Connectivity Map Batch 02 Random Load - CMAP11

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	88.22 0.16 % 94.03
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-05microM of thioridazine					86.9406 1.08 % 92.93
HL60 perturbed by 1e-07microM of LY-294002					88.2189 0.33 % 93.94
PC3 perturbed by 1e-06microM of tanespimycin					90.333 0.05 % 95.14
HL60 perturbed by 0.001microM of valproic acid					87.3229 0.16 % 93.58
HL60 perturbed by 1e-06microM of fulvestrant					89.1419 0.12 % 94.51
MCF7 perturbed by 2.04e-05microM of tolazoline					93.0464 6.02 % 93.51
vehicle					93.357 0.05 % 96.65
MCF7 perturbed by 2.26e-05microM of cotinine					93.2452 0 % 96.62
MCF7 perturbed by 8.2e-06microM of verapamil					90.5574 1.59 % 94.48
MCF7 perturbed by 1.14e-05microM of camptothecin					91.4314 0.16 % 95.64
MCF7 perturbed by 1.58e-05microM of ketoprofen					92.6373 0.8 % 95.92
vehicle					93.1566 0 % 96.58
HL60 perturbed by 1.38e-05microM of etiocholanolone					91.1007 0.02 % 95.54
HL60 perturbed by 1.44e-05microM of sulfabenzamide					90.9899 0.17 % 95.41
HL60 perturbed by 9.6e-06microM of solasodine					89.1899 0.35 % 94.42
HL60 perturbed by 8.6e-06microM of clemastine					91.8598 0.04 % 95.91
HL60 perturbed by 9.8e-06microM of pergolide					91.3885 4.11 % 93.64
HL60 perturbed by 1.1e-05microM of fenofibrate					92.1865 0.1 % 96.04
HL60 perturbed by 1.26e-05microM of doxepin					92.2071 0.16 % 96.02
PC3 perturbed by 2.84e-05microM of ethosuximide					88.041 3.01 % 92.52
PC3 perturbed by 1.12e-05microM of aceclofenac					88.4349 1.99 % 93.22
PC3 perturbed by 1.02e-05microM of chlorphenamine					86.4242 9.76 % 88.33
vehicle					93.0749 0.55 % 96.26
HL60 perturbed by 9.6e-06microM of amantadine					88.1613 1.17 % 93.49
HL60 perturbed by 5.8e-06microM of meclocycline					89.693 4.01 % 92.84
HL60 perturbed by 9.4e-06microM of benzbromarone					89.8137 4.44 % 92.69
HL60 perturbed by 1e-07microM of trichostatin A					90.4407 1.25 % 94.6
HL60 perturbed by 1.48e-05microM of apigenin					89.0962 1.73 % 93.68
HL60 perturbed by 1.28e-05microM of amitriptyline					88.8208 0.03 % 94.39
PC3 perturbed by 1.58e-05microM of sulfacetamide					88.0022 1.48 % 93.26
HL60 perturbed by 1.58e-05microM of triamterene					87.0256 0.86 % 93.08
HL60 perturbed by 4.4e-06microM of amphotericin B					91.6194 0.02 % 95.8
HL60 perturbed by 3.24e-05microM of pyrazinamide					89.7521 0.32 % 94.71
HL60 perturbed by 8.4e-06microM of butoconazole					91.3723 0.13 % 95.62
HL60 perturbed by 1.64e-05microM of salsolidin					91.147 0.06 % 95.54
MCF7 perturbed by 2.36e-05microM of tranylcypromine					92.6574 0.02 % 96.32
HL60 perturbed by 1.1e-05microM of furaltadone					90.8546 0.51 % 95.17
HL60 perturbed by 8.2e-06microM of flunixin					90.7673 14.6 % 88.09
MCF7 perturbed by 8.4e-06microM of isopropamide iodide					89.5363 0.27 % 94.63
MCF7 perturbed by 1.16e-05microM of medrysone					91.6004 0.01 % 95.8
MCF7 perturbed by 1.4e-05microM of kaempferol					90.8277 3.35 % 93.74
MCF7 perturbed by 4.2e-06microM of asiaticoside					90.9593 1.84 % 94.56
MCF7 perturbed by 1.38e-05microM of proguanil					91.7153 3.78 % 93.97
HL60 perturbed by 1e-06microM of trichostatin A					90.7501 2 % 94.37
HL60 perturbed by 2.14e-05microM of amrinone					91.2446 0.81 % 95.22
HL60 perturbed by 1e-06microM of nordihydroguaiaretic acid					91.0186 2.25 % 94.38
