Connectivity Map Batch 02 Random Load - CMAP10

From ArrayWiki

PubMed ID:	17008526
Contact:	Justin Lamb Broad Institute of MIT and Harvard
Species:	homo sapiens (cell lines)
Platform:	HT_HG-U133A
Number of Samples:	201
Date Range:	12/31/1969 - 12/31/1969
Experiment Quality:	86.98 2.59 % 92.2
Link to Repository:
Original Intensity Data:	Download
Clean Intensity Data:	Download
Original PLIER Data:	Download
Clean PLIER Data:	Download
Clean CEL Files:	Download
Data Rank:

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this 'Connectivity Map' resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Contents 1 Contributors 2 Protocols 3 References 4 Links 5 Analysis 6 Samples/Quality Control

[edit] Contributors

[edit] Protocols

[edit] References

[edit] Links

[edit] Analysis

Gel Plots

Before Normalization

After Normalization & Cleaning

[edit] Samples/Quality Control

Sample	Date Scanned	Source Link	Probe Variance Data	Artifact Mask	Quality Score
HL60 perturbed by 1e-05microM of fluphenazine					86.9522 2.55 % 92.2
HL60 perturbed by 1e-07microM of sirolimus					86.9845 2.06 % 92.46
MCF7 perturbed by 1.92e-05microM of moroxydine					93.0686 0.39 % 96.34
MCF7 perturbed by 1.08e-05microM of minaprine					92.6292 2.59 % 95.02
MCF7 perturbed by 1.12e-05microM of vincamine					93.0176 0.01 % 96.51
MCF7 perturbed by 1.68e-05microM of salbutamol					92.427 0.21 % 96.11
HL60 perturbed by 1.36e-05microM of canavanine					91.4905 0.03 % 95.73
vehicle					90.8766 0.04 % 95.42
HL60 perturbed by 1.34e-05microM of fenbendazole					90.8123 3.92 % 93.45
HL60 perturbed by 1.42e-05microM of niflumic acid					91.4066 1.02 % 95.19
HL60 perturbed by 1.04e-05microM of fenoterol					91.6748 0.04 % 95.82
vehicle					91.725 0.01 % 95.86
PC3 perturbed by 1.8e-05microM of mafenide					88.6686 3.26 % 92.7
PC3 perturbed by 1.52e-05microM of tolfenamic acid					86.6646 3.6 % 91.53
PC3 perturbed by 2.8e-06microM of dihydrostreptomycin					88.5352 2.64 % 92.95
PC3 perturbed by 1.62e-05microM of pindolol					87.4682 2.51 % 92.48
MCF7 perturbed by 1e-05microM of fluphenazine					93.0688 0.14 % 96.47
MCF7 perturbed by 1e-05microM of LY-294002					92.7482 0 % 96.37
HL60 perturbed by 1.7e-05microM of arecoline					90.212 1.32 % 94.44
HL60 perturbed by 9.6e-06microM of coralyne					90.0716 1.45 % 94.31
HL60 perturbed by 8e-06microM of bacampicillin					89.8553 1.93 % 93.96
HL60 perturbed by 1.06e-05microM of digitoxigenin					89.9279 0.64 % 94.65
HL60 perturbed by 1.22e-05microM of clozapine					90.5621 1.95 % 94.31
HL60 perturbed by 5.8e-06microM of pepstatin					90.2902 1.26 % 94.52
PC3 perturbed by 3.2e-06microM of atracurium besilate					89.6682 1.49 % 94.09
HL60 perturbed by 1.02e-05microM of triflupromazine					84.3084 9.81 % 87.25
vehicle					89.2419 0.91 % 94.16
HL60 perturbed by 1.14e-05microM of biperiden					90.3318 1.64 % 94.35
