Connectivity Map Batch 02 Random Load - CMAP15

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	93.42 0.03 % 96.69
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
vehicle					88.8698 1.83 % 93.52
MCF7 perturbed by 1e-05microM of hexamethonium bromide					93.4161 0.04 % 96.69
MCF7 perturbed by 1.16e-05microM of oxybuprocaine					93.564 0 % 96.78
HL60 perturbed by 1.08e-05microM of finasteride					91.0334 0.03 % 95.5
HL60 perturbed by 1.4e-05microM of acacetin					90.6292 0.24 % 95.19
vehicle					91.121 0.04 % 95.54
HL60 perturbed by 1.28e-05microM of heliotrine					91.3159 0.04 % 95.64
HL60 perturbed by 1.02e-05microM of perhexiline					90.8961 2.66 % 94.12
HL60 perturbed by 9e-06microM of telenzepine					91.5398 0.48 % 95.53
PC3 perturbed by 1.44e-05microM of pentoxifylline					89.5714 0.63 % 94.47
PC3 perturbed by 1.12e-05microM of pyrantel					88.7458 1.58 % 93.58
MCF7 perturbed by 1.58e-05microM of triamterene					92.3972 0.08 % 96.16
MCF7 perturbed by 1.12e-05microM of chlorpromazine					92.8371 0 % 96.42
HL60 perturbed by 1.58e-05microM of tacrine					88.9373 0.64 % 94.15
HL60 perturbed by 7e-06microM of cefotetan					89.5789 2.12 % 93.73
HL60 perturbed by 5.2e-06microM of levothyroxine sodium					89.7884 0.08 % 94.85
PC3 perturbed by 1.2e-05microM of isoxicam					82.5186 3.29 % 89.62
HL60 perturbed by 1.02e-05microM of pirenperone					90.6958 0.04 % 95.33
vehicle					90.2911 0.92 % 94.69
HL60 perturbed by 8.6e-06microM of meclozine					91.0151 0.13 % 95.44
MCF7 perturbed by 1e-07microM of trichostatin A					92.4173 0.89 % 95.76
MCF7 perturbed by 1.8e-05microM of mafenide					92.9806 0.09 % 96.45
MCF7 perturbed by 9.4e-06microM of pirenzepine					92.1739 0.29 % 95.94
MCF7 perturbed by 9.6e-06microM of mefloquine					92.6658 0.24 % 96.21
vehicle					91.2761 0.03 % 95.62
MCF7 perturbed by 2.02e-05microM of mimosine					91.2572 0.05 % 95.6
MCF7 perturbed by 1.1e-05microM of bezafibrate					93.2061 0.02 % 96.59
vehicle					93.3222 0.01 % 96.66
MCF7 perturbed by 1.54e-05microM of ifosfamide					91.8443 0 % 95.92
MCF7 perturbed by 1.5e-05microM of diethylstilbestrol					92.7612 0.02 % 96.37
MCF7 perturbed by 8.4e-06microM of cefazolin					91.1544 0 % 95.58
MCF7 perturbed by 1e-05microM of glycopyrronium bromide					89.9279 0.01 % 94.96
MCF7 perturbed by 1.1e-05microM of cloperastine					92.4433 0 % 96.22
MCF7 perturbed by 1.84e-05microM of mephenytoin					91.1535 2.99 % 94.08
MCF7 perturbed by 9.8e-06microM of risperidone					91.573 3.15 % 94.21
MCF7 perturbed by 1.36e-05microM of dexpropranolol					90.8517 1.64 % 94.6
HL60 perturbed by 5e-06microM of iopromide					88.4847 4.3 % 92.09
HL60 perturbed by 1e-07microM of trichostatin A					89.2735 1.85 % 93.71
