Connectivity Map Batch 02 Random Load - CMAP17

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	90.12 0.05 % 95.04
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
vehicle					82.8805 10.05 % 86.41
PC3 perturbed by 1e-06microM of trichostatin A					90.1238 0.03 % 95.05
PC3 perturbed by 1e-05microM of vorinostat					86.0269 0.19 % 92.92
PC3 perturbed by 1e-07microM of LY-294002					90.3468 0.05 % 95.15
PC3 perturbed by 1e-06microM of fulvestrant					90.6211 0.1 % 95.26
MCF7 perturbed by 1.54e-05microM of khellin					92.7175 0.62 % 96.05
MCF7 perturbed by 1.6e-05microM of diflunisal					93.1221 0.02 % 96.55
MCF7 perturbed by 9.8e-06microM of thioridazine					91.6005 4.39 % 93.61
MCF7 perturbed by 1.08e-05microM of ciprofloxacin					92.6558 1.6 % 95.53
MCF7 perturbed by 6.4e-06microM of apomorphine					93.0108 0.38 % 96.32
MCF7 perturbed by 8.6e-06microM of metaraminol					92.7881 10.98 % 90.9
vehicle					91.0832 1.68 % 94.7
HL60 perturbed by 3.2e-06microM of beta-escin					91.1874 0.04 % 95.58
HL60 perturbed by 1.3e-05microM of orphenadrine					91.3411 3.63 % 93.86
HL60 perturbed by 1.04e-05microM of homochlorcyclizine					89.528 0.03 % 94.75
HL60 perturbed by 9e-06microM of lincomycin					90.3137 0.02 % 95.15
vehicle					87.9914 1.29 % 93.35
PC3 perturbed by 1.3e-05microM of nimesulide					87.7203 2.45 % 92.64
PC3 perturbed by 1.66e-05microM of levamisole					87.9503 2.79 % 92.58
PC3 perturbed by 7e-06microM of tamoxifen					87.5812 1.86 % 92.86
MCF7 perturbed by 1.16e-05microM of nifedipine					92.1026 0.12 % 95.99
HL60 perturbed by 9.8e-06microM of ginkgolide A					90.2178 5.58 % 92.32
HL60 perturbed by 1.42e-05microM of N6-methyladenosine					89.031 2.05 % 93.49
HL60 perturbed by 1.48e-05microM of procainamide					89.4076 1.74 % 93.83
PC3 perturbed by 1.14e-05microM of adiphenine					90.2426 0 % 95.12
PC3 perturbed by 6.6e-06microM of benzonatate					90.1662 4.84 % 92.67
HL60 perturbed by 1.26e-05microM of moxisylyte					89.4186 0.56 % 94.43
HL60 perturbed by 1.48e-05microM of todralazine					85.1209 2.73 % 91.2
PC3 perturbed by 1.46e-05microM of meticrane					90.076 0.68 % 94.7
HL60 perturbed by 2.32e-05microM of menadione					90.0813 0.16 % 94.96
HL60 perturbed by 1.64e-05microM of biotin					90.0256 0.6 % 94.71
MCF7 perturbed by 2.84e-05microM of ethosuximide					92.902 1.1 % 95.9
MCF7 perturbed by 4.2e-06microM of neomycin					92.335 0.3 % 96.02
MCF7 perturbed by 1.42e-05microM of xylometazoline					92.6638 0.01 % 96.32
MCF7 perturbed by 8.2e-06microM of nicergoline					92.3828 0.43 % 95.98
MCF7 perturbed by 1.74e-05microM of diazoxide					93.0206 0.18 % 96.42
MCF7 perturbed by 7e-06microM of tamoxifen					92.6785 0.56 % 96.06
HL60 perturbed by 7.6e-06microM of alclometasone					90.6634 0.08 % 95.29
HL60 perturbed by 1.18e-05microM of dicoumarol					86.6407 10.93 % 87.85
HL60 perturbed by 1.42e-05microM of sulfamethoxypyridazine					90.95 1.26 % 94.84
MCF7 perturbed by 8.2e-06microM of clebopride					92.2297 0.01 % 96.11
MCF7 perturbed by 1.84e-05microM of securinine					89.888 0.1 % 94.9
MCF7 perturbed by 1.7e-05microM of methazolamide					91.1594 0.17 % 95.5
MCF7 perturbed by 1.34e-05microM of sulfadimidine					90.4072 0.07 % 95.17
MCF7 perturbed by 1.02e-05microM of pridinol					91.4686 0.36 % 95.56
MCF7 perturbed by 1.28e-05microM of levonorgestrel					92.1239 0 % 96.06
MCF7 perturbed by 1.34e-05microM of hexylcaine					91.9957 0.01 % 95.99
