Connectivity Map Batch 02 Random Load - CMAP18

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	89.13 0.41 % 94.36
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
PC3 perturbed by 1e-05microM of 15-delta prostaglandin J2					88.4382 0.08 % 94.18
HL60 perturbed by 1e-07microM of monorden					89.1281 0.7 % 94.21
HL60 perturbed by 1e-05microM of vorinostat					87.1439 0.66 % 93.24
PC3 perturbed by 1e-07microM of monorden					87.5006 0.41 % 93.55
MCF7 perturbed by 1.06e-05microM of haloperidol					93.2238 0.07 % 96.58
MCF7 perturbed by 1.34e-05microM of hydrochlorothiazide					92.5823 1.34 % 95.62
MCF7 perturbed by 1.26e-05microM of amprolium					92.8662 3.04 % 94.91
MCF7 perturbed by 1.24e-05microM of cyproheptadine					92.7279 1.77 % 95.48
MCF7 perturbed by 1.06e-05microM of indapamide					92.5865 0.31 % 96.14
HL60 perturbed by 7.4e-06microM of helveticoside					91.1572 0.05 % 95.56
HL60 perturbed by 1.08e-05microM of bicuculline					91.0907 0.04 % 95.53
HL60 perturbed by 9.6e-06microM of mepenzolate bromide					90.7647 0.09 % 95.34
HL60 perturbed by 1.1e-05microM of prednisolone					91.331 0.21 % 95.56
HL60 perturbed by 1.02e-05microM of diethylcarbamazine					91.6717 0.2 % 95.74
HL60 perturbed by 8.4e-06microM of flunarizine					91.7734 0.08 % 95.85
vehicle					91.7504 2.15 % 94.8
HL60 perturbed by 6e-06microM of dilazep					91.9795 0.11 % 95.94
PC3 perturbed by 1.34e-05microM of oxymetazoline					87.4685 1.43 % 93.02
PC3 perturbed by 8.2e-06microM of nicergoline					88.6992 0.63 % 94.04
vehicle					88.7907 1.24 % 93.77
MCF7 perturbed by 1e-08microM of estradiol					92.5915 0.01 % 96.29
MCF7 perturbed by 1.8e-05microM of acetazolamide					91.9992 0.21 % 95.9
HL60 perturbed by 8.8e-06microM of primaquine					89.5442 0.82 % 94.36
HL60 perturbed by 1.26e-05microM of myricetin					89.7846 1.79 % 94
HL60 perturbed by 1.7e-05microM of epirizole					87.9188 2 % 92.96
HL60 perturbed by 7.2e-06microM of cefotiam					90.9046 1.69 % 94.61
HL60 perturbed by 1.16e-05microM of metixene					89.4853 0.17 % 94.66
HL60 perturbed by 2.14e-05microM of carbimazole					91.255 0.12 % 95.57
HL60 perturbed by 1.24e-05microM of etifenin					90.6983 1.12 % 94.79
MCF7 perturbed by 1.82e-05microM of ornidazole					92.2593 0.12 % 96.07
MCF7 perturbed by 2.36e-05microM of chlorzoxazone					92.6609 0.01 % 96.33
HL60 perturbed by 1.48e-05microM of sulfamethizole					91.4491 0.02 % 95.71
HL60 perturbed by 1.16e-05microM of fluorocurarine					90.7862 3.3 % 93.74
HL60 perturbed by 9.4e-06microM of bendroflumethiazide					90.7512 0.77 % 94.99
HL60 perturbed by 9.2e-06microM of estropipate					89.5753 5.31 % 92.13
MCF7 perturbed by 7.8e-06microM of flupentixol					91.9747 0.04 % 95.97
MCF7 perturbed by 7.6e-06microM of dequalinium chloride					92.9914 1.5 % 95.75
