Connectivity Map Batch 02 Random Load - CMAP13

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	89.45 1.19 % 94.13
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
vehicle					89.8175 0.17 % 94.83
PC3 perturbed by 1e-05microM of LY-294002					89.4531 0.11 % 94.67
HL60 perturbed by 1e-08microM of alpha-estradiol					86.5401 3.05 % 91.74
HL60 perturbed by 1e-07microM of trichostatin A					86.7474 1.19 % 92.78
MCF7 perturbed by 2.34e-05microM of metronidazole					93.3059 1.83 % 95.74
MCF7 perturbed by 5e-06microM of midecamycin					93.3284 0.65 % 96.34
vehicle					93.3351 0.37 % 96.48
MCF7 perturbed by 1.16e-05microM of cinchocaine					93.2372 0.03 % 96.6
MCF7 perturbed by 2.04e-05microM of hydralazine					92.3593 0.12 % 96.12
HL60 perturbed by 1.3e-05microM of foliosidine					90.1977 0.42 % 94.89
HL60 perturbed by 1.4e-05microM of sulmazole					91.122 0.07 % 95.53
HL60 perturbed by 1.16e-05microM of bromopride					91.9784 0.25 % 95.86
HL60 perturbed by 6.4e-06microM of resc1amine					90.9486 0.47 % 95.24
vehicle					92.2308 0.13 % 96.05
HL60 perturbed by 1.44e-05microM of flutamide					92.0482 0.13 % 95.96
PC3 perturbed by 1.42e-05microM of flufenamic acid					87.146 1.69 % 92.73
PC3 perturbed by 1.34e-05microM of acetylsalicylsalicylic acid					85.9664 5.3 % 90.34
vehicle					88.8612 1.32 % 93.77
PC3 perturbed by 2.9e-05microM of pentetrazol					88.5145 1.97 % 93.27
MCF7 perturbed by 1e-05microM of 15-delta prostaglandin J2					92.5724 0.01 % 96.28
MCF7 perturbed by 1e-06microM of tanespimycin					93.1879 0 % 96.59
MCF7 perturbed by 1e-07microM of sirolimus					92.7361 0 % 96.37
MCF7 perturbed by 1.6e-05microM of sulfadiazine					93.0373 0.17 % 96.43
MCF7 perturbed by 1e-06microM of tanespimycin					92.3541 0.01 % 96.17
MCF7 perturbed by 1e-08microM of alpha-estradiol					93.0723 0 % 96.54
vehicle					89.2157 2.17 % 93.52
vehicle					87.5417 2.14 % 92.7
HL60 perturbed by 4.8e-06microM of iohexol					90.3329 1.2 % 94.57
HL60 perturbed by 1e-07microM of trichostatin A					90.9037 0.18 % 95.36
vehicle					92.0506 0.32 % 95.87
MCF7 perturbed by 2.6e-06microM of gentamicin					93.319 0.57 % 96.37
vehicle					92.3784 0.36 % 96.01
MCF7 perturbed by 2.04e-05microM of pargyline					92.8461 0.98 % 95.93
HL60 perturbed by 5.8e-06microM of metoprolol					89.3598 25.01 % 82.18
HL60 perturbed by 1.72e-05microM of isocarboxazid					92.1703 0.47 % 95.85
HL60 perturbed by 1e-07microM of trichostatin A					89.7025 0.62 % 94.54
vehicle					91.2536 2.4 % 94.43
HL60 perturbed by 1.36e-05microM of meclofenoxate					89.1412 38.33 % 75.41
MCF7 perturbed by 8.4e-06microM of naftidrofuryl					91.2235 1.9 % 94.66
MCF7 perturbed by 8.8e-06microM of cefoxitin					90.2553 0.48 % 94.89
MCF7 perturbed by 8.2e-06microM of prednicarbate					91.7961 2.17 % 94.81
vehicle					90.8868 3.84 % 93.53
HL60 perturbed by 1.02e-05microM of proadifen					90.3553 0.05 % 95.15
MCF7 perturbed by 1.14e-05microM of biperiden					91.7455 0 % 95.87
MCF7 perturbed by 1.26e-05microM of myricetin					90.419 0.01 % 95.2
MCF7 perturbed by 1.36e-05microM of N-acetylmuramic acid					91.0122 0.21 % 95.4
MCF7 perturbed by 1.38e-05microM of epiandrosterone					92.2823 0.01 % 96.14
MCF7 perturbed by 1.04e-05microM of colecalciferol					91.9652 0.29 % 95.84
