Connectivity Map Batch 02 Random Load - CMAP14

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	87.46 0.03 % 93.71
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-08microM of estradiol					89.2266 1.55 % 93.84
HL60 perturbed by 1e-05microM of LY-294002					87.4597 1.02 % 93.22
PC3 perturbed by 1e-06microM of chlorpromazine					89.6602 0.33 % 94.67
MCF7 perturbed by 1.48e-05microM of amylocaine					93.3173 0.03 % 96.64
vehicle					93.1051 0 % 96.55
MCF7 perturbed by 9.8e-06microM of zimeldine					92.9931 0.01 % 96.49
HL60 perturbed by 1.06e-05microM of karakoline					90.3815 0.03 % 95.17
HL60 perturbed by 1e-05microM of Prestwick-675					90.9841 0.02 % 95.48
HL60 perturbed by 1.12e-05microM of vincamine					91.2391 3.07 % 94.08
HL60 perturbed by 1.34e-05microM of norethisterone					91.4288 0.3 % 95.57
HL60 perturbed by 1.58e-05microM of sulfamethoxazole					91.6558 1.01 % 95.32
vehicle					88.3861 1.77 % 93.31
PC3 perturbed by 1.3e-05microM of nifenazone					87.8285 2.63 % 92.6
PC3 perturbed by 9.4e-06microM of pirenzepine					87.6853 2.01 % 92.84
PC3 perturbed by 1e-07microM of trichostatin A					86.149 3.19 % 91.48
PC3 perturbed by 1.54e-05microM of thalidomide					87.3708 3.26 % 92.05
MCF7 perturbed by 1e-06microM of tanespimycin					91.6814 0.08 % 95.8
HL60 perturbed by 1.46e-05microM of estradiol					89.6797 2.37 % 93.65
HL60 perturbed by 1.42e-05microM of guanfacine					90.5473 1.39 % 94.58
HL60 perturbed by 1.58e-05microM of lysergol					89.7568 0.57 % 94.59
HL60 perturbed by 1e-05microM of bepridil					89.8074 1.68 % 94.07
vehicle					90.3964 2.82 % 93.79
HL60 perturbed by 1.6e-05microM of sulfadiazine					89.2927 0.35 % 94.47
HL60 perturbed by 1.94e-05microM of dexpanthenol					89.5266 1.37 % 94.08
PC3 perturbed by 1.48e-05microM of todralazine					88.7063 1.34 % 93.68
PC3 perturbed by 2.52e-05microM of allantoin					89.906 1.52 % 94.19
HL60 perturbed by 1.46e-05microM of meticrane					90.4742 0.13 % 95.17
HL60 perturbed by 2.02e-05microM of nitrofural					90.6039 0.02 % 95.29
HL60 perturbed by 9.8e-06microM of lovastatin					89.9066 0.23 % 94.84
HL60 perturbed by 1.88e-05microM of serotonin					90.4368 0.08 % 95.18
HL60 perturbed by 1e-07microM of trichostatin A					90.7973 0.02 % 95.39
HL60 perturbed by 3e-06microM of colistin					90.5468 0.11 % 95.22
vehicle					92.5999 0.97 % 95.81
MCF7 perturbed by 9.2e-06microM of dexamethasone					92.6379 1.37 % 95.63
MCF7 perturbed by 8.6e-06microM of clindamycin					93.0973 1.24 % 95.93
vehicle					92.2979 1.81 % 95.24
HL60 perturbed by 9.6e-06microM of podophyllotoxin					88.7727 0.02 % 94.38
vehicle					89.8099 3.67 % 93.07
HL60 perturbed by 1.5e-05microM of diethylstilbestrol					91.0026 0.11 % 95.44
HL60 perturbed by 9.8e-06microM of strophanthidin					90.4528 0.37 % 95.04
HL60 perturbed by 1e-07microM of trichostatin A					91.3601 0.24 % 95.56
MCF7 perturbed by 6.6e-06microM of prochlorperazine					92.5965 0.01 % 96.29
vehicle					91.9052 0 % 95.95
vehicle					91.7473 0.08 % 95.83
MCF7 perturbed by 7.8e-06microM of raloxifene					92.0654 0 % 96.03
MCF7 perturbed by 1.32e-05microM of oxprenolol					89.5172 4.23 % 92.64
MCF7 perturbed by 1.64e-05microM of etomidate					89.9867 7.26 % 91.36
vehicle					90.123 5.58 % 92.27
HL60 perturbed by 7.8e-06microM of bucladesine					89.8541 4.16 % 92.84
HL60 perturbed by 8.4e-06microM of doxycycline					90.2112 6.03 % 92.09