MCF7 perturbed by 3.2e-06microM of ioxaglic acid					88.5726 5.29 % 91.64
HL60 perturbed by 5.2e-06microM of iopamidol					89.2655 0.24 % 94.51
HL60 perturbed by 1.34e-05microM of hexylcaine					88.2607 1.02 % 93.62
MCF7 perturbed by 1.16e-05microM of metixene					90.6045 0.01 % 95.3
MCF7 perturbed by 4e-06microM of Chicago Sky Blue 6B					90.0584 0.01 % 95.02
MCF7 perturbed by 1.72e-05microM of melatonin					89.2344 1.27 % 93.98
MCF7 perturbed by 9.6e-06microM of ambroxol					91.1902 3.35 % 93.92
vehicle					91.087 14.04 % 88.52
MCF7 perturbed by 5e-06microM of midecamycin					90.6196 10.39 % 90.12
MCF7 perturbed by 6.4e-06microM of apomorphine					91.5697 4.5 % 93.53
MCF7 perturbed by 2.04e-05microM of meglumine					92.4413 2.41 % 95.02
vehicle					88.9659 1.29 % 93.84
PC3 perturbed by 1.34e-05microM of sulfadimidine					89.415 0.07 % 94.67
PC3 perturbed by 8.6e-06microM of benfotiamine					88.7808 2.65 % 93.07
MCF7 perturbed by 1.4e-05microM of tropicamide					88.0429 1.2 % 93.42
MCF7 perturbed by 2.3e-05microM of gramine					91.0438 2.13 % 94.46
MCF7 perturbed by 1e-05microM of LY-294002					91.0455 0.57 % 95.24
MCF7 perturbed by 1e-07microM of alvespimycin					91.228 0.81 % 95.21
vehicle					91.8347 0.98 % 95.43
MCF7 perturbed by 1.62e-05microM of naphazoline					91.5977 1.16 % 95.22
MCF7 perturbed by 1.22e-05microM of diloxanide					90.5684 0 % 95.28
MCF7 perturbed by 1.26e-05microM of tolmetin					90.1798 2.54 % 93.82
MCF7 perturbed by 3.5e-05microM of Prestwick-860					92.1994 0.04 % 96.08
vehicle					92.2669 0.04 % 96.12
MCF7 perturbed by 9.8e-06microM of trimipramine					91.2166 0.07 % 95.57
MCF7 perturbed by 2.8e-05microM of trimethadione					90.9883 0 % 95.49
vehicle					91.5209 0.02 % 95.75
MCF7 perturbed by 6.4e-06microM of co-dergocrine mesilate					90.8179 0.86 % 94.98
MCF7 perturbed by 1.34e-05microM of sulfadimidine					90.9086 0.74 % 95.09
MCF7 perturbed by 9.6e-06microM of solasodine					87.9868 3.59 % 92.2
PC3 perturbed by 1.06e-05microM of karakoline					88.7098 0 % 94.35
vehicle					89.1348 4.28 % 92.43
HL60 perturbed by 1.94e-05microM of dexibuprofen					90.0295 0.04 % 94.99
HL60 perturbed by 1.94e-05microM of trapidil					89.7864 0.07 % 94.86
HL60 perturbed by 1.02e-05microM of alfadolone					90.602 0.03 % 95.29
vehicle					90.8635 0.04 % 95.41
HL60 perturbed by 3.04e-05microM of aminocaproic acid					90.8038 0.03 % 95.39
MCF7 perturbed by 1.18e-05microM of trimetazidine					92.0002 0.97 % 95.52
MCF7 perturbed by 7.4e-06microM of mesoridazine					91.9656 1.46 % 95.25
MCF7 perturbed by 2.4e-06microM of thiostrepton					91.7716 0.42 % 95.68
PC3 perturbed by 1.26e-05microM of phentolamine					91.3143 0.03 % 95.64
PC3 perturbed by 7.4e-06microM of helveticoside					91.5295 2.25 % 94.64
PC3 perturbed by 1.26e-05microM of myricetin					90.6855 0.89 % 94.9
PC3 perturbed by 3.5e-05microM of Prestwick-864					91.0019 0.64 % 95.18
vehicle					92.2896 7.1 % 92.6
MCF7 perturbed by 1.32e-05microM of desipramine					92.5978 2.12 % 95.24
vehicle					91.7358 0 % 95.87
vehicle					91.4297 0.42 % 95.51
PC3 perturbed by 1.1e-05microM of atovaquone					91.3538 0.04 % 95.66
PC3 perturbed by 1.16e-05microM of trimethylcolchicinic acid					90.5099 0.22 % 95.14
MCF7 perturbed by 1.06e-05microM of indapamide					90.4398 0.14 % 95.15
MCF7 perturbed by 1.62e-05microM of tinidazole					90.8849 1.47 % 94.71