HL60 perturbed by 1e-07microM of alvespimycin					89.7675 0.06 % 94.85
HL60 perturbed by 1e-06microM of fulvestrant					90.6905 0.01 % 95.34
MCF7 perturbed by 9.6e-06microM of amantadine					88.6008 0.02 % 94.29
MCF7 perturbed by 1.18e-05microM of hexetidine					89.3402 1.14 % 94.1
MCF7 perturbed by 4.4e-06microM of amphotericin B					91.2237 0 % 95.61
MCF7 perturbed by 1.18e-05microM of danazol					90.7693 8.33 % 91.22
MCF7 perturbed by 7.8e-06microM of flupentixol					92.0685 6.11 % 92.98
MCF7 perturbed by 5.4e-06microM of erythromycin					93.1723 2.12 % 95.53
PC3 perturbed by 7.8e-06microM of gossypol					90.0887 0.52 % 94.78
PC3 perturbed by 1.86e-05microM of mexiletine					90.6429 2.29 % 94.18
PC3 perturbed by 1.66e-05microM of phenformin					90.7988 0.92 % 94.94
PC3 perturbed by 1.24e-05microM of promazine					90.7482 2.74 % 94
PC3 perturbed by 2.52e-05microM of citiolone					89.6732 2.56 % 93.56
MCF7 perturbed by 1.1e-05microM of cloperastine					88.2572 1.77 % 93.24
vehicle					88.4205 0.89 % 93.76
MCF7 perturbed by 9e-06microM of folic acid					90.4344 0.31 % 95.06
MCF7 perturbed by 1.54e-05microM of salsolinol					91.7846 0.01 % 95.89
MCF7 perturbed by 1e-07microM of estradiol					92.6003 0.06 % 96.27
MCF7 perturbed by 0.001microM of valproic acid					92.7574 0.51 % 96.13
MCF7 perturbed by 6e-06microM of cephaeline					91.7089 0.66 % 95.53
MCF7 perturbed by 1e-06microM of tanespimycin					91.9636 0.5 % 95.73
MCF7 perturbed by 7e-06microM of daunorubicin					90.464 2.58 % 93.94
MCF7 perturbed by 1.28e-05microM of maprotiline					92.0175 0.18 % 95.92
MCF7 perturbed by 1.06e-05microM of eticlopride					92.1588 0.12 % 96.02
MCF7 perturbed by 1.22e-05microM of chloropyramine					92.8913 1.26 % 95.81
MCF7 perturbed by 1.38e-05microM of (+/-)-catechin					93.0121 0.03 % 96.49
MCF7 perturbed by 1.56e-05microM of ganciclovir					92.8529 0 % 96.42
vehicle					92.2231 0.5 % 95.86
vehicle					92.6064 0.17 % 96.22
MCF7 perturbed by 3.5e-05microM of Prestwick-864					92.5949 0 % 96.3
MCF7 perturbed by 7.2e-06microM of cefsulodin					91.5747 1.07 % 95.25
MCF7 perturbed by 1.28e-05microM of ethisterone					90.8668 1.62 % 94.62
PC3 perturbed by 7.8e-06microM of gossypol					90.548 0 % 95.27
PC3 perturbed by 1.06e-05microM of Prestwick-685					91.8747 3.27 % 94.3
PC3 perturbed by 2.2e-05microM of mephenesin					91.5396 0.01 % 95.76
PC3 perturbed by 1.1e-05microM of clemizole					91.3655 0.01 % 95.68
PC3 perturbed by 9.8e-06microM of flumetasone					91.9071 0 % 95.95
HL60 perturbed by 1.22e-05microM of desoxycortone					91.031 3.14 % 93.95
HL60 perturbed by 1.3e-05microM of nisoxetine					91.5125 0.02 % 95.75
HL60 perturbed by 1.5e-05microM of (-)-atenolol					90.9894 0.47 % 95.26
vehicle					91.9811 1 % 95.49
PC3 perturbed by 9.4e-06microM of bendroflumethiazide					92.241 0.66 % 95.79
PC3 perturbed by 4.2e-06microM of benzathine benzylpenicillin					90.8161 0.49 % 95.16
PC3 perturbed by 1.24e-05microM of gelsemine					89.7298 0.36 % 94.69
PC3 perturbed by 9.8e-06microM of thioridazine					91.401 0.05 % 95.68
PC3 perturbed by 9.6e-06microM of sitosterol					91.343 1.22 % 95.06
PC3 perturbed by 1.34e-05microM of ticlopidine					92.6467 4.53 % 94.06
PC3 perturbed by 1.16e-05microM of cinchocaine					91.6779 5.08 % 93.3
PC3 perturbed by 5e-06microM of troleandomycin					90.9481 0.05 % 95.45
vehicle					90.7938 0.64 % 95.08
vehicle					92.4901 2.12 % 95.18