vehicle					90.2369 1.57 % 94.33
HL60 perturbed by 8.6e-06microM of glycocholic acid					89.4665 0.22 % 94.62
vehicle					89.2297 0.16 % 94.53
vehicle					90.6106 0.12 % 95.25
HL60 perturbed by 1.72e-05microM of betahistine					89.9555 0.42 % 94.77
MCF7 perturbed by 9.2e-06microM of aztreonam					92.9466 2.65 % 95.15
MCF7 perturbed by 1.78e-05microM of etofylline					91.8969 0.89 % 95.5
HL60 perturbed by 1.76e-05microM of trioxysalen					90.9526 0.81 % 95.07
vehicle					92.82 0.68 % 96.07
MCF7 perturbed by 1.14e-05microM of chlorprothixene					91.6776 2.28 % 94.7
MCF7 perturbed by 1.28e-05microM of sulfadimethoxine					90.9882 0.01 % 95.49
MCF7 perturbed by 9.4e-06microM of bendroflumethiazide					89.3862 0.01 % 94.69
MCF7 perturbed by 1.36e-05microM of meclofenoxate					91.0764 0 % 95.54
MCF7 perturbed by 7.2e-06microM of ribostamycin					92.2003 1.42 % 95.39
vehicle					90.5577 4.18 % 93.19
MCF7 perturbed by 1.12e-05microM of piperidolate					90.1079 4.23 % 92.94
HL60 perturbed by 8.4e-06microM of isopropamide iodide					89.9345 0.06 % 94.94
MCF7 perturbed by 4.8e-06microM of iohexol					90.8343 0 % 95.42
vehicle					91.459 0.01 % 95.73
vehicle					89.0221 0.13 % 94.45
MCF7 perturbed by 1.86e-05microM of niridazole					89.6668 0.03 % 94.82
MCF7 perturbed by 5.2e-06microM of levothyroxine sodium					91.0753 0.01 % 95.53
MCF7 perturbed by 2.24e-05microM of fusaric acid					90.1219 3.23 % 93.45
MCF7 perturbed by 1.24e-05microM of promethazine					91.1423 7.75 % 91.7
MCF7 perturbed by 1.32e-05microM of diclofenamide					92.6813 0.74 % 95.97
PC3 perturbed by 1.12e-05microM of benzamil					89.5566 4.42 % 92.57
MCF7 perturbed by 1.18e-05microM of metoclopramide					87.9799 2.17 % 92.9
MCF7 perturbed by 8.4e-06microM of Prestwick-664					88.3897 1.25 % 93.57
MCF7 perturbed by 1.42e-05microM of sulfamethoxypyridazine					86.8485 2.18 % 92.34
MCF7 perturbed by 7.2e-06microM of fenoprofen					86.398 0.54 % 92.93
MCF7 perturbed by 1.18e-05microM of canadine					90.1023 0 % 95.05
MCF7 perturbed by 1.24e-05microM of gelsemine					88.2266 4.27 % 91.98
MCF7 perturbed by 8.2e-06microM of glimepiride					90.5203 2.44 % 94.04
MCF7 perturbed by 1.32e-05microM of hydrocotarnine					90.3139 2.65 % 93.83
MCF7 perturbed by 7.2e-06microM of emetine					89.7543 3.88 % 92.94
MCF7 perturbed by 1.04e-05microM of dipivefrine					89.4215 0 % 94.71
MCF7 perturbed by 1.78e-05microM of aciclovir					91.5489 1.76 % 94.89
MCF7 perturbed by 1.02e-05microM of digoxigenin					90.9129 0.16 % 95.37
MCF7 perturbed by 1e-05microM of vorinostat					92.1319 0.26 % 95.94
MCF7 perturbed by 1.1e-05microM of cefalexin					92.3739 1.34 % 95.52
MCF7 perturbed by 1.54e-05microM of khellin					91.1747 1.48 % 94.85
MCF7 perturbed by 5e-06microM of protoveratrine A					90.7632 6.37 % 92.2