MCF7 perturbed by 1.46e-05microM of naringenin					92.6549 0.01 % 96.32
vehicle					90.8104 1.13 % 94.84
MCF7 perturbed by 7.6e-06microM of ceforanide					91.7087 0 % 95.85
MCF7 perturbed by 8.2e-06microM of dicloxacillin					90.7491 0.01 % 95.37
MCF7 perturbed by 1.1e-05microM of hydrocortisone					91.5566 0 % 95.78
MCF7 perturbed by 1.36e-05microM of benserazide					90.7047 10.09 % 90.31
MCF7 perturbed by 1e-07microM of trichostatin A					91.6472 3.99 % 93.83
MCF7 perturbed by 1e-07microM of trichostatin A					92.1053 4.23 % 93.94
MCF7 perturbed by 1.14e-05microM of chlorprothixene					92.8712 0.27 % 96.3
MCF7 perturbed by 5e-06microM of ioversol					92.0552 5.73 % 93.16
vehicle					88.9663 1.72 % 93.63
MCF7 perturbed by 1.38e-05microM of etiocholanolone					88.002 0.54 % 93.73
MCF7 perturbed by 9e-06microM of quipazine					89.6438 0 % 94.82
MCF7 perturbed by 1e-07microM of trichostatin A					91.1021 1.3 % 94.9
MCF7 perturbed by 1.36e-05microM of cinchonine					90.7073 0.16 % 95.27
MCF7 perturbed by 1.14e-05microM of biperiden					92.1485 0.43 % 95.86
MCF7 perturbed by 1e-06microM of geldanamycin					91.8532 0.27 % 95.79
MCF7 perturbed by 1.72e-05microM of betahistine					91.4378 2.11 % 94.66
MCF7 perturbed by 2.02e-05microM of theophylline					91.2718 0.06 % 95.61
vehicle					91.6649 0 % 95.83
vehicle					91.9554 0.01 % 95.97
MCF7 perturbed by 1.26e-05microM of phentolamine					91.3943 0.02 % 95.69
MCF7 perturbed by 7.4e-06microM of piperacillin					89.2878 4.44 % 92.42
PC3 perturbed by 5e-06microM of atractyloside					89.2382 0 % 94.62
PC3 perturbed by 1.3e-05microM of foliosidine					90.7812 0 % 95.39
PC3 perturbed by 7.2e-06microM of fenoprofen					87.2921 2.17 % 92.56
PC3 perturbed by 1.16e-05microM of medrysone					89.7458 0 % 94.87
HL60 perturbed by 7.6e-06microM of deptropine					90.3108 2.09 % 94.11
HL60 perturbed by 1.9e-05microM of altretamine					90.6719 0.04 % 95.32
HL60 perturbed by 9.4e-06microM of urapidil					90.7118 2.81 % 93.95
vehicle					90.2877 0.09 % 95.1
MCF7 perturbed by 3.24e-05microM of pyrazinamide					91.8914 0.09 % 95.9
vehicle					90.9141 2.11 % 94.4
PC3 perturbed by 4e-06microM of lanatoside C					91.4266 0.02 % 95.7
PC3 perturbed by 1.96e-05microM of ethotoin					92.0087 0.22 % 95.9
PC3 perturbed by 8.4e-06microM of flecainide					91.9315 0.36 % 95.78
PC3 perturbed by 8e-06microM of fluticasone					91.4085 0.2 % 95.61
PC3 perturbed by 9.2e-06microM of brompheniramine					89.8502 0 % 94.93
PC3 perturbed by 1.54e-05microM of suprofen					91.0394 0 % 95.52
PC3 perturbed by 2.3e-05microM of gramine					90.4126 0 % 95.2
PC3 perturbed by 1.54e-05microM of carbarsone					91.8541 0.14 % 95.86
MCF7 perturbed by 7.2e-06microM of terbutaline					92.1995 2.41 % 94.9
