Connectivity Map Batch 02 Random Load - CMAP16

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.44 0 % 93.72
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-05microM of genistein					89.7125 0.83 % 94.44
HL60 perturbed by 1e-05microM of rosiglitazone					87.4423 0.88 % 93.28
PC3 perturbed by 1e-05microM of troglitazone					88.7327 1 % 93.87
MCF7 perturbed by 9e-06microM of loxapine					93.0092 0 % 96.5
MCF7 perturbed by 1e-07microM of trichostatin A					92.8031 0 % 96.4
MCF7 perturbed by 1.26e-05microM of phentolamine					93.1305 0 % 96.57
MCF7 perturbed by 1.12e-05microM of griseofulvin					91.4742 4.22 % 93.63
HL60 perturbed by 7.4e-06microM of Prestwick-692					90.6156 0.03 % 95.29
HL60 perturbed by 1.36e-05microM of picrotoxinin					88.1196 4.25 % 91.94
HL60 perturbed by 1.44e-05microM of Prestwick-674					89.361 0.05 % 94.66
HL60 perturbed by 9.6e-06microM of acemetacin					91.1752 0.01 % 95.58
HL60 perturbed by 1.72e-05microM of aminoglutethimide					91.3704 0.11 % 95.63
PC3 perturbed by 8.8e-06microM of cloxacillin					89.3138 0.67 % 94.32
PC3 perturbed by 3e-06microM of dihydroergotamine					89.2557 0.3 % 94.48
MCF7 perturbed by 1.28e-05microM of amitriptyline					92.252 0 % 96.13
MCF7 perturbed by 2.2e-05microM of heptaminol					92.4305 0 % 96.22
MCF7 perturbed by 1e-05microM of thioridazine					92.3829 0.2 % 96.09
MCF7 perturbed by 2.7e-05microM of betazole					92.1491 0.04 % 96.06
MCF7 perturbed by 0.001microM of valproic acid					92.5179 0 % 96.26
vehicle					92.4562 0.17 % 96.14
MCF7 perturbed by 1e-06microM of tanespimycin					92.4196 0 % 96.21
MCF7 perturbed by 2.62e-05microM of 8-azaguanine					91.5669 0.02 % 95.77
HL60 perturbed by 6.6e-06microM of hesperidin					89.5552 0.45 % 94.55
HL60 perturbed by 1.24e-05microM of ritodrine					89.3548 0.68 % 94.34
HL60 perturbed by 8e-06microM of calcium pantothenate					89.8306 0.3 % 94.76
HL60 perturbed by 1.16e-05microM of corticosterone					89.5425 0.1 % 94.72
HL60 perturbed by 1.74e-05microM of naproxen					88.116 0.12 % 94
HL60 perturbed by 1.38e-05microM of diphenhydramine					89.448 0.05 % 94.7
vehicle					89.7943 5.85 % 91.97
HL60 perturbed by 2.8e-06microM of sisomicin					89.9193 0.05 % 94.94
vehicle					90.2557 0.05 % 95.1
vehicle					89.2799 0.82 % 94.23
MCF7 perturbed by 1.96e-05microM of ampyrone					92.8798 0.24 % 96.32
MCF7 perturbed by 1.34e-05microM of oxymetazoline					92.1465 0.2 % 95.97
HL60 perturbed by 9.4e-06microM of mephentermine					89.4112 4.86 % 92.28
HL60 perturbed by 5.4e-06microM of butirosin					90.7478 0.01 % 95.37
HL60 perturbed by 9.8e-06microM of flumetasone					90.1898 0.36 % 94.91
MCF7 perturbed by 1e-07microM of trichostatin A					89.6753 0.01 % 94.83
MCF7 perturbed by 1.18e-05microM of dicoumarol					89.8382 0.02 % 94.91
MCF7 perturbed by 1.5e-05microM of vidarabine					91.8377 0.05 % 95.9
MCF7 perturbed by 2.62e-05microM of mesalazine					91.4373 3.06 % 94.19
MCF7 perturbed by 1.36e-05microM of trifluridine					91.8176 2.18 % 94.82
vehicle					91.012 2.34 % 94.33
HL60 perturbed by 1e-05microM of clozapine					88.5968 5.19 % 91.7
HL60 perturbed by 1e-06microM of chlorpromazine					89.4222 1.45 % 93.99
HL60 perturbed by 1e-06microM of tretinoin					89.4425 0.08 % 94.68
MCF7 perturbed by 8.6e-06microM of glycocholic acid					89.7605 0 % 94.88
MCF7 perturbed by 7.8e-06microM of mitoxantrone					89.9203 10.65 % 89.64