MCF7 perturbed by 1.58e-05microM of lysergol					92.0664 1.42 % 95.32
vehicle					91.0279 0.07 % 95.48
MCF7 perturbed by 2.32e-05microM of 2-aminobenzenesulfonamide					91.1164 0.17 % 95.47
vehicle					92.4032 0.04 % 96.18
MCF7 perturbed by 9.6e-06microM of simvastatin					92.7939 0.43 % 96.18
MCF7 perturbed by 8.8e-06microM of nafcillin					90.5633 0.97 % 94.8
MCF7 perturbed by 5e-06microM of ioversol					90.3109 0.01 % 95.15
MCF7 perturbed by 1.1e-05microM of cefadroxil					91.7624 0.8 % 95.48
PC3 perturbed by 1e-06microM of 0179445-0000					87.5681 0.18 % 93.69
PC3 perturbed by 1.58e-05microM of fenbufen					90.4982 0.08 % 95.21
HL60 perturbed by 2.08e-05microM of scopoletin					90.9578 0.28 % 95.34
HL60 perturbed by 1.3e-05microM of clioquinol					90.7237 0.27 % 95.23
MCF7 perturbed by 2.6e-06microM of vancomycin					91.1382 0.9 % 95.12
MCF7 perturbed by 8.6e-06microM of tobramycin					90.0822 2.05 % 94.02
MCF7 perturbed by 1.16e-05microM of omeprazole					91.7146 0.42 % 95.65
PC3 perturbed by 1.06e-05microM of indapamide					91.1983 0.58 % 95.31
PC3 perturbed by 1e-06microM of citalopram					91.5301 0.68 % 95.42
vehicle					90.5841 0.7 % 94.94
vehicle					88.0222 0.7 % 93.66
vehicle					91.5813 0.56 % 95.51
PC3 perturbed by 2.8e-06microM of sisomicin					91.2349 0.52 % 95.36
PC3 perturbed by 7.2e-06microM of cefsulodin					90.6605 1.66 % 94.5
vehicle					89.2818 0 % 94.64
vehicle					92.6544 2.12 % 95.27
PC3 perturbed by 1.06e-05microM of digitoxigenin					90.6544 9.49 % 90.58
PC3 perturbed by 1.18e-05microM of scopolamine					90.955 12.13 % 89.41
vehicle					90.888 1.45 % 94.72
PC3 perturbed by 1.12e-05microM of conessine					91.1151 1.4 % 94.86
PC3 perturbed by 4.8e-06microM of roxithromycin					90.8957 2.13 % 94.38
HL60 perturbed by 1.22e-05microM of levobunolol					90.3232 4.74 % 92.79
HL60 perturbed by 1.06e-05microM of eticlopride					90.7431 9.44 % 90.65
HL60 perturbed by 9.2e-06microM of oxolamine					91.1034 7.59 % 91.76
HL60 perturbed by 1.18e-05microM of amiprilose					91.0601 3.88 % 93.59
HL60 perturbed by 1e-05microM of phthalylsulfathiazole					90.2265 6.6 % 91.81
MCF7 perturbed by 1e-06microM of CP-690334-01					91.1608 0.52 % 95.32
HL60 perturbed by 1.46e-05microM of methyldopate					89.6174 4.46 % 92.58
vehicle					91.0224 0.03 % 95.5
HL60 perturbed by 1.74e-05microM of tocainide					90.9362 0.03 % 95.45
HL60 perturbed by 1.4e-05microM of nifurtimox					91.3851 0.04 % 95.67
MCF7 perturbed by 1.3e-05microM of tolnaftate					91.0043 2.36 % 94.32
MCF7 perturbed by 1.38e-05microM of (+/-)-catechin					90.4975 3.02 % 93.74
vehicle					91.2996 1.86 % 94.72
PC3 perturbed by 1e-07microM of trichostatin A					89.4007 4.77 % 92.31
PC3 perturbed by 1.3e-05microM of nisoxetine					90.4022 2.56 % 93.92
MCF7 perturbed by 1e-06microM of spiradoline					89.9463 0.39 % 94.78
vehicle					91.9179 0.16 % 95.88