MCF7 perturbed by 1.9e-05microM of methyldopa					92.4452 5.18 % 93.63
MCF7 perturbed by 1e-05microM of mepyramine					92.6342 6.75 % 92.94
MCF7 perturbed by 1.32e-05microM of etacrynic acid					92.1328 9.03 % 91.55
MCF7 perturbed by 1.16e-05microM of betaxolol					92.7723 2.15 % 95.31
PC3 perturbed by 1.28e-05microM of dydrogesterone					91.3175 0.05 % 95.64
HL60 perturbed by 2.22e-05microM of theobromine					91.2696 2.08 % 94.6
HL60 perturbed by 2.02e-05microM of theophylline					91.3199 1.85 % 94.74
MCF7 perturbed by 1e-05microM of CP-690334-01					90.4828 0.8 % 94.84
MCF7 perturbed by 4e-06microM of lanatoside C					91.0141 1.21 % 94.9
HL60 perturbed by 8e-06microM of fluticasone					90.349 3.05 % 93.65
HL60 perturbed by 1.36e-05microM of S-propranolol					90.8442 2.67 % 94.09
HL60 perturbed by 1.52e-05microM of roxarsone					90.7084 3.54 % 93.59
HL60 perturbed by 1.5e-05microM of pronetalol					90.8099 2.63 % 94.09
vehicle					91.356 0.02 % 95.67
MCF7 perturbed by 1.36e-05microM of picrotoxinin					91.3281 0 % 95.66
MCF7 perturbed by 1.12e-05microM of idoxuridine					92.0041 0.35 % 95.83
MCF7 perturbed by 1.1e-05microM of atovaquone					91.0139 0.58 % 95.22
MCF7 perturbed by 1.08e-05microM of galantamine					91.2048 0.16 % 95.52
PC3 perturbed by 1.38e-05microM of hyoscyamine					90.2585 1.42 % 94.42
PC3 perturbed by 7.2e-06microM of antimycin A					89.5803 1.48 % 94.05
PC3 perturbed by 1e-06microM of CP-320650-01					91.8112 0.01 % 95.9
PC3 perturbed by 1e-06microM of CP-690334-01					91.5383 0.39 % 95.57
PC3 perturbed by 1e-06microM of withaferin A					91.8202 0.01 % 95.9
PC3 perturbed by 1.36e-05microM of N-acetylmuramic acid					91.5905 0.45 % 95.57
PC3 perturbed by 2.4e-06microM of thiostrepton					91.9648 0.02 % 95.97
PC3 perturbed by 1.12e-05microM of hycanthone					92.7018 0.22 % 96.24
PC3 perturbed by 1.64e-05microM of flurbiprofen					91.9272 0.43 % 95.75
PC3 perturbed by 2.3e-05microM of N-acetyl-L-leucine					91.7809 0.33 % 95.73
PC3 perturbed by 1.5e-05microM of practolol					90.6986 2.23 % 94.23
PC3 perturbed by 6.6e-06microM of naringin					92.2062 0.51 % 95.85
MCF7 perturbed by 7.8e-06microM of calcium folinate					92.6048 0 % 96.3
MCF7 perturbed by 1.38e-05microM of etiocholanolone					91.9308 0.07 % 95.93
MCF7 perturbed by 6.8e-06microM of alexidine					90.9876 2.4 % 94.29
MCF7 perturbed by 1.06e-05microM of karakoline					92.8895 0.13 % 96.38
MCF7 perturbed by 1e-06microM of PNU-0251126					91.8551 0.36 % 95.75
MCF7 perturbed by 7.4e-06microM of pentolonium					91.8585 0.19 % 95.84
MCF7 perturbed by 1.16e-05microM of medrysone					92.0212 0.1 % 95.96
MCF7 perturbed by 8e-06microM of demeclocycline					91.6097 0.64 % 95.48
PC3 perturbed by 5e-06microM of iopromide					91.7917 0.63 % 95.58