MCF7 perturbed by 1.26e-05microM of nilutamide					92.0003 13.54 % 89.23
MCF7 perturbed by 1.16e-05microM of fluoxetine					93.0652 4.57 % 94.25
MCF7 perturbed by 1.94e-05microM of dexibuprofen					91.7584 7.25 % 92.26
vehicle					93.1237 4.24 % 94.44
PC3 perturbed by 1.38e-05microM of etiocholanolone					91.0217 1.01 % 95.01
PC3 perturbed by 1e-05microM of PHA-00851261E					88.3625 2.61 % 92.88
vehicle					90.8838 2.01 % 94.44
vehicle					86.8876 5.46 % 90.71
MCF7 perturbed by 1.16e-05microM of bromopride					87.5922 2.38 % 92.61
MCF7 perturbed by 1.12e-05microM of epivincamine					90.8931 0.13 % 95.38
MCF7 perturbed by 9.6e-06microM of noscapine					90.1146 0 % 95.06
MCF7 perturbed by 1e-08microM of wortmannin					92.6941 0.76 % 95.97
MCF7 perturbed by 1e-05microM of trifluoperazine					92.8552 1.11 % 95.87
MCF7 perturbed by 5.4e-06microM of ouabain					92.6827 2.22 % 95.23
MCF7 perturbed by 1.34e-05microM of hydrochlorothiazide					93.188 2.13 % 95.53
MCF7 perturbed by 1.18e-05microM of famotidine					92.4554 0.93 % 95.76
MCF7 perturbed by 2.28e-05microM of hymecromone					93.1369 0.04 % 96.55
MCF7 perturbed by 9.2e-06microM of brompheniramine					93.1064 0.24 % 96.43
MCF7 perturbed by 1.2e-05microM of sanguinarine					92.7778 1.74 % 95.52
MCF7 perturbed by 4.8e-06microM of rifampicin					92.554 0.11 % 96.22
MCF7 perturbed by 1.18e-05microM of dantrolene					92.1333 0.63 % 95.75
MCF7 perturbed by 1e-06microM of 0317956-0000					90.744 1.65 % 94.55
PC3 perturbed by 1e-05microM of 0179445-0000					91.8727 0.59 % 95.64
vehicle					91.9838 0 % 95.99
HL60 perturbed by 1.34e-05microM of azapropazone					91.3711 0.03 % 95.67
HL60 perturbed by 1.08e-05microM of isradipine					91.3237 2.03 % 94.65
HL60 perturbed by 1.76e-05microM of nabumetone					91.3861 0.03 % 95.68
MCF7 perturbed by 3.14e-05microM of 6-azathymine					92.7924 1.59 % 95.6
MCF7 perturbed by 1.66e-05microM of molsidomine					92.6737 0.77 % 95.95
PC3 perturbed by 1e-05microM of PHA-00745360					93.1614 1.09 % 96.04
PC3 perturbed by 1.4e-05microM of acacetin					92.5434 0.15 % 96.2
PC3 perturbed by 1.34e-05microM of sulfadimidine					91.5266 1.85 % 94.84
PC3 perturbed by 7e-06microM of cefotetan					92.4009 0.15 % 96.13
MCF7 perturbed by 1e-07microM of trichostatin A					93.2517 2.14 % 95.56
vehicle					93.7883 2.14 % 95.82
PC3 perturbed by 1.26e-05microM of amprolium					91.2733 0.16 % 95.56
PC3 perturbed by 8.6e-06microM of naftopidil					91.1583 0 % 95.58
PC3 perturbed by 1.6e-05microM of pyrimethamine					91.517 0 % 95.76
PC3 perturbed by 1.04e-05microM of benperidol					90.5507 0.97 % 94.79
PC3 perturbed by 1.08e-05microM of SR-95531					92.2457 0.01 % 96.12
vehicle					91.3955 1.58 % 94.91
HL60 perturbed by 9.6e-06microM of bretylium tosilate					91.5931 2.6 % 94.49
vehicle					90.9954 2.21 % 94.39
MCF7 perturbed by 8.6e-06microM of methylbenzethonium chloride					91.7764 1.57 % 95.1
MCF7 perturbed by 4.8e-06microM of spiramycin					92.4161 0.94 % 95.74
vehicle					92.3575 1.23 % 95.56
MCF7 perturbed by 8.6e-06microM of benfotiamine					92.4282 1.14 % 95.64
vehicle					92.836 1.38 % 95.73
MCF7 perturbed by 1.3e-05microM of pempidine					92.405 1.89 % 95.26
HL60 perturbed by 1.56e-05microM of procarbazine					91.6687 0.04 % 95.81
HL60 perturbed by 1.44e-05microM of oxamniquine					91.4826 9.98 % 90.75