MCF7 perturbed by 1.22e-05microM of pramocaine					91.0795 0.92 % 95.08
MCF7 perturbed by 1.18e-05microM of dicoumarol					91.5162 3.54 % 93.99
MCF7 perturbed by 9.2e-06microM of flunisolide					91.4761 2.68 % 94.4
vehicle					91.8412 1.95 % 94.94
MCF7 perturbed by 1.16e-05microM of gibberellic acid					89.0769 3.41 % 92.84
PC3 perturbed by 1.46e-05microM of harmalol					91.1253 0.62 % 95.25
PC3 perturbed by 1.7e-05microM of dropropizine					91.5699 0.37 % 95.6
PC3 perturbed by 1e-05microM of PHA-00745360					92.1826 0.01 % 96.09
PC3 perturbed by 1e-06microM of PHA-00745360					91.5816 0.56 % 95.51
vehicle					91.5006 0.07 % 95.72
PC3 perturbed by 1.18e-05microM of chlorcyclizine					90.8963 3.13 % 93.89
PC3 perturbed by 1.5e-05microM of Prestwick-1080					90.4162 0.25 % 95.08
MCF7 perturbed by 1.38e-05microM of Prestwick-642					92.4884 0.11 % 96.19
MCF7 perturbed by 3.5e-05microM of thiamazole					91.8295 0.03 % 95.9
vehicle					92.1899 0.4 % 95.9
PC3 perturbed by 9e-06microM of bephenium hydroxynaphthoate					92.311 1.68 % 95.31
PC3 perturbed by 1.24e-05microM of enoxacin					91.6057 0.19 % 95.71
PC3 perturbed by 8.4e-06microM of lorglumide					92.1525 0.67 % 95.74
PC3 perturbed by 1e-05microM of phthalylsulfathiazole					92.5864 1.24 % 95.67
PC3 perturbed by 1.76e-05microM of metyrapone					91.9335 1.1 % 95.41
MCF7 perturbed by 1.12e-05microM of benzamil					91.7149 0.65 % 95.53
vehicle					92.0737 0.15 % 95.96
PC3 perturbed by 1e-07microM of trichostatin A					91.0859 0.14 % 95.47
PC3 perturbed by 1e-08microM of alpha-estradiol					91.7336 0.85 % 95.44
PC3 perturbed by 1.5e-05microM of clonidine					91.5706 0.03 % 95.77
PC3 perturbed by 9.6e-06microM of cyproterone					92.7036 0.44 % 96.13
PC3 perturbed by 9.2e-06microM of estropipate					91.7621 0.14 % 95.81
PC3 perturbed by 1.22e-05microM of Prestwick-857					92.1614 0.03 % 96.07
PC3 perturbed by 1.08e-05microM of acebutolol					92.6516 0 % 96.33
PC3 perturbed by 1.1e-05microM of (+)-isoprenaline					91.9851 2.37 % 94.81
PC3 perturbed by 1.58e-05microM of lysergol					92.0924 0.06 % 96.02
PC3 perturbed by 1.3e-05microM of clorgiline					92.5282 0.11 % 96.21
PC3 perturbed by 1.04e-05microM of colecalciferol					91.2876 0.01 % 95.64
PC3 perturbed by 6.6e-06microM of clomifene					92.1309 0.16 % 95.99
PC3 perturbed by 1.16e-05microM of fluoxetine					92.3952 0.27 % 96.06
PC3 perturbed by 1.1e-05microM of adenosine phosphate					90.5784 0.07 % 95.25
PC3 perturbed by 7.8e-06microM of mitoxantrone					91.4871 1.89 % 94.8
MCF7 perturbed by 1.44e-05microM of chlorpropamide					92.8447 0.18 % 96.33
PC3 perturbed by 9.6e-06microM of podophyllotoxin					90.7997 0.04 % 95.38
PC3 perturbed by 1.08e-05microM of c1arizine					91.4368 2.07 % 94.68
MCF7 perturbed by 1.82e-05microM of ornidazole					90.4803 0.57 % 94.96
MCF7 perturbed by 1.08e-05microM of rimexolone					91.3158 2.41 % 94.45
MCF7 perturbed by 1e-07microM of trichostatin A					91.5734 0.3 % 95.64
PC3 perturbed by 1.6e-05microM of phenazopyridine					92.0287 0.28 % 95.87
PC3 perturbed by 7.8e-06microM of raloxifene					92.0774 0.49 % 95.79
PC3 perturbed by 2.84e-05microM of tropine					92.1287 0.36 % 95.88
PC3 perturbed by 1.48e-05microM of hexestrol					92.8178 0.52 % 96.15
MCF7 perturbed by 7.6e-06microM of ketoconazole					87.8788 1.19 % 93.35
MCF7 perturbed by 5.4e-06microM of bromocriptine					90.6495 0.37 % 95.14