PC3 perturbed by 1e-05microM of LY-294002					92.2427 0.11 % 96.07
PC3 perturbed by 1.12e-05microM of epivincamine					92.3915 0.49 % 95.95
PC3 perturbed by 1e-06microM of tretinoin					92.4198 0.29 % 96.06
PC3 perturbed by 2.32e-05microM of sulfanilamide					92.1983 0.03 % 96.09
PC3 perturbed by 1e-05microM of haloperidol					91.9827 0.81 % 95.58
PC3 perturbed by 8.2e-06microM of glimepiride					92.1421 0.26 % 95.94
PC3 perturbed by 8.4e-06microM of fluspirilene					92.319 1.59 % 95.37
PC3 perturbed by 1.54e-05microM of carisoprodol					91.9877 0.06 % 95.96
PC3 perturbed by 9.6e-06microM of ambroxol					88.5095 0.59 % 93.96
PC3 perturbed by 1.24e-05microM of promethazine					92.0663 0.11 % 95.98
PC3 perturbed by 5e-06microM of midecamycin					92.0226 0.04 % 95.99
PC3 perturbed by 2.18e-05microM of carbachol					91.8907 0.01 % 95.94
PC3 perturbed by 1.1e-05microM of hydrocortisone					91.1336 0.28 % 95.43
MCF7 perturbed by 1.06e-05microM of propafenone					93.1524 0.07 % 96.54
MCF7 perturbed by 9.4e-06microM of flavoxate					91.8752 0 % 95.94
PC3 perturbed by 9.4e-06microM of ketotifen					90.8748 0.3 % 95.29
vehicle					91.3563 1.56 % 94.9
vehicle					91.3519 2.88 % 94.24
vehicle					91.9211 0.97 % 95.47
MCF7 perturbed by 7.2e-06microM of antimycin A					91.2316 0.01 % 95.61
MCF7 perturbed by 1.36e-05microM of Prestwick-920					91.6664 0.6 % 95.53
PC3 perturbed by 9.2e-06microM of dexamethasone					92.0239 0.01 % 96.01
PC3 perturbed by 1e-07microM of trichostatin A					91.7795 0.05 % 95.87
MCF7 perturbed by 4.8e-06microM of iohexol					90.7816 0.43 % 95.18
MCF7 perturbed by 1.3e-05microM of capsaicin					91.1466 0.21 % 95.47
MCF7 perturbed by 4e-06microM of tyloxapol					89.4451 4.3 % 92.57
PC3 perturbed by 1e-06microM of trichostatin A					89.5563 2.33 % 93.61
vehicle					92.0706 0 % 96.04
MCF7 perturbed by 1.16e-05microM of testosterone					90.5416 3.05 % 93.74
MCF7 perturbed by 1e-06microM of tanespimycin					90.2409 3.01 % 93.62
MCF7 perturbed by 1.18e-05microM of phenoxybenzamine					91.6492 0.13 % 95.76
MCF7 perturbed by 2.4e-05microM of oxedrine					90.5487 2.98 % 93.78
MCF7 perturbed by 8.4e-06microM of terfenadine					90.8141 0.45 % 95.18
vehicle					88.6575 2.09 % 93.28
MCF7 perturbed by 1.34e-05microM of fenspiride					92.8032 0 % 96.4
MCF7 perturbed by 1.38e-05microM of ciprofibrate					93.4942 0.23 % 96.63
MCF7 perturbed by 9.6e-06microM of methanthelinium bromide					93.2502 0.04 % 96.61
HL60 perturbed by 1.22e-05microM of azaperone					89.2348 3.5 % 92.87
HL60 perturbed by 9.4e-06microM of ticarcillin					88.6297 4.35 % 92.14
HL60 perturbed by 1e-06microM of nordihydroguaiaretic acid					87.8807 0.6 % 93.64
HL60 perturbed by 5.2e-06microM of saquinavir					88.6023 0.03 % 94.29