MCF7 perturbed by 1e-05microM of metergoline					91.9854 9.74 % 91.12
MCF7 perturbed by 1.42e-05microM of N6-methyladenosine					91.8201 3.87 % 93.98
PC3 perturbed by 1e-06microM of 0317956-0000					88.6463 0.1 % 94.27
vehicle					90.2398 0.01 % 95.11
PC3 perturbed by 9.2e-06microM of flunisolide					90.8388 0.67 % 95.09
MCF7 perturbed by 1.16e-05microM of medrysone					85.8218 1.91 % 91.95
vehicle					89.7021 0 % 94.85
MCF7 perturbed by 1.08e-05microM of berberine					89.4493 0.07 % 94.69
MCF7 perturbed by 1.62e-05microM of ellipticine					90.3217 6.65 % 91.84
MCF7 perturbed by 1.6e-05microM of harmine					89.6263 17.89 % 85.87
MCF7 perturbed by 1e-07microM of LY-294002					91.6884 0.49 % 95.6
MCF7 perturbed by 1.04e-05microM of etynodiol					91.2962 1.28 % 95.01
vehicle					90.4599 0.25 % 95.11
MCF7 perturbed by 1.04e-05microM of brinzolamide					91.1988 1 % 95.1
MCF7 perturbed by 9e-06microM of hydroxyzine					91.9482 0.51 % 95.72
MCF7 perturbed by 8.8e-06microM of methotrexate					92.301 0.55 % 95.88
MCF7 perturbed by 1.2e-05microM of nizatidine					91.1865 0.01 % 95.59
MCF7 perturbed by 1.18e-05microM of amiprilose					91.9554 0.02 % 95.97
MCF7 perturbed by 9.2e-06microM of ethaverine					92.3559 0 % 96.18
MCF7 perturbed by 1.12e-05microM of pheniramine					91.8858 0.9 % 95.49
MCF7 perturbed by 2.8e-06microM of sisomicin					91.6163 1.4 % 95.11
MCF7 perturbed by 1.22e-05microM of boldine					90.6826 0.86 % 94.91
MCF7 perturbed by 1e-07microM of trichostatin A					90.5854 0.14 % 95.22
vehicle					89.4817 2.48 % 93.5
PC3 perturbed by 1.08e-05microM of finasteride					89.5345 0 % 94.77
PC3 perturbed by 1e-06microM of PNU-0251126					89.9384 0 % 94.97
PC3 perturbed by 1.7e-05microM of isosorbide					88.0926 0 % 94.05
PC3 perturbed by 1.1e-05microM of cloperastine					89.6193 0.66 % 94.48
PC3 perturbed by 1.1e-05microM of tiapride					87.877 0 % 93.94
vehicle					90.0187 3.19 % 93.42
HL60 perturbed by 1.46e-05microM of rolipram					90.7823 0.02 % 95.38
MCF7 perturbed by 1e-07microM of trichostatin A					90.3969 2.41 % 93.99
MCF7 perturbed by 1.06e-05microM of propafenone					90.5594 1.25 % 94.66
MCF7 perturbed by 8.6e-06microM of cetirizine					90.6724 1.12 % 94.78
vehicle					91.7027 0.27 % 95.71
PC3 perturbed by 1e-06microM of CP-320650-01					91.9797 0.38 % 95.8
PC3 perturbed by 3.5e-05microM of thiamazole					92.055 0.14 % 95.96
PC3 perturbed by 1.06e-05microM of lithocholic acid					91.7957 0.1 % 95.85
vehicle					90.8777 2.76 % 94.06
PC3 perturbed by 1.84e-05microM of ethoxyquin					91.1945 1.31 % 94.94
PC3 perturbed by 1.1e-05microM of furaltadone					91.6047 0.94 % 95.33
PC3 perturbed by 1.62e-05microM of parbendazole					92.0364 0.21 % 95.91
PC3 perturbed by 1.3e-05microM of nadolol					90.3905 0.15 % 95.12
PC3 perturbed by 2.34e-05microM of metronidazole					90.2258 0.05 % 95.09
PC3 perturbed by 1.78e-05microM of furazolidone					90.018 0.53 % 94.74
PC3 perturbed by 1.4e-05microM of sulmazole					89.6495 0.16 % 94.75
PC3 perturbed by 1.48e-05microM of amylocaine					90.091 0.05 % 95.02
PC3 perturbed by 8.4e-06microM of metacycline					88.9159 0.22 % 94.35
PC3 perturbed by 1.58e-05microM of cimetidine					90.167 0.24 % 94.97
MCF7 perturbed by 1.5e-05microM of tremorine					91.6078 7.66 % 91.97
MCF7 perturbed by 1.4e-05microM of alprenolol					90.523 2.84 % 93.84
MCF7 perturbed by 7.8e-06microM of mitoxantrone					91.7486 2.14 % 94.81
