 0.04 % 95.96
vehicle					89.809 1.96 % 93.92
MCF7 perturbed by 1.12e-05microM of hycanthone					89.4026 1.23 % 94.09
MCF7 perturbed by 1e-05microM of thioridazine					93.2338 0.24 % 96.5
PC3 perturbed by 1e-08microM of estradiol					91.5739 1.31 % 95.13
MCF7 perturbed by 8.4e-06microM of clofazimine					91.9291 0.17 % 95.88
MCF7 perturbed by 1.14e-05microM of biperiden					91.9587 3.73 % 94.11
vehicle					91.1125 2.44 % 94.34
MCF7 perturbed by 1e-05microM of thioridazine					92.705 2.35 % 95.18
MCF7 perturbed by 1.88e-05microM of serotonin					92.5018 0.39 % 96.06
MCF7 perturbed by 1e-05microM of trifluoperazine					90.792 0.1 % 95.35
vehicle					92.5715 3.4 % 94.58
MCF7 perturbed by 1e-07microM of alvespimycin					90.1966 0.17 % 95.01
vehicle					91.9531 0.06 % 95.94
MCF7 perturbed by 1.96e-05microM of ampyrone					92.5911 0.04 % 96.28
MCF7 perturbed by 1.06e-05microM of methylprednisolone					90.0866 2.81 % 93.64
MCF7 perturbed by 8.6e-06microM of pimozide					92.3342 0.04 % 96.15
MCF7 perturbed by 1.96e-05microM of Prestwick-1103					91.8517 0.12 % 95.86
vehicle					92.6462 0.28 % 96.18
MCF7 perturbed by 1.6e-05microM of Trolox C					92.9649 0.12 % 96.42
vehicle					93.6722 1.42 % 96.13
MCF7 perturbed by 5.6e-06microM of demecarium bromide					92.9963 3.3 % 94.85
vehicle					93.5565 3.08 % 95.24
vehicle					92.8218 2.42 % 95.2
vehicle					89.7752 3.65 % 93.06
HL60 perturbed by 8e-06microM of sertaconazole					89.6238 3.05 % 93.29
HL60 perturbed by 1e-07microM of sirolimus					88.2304 0.06 % 94.09
vehicle					91.1475 2.89 % 94.13
PC3 perturbed by 1e-05microM of SC-560					80.3822 2.4 % 88.99
PC3 perturbed by 1e-06microM of SB-202190					77.3289 4.04 % 86.64
MCF7 perturbed by 1e-05microM of 0297417-0002B					77.9906 2.58 % 87.71
MCF7 perturbed by 1e-05microM of AG-013608					93.5308 4.84 % 94.34
MCF7 perturbed by 0.0002microM of valproic acid					81.7012 1.16 % 90.27
MCF7 perturbed by 9.2e-06microM of timolol					91.5397 0.03 % 95.76
MCF7 perturbed by 8.2e-06microM of isometheptene					92.3331 0.08 % 96.13
MCF7 perturbed by 1.94e-05microM of dexibuprofen					92.7613 0.01 % 96.37
MCF7 perturbed by 2.08e-05microM of scopoletin					92.5511 0 % 96.28
MCF7 perturbed by 7.4e-06microM of halofantrine					92.3916 0.01 % 96.19
MCF7 perturbed by 1.48e-05microM of estrone					92.1747 0.21 % 95.98
vehicle					90.6605 3.31 % 93.67
MCF7 perturbed by 1e-06microM of fulvestrant					82.7165 5.95 % 88.38
MCF7 perturbed by 9.4e-06microM of pirenzepine					85.6654 1.47 % 92.1
MCF7 perturbed by 1.14e-05microM of vinpocetine					82.1155 2.99 % 89.56
MCF7 perturbed by 1.02e-05microM of proadifen					86.1172 0.17 % 92.97
MCF7 perturbed by 9.6e-06microM of tomatidine					86.4343 2.29 % 92.07
MCF7 perturbed by 1.28e-05microM of sulfadoxine					86.1235 0.16 % 92.98
PC3 perturbed by 1.2e-05microM of hydroflumethiazide					83.4524 3.85 % 89.8
PC3 perturbed by 1.26e-05microM of moxisylyte					81.0013 2.43 % 89.29
PC3 perturbed by 1.08e-05microM of morantel					80.2715 1.24 % 89.52
vehicle					77.4422 0.61 % 88.42
MCF7 perturbed by 9.6e-06microM of gabexate					78.4328 0.09 % 89.17
MCF7 perturbed by 4.2e-06microM of benzathine benzylpenicillin					77.2642 0.04 % 88.61
MCF7 perturbed by 1.84e-05microM of etilefrine					78.0462 0.57 % 88.74
PC3 perturbed by 1e-05microM of glycopyrronium bromide					75.0915 1.58 % 86.76
MCF7 perturbed by 1.4e-05microM of letrozole					76.397 1.52 % 87.44
MCF7 perturbed by 1.5e-05microM of pronetalol					79.5198 0.34 % 89.59
vehicle					82.6732 0.04 % 91.32
MCF7 perturbed by 1e-04microM of lomustine					80.2141 0.02 % 90.1
MCF7 perturbed by 1.16e-05microM of difenidol					80.6401 0.1 % 90.27
vehicle					83.1276 2.5 % 90.31