vehicle					90.98 3.73 % 93.62
HL60 perturbed by 8.8e-06microM of cefalonium					90.9516 3.42 % 93.77
HL60 perturbed by 7.4e-06microM of apramycin					90.8922 3.71 % 93.59
HL60 perturbed by 1.4e-05microM of letrozole					90.8126 0.12 % 95.35
MCF7 perturbed by 1.2e-05microM of seneciphylline					90.7402 2.72 % 94.01
PC3 perturbed by 1.8e-05microM of mafenide					91.3482 1.06 % 95.14
vehicle					90.9235 0.65 % 95.14
PC3 perturbed by 9.6e-06microM of prenylamine					91.7942 0.01 % 95.89
PC3 perturbed by 8.4e-06microM of rilmenidine					92.2564 0.03 % 96.11
PC3 perturbed by 1e-05microM of CP-320650-01					90.692 0.09 % 95.3
PC3 perturbed by 1.14e-05microM of camptothecin					90.9125 1.82 % 94.55
PC3 perturbed by 3.92e-05microM of levcycloserine					92.3029 0.37 % 95.97
MCF7 perturbed by 1.84e-05microM of etilefrine					93.7274 0.03 % 96.85
MCF7 perturbed by 1.08e-05microM of bicuculline					93.7943 0.12 % 96.84
PC3 perturbed by 1.9e-05microM of methyldopa					92.8819 0 % 96.44
PC3 perturbed by 1e-07microM of trichostatin A					92.356 1.12 % 95.62
PC3 perturbed by 1e-07microM of trichostatin A					92.4258 0.04 % 96.19
PC3 perturbed by 8e-06microM of dipyridamole					92.6163 0 % 96.31
PC3 perturbed by 1.1e-05microM of naloxone					92.2587 3.53 % 94.36
PC3 perturbed by 8.6e-06microM of meclozine					93.3013 0.27 % 96.51
MCF7 perturbed by 5.8e-06microM of monensin					92.3373 0.05 % 96.14
MCF7 perturbed by 1e-05microM of 0179445-0000					91.4636 3.18 % 94.14
vehicle					92.1273 0.87 % 95.63
MCF7 perturbed by 9.8e-06microM of flumetasone					92.7968 0.03 % 96.38
MCF7 perturbed by 1.12e-05microM of griseofulvin					92.4578 0.02 % 96.22
PC3 perturbed by 1e-07microM of monorden					93.0325 3.15 % 94.94
PC3 perturbed by 1e-07microM of sirolimus					92.7117 0.41 % 96.15
PC3 perturbed by 2.22e-05microM of stachydrine					92.9028 2.77 % 95.07
vehicle					93.021 0.05 % 96.49
vehicle					92.0182 1.29 % 95.36
PC3 perturbed by 9.4e-06microM of benzbromarone					93.0289 0.03 % 96.5
vehicle					92.8599 0.02 % 96.42
PC3 perturbed by 1.5e-05microM of zidovudine					91.9666 0.57 % 95.7
PC3 perturbed by 6.4e-06microM of apomorphine					91.9649 0.52 % 95.72
MCF7 perturbed by 1.02e-05microM of raubasine					92.8913 0.94 % 95.98
MCF7 perturbed by 9.6e-06microM of coralyne					92.4701 0.21 % 96.13
vehicle					94.1322 0.08 % 97.03
vehicle					93.8476 0.2 % 96.83
MCF7 perturbed by 8.4e-06microM of metitepine					93.1821 0.52 % 96.33
vehicle					93.6626 0.76 % 96.45
MCF7 perturbed by 1.08e-05microM of dextromethorphan					93.8182 0.52 % 96.65
MCF7 perturbed by 1e-05microM of scopolamine N-oxide					93.3232 0 % 96.66
PC3 perturbed by 8e-06microM of glibenclamide					91.5683 0.39 % 95.59
vehicle					92.4682 0.94 % 95.76
MCF7 perturbed by 8.2e-06microM of prednicarbate					92.1451 2.72 % 94.71
vehicle					90.542 1.22 % 94.66
MCF7 perturbed by 1.42e-05microM of niflumic acid					92.6246 1.05 % 95.79
MCF7 perturbed by 2.42e-05microM of metformin					92.5752 2.69 % 94.94
vehicle					92.7004 0.39 % 96.15
MCF7 perturbed by 1.76e-05microM of resveratrol					92.7733 0.32 % 96.23
PC3 perturbed by 9.8e-06microM of sulfinpyrazone					92.7495 0.82 % 95.97
PC3 perturbed by 1.3e-05microM of butacaine					93.1217 0.4 % 96.36
PC3 perturbed by 1.52e-05microM of cinoxacin					93.4003 0.7 % 96.35