MCF7 perturbed by 7.6e-06microM of terconazole					92.3142 0 % 96.16
PC3 perturbed by 1.02e-05microM of digoxigenin					91.2347 0.36 % 95.44
PC3 perturbed by 1.02e-05microM of pentetic acid					91.8278 1.13 % 95.35
vehicle					91.7675 1.08 % 95.34
vehicle					90.4604 1.72 % 94.37
MCF7 perturbed by 1.72e-05microM of isocarboxazid					91.9416 0.63 % 95.65
PC3 perturbed by 1.4e-05microM of luteolin					91.7069 2.05 % 94.83
PC3 perturbed by 1.4e-05microM of nifurtimox					90.863 0.07 % 95.4
PC3 perturbed by 1.28e-05microM of amoxapine					92.0464 0.01 % 96.02
PC3 perturbed by 1.14e-05microM of retrorsine					90.9195 1.65 % 94.64
vehicle					90.9729 1.52 % 94.73
vehicle					90.3664 2.13 % 94.12
MCF7 perturbed by 2.24e-05microM of ascorbic acid					93.0434 1.39 % 95.83
MCF7 perturbed by 7e-06microM of iopanoic acid					92.1108 0.56 % 95.78
MCF7 perturbed by 1.66e-05microM of molsidomine					91.7384 0.49 % 95.62
PC3 perturbed by 8.4e-06microM of doxycycline					90.8448 2.13 % 94.36
PC3 perturbed by 9.4e-06microM of mifepristone					90.9324 0.63 % 95.15
vehicle					90.8396 0.95 % 94.95
PC3 perturbed by 4.6e-06microM of ivermectin					88.3999 0.68 % 93.86
MCF7 perturbed by 7.6e-06microM of mometasone					91.2258 1.55 % 94.84
MCF7 perturbed by 1.24e-05microM of pirlindole					91.7328 1.36 % 95.19
MCF7 perturbed by 1.7e-05microM of dropropizine					91.5949 0.42 % 95.59
MCF7 perturbed by 1.14e-05microM of torasemide					91.9343 1.09 % 95.42
PC3 perturbed by 1.32e-05microM of etacrynic acid					91.4935 1.57 % 94.96
PC3 perturbed by 1.76e-05microM of trioxysalen					91.6918 2.51 % 94.59
PC3 perturbed by 1.5e-05microM of dienestrol					90.7527 0.95 % 94.9
MCF7 perturbed by 1e-07microM of sirolimus					91.7771 0.79 % 95.49
MCF7 perturbed by 1e-05microM of genistein					89.7558 0.41 % 94.67
MCF7 perturbed by 1.06e-05microM of haloperidol					90.8897 1.64 % 94.62
MCF7 perturbed by 1e-05microM of haloperidol					89.9372 2.47 % 93.73
MCF7 perturbed by 1e-07microM of sirolimus					91.5292 0.02 % 95.75
vehicle					90.4825 1.5 % 94.49
MCF7 perturbed by 1.02e-05microM of yohimbine					91.0389 2.57 % 94.23
MCF7 perturbed by 1.12e-05microM of piperidolate					90.8827 3.95 % 93.46
MCF7 perturbed by 2.8e-06microM of netilmicin					91.6215 1.17 % 95.23
MCF7 perturbed by 1.46e-05microM of meticrane					91.8597 0 % 95.93
MCF7 perturbed by 1.04e-05microM of racecadotril					92.1281 3.04 % 94.55
MCF7 perturbed by 8.4e-06microM of tetracycline					93.2836 0.15 % 96.56
MCF7 perturbed by 9.2e-06microM of dexamethasone					93.1457 2.74 % 95.2
HL60 perturbed by 1e-05microM of LY-294002					89.0658 3.25 % 92.91
HL60 perturbed by 1e-07microM of monorden					88.8028 4.76 % 92.02
HL60 perturbed by 0.001microM of valproic acid					89.1934 3.96 % 92.62
HL60 perturbed by 6e-06microM of natamycin					88.6263 4.15 % 92.24