MCF7 perturbed by 1.42e-05microM of N6-methyladenosine					92.3331 0.12 % 96.11
MCF7 perturbed by 2.4e-05microM of oxedrine					89.5735 2.75 % 93.41
HL60 perturbed by 1e-05microM of 15-delta prostaglandin J2					89.2218 0.05 % 94.58
HL60 perturbed by 1e-05microM of LY-294002					89.5881 6.11 % 91.74
HL60 perturbed by 1e-06microM of geldanamycin					88.6603 7.89 % 90.39
HL60 perturbed by 2.18e-05microM of corbadrine					91.0146 0.03 % 95.49
MCF7 perturbed by 1.32e-05microM of neostigmine bromide					88.376 1.16 % 93.61
MCF7 perturbed by 5.2e-06microM of digoxin					92.3226 0.01 % 96.16
MCF7 perturbed by 7.8e-06microM of chlortetracycline					90.3295 10.3 % 90.01
vehicle					91.8451 9.79 % 91.03
PC3 perturbed by 1e-06microM of PNU-0230031					90.62 0.95 % 94.84
PC3 perturbed by 1.4e-05microM of tropicamide					90.5546 1.49 % 94.53
PC3 perturbed by 4.8e-06microM of spiramycin					89.6886 0.26 % 94.71
PC3 perturbed by 7.4e-06microM of piperacillin					88.774 0.92 % 93.93
PC3 perturbed by 1.36e-05microM of meclofenoxate					90.2645 4.05 % 93.11
MCF7 perturbed by 7.8e-06microM of gossypol					87.304 2.28 % 92.51
MCF7 perturbed by 1.36e-05microM of meclofenoxate					87.6059 1.68 % 92.96
MCF7 perturbed by 1.3e-05microM of quinisocaine					90.6015 6.88 % 91.86
MCF7 perturbed by 1.12e-05microM of yohimbic acid					89.5792 0.02 % 94.78
MCF7 perturbed by 9.6e-06microM of tomatidine					89.5866 6.59 % 91.5
MCF7 perturbed by 0.0005microM of valproic acid					91.0005 0.85 % 95.08
MCF7 perturbed by 1e-08microM of fulvestrant					91.6059 1.92 % 94.84
MCF7 perturbed by 6.2e-06microM of liothyronine					91.7976 2.38 % 94.71
MCF7 perturbed by 9e-06microM of propantheline bromide					92.1984 2.61 % 94.79
MCF7 perturbed by 9.8e-06microM of spectinomycin					90.9829 1.79 % 94.6
MCF7 perturbed by 1.78e-05microM of furazolidone					92.3214 0.28 % 96.02
MCF7 perturbed by 8.8e-06microM of nafcillin					91.8642 0.01 % 95.93
vehicle					89.4696 2.88 % 93.3
MCF7 perturbed by 1.24e-05microM of promazine					90.2813 2.02 % 94.13
PC3 perturbed by 1e-06microM of 0173570-0000					90.2621 0.01 % 95.13
PC3 perturbed by 8.4e-06microM of cefazolin					90.5215 0.87 % 94.83
PC3 perturbed by 8.2e-06microM of flunixin					91.1028 0 % 95.55
HL60 perturbed by 8.4e-06microM of flucloxacillin					90.7115 0.17 % 95.27
HL60 perturbed by 1.08e-05microM of Prestwick-981					89.5471 0.04 % 94.75
MCF7 perturbed by 1.18e-05microM of thiamine					91.9376 0.38 % 95.78
MCF7 perturbed by 5.6e-06microM of dihydroergocristine					92.2189 0.9 % 95.66
MCF7 perturbed by 1.8e-05microM of etamivan					92.6892 0.49 % 96.1
PC3 perturbed by 2.02e-05microM of guaifenesin					92.5627 0.57 % 96
PC3 perturbed by 1.4e-05microM of sulfachlorpyridazine					91.5676 0.88 % 95.35