PC3 perturbed by 9.6e-06microM of nimodipine					91.034 0.04 % 95.5
PC3 perturbed by 1.86e-05microM of 10-methoxyharmalan					90.9402 3.26 % 93.84
PC3 perturbed by 1e-05microM of sulfasalazine					90.7283 3.46 % 93.63
PC3 perturbed by 1e-04microM of carmustine					80.5505 3.4 % 88.57
MCF7 perturbed by 1e-06microM of SB-202190					78.6618 1.09 % 88.79
MCF7 perturbed by 1e-05microM of 0225151-0000					93.3285 0.05 % 96.64
PC3 perturbed by 5e-05microM of 5707885					92.5369 0.15 % 96.2
MCF7 perturbed by 2.52e-05microM of betonicine					91.1769 3.11 % 94.03
MCF7 perturbed by 1.58e-05microM of naproxen					90.1987 0.1 % 95.05
vehicle					92.0182 0 % 96.01
MCF7 perturbed by 1e-06microM of tanespimycin					80.6776 0.8 % 89.94
MCF7 perturbed by 7.8e-06microM of chloroquine					86.0499 1.12 % 92.47
MCF7 perturbed by 1.4e-05microM of etodolac					85.5266 1.32 % 92.1
MCF7 perturbed by 1.66e-05microM of idazoxan					92.0728 0.02 % 96.03
MCF7 perturbed by 2.06e-05microM of aminohippuric acid					90.8983 0 % 95.45
PC3 perturbed by 1e-05microM of 16-16-dimethylprostaglandin E2					90.9882 2.9 % 94.04
MCF7 perturbed by 1e-08microM of fulvestrant					84.1993 5.48 % 89.36
MCF7 perturbed by 1e-05microM of 15-delta prostaglandin J2					83.2222 3.71 % 89.75
MCF7 perturbed by 9.4e-06microM of ketotifen					86.4003 0.7 % 92.85
PC3 perturbed by 1.18e-05microM of disopyramide					86.2319 3.9 % 91.16
PC3 perturbed by 1.12e-05microM of aceclofenac					82.505 7.2 % 87.65
PC3 perturbed by 1.12e-05microM of laudanosine					82.1194 1.7 % 90.21
vehicle					83.2851 2.01 % 90.64
PC3 perturbed by 1.08e-05microM of iobenguane					82.4868 0.6 % 90.94
PC3 perturbed by 2.36e-05microM of tranylcypromine					81.2786 3.53 % 88.87
PC3 perturbed by 1.34e-05microM of imipenem					82.8408 1.43 % 90.71
MCF7 perturbed by 8e-06microM of harpagoside					78.733 0.12 % 89.3
MCF7 perturbed by 8.8e-06microM of cefalonium					75.1607 1.35 % 86.91
MCF7 perturbed by 1e-07microM of thapsigargin					79.6438 0.55 % 89.55
PC3 perturbed by 1e-05microM of 0198306-0000					81.1727 0.02 % 90.58
PC3 perturbed by 1e-05microM of PHA-00816795					77.3055 0.1 % 88.6
vehicle					81.1514 0.38 % 90.39
MCF7 perturbed by 9.8e-06microM of glafenine					84.8171 0.72 % 92.05
MCF7 perturbed by 1.26e-05microM of doxepin					80.3603 3.88 % 88.24
MCF7 perturbed by 2.8e-06microM of bacitracin					81.6272 0.18 % 90.72
MCF7 perturbed by 1e-06microM of trichostatin A					81.0593 4.4 % 88.33
MCF7 perturbed by 1e-05microM of CP-645525-01					80.4717 8.01 % 86.23
vehicle					80.5652 6.66 % 86.95
MCF7 perturbed by 1e-05microM of BCB000039					79.3 7.25 % 86.03
PC3 perturbed by 1e-05microM of BCB000038					79.2448 2.77 % 88.24
MCF7 perturbed by 1e-05microM of meteneprost					81.0639 2.68 % 89.19