PC3 perturbed by 1.2e-05microM of nizatidine					90.3259 4.08 % 93.12
PC3 perturbed by 1.08e-05microM of isradipine					89.9927 4.49 % 92.75
PC3 perturbed by 7.8e-06microM of nicardipine					90.5365 5.08 % 92.73
MCF7 perturbed by 1e-05microM of NS-398					78.0427 2.31 % 87.86
MCF7 perturbed by 1e-05microM of pioglitazone					79.2625 2.7 % 88.28
MCF7 perturbed by 1e-06microM of SB-203580					79.7035 2.22 % 88.74
MCF7 perturbed by 1e-06microM of trichostatin A					83.5263 2.71 % 90.41
MCF7 perturbed by 1e-05microM of F0447-0125					92.899 0 % 96.45
PC3 perturbed by 1e-05microM of 0225151-0000					92.3134 0 % 96.16
MCF7 perturbed by 1.4e-05microM of sulfachlorpyridazine					92.2013 0.16 % 96.02
MCF7 perturbed by 9.8e-06microM of strophanthidin					92.3366 0.05 % 96.14
MCF7 perturbed by 9.2e-06microM of fludroxycortide					91.7939 0 % 95.9
MCF7 perturbed by 1e-07microM of monorden					83.6034 1.84 % 90.88
MCF7 perturbed by 9.6e-06microM of nimodipine					92.0984 0.28 % 95.91
vehicle					92.1523 0.17 % 95.99
MCF7 perturbed by 1.18e-05microM of (-)-MK-801					91.3849 0.29 % 95.55
MCF7 perturbed by 9e-06microM of denatonium benzoate					92.185 0.07 % 96.06
MCF7 perturbed by 1.76e-05microM of metyrapone					91.7646 1.83 % 94.97
MCF7 perturbed by 1e-08microM of estradiol					84.0585 1.86 % 91.1
vehicle					80.8102 4.7 % 88.06
MCF7 perturbed by 1e-07microM of sirolimus					81.7457 3.06 % 89.34
MCF7 perturbed by 1e-07microM of LY-294002					84.5087 2.43 % 91.04
vehicle					86.2111 5.13 % 90.54
MCF7 perturbed by 1.02e-05microM of triamcinolone					83.8152 1.23 % 91.29
MCF7 perturbed by 2.8e-06microM of streptomycin					85.3809 0.59 % 92.4
MCF7 perturbed by 1.02e-05microM of pridinol					80.9379 2.36 % 89.29
PC3 perturbed by 1.54e-05microM of thalidomide					80.2351 1.67 % 89.28
PC3 perturbed by 1.36e-05microM of vinburnine					78.5021 0.13 % 89.18
PC3 perturbed by 9.6e-06microM of ramipril					76.3255 3.9 % 86.21
PC3 perturbed by 2e-05microM of ronidazole					75.014 1.6 % 86.71
PC3 perturbed by 7.2e-06microM of ribostamycin					76.7602 2.53 % 87.12
vehicle					77.4978 0.05 % 88.73
PC3 perturbed by 1e-06microM of PNU-0251126					74.9203 2.57 % 86.17
MCF7 perturbed by 1.3e-05microM of epitiostanol					76.0349 0.21 % 87.91
MCF7 perturbed by 1.4e-05microM of nifurtimox					76.2284 1.1 % 87.57
PC3 perturbed by 1.48e-05microM of riluzole					76.6025 0.66 % 87.97
MCF7 perturbed by 1e-06microM of fulvestrant					76.5668 0.06 % 88.25
MCF7 perturbed by 3.2e-06microM of ioxaglic acid					79.1787 0.43 % 89.38
MCF7 perturbed by 1.02e-05microM of diethylcarbamazine					81.3532 5.36 % 88
MCF7 perturbed by 1.72e-05microM of aminoglutethimide					80.4607 0.62 % 89.92
MCF7 perturbed by 1.2e-05microM of piroxicam					84.1949 0.36 % 91.92
MCF7 perturbed by 1e-05microM of suramin sodium					79.3005 5.51 % 86.89