vehicle					92.3185 0.44 % 95.94
PC3 perturbed by 1.5e-05microM of Prestwick-1080					91.806 0.19 % 95.81
PC3 perturbed by 1.96e-05microM of 4-hydroxyphenazone					91.5712 0.98 % 95.3
PC3 perturbed by 2.28e-05microM of N-acetyl-L-aspartic acid					92.0129 0.42 % 95.8
PC3 perturbed by 1.3e-05microM of sotalol					91.3632 0.14 % 95.61
PC3 perturbed by 2.34e-05microM of propylthiouracil					90.741 0.01 % 95.36
vehicle					91.6735 0.42 % 95.63
MCF7 perturbed by 1.48e-05microM of zaprinast					92.1999 2.12 % 95.04
MCF7 perturbed by 1.18e-05microM of dobutamine					92.8995 2.1 % 95.4
PC3 perturbed by 1.6e-05microM of diflunisal					91.6637 0 % 95.83
PC3 perturbed by 1.74e-05microM of tocainide					91.1777 0.01 % 95.59
HL60 perturbed by 1.48e-05microM of arcaine					90.1459 8.74 % 90.7
HL60 perturbed by 7e-06microM of latamoxef					89.3778 25.93 % 81.73
vehicle					91.2191 1.53 % 94.84
MCF7 perturbed by 8e-06microM of fluocinonide					91.9905 1.04 % 95.48
MCF7 perturbed by 1.36e-05microM of oxaprozin					92.5902 0.7 % 95.95
HL60 perturbed by 7.4e-06microM of levopropoxyphene					90.7516 0.06 % 95.35
HL60 perturbed by 5.8e-06microM of penbutolol					91.2371 0.27 % 95.48
MCF7 perturbed by 1.16e-05microM of buflomedil					92.5014 2.1 % 95.2
MCF7 perturbed by 1.46e-05microM of nifuroxazide					91.8297 2.07 % 94.88
MCF7 perturbed by 1.4e-05microM of letrozole					90.1174 0.34 % 94.89
PC3 perturbed by 9.2e-06microM of vitexin					91.6623 0.66 % 95.5
PC3 perturbed by 1.72e-05microM of captopril					91.2371 2.47 % 94.38
vehicle					90.9459 0.25 % 95.35
PC3 perturbed by 1.34e-05microM of nialamide					91.8996 0.18 % 95.86
MCF7 perturbed by 1.48e-05microM of lidocaine					91.7216 0 % 95.86
MCF7 perturbed by 1.62e-05microM of tinidazole					93.1416 0 % 96.57
MCF7 perturbed by 2.68e-05microM of 2-6-dimethylpiperidine					92.9596 0.05 % 96.46
vehicle					93.0081 0.35 % 96.33
MCF7 perturbed by 1e-07microM of trichostatin A					91.7492 0.01 % 95.87
PC3 perturbed by 1.14e-05microM of biperiden					91.9182 1.02 % 95.45
PC3 perturbed by 9.6e-06microM of dehydrocholic acid					92.316 1.06 % 95.63
PC3 perturbed by 5.8e-06microM of amiodarone					91.6512 0.84 % 95.4
PC3 perturbed by 1.5e-05microM of equilin					92.8964 0.03 % 96.43
PC3 perturbed by 6.8e-06microM of doxorubicin					91.404 7.18 % 92.11
vehicle					91.2306 0.79 % 95.22
MCF7 perturbed by 1.4e-05microM of tropicamide					91.558 0.96 % 95.3
MCF7 perturbed by 2.04e-05microM of hydralazine					91.4511 1.38 % 95.04
MCF7 perturbed by 8.2e-06microM of flunixin					92.5765 0.53 % 96.03
vehicle					91.8484 1.27 % 95.29
PC3 perturbed by 8.6e-06microM of clobetasol					93.1098 2.39 % 95.36
PC3 perturbed by 1e-07microM of alvespimycin					91.9773 0 % 95.99