PC3 perturbed by 1.16e-05microM of clotrimazole					91.6538 0.21 % 95.72
PC3 perturbed by 1e-04microM of H-7					91.8642 0.93 % 95.47
PC3 perturbed by 1e-05microM of AG-013608					90.6806 2.81 % 93.94
PC3 perturbed by 1e-06microM of fulvestrant					92.4742 0.02 % 96.23
MCF7 perturbed by 1.78e-05microM of aciclovir					91.8198 0.09 % 95.86
MCF7 perturbed by 1.42e-05microM of guanfacine					91.6961 0.13 % 95.78
MCF7 perturbed by 1.24e-05microM of enoxacin					91.5729 1.59 % 94.99
MCF7 perturbed by 1.4e-05microM of alprenolol					91.324 4.01 % 93.66
MCF7 perturbed by 2.46e-05microM of anabasine					93.2666 0 % 96.63
MCF7 perturbed by 9.6e-06microM of cyproterone					92.9841 1.39 % 95.8
MCF7 perturbed by 7.6e-06microM of gliquidone					91.5105 0 % 95.76
MCF7 perturbed by 1.16e-05microM of nifedipine					93.5014 0 % 96.75
MCF7 perturbed by 1.5e-05microM of tremorine					93.7565 5 % 94.38
HL60 perturbed by 1e-05microM of haloperidol					88.847 4.35 % 92.25
HL60 perturbed by 2e-05microM of ronidazole					90.2057 3.75 % 93.23
PC3 perturbed by 1.18e-05microM of esculin					91.6255 3.21 % 94.21
PC3 perturbed by 1.72e-05microM of melatonin					91.1714 3.48 % 93.85
PC3 perturbed by 1.14e-05microM of ranitidine					91.6925 3.55 % 94.07
PC3 perturbed by 1e-06microM of trichostatin A					75.0892 4.96 % 85.07
MCF7 perturbed by 1e-05microM of PF-00562151-00					83.3916 2.06 % 90.67
MCF7 perturbed by 1e-05microM of SC-560					77.6466 2.7 % 87.48
MCF7 perturbed by 1e-05microM of 3-nitropropionic acid					93.6865 0.73 % 96.48
PC3 perturbed by 1e-05microM of PF-01378883-00					92.7238 0.04 % 96.34
MCF7 perturbed by 1e-05microM of F0447-0125					93.742 0.6 % 96.57
PC3 perturbed by 2e-05microM of erastin					93.2151 0.45 % 96.38
MCF7 perturbed by 1.6e-05microM of sulfapyridine					91.8445 0.15 % 95.85
MCF7 perturbed by 1.16e-05microM of Prestwick-665					92.9029 3.21 % 94.84
MCF7 perturbed by 8.6e-06microM of benfotiamine					93.4929 0.02 % 96.74
MCF7 perturbed by 1.18e-05microM of disopyramide					82.472 2.98 % 89.74
MCF7 perturbed by 1.24e-05microM of naftifine					81.301 2.57 % 89.37
MCF7 perturbed by 1.04e-05microM of etynodiol					91.5251 0.45 % 95.54
MCF7 perturbed by 1.08e-05microM of nomegestrol					92.7131 0.04 % 96.34
vehicle					90.1503 0.26 % 94.95
MCF7 perturbed by 1.34e-05microM of protriptyline					91.8283 0.01 % 95.91
MCF7 perturbed by 1.58e-05microM of chrysin					92.2692 1.97 % 95.15
vehicle					91.9088 3.68 % 94.12
PC3 perturbed by 1e-05microM of alprostadil					91.5676 3.32 % 94.12
PC3 perturbed by 1.64e-05microM of ribavirin					84.2313 0.59 % 91.82
PC3 perturbed by 1.58e-05microM of harmol					82.5271 4.29 % 89.12
PC3 perturbed by 1.8e-05microM of etamivan					81.0564 4.97 % 88.04
vehicle					75.7628 0.03 % 87.87
PC3 perturbed by 1.02e-05microM of oxybutynin					75.1148 1.89 % 86.61
MCF7 perturbed by 1.3e-05microM of sotalol					76.4255 1.26 % 87.58
MCF7 perturbed by 1.08e-05microM of etofenamate					74.6405 0.4 % 87.12
PC3 perturbed by 1.12e-05microM of griseofulvin					77.3288 1.63 % 87.85
PC3 perturbed by 1e-06microM of trichostatin A					75.6493 0.27 % 87.69
MCF7 perturbed by 1.08e-05microM of Prestwick-981					80.2392 0.11 % 90.07
vehicle					83.0828 5.51 % 88.79
MCF7 perturbed by 1e-05microM of CP-319743					78.8404 4.63 % 87.1