HL60 perturbed by 1.28e-05microM of zomepirac					90.2948 0.21 % 95.04
vehicle					91.1207 0.01 % 95.56
MCF7 perturbed by 1.06e-05microM of digitoxigenin					91.8626 0.01 % 95.93
MCF7 perturbed by 5.8e-06microM of pepstatin					92.3899 0.01 % 96.19
MCF7 perturbed by 1.48e-05microM of pilocarpine					90.7878 0.03 % 95.38
MCF7 perturbed by 9.2e-06microM of dl-alpha tocopherol					89.9989 0.17 % 94.91
MCF7 perturbed by 8.8e-06microM of cefixime					90.8718 0.11 % 95.38
MCF7 perturbed by 8.4e-06microM of butoconazole					91.127 0.86 % 95.13
MCF7 perturbed by 7.2e-06microM of cefotiam					92.1086 3.22 % 94.44
MCF7 perturbed by 2.14e-05microM of phenylpropanolamine					92.1315 4.94 % 93.6
PC3 perturbed by 1.58e-05microM of fenbufen					90.0406 0.41 % 94.82
MCF7 perturbed by 1.52e-05microM of sulfamerazine					87.4159 0.47 % 93.47
vehicle					90.9626 0.05 % 95.46
MCF7 perturbed by 1.58e-05microM of DL-thiorphan					91.0758 3.02 % 94.03
MCF7 perturbed by 6.4e-06microM of resc1amine					89.3388 1.89 % 93.72
vehicle					92.5254 0.15 % 96.19
MCF7 perturbed by 9.8e-06microM of thioperamide					91.9869 0.68 % 95.66
MCF7 perturbed by 0.0002microM of valproic acid					92.0258 0.39 % 95.82
MCF7 perturbed by 1e-05microM of SR-95639A					92.0078 0.55 % 95.73
MCF7 perturbed by 1.04e-05microM of cefaclor					91.3593 0.55 % 95.4
MCF7 perturbed by 9.2e-06microM of Prestwick-984					91.7724 0.58 % 95.6
MCF7 perturbed by 6.6e-06microM of iocetamic acid					90.8315 3.01 % 93.91
MCF7 perturbed by 5e-06microM of xamoterol					91.6938 0 % 95.85
MCF7 perturbed by 1.28e-05microM of mestranol					92.3468 0.74 % 95.8
MCF7 perturbed by 1.3e-05microM of capsaicin					92.064 0 % 96.03
MCF7 perturbed by 9.8e-06microM of thioridazine					92.1622 0.26 % 95.95
MCF7 perturbed by 1.08e-05microM of etofenamate					91.9533 0.96 % 95.5
PC3 perturbed by 2.52e-05microM of betonicine					89.918 0 % 94.96
MCF7 perturbed by 7.6e-06microM of mometasone					91.7341 0.99 % 95.37
MCF7 perturbed by 3e-06microM of colistin					90.9023 2.21 % 94.35
MCF7 perturbed by 1.54e-05microM of tiaprofenic acid					91.4325 2.11 % 94.66
vehicle					92.4606 0.54 % 95.96
PC3 perturbed by 6.6e-06microM of carbenoxolone					90.7317 1.22 % 94.76
PC3 perturbed by 1.12e-05microM of pheniramine					90.0945 0.26 % 94.92
PC3 perturbed by 1.28e-05microM of tolazamide					91.004 1.34 % 94.83
PC3 perturbed by 8.6e-06microM of tobramycin					90.6695 1.82 % 94.42
PC3 perturbed by 2.24e-05microM of phenacetin					91.1375 1.04 % 95.05
MCF7 perturbed by 1.06e-05microM of quinidine					92.1527 4.1 % 94.03
MCF7 perturbed by 1.12e-05microM of hycanthone					91.9976 2.12 % 94.94
MCF7 perturbed by 9.4e-06microM of mifepristone					91.7977 14.14 % 88.83
MCF7 perturbed by 8.6e-06microM of pimozide					91.9836 4.32 % 93.83
vehicle					88.8507 0.76 % 94.05
PC3 perturbed by 1.08e-05microM of galantamine					90.1805 1.45 % 94.36
HL60 perturbed by 1.78e-05microM of furazolidone					89.4895 16.77 % 86.36
HL60 perturbed by 9.8e-06microM of trimipramine					91.1387 1.18 % 94.98
HL60 perturbed by 1.54e-05microM of suprofen					90.9383 5.59 % 92.67
HL60 perturbed by 7.2e-06microM of cefsulodin					90.7448 1 % 94.87
vehicle					91.0738 2.18 % 94.44
MCF7 perturbed by 1e-05microM of PHA-00851261E					90.8509 0.24 % 95.3
MCF7 perturbed by 1.18e-05microM of ciclacillin					91.9933 1.1 % 95.45