PC3 perturbed by 1e-07microM of estradiol					92.1889 1.29 % 95.45
PC3 perturbed by 1.18e-05microM of famotidine					92.7272 0.21 % 96.26
PC3 perturbed by 6.6e-06microM of amikacin					90.4511 0.23 % 95.11
PC3 perturbed by 8.6e-06microM of glycocholic acid					92.1331 0.14 % 96
PC3 perturbed by 1.4e-05microM of lynestrenol					92.7167 0.02 % 96.35
PC3 perturbed by 9.4e-06microM of urapidil					91.7372 0 % 95.87
PC3 perturbed by 3.1e-05microM of flucytosine					91.5156 0.85 % 95.33
PC3 perturbed by 9.2e-06microM of fluvastatin					91.6527 0.47 % 95.59
MCF7 perturbed by 1.56e-05microM of ganciclovir					92.7442 0.22 % 96.26
PC3 perturbed by 1.42e-05microM of sulfamonomethoxine					91.4382 0.39 % 95.53
vehicle					90.461 3.76 % 93.35
PC3 perturbed by 8.2e-06microM of cefmetazole					91.6046 0.54 % 95.53
PC3 perturbed by 9.8e-06microM of ipratropium bromide					91.5183 0.36 % 95.58
MCF7 perturbed by 2.04e-05microM of bethanechol					91.5962 3.45 % 94.07
MCF7 perturbed by 1e-07microM of trichostatin A					91.4663 1.79 % 94.84
MCF7 perturbed by 1.24e-05microM of chloramphenicol					91.4194 0.92 % 95.25
PC3 perturbed by 1.16e-05microM of fluorocurarine					92.0332 0.7 % 95.67
PC3 perturbed by 9.6e-06microM of spironolactone					93.0831 0.54 % 96.27
MCF7 perturbed by 1.86e-05microM of niridazole					91.2243 2.45 % 94.39
vehicle					91.2313 1.55 % 94.84
PC3 perturbed by 1e-07microM of sirolimus					91.7839 0 % 95.89
PC3 perturbed by 1e-06microM of trichostatin A					91.6433 0.03 % 95.81
PC3 perturbed by 1e-07microM of valinomycin					91.5926 0.1 % 95.74
MCF7 perturbed by 1e-06microM of tanespimycin					91.4529 1.3 % 95.08
MCF7 perturbed by 1e-07microM of estradiol					90.4205 0.29 % 95.06
MCF7 perturbed by 1.02e-05microM of oxybutynin					90.175 2.97 % 93.6
vehicle					91.6916 0.14 % 95.77
MCF7 perturbed by 6.6e-06microM of lymecycline					92.3498 0 % 96.17
MCF7 perturbed by 1.34e-05microM of imipenem					92.8012 0.03 % 96.38
vehicle					90.4266 0.2 % 95.11
MCF7 perturbed by 1.44e-05microM of bupropion					93.3518 0.08 % 96.63
HL60 perturbed by 1.84e-05microM of mephenytoin					87.9327 5.34 % 91.3
HL60 perturbed by 1.24e-05microM of oxyphenbutazone					85.8975 4.22 % 90.84
vehicle					88.7163 3.48 % 92.62
HL60 perturbed by 1.62e-05microM of (-)-isoprenaline					88.839 3.45 % 92.7
PC3 perturbed by 1.28e-05microM of amitriptyline					91.2072 3.03 % 94.09
PC3 perturbed by 1.44e-05microM of chlorpropamide					91.1765 3.44 % 93.87
PC3 perturbed by 2.64e-05microM of paracetamol					91.6591 0.64 % 95.51
PC3 perturbed by 9.4e-06microM of flavoxate					90.9494 3.39 % 93.78
MCF7 perturbed by 1e-06microM of trichostatin A					77.9896 2.72 % 87.63
MCF7 perturbed by 1e-06microM of SB-203580					77.9956 3.32 % 87.34
vehicle					79.169 2.5 % 88.33