MCF7 perturbed by 7.8e-06microM of mepacrine					92.9242 4.81 % 94.06
PC3 perturbed by 1.42e-05microM of hydroxyachillin					90.6189 0.27 % 95.17
PC3 perturbed by 6.6e-06microM of reserpine					91.4995 0.43 % 95.54
HL60 perturbed by 2.28e-05microM of hymecromone					91.4449 5.38 % 93.03
vehicle					91.7289 0.19 % 95.77
HL60 perturbed by 9.2e-06microM of benzthiazide					91.7654 3.16 % 94.3
vehicle					91.6827 2.53 % 94.57
MCF7 perturbed by 9.4e-06microM of fludrocortisone					90.7823 0.18 % 95.3
MCF7 perturbed by 1e-06microM of paroxetine					91.8806 0.17 % 95.85
MCF7 perturbed by 1.24e-05microM of lycorine					91.3173 1.28 % 95.02
MCF7 perturbed by 7.4e-06microM of piperacillin					91.3864 1.77 % 94.81
vehicle					91.9215 0.74 % 95.59
HL60 perturbed by 9.2e-06microM of fluvoxamine					90.8418 3.08 % 93.88
vehicle					89.7857 0.01 % 94.89
MCF7 perturbed by 9e-06microM of propantheline bromide					92.4381 1.8 % 95.32
MCF7 perturbed by 8.6e-06microM of oxetacaine					92.5765 1.94 % 95.32
PC3 perturbed by 1.62e-05microM of dapsone					90.7288 3.48 % 93.62
PC3 perturbed by 1.66e-05microM of mefenamic acid					89.3701 2.35 % 93.51
PC3 perturbed by 1.1e-05microM of prednisolone					90.3147 2.2 % 94.06
PC3 perturbed by 1.18e-05microM of trimetazidine					91.1506 1.21 % 94.97
PC3 perturbed by 2.82e-05microM of piracetam					89.7664 1.11 % 94.33
vehicle					91.7956 0.12 % 95.84
vehicle					91.3127 0.65 % 95.33
PC3 perturbed by 1.82e-05microM of harman					91.7499 0.58 % 95.59
PC3 perturbed by 1.48e-05microM of apigenin					90.974 0.22 % 95.38
MCF7 perturbed by 1.46e-05microM of naringenin					92.1909 0.03 % 96.08
MCF7 perturbed by 9.2e-06microM of vitexin					93.3642 0.02 % 96.67
MCF7 perturbed by 1.22e-05microM of pramocaine					92.4206 0 % 96.21
MCF7 perturbed by 1.16e-05microM of dicycloverine					90.6688 0.64 % 95.02
PC3 perturbed by 7.6e-06microM of vanoxerine					92.384 0.28 % 96.05
PC3 perturbed by 3.5e-05microM of Prestwick-860					91.7963 1.25 % 95.27
PC3 perturbed by 7e-06microM of latamoxef					91.8897 1.36 % 95.26
MCF7 perturbed by 9e-06microM of levomepromazine					92.2302 0.74 % 95.74
MCF7 perturbed by 1.08e-05microM of finasteride					91.9492 0.25 % 95.85
MCF7 perturbed by 1.56e-05microM of prilocaine					90.5621 2.02 % 94.27
MCF7 perturbed by 8.8e-06microM of halcinonide					91.3899 0.17 % 95.61
MCF7 perturbed by 1.58e-05microM of fenbufen					90.841 0.66 % 95.09
PC3 perturbed by 1.04e-05microM of palmatine					92.2033 0.04 % 96.08
PC3 perturbed by 2e-05microM of monobenzone					91.2734 0.14 % 95.57
PC3 perturbed by 8.6e-06microM of cisapride					92.2206 0 % 96.11
PC3 perturbed by 1.48e-05microM of zaprinast					92.5744 0.2 % 96.19
vehicle					91.8052 0.17 % 95.82
vehicle					92.7547 0.29 % 96.23
MCF7 perturbed by 8.4e-06microM of tribenoside					91.7121 0 % 95.86
PC3 perturbed by 9e-06microM of quipazine					91.1473 6.47 % 92.34
PC3 perturbed by 2.34e-05microM of gabapentin					91.456 2.46 % 94.5
PC3 perturbed by 9.8e-06microM of strophanthidin					91.1189 0.05 % 95.53
PC3 perturbed by 1e-05microM of mepyramine					91.7344 0.3 % 95.72
PC3 perturbed by 8.6e-06microM of clindamycin					91.4834 0.01 % 95.74
PC3 perturbed by 1.26e-05microM of diclofenac					90.4397 1.28 % 94.58
MCF7 perturbed by 1.22e-05microM of scoulerine					92.307 1.75 % 95.28
MCF7 perturbed by 1.58e-05microM of diprophylline					92.4275 1.32 % 95.55