MCF7 perturbed by 4.8e-06microM of rifabutin					89.057 0.28 % 94.39
HL60 perturbed by 1.86e-05microM of memantine					91.0769 3.2 % 93.94
HL60 perturbed by 8.4e-06microM of pivmecillinam					91.1807 1.01 % 95.08
MCF7 perturbed by 2.04e-05microM of tolazoline					91.3221 3.96 % 93.68
MCF7 perturbed by 1.3e-05microM of quinisocaine					92.1956 2.52 % 94.84
MCF7 perturbed by 7.6e-06microM of orciprenaline					90.9533 2.48 % 94.24
MCF7 perturbed by 2.58e-05microM of Prestwick-967					91.3081 2.47 % 94.42
PC3 perturbed by 8.4e-06microM of ifenprodil					87.3162 3.12 % 92.1
PC3 perturbed by 1.44e-05microM of flutamide					89.5962 1 % 94.3
MCF7 perturbed by 3.2e-06microM of beta-escin					91.6295 0 % 95.81
MCF7 perturbed by 1.38e-05microM of quinethazone					92.2477 0.01 % 96.12
PC3 perturbed by 1.78e-05microM of 3-hydroxy-DL-kynurenine					92.0961 1.33 % 95.38
MCF7 perturbed by 1e-05microM of PNU-0230031					92.0217 1.26 % 95.38
MCF7 perturbed by 1.58e-05microM of ketoprofen					91.3818 3.61 % 93.89
MCF7 perturbed by 1.16e-05microM of bromopride					91.1189 1.43 % 94.84
MCF7 perturbed by 8.6e-06microM of metaraminol					91.7305 1.33 % 95.2
MCF7 perturbed by 1.74e-05microM of kawain					91.8949 1.03 % 95.43
PC3 perturbed by 2.2e-05microM of dacarbazine					92.1285 0.11 % 96.01
PC3 perturbed by 1e-07microM of trichostatin A					91.6979 0.3 % 95.7
PC3 perturbed by 1.04e-05microM of etynodiol					91.787 0 % 95.89
PC3 perturbed by 1.44e-05microM of sulfabenzamide					91.9149 0.01 % 95.95
PC3 perturbed by 8e-06microM of harpagoside					92.2489 0 % 96.12
vehicle					91.6483 0 % 95.82
PC3 perturbed by 1.72e-05microM of betahistine					91.2697 0 % 95.63
PC3 perturbed by 1.36e-05microM of benserazide					91.2062 0.51 % 95.35
PC3 perturbed by 1.32e-05microM of pipemidic acid					90.7972 1.95 % 94.42
PC3 perturbed by 1.08e-05microM of ciprofloxacin					91.6899 1.27 % 95.21
PC3 perturbed by 1.46e-05microM of rolipram					91.1595 1.88 % 94.64
vehicle					91.1707 0 % 95.58
MCF7 perturbed by 8.8e-06microM of methotrexate					92.0372 0.43 % 95.8
MCF7 perturbed by 2.7e-05microM of betazole					93.2155 0.04 % 96.59
PC3 perturbed by 1.16e-05microM of bergenin					91.1838 0.16 % 95.51
PC3 perturbed by 9.4e-06microM of pirenzepine					90.8379 0.21 % 95.31
MCF7 perturbed by 1.12e-05microM of sulindac					91.5028 0.15 % 95.68
PC3 perturbed by 1.02e-05microM of alpha-yohimbine					90.9382 0.02 % 95.46
PC3 perturbed by 1.34e-05microM of tretinoin					91.7231 0.36 % 95.68
MCF7 perturbed by 8.8e-06microM of terguride					88.5958 3.07 % 92.76
MCF7 perturbed by 1e-05microM of colchicine					90.2928 0.13 % 95.08
MCF7 perturbed by 1.1e-05microM of bisacodyl					91.2802 0.46 % 95.41
MCF7 perturbed by 1e-06microM of fulvestrant					92.1152 1 % 95.56
vehicle					91.406 2.23 % 94.59
MCF7 perturbed by 1.9e-05microM of methyldopa					91.4142 0 % 95.71
MCF7 perturbed by 1e-06microM of nordihydroguaiaretic acid					91.7159 0 % 95.86
MCF7 perturbed by 1e-05microM of prochlorperazine					91.6245 3.05 % 94.29
MCF7 perturbed by 1.1e-05microM of cefalexin					90.7668 2.66 % 94.05
MCF7 perturbed by 5e-06microM of iopromide					91.4324 0.03 % 95.7
MCF7 perturbed by 9.2e-06microM of clidinium bromide					90.7794 0.02 % 95.38
MCF7 perturbed by 9.2e-06microM of diperodon					89.0217 2.69 % 93.17
MCF7 perturbed by 1e-07microM of trichostatin A					90.3647 1.72 % 94.32