MCF7 perturbed by 1.16e-05microM of benzydamine					92.5609 4.75 % 93.91
vehicle					92.307 2.87 % 94.72
MCF7 perturbed by 1.5e-05microM of practolol					92.4228 2.11 % 95.16
PC3 perturbed by 1.3e-05microM of epitiostanol					89.7371 0.37 % 94.69
PC3 perturbed by 1.28e-05microM of mestranol					91.0491 2.44 % 94.3
PC3 perturbed by 1.4e-05microM of letrozole					89.2809 0.09 % 94.6
PC3 perturbed by 8e-06microM of calcium pantothenate					91.1361 1 % 95.07
HL60 perturbed by 3.24e-05microM of nicotinic acid					90.8018 1.33 % 94.73
HL60 perturbed by 9.6e-06microM of aminophylline					91.1668 0.19 % 95.49
HL60 perturbed by 9.2e-06microM of fluvastatin					90.8431 1.49 % 94.68
HL60 perturbed by 5.2e-06microM of viomycin					90.4843 0.15 % 95.17
HL60 perturbed by 1.5e-05microM of zardaverine					89.6344 3.44 % 93.1
HL60 perturbed by 2.8e-06microM of netilmicin					90.3587 0.21 % 95.07
HL60 perturbed by 9.6e-06microM of sitosterol					91.0755 0.25 % 95.41
MCF7 perturbed by 1.54e-05microM of salsolinol					91.1495 0.01 % 95.57
PC3 perturbed by 1.24e-05microM of bupivacaine					90.1874 1.38 % 94.4
PC3 perturbed by 7.4e-06microM of Prestwick-692					90.1497 2.15 % 94
PC3 perturbed by 7.6e-06microM of terconazole					90.4149 0.39 % 95.01
vehicle					91.4394 0.18 % 95.63
PC3 perturbed by 1.18e-05microM of sulpiride					91.1288 0.42 % 95.35
MCF7 perturbed by 6.6e-06microM of iocetamic acid					92.1246 0.2 % 95.96
MCF7 perturbed by 1.6e-05microM of etidronic acid					91.628 0.05 % 95.79
PC3 perturbed by 1.9e-05microM of altretamine					92.3431 0.01 % 96.17
MCF7 perturbed by 1e-07microM of trichostatin A					92.2038 0.3 % 95.95
MCF7 perturbed by 1e-06microM of 0175029-0000					90.6047 0.48 % 95.06
MCF7 perturbed by 8.4e-06microM of Prestwick-664					91.5721 0.23 % 95.67
PC3 perturbed by 2.14e-05microM of amrinone					92.3396 1.21 % 95.56
PC3 perturbed by 1e-06microM of tanespimycin					91.408 0.66 % 95.37
PC3 perturbed by 9.6e-06microM of cefalotin					92.0512 1 % 95.53
PC3 perturbed by 9.8e-06microM of lovastatin					90.7786 0.01 % 95.39
PC3 perturbed by 1.04e-05microM of megestrol					91.9323 0 % 95.97
vehicle					91.7181 1.13 % 95.29
PC3 perturbed by 1.46e-05microM of estradiol					92.2574 0.04 % 96.11
PC3 perturbed by 7.8e-06microM of flupentixol					91.7166 0.15 % 95.78
PC3 perturbed by 2.14e-05microM of phenylpropanolamine					90.7005 0.57 % 95.07
PC3 perturbed by 1.04e-05microM of benfluorex					91.644 0.21 % 95.72
MCF7 perturbed by 1.76e-05microM of oxybenzone					92.9688 0.03 % 96.47
PC3 perturbed by 2.92e-05microM of isoniazid					89.968 0.66 % 94.66
vehicle					91.2363 1.14 % 95.05
PC3 perturbed by 2.8e-06microM of streptomycin					91.2623 0.92 % 95.17
PC3 perturbed by 1.36e-05microM of cinchonidine					91.4887 0.05 % 95.72
MCF7 perturbed by 9.4e-06microM of pizotifen					91.578 0.14 % 95.72
MCF7 perturbed by 1.14e-05microM of tridihexethyl					91.5421 0.19 % 95.68
MCF7 perturbed by 1.12e-05microM of homatropine					91.8781 0.01 % 95.94
MCF7 perturbed by 1.24e-05microM of gliclazide					91.745 0.67 % 95.54
MCF7 perturbed by 1.3e-05microM of nisoxetine					91.7614 0.03 % 95.87
PC3 perturbed by 1.46e-05microM of Prestwick-1085					92.686 0.05 % 96.32
MCF7 perturbed by 1.46e-05microM of chlormezanone					88.2525 1.28 % 93.49
PC3 perturbed by 1e-06microM of tanespimycin					92.11 0.01 % 96.05