PC3 perturbed by 1e-05microM of F0447-0125					92.4826 1.66 % 95.41
MCF7 perturbed by 1e-05microM of PF-01378883-00					92.9123 2.38 % 95.26
MCF7 perturbed by 1e-05microM of orlistat					93.0439 1.93 % 95.56
PC3 perturbed by 5e-05microM of 5707885					92.3341 0 % 96.17
MCF7 perturbed by 2.06e-05microM of butamben					91.7323 0 % 95.87
MCF7 perturbed by 4.8e-06microM of abamectin					93.0631 0 % 96.53
MCF7 perturbed by 8.6e-06microM of delsoline					93.1186 0 % 96.56
MCF7 perturbed by 9.6e-06microM of cefalotin					92.5902 0.01 % 96.29
MCF7 perturbed by 1e-05microM of LY-294002					82.0727 1.57 % 90.25
MCF7 perturbed by 1e-07microM of LY-294002					81.2978 0.85 % 90.22
MCF7 perturbed by 7.4e-06microM of mesoridazine					84.7696 2.13 % 91.32
MCF7 perturbed by 1.64e-05microM of ribavirin					90.9007 0.07 % 95.41
MCF7 perturbed by 1.32e-05microM of pipemidic acid					92.3446 0.1 % 96.12
MCF7 perturbed by 1.2e-05microM of alfaxalone					91.8121 0 % 95.9
MCF7 perturbed by 1.1e-05microM of nitrendipine					91.7218 0 % 95.86
MCF7 perturbed by 8.4e-06microM of lorglumide					91.9398 0.01 % 95.97
MCF7 perturbed by 1.3e-05microM of nisoxetine					91.7343 0.65 % 95.54
MCF7 perturbed by 2.24e-05microM of esculetin					91.9488 0 % 95.97
vehicle					91.6947 3.66 % 94.02
PC3 perturbed by 1.5e-05microM of STOCK1N-35696					89.5053 4.13 % 92.69
vehicle					81.1543 7.13 % 87.01
MCF7 perturbed by 1.4e-05microM of kaempferol					82.8607 1.73 % 90.57
MCF7 perturbed by 6.4e-06microM of tetrandrine					85.159 1.74 % 91.71
vehicle					83.9552 1.93 % 91.01
MCF7 perturbed by 1.6e-05microM of harmine					82.09 3.32 % 89.38
MCF7 perturbed by 9.2e-06microM of suxibuzone					84.8139 0.19 % 92.31
MCF7 perturbed by 6e-06microM of natamycin					83.5919 0.64 % 91.48
PC3 perturbed by 1.24e-05microM of articaine					82.7326 2.91 % 89.91
PC3 perturbed by 2.26e-05microM of Prestwick-972					81.0554 1.26 % 89.9
PC3 perturbed by 1.16e-05microM of nifedipine					81.9912 1.91 % 90.04
PC3 perturbed by 1.02e-05microM of yohimbine					75.0729 0.12 % 87.48
vehicle					77.7099 0.83 % 88.44
PC3 perturbed by 1.1e-05microM of tiapride					76.8304 0.61 % 88.11
MCF7 perturbed by 5e-07microM of colforsin					78.7104 0.12 % 89.3
PC3 perturbed by 1e-05microM of alsterpaullone					77.4953 0.1 % 88.7
MCF7 perturbed by 5.8e-06microM of penbutolol					81.0332 0.06 % 90.48
MCF7 perturbed by 9.8e-06microM of pimethixene					78.1311 0.46 % 88.84
MCF7 perturbed by 9e-06microM of telenzepine					81.769 0.59 % 90.59
MCF7 perturbed by 1e-05microM of BCB000040					81.756 3.38 % 89.19
PC3 perturbed by 1e-05microM of 15(S)-15-methylprostaglandin E2					82.1029 2.19 % 89.96
PC3 perturbed by 1e-05microM of 16-phenyltetranorprostaglandin E2					80.7739 2.35 % 89.21