MCF7 perturbed by 1.08e-05microM of iobenguane					92.9888 0.01 % 96.49
MCF7 perturbed by 6e-06microM of propidium iodide					92.4918 8.33 % 92.08
MCF7 perturbed by 3.5e-05microM of chloropyrazine					93.2314 0.62 % 96.31
MCF7 perturbed by 6.2e-06microM of thioproperazine					93.4217 0.97 % 96.22
MCF7 perturbed by 1.06e-05microM of quinidine					93.151 1.87 % 95.64
MCF7 perturbed by 9e-06microM of cefuroxime					93.4439 0.01 % 96.72
MCF7 perturbed by 1.42e-05microM of sulfametoxydiazine					92.7575 3.47 % 94.64
MCF7 perturbed by 1.58e-05microM of DL-thiorphan					92.259 4.99 % 93.63
HL60 perturbed by 1e-05microM of trifluoperazine					88.2792 4.23 % 92.03
HL60 perturbed by 1e-06microM of tanespimycin					86.7608 3.02 % 91.87
HL60 perturbed by 1e-06microM of fulvestrant					88.8057 3.73 % 92.54
PC3 perturbed by 9.8e-06microM of remoxipride					90.1851 3.38 % 93.4
PC3 perturbed by 1.5e-05microM of azacyclonol					90.2051 3.95 % 93.13
PC3 perturbed by 1.04e-05microM of fenoterol					90.4241 2.97 % 93.73
PC3 perturbed by 1e-05microM of 0175029-0000					78.5825 5.7 % 86.44
vehicle					78.1691 1.65 % 88.26
PC3 perturbed by 1e-05microM of NS-398					79.46 1.92 % 88.77
vehicle					91.101 0 % 95.55
MCF7 perturbed by 1.38e-05microM of etiocholanolone					89.9571 0 % 94.98
MCF7 perturbed by 5.4e-06microM of butirosin					89.2007 0 % 94.6
MCF7 perturbed by 8.2e-06microM of enalapril					80.6106 0.64 % 89.99
MCF7 perturbed by 1.22e-05microM of prasterone					91.9004 0.78 % 95.56
MCF7 perturbed by 1.08e-05microM of isradipine					90.3129 0.24 % 95.03
MCF7 perturbed by 1.18e-05microM of phenoxybenzamine					91.6989 0.06 % 95.82
MCF7 perturbed by 4e-06microM of tyloxapol					90.975 2.79 % 94.09
MCF7 perturbed by 1e-05microM of PNU-0293363					91.9437 1.72 % 95.11
MCF7 perturbed by 1.5e-05microM of STOCK1N-35696					92.7268 0 % 96.36
vehicle					90.5689 3.28 % 93.64
PC3 perturbed by 2e-05microM of 5194442					91.3996 3.28 % 94.06
MCF7 perturbed by 1e-04microM of acetylsalicylic acid					83.9734 1.27 % 91.35
MCF7 perturbed by 2.92e-05microM of isoniazid					86.7281 0.2 % 93.27
MCF7 perturbed by 4.8e-06microM of abamectin					82.0681 1.32 % 90.37
PC3 perturbed by 5.2e-06microM of viomycin					85.4324 1.82 % 91.8
vehicle					85.4769 2.77 % 91.35
PC3 perturbed by 1.58e-05microM of triamterene					83.8676 2.22 % 90.83
PC3 perturbed by 1e-07microM of trichostatin A					86.782 0.9 % 92.94
PC3 perturbed by 6.2e-06microM of aconitine					77.3139 1.02 % 88.15
PC3 perturbed by 1.08e-05microM of berberine					77.1458 0.56 % 88.29
PC3 perturbed by 1.32e-05microM of nocodazole					76.7213 0.55 % 88.09
PC3 perturbed by 8.6e-06microM of pimozide					75.6031 0.55 % 87.52
vehicle					77.7063 1 % 88.35
PC3 perturbed by 1e-05microM of PNU-0251126					74.8631 0.65 % 87.11
PC3 perturbed by 1.1e-05microM of ofloxacin					75.1965 1.56 % 86.82
PC3 perturbed by 1.68e-05microM of salbutamol					75.6053 0.32 % 87.64
PC3 perturbed by 1e-05microM of CAY-10397					77.1971 1.31 % 87.94
PC3 perturbed by 1e-05microM of PHA-00846566E					76.4252 0 % 88.21
vehicle					79.1495 0.08 % 89.54
MCF7 perturbed by 9.6e-06microM of acemetacin					81.6052 0.02 % 90.79
MCF7 perturbed by 1.16e-05microM of difenidol					83.2371 0.02 % 91.61
vehicle					81.4352 2.74 % 89.35
PC3 perturbed by 1e-06microM of fulvestrant					85.049 2.17 % 91.44
MCF7 perturbed by 1e-05microM of BCB000040					81.1108 2.4 % 89.35