MCF7 perturbed by 1e-05microM of PF-00875133-00					92.435 0.55 % 95.94
MCF7 perturbed by 1e-04microM of acetylsalicylic acid					91.7055 0.43 % 95.64
MCF7 perturbed by 2.36e-05microM of tranylcypromine					92.4774 0.07 % 96.2
MCF7 perturbed by 1.06e-05microM of lobeline					92.2417 1.66 % 95.29
MCF7 perturbed by 1.62e-05microM of ellipticine					91.4842 4.38 % 93.55
MCF7 perturbed by 1.34e-05microM of hexylcaine					92.3924 0 % 96.2
HL60 perturbed by 8.8e-06microM of repaglinide					88.6322 4.05 % 92.29
PC3 perturbed by 2.32e-05microM of 2-aminobenzenesulfonamide					90.3563 2.59 % 93.89
PC3 perturbed by 1.7e-05microM of arecoline					89.9817 2.95 % 93.51
PC3 perturbed by 1.66e-05microM of molsidomine					90.2699 3.42 % 93.43
vehicle					79.6666 1.52 % 89.07
MCF7 perturbed by 1e-05microM of PF-00562151-00					79.6617 1.85 % 88.91
PC3 perturbed by 1e-06microM of AH-23848					78.1389 1.94 % 88.1
MCF7 perturbed by 1e-04microM of carmustine					78.7969 4.42 % 87.19
PC3 perturbed by 1e-05microM of scriptaid					79.3722 2.42 % 88.48
MCF7 perturbed by 2e-05microM of erastin					92.8571 0 % 96.43
vehicle					92.4548 0 % 96.23
MCF7 perturbed by 7.8e-06microM of gossypol					90.7839 3.23 % 93.78
MCF7 perturbed by 9e-06microM of cefuroxime					91.8917 0.08 % 95.9
MCF7 perturbed by 9.2e-06microM of suxibuzone					90.3633 0 % 95.18
vehicle					81.6204 1.23 % 90.19
vehicle					83.7982 1.3 % 91.25
vehicle					80.9444 1.54 % 89.7
MCF7 perturbed by 8.4e-06microM of flunarizine					81.7194 0.88 % 90.42
MCF7 perturbed by 1.26e-05microM of nilutamide					92.121 0.54 % 95.79
MCF7 perturbed by 3.1e-05microM of nipecotic acid					91.4169 0.01 % 95.7
MCF7 perturbed by 1e-07microM of trichostatin A					91.7309 0.19 % 95.77
MCF7 perturbed by 1.06e-05microM of ketorolac					92.0528 0.01 % 96.02
MCF7 perturbed by 2.32e-05microM of pralidoxime					91.6993 0.01 % 95.84
vehicle					92.0293 1.57 % 95.23
MCF7 perturbed by 1e-06microM of trichostatin A					91.0393 3.37 % 93.83
MCF7 perturbed by 1e-05microM of haloperidol					83.4357 1.21 % 91.11
MCF7 perturbed by 1e-05microM of troglitazone					84.2978 1.99 % 91.15
MCF7 perturbed by 1.48e-05microM of leflunomide					85.9132 0.18 % 92.86
MCF7 perturbed by 1.36e-05microM of trifluridine					82.8346 5.92 % 88.46
MCF7 perturbed by 8.8e-06microM of repaglinide					84.2151 2.03 % 91.09
vehicle					84.2898 3.85 % 90.22
PC3 perturbed by 1.38e-05microM of midodrine					78.521 0.71 % 88.9
PC3 perturbed by 8.8e-06microM of cefoxitin					76.8469 1.48 % 87.69
PC3 perturbed by 1.22e-05microM of monocrotaline					75.6101 0.41 % 87.6
PC3 perturbed by 5e-06microM of merbromin					79.3162 0.03 % 89.64
MCF7 perturbed by 9.2e-06microM of zuclopenthixol					78.0672 0.09 % 88.99
MCF7 perturbed by 5.4e-06microM of alcuronium chloride					75.228 0.54 % 87.35
PC3 perturbed by 1.06e-05microM of Prestwick-685					79.7967 0.03 % 89.89
PC3 perturbed by 2.2e-05microM of mephenesin					74.7249 1.94 % 86.39
vehicle					75.5069 0.25 % 87.63
PC3 perturbed by 1e-05microM of SC-19220					77.7366 2.39 % 87.68
MCF7 perturbed by 1e-05microM of SC-19220					78.127 0.11 % 89.01
MCF7 perturbed by 8.6e-06microM of clemastine					81.0449 0.01 % 90.52
MCF7 perturbed by 1.94e-05microM of trapidil					82.5863 0.01 % 91.29
PC3 perturbed by 1e-06microM of trichostatin A					77.8299 12.02 % 82.91
PC3 perturbed by 1e-06microM of daunorubicin					79.2084 8.71 % 85.25