MCF7 perturbed by 1e-06microM of tanespimycin					92.5205 0.81 % 95.85
MCF7 perturbed by 1e-06microM of rotenone					93.0081 0.45 % 96.28
MCF7 perturbed by 1e-06microM of trichostatin A					92.8335 0.26 % 96.29
MCF7 perturbed by 1e-07microM of monorden					92.6063 0.01 % 96.3
MCF7 perturbed by 1e-06microM of tanespimycin					92.3077 1.19 % 95.56
MCF7 perturbed by 1.44e-05microM of azathioprine					92.8095 0.19 % 96.31
MCF7 perturbed by 1e-07microM of sirolimus					90.8707 0.18 % 95.34
MCF7 perturbed by 1e-07microM of LY-294002					91.5762 0.37 % 95.6
MCF7 perturbed by 8e-06microM of dipyridamole					92.7515 0.01 % 96.37
MCF7 perturbed by 8.4e-06microM of lorglumide					92.7615 0.42 % 96.17
vehicle					91.1011 0.19 % 95.46
MCF7 perturbed by 5.8e-06microM of metoprolol					90.4316 0.51 % 94.96
MCF7 perturbed by 9.8e-06microM of carbinoxamine					91.2882 1.62 % 94.83
vehicle					92.3728 0.92 % 95.73
MCF7 perturbed by 8.4e-06microM of pivmecillinam					92.3766 0 % 96.19
MCF7 perturbed by 7.2e-06microM of terbutaline					92.8714 7.41 % 92.73
MCF7 perturbed by 1.48e-05microM of hexestrol					93.3729 0.83 % 96.27
vehicle					88.5163 4.6 % 91.96
HL60 perturbed by 9.8e-06microM of piperacetazine					89.716 3.49 % 93.11
vehicle					88.38 0.65 % 93.87
PC3 perturbed by 1.34e-05microM of oxymetazoline					90.2378 3.75 % 93.24
PC3 perturbed by 1.1e-05microM of nitrendipine					90.6939 3.36 % 93.66
vehicle					91.5497 3.67 % 93.94
PC3 perturbed by 8e-06microM of chlorhexidine					90.7598 3.29 % 93.73
MCF7 perturbed by 1e-06microM of AH-23848					77.971 3.75 % 87.11
MCF7 perturbed by 3.8e-05microM of BAS-012416453					77.51 1.72 % 87.89
PC3 perturbed by 1e-05microM of AG-012559					78.411 1.27 % 88.57
MCF7 perturbed by 1.42e-05microM of ramifenazone					92.423 2.19 % 95.12
MCF7 perturbed by 1.24e-05microM of sulfaquinoxaline					91.4917 0.29 % 95.6
MCF7 perturbed by 9.6e-06microM of mepenzolate bromide					91.5844 0 % 95.79
MCF7 perturbed by 7.8e-06microM of eldeline					92.3861 0.01 % 96.19
MCF7 perturbed by 1e-06microM of chlorpromazine					80.2113 1.31 % 89.45
MCF7 perturbed by 1.26e-05microM of moxisylyte					80.3218 2.48 % 88.92
MCF7 perturbed by 9.8e-06microM of remoxipride					91.2964 3.04 % 94.13
MCF7 perturbed by 2.04e-05microM of meglumine					90.6262 0.06 % 95.28
vehicle					90.5124 0.02 % 95.25
PC3 perturbed by 1e-05microM of AG-028671					90.4946 4.18 % 93.16
MCF7 perturbed by 1.26e-05microM of diclofenac					80.7811 1.92 % 89.43
PC3 perturbed by 8.6e-06microM of moracizine					79.6724 3.11 % 88.28
PC3 perturbed by 8.4e-06microM of flunarizine					81.5193 2.48 % 89.52
PC3 perturbed by 1.28e-05microM of triprolidine					84.3629 0.64 % 91.86
vehicle					80.403 3.05 % 88.67
MCF7 perturbed by 1.66e-05microM of moxonidine					73.6036 2.78 % 85.41
MCF7 perturbed by 1.44e-05microM of oxamniquine					76.719 0.81 % 87.96
PC3 perturbed by 1e-05microM of Prestwick-675					76.4633 0.28 % 88.09
PC3 perturbed by 7.4e-06microM of pentolonium					75.1163 3.97 % 85.57
vehicle					76.8992 0.43 % 88.24
MCF7 perturbed by 1.24e-05microM of acetohexamide					81.9054 0 % 90.95
MCF7 perturbed by 1.7e-05microM of dropropizine					80.8798 0.44 % 90.22
MCF7 perturbed by 7.4e-06microM of halofantrine					83.4428 0 % 91.72
MCF7 perturbed by 1.34e-05microM of norethisterone					78.0586 3.19 % 87.43
MCF7 perturbed by 1e-05microM of CP-645525-01					80.5662 4.19 % 88.19