MCF7 perturbed by 6.6e-06microM of naringin					91.1427 0.14 % 95.5
vehicle					92.4744 0 % 96.24
MCF7 perturbed by 1.22e-05microM of clozapine					90.6016 4.6 % 93
vehicle					92.0163 0.12 % 95.95
vehicle					89.7743 6.24 % 91.77
MCF7 perturbed by 7e-06microM of tamoxifen					90.7197 0 % 95.36
MCF7 perturbed by 6e-06microM of thiethylperazine					92.7334 3.03 % 94.85
HL60 perturbed by 1e-08microM of wortmannin					88.8281 3.47 % 92.68
vehicle					86.5323 8.31 % 89.11
vehicle					88.9379 3.61 % 92.66
HL60 perturbed by 1e-05microM of LY-294002					88.3079 4.64 % 91.84
HL60 perturbed by 5e-05microM of valproic acid					88.6322 3.65 % 92.49
HL60 perturbed by 0.0002microM of valproic acid					89.3756 3.75 % 92.81
PC3 perturbed by 1.02e-05microM of raubasine					90.8314 3.06 % 93.89
PC3 perturbed by 3.8e-05microM of BAS-012416453					75.6359 2.69 % 86.47
MCF7 perturbed by 1e-05microM of 3-nitropropionic acid					92.1749 1.29 % 95.44
PC3 perturbed by 1e-05microM of PF-01378883-00					92.8927 0 % 96.45
PC3 perturbed by 1e-05microM of orlistat					92.1211 1.55 % 95.29
MCF7 perturbed by 1e-05microM of C-75					92.1033 3.03 % 94.54
PC3 perturbed by 1e-05microM of AG-013608					90.3077 0 % 95.15
MCF7 perturbed by 1.48e-05microM of sulfamethizole					92.4111 0 % 96.21
MCF7 perturbed by 1.06e-05microM of famprofazone					92.4673 0.03 % 96.22
MCF7 perturbed by 0.0005microM of valproic acid					84.863 1.24 % 91.81
MCF7 perturbed by 9.8e-06microM of pergolide					82.72 1.15 % 90.79
MCF7 perturbed by 5.6e-06microM of dihydroergocristine					85.9549 2.31 % 91.82
MCF7 perturbed by 1.2e-05microM of Prestwick-1082					83.0547 2.14 % 90.46
vehicle					82.7825 2.03 % 90.38
MCF7 perturbed by 6.4e-06microM of tiratricol					81.6798 3.31 % 89.18
MCF7 perturbed by 2.26e-05microM of Prestwick-972					92.3406 0 % 96.17
MCF7 perturbed by 1e-05microM of alprostadil					91.2568 2.21 % 94.52
MCF7 perturbed by 1e-05microM of haloperidol					86.2249 4.09 % 91.07
MCF7 perturbed by 8.4e-06microM of doxycycline					84.1402 0.48 % 91.83
MCF7 perturbed by 1.18e-05microM of convolamine					83.5438 2.67 % 90.44
MCF7 perturbed by 9.4e-06microM of ticarcillin					83.7157 2.32 % 90.7
vehicle					83.9327 2.69 % 90.62
PC3 perturbed by 9.8e-06microM of pergolide					84.1445 0.6 % 91.77
vehicle					83.5406 4.24 % 89.65
PC3 perturbed by 2.8e-06microM of netilmicin					82.953 1.16 % 90.9
PC3 perturbed by 7.4e-06microM of mesoridazine					83.3052 2.97 % 90.17
PC3 perturbed by 6.6e-06microM of lymecycline					81.965 1.91 % 90.03
PC3 perturbed by 1.7e-05microM of epirizole					82.3383 2.32 % 90.01
vehicle					77.8815 0.51 % 88.69
MCF7 perturbed by 1e-07microM of trichostatin A					78.1238 0.26 % 88.93
MCF7 perturbed by 1e-05microM of 0316684-0000					80.0143 0.37 % 89.82
MCF7 perturbed by 1e-06microM of SB-202190					78.2678 0.49 % 88.89
PC3 perturbed by 5e-07microM of colforsin					80.9454 0.11 % 90.42
MCF7 perturbed by 1.1e-05microM of prednisolone					80.5787 1.62 % 89.48
MCF7 perturbed by 9e-06microM of econazole					78.7025 0.18 % 89.26
MCF7 perturbed by 1.28e-05microM of triprolidine					85.2725 0.01 % 92.63
MCF7 perturbed by 9.8e-06microM of trazodone					78.9007 0.07 % 89.42
MCF7 perturbed by 9e-06microM of lisinopril					81.4094 0.04 % 90.68
MCF7 perturbed by 1e-05microM of meteneprost					81.2164 2.99 % 89.11
PC3 perturbed by 1e-04microM of semustine					77.713 4